F Lanza

Summary

Country: France

Publications

  1. ncbi A Leu7Pro mutation in the signal peptide of platelet glycoprotein (GP)IX in a case of Bernard-Soulier syndrome abolishes surface expression of the GPIb-V-IX complex
    Francois Lanza
    INSERM U 311, Etablissement Francais du Sang Alsace, Strasbourg, France
    Br J Haematol 118:260-6. 2002
  2. ncbi Bernard-Soulier syndrome (hemorrhagiparous thrombocytic dystrophy)
    Francois Lanza
    EFS Alsace, Strasbourg, France
    Orphanet J Rare Dis 1:46. 2006
  3. ncbi [Murine models of platelet diseases]
    F Lanza
    INSERM U 311, EFS Alsace, 10 rue Spielmann, 67065 Strasbourg, France
    Transfus Clin Biol 14:35-40. 2007
  4. ncbi GPV is a marker of in vivo platelet activation--study in a rat thrombosis model
    C Ravanat
    INSERM U 311, Biologie et Pharmacologie de l Hémostase et de la Thrombose, Etablissement de Transfusion Sanguine de Strasbourg, France
    Thromb Haemost 83:327-33. 2000
  5. ncbi Inhibition of adhesive and signaling functions of the platelet GPIb-V-IX complex by a cell penetrating GPIbalpha peptide
    T David
    INSERM U311, Strasbourg EFS Alsace, Strasbourg, France
    J Thromb Haemost 4:2645-55. 2006
  6. ncbi Decreased thrombotic tendency in mouse models of the Bernard-Soulier syndrome
    C Strassel
    INSERM U 311, Etablissement Francais du Sang Alsace, 10 rue Spielmann, BP 36, 67065 Strasbourg Cedex, France
    Arterioscler Thromb Vasc Biol 27:241-7. 2007
  7. ncbi Synthesis of GPIb beta with novel transmembrane and cytoplasmic sequences in a Bernard-Soulier patient resulting in GPIb-defective signaling in CHO cells
    C Strassel
    INSERM U.311, , Alsace, Strasbourg, France
    J Thromb Haemost 4:217-28. 2006
  8. ncbi A novel monoclonal antibody against the extracellular domain of GPIbbeta modulates vWF mediated platelet adhesion
    C Perrault
    INSERM U 311, Etablissement Francais du Sang Alsace, Strasbourg, France
    Thromb Haemost 86:1238-48. 2001
  9. ncbi Arterial thrombosis: relevance of a model with two levels of severity assessed by histologic, ultrastructural and functional characterization
    B Hechler
    UMR S949 INSERM, Universite de Strasbourg, Etablissement Francais du Sang Alsace, Strasbourg, France
    J Thromb Haemost 8:173-84. 2010
  10. ncbi Identification of five novel 14-3-3 isoforms interacting with the GPIb-IX complex in platelets
    P H Mangin
    INSERM UMR_S 949, EFS Alsace, Universite de Strasbourg, Strasbourg, France
    J Thromb Haemost 7:1550-5. 2009

Collaborators

Detail Information

Publications27

  1. ncbi A Leu7Pro mutation in the signal peptide of platelet glycoprotein (GP)IX in a case of Bernard-Soulier syndrome abolishes surface expression of the GPIb-V-IX complex
    Francois Lanza
    INSERM U 311, Etablissement Francais du Sang Alsace, Strasbourg, France
    Br J Haematol 118:260-6. 2002
    ..This provides further evidence for a critical role of GPIX in controlling biosynthesis of the GPIb-IX complex...
  2. ncbi Bernard-Soulier syndrome (hemorrhagiparous thrombocytic dystrophy)
    Francois Lanza
    EFS Alsace, Strasbourg, France
    Orphanet J Rare Dis 1:46. 2006
    ..Treatment of bleeding or prophylaxis during surgical procedures usually requires platelet transfusion...
  3. ncbi [Murine models of platelet diseases]
    F Lanza
    INSERM U 311, EFS Alsace, 10 rue Spielmann, 67065 Strasbourg, France
    Transfus Clin Biol 14:35-40. 2007
    ..Finally, mouse models of auto- or allo-immune thrombocytopenia have been developed to study the mechanisms of platelet destruction or removal...
  4. ncbi GPV is a marker of in vivo platelet activation--study in a rat thrombosis model
    C Ravanat
    INSERM U 311, Biologie et Pharmacologie de l Hémostase et de la Thrombose, Etablissement de Transfusion Sanguine de Strasbourg, France
    Thromb Haemost 83:327-33. 2000
    ....
  5. ncbi Inhibition of adhesive and signaling functions of the platelet GPIb-V-IX complex by a cell penetrating GPIbalpha peptide
    T David
    INSERM U311, Strasbourg EFS Alsace, Strasbourg, France
    J Thromb Haemost 4:2645-55. 2006
    ..This interaction also plays an important role in initiating platelet activation through the generation of intracellular signals resulting in platelet shape change and integrin alpha(IIb)beta3 activation...
  6. ncbi Decreased thrombotic tendency in mouse models of the Bernard-Soulier syndrome
    C Strassel
    INSERM U 311, Etablissement Francais du Sang Alsace, 10 rue Spielmann, BP 36, 67065 Strasbourg Cedex, France
    Arterioscler Thromb Vasc Biol 27:241-7. 2007
    ..To evaluate the consequences of GPIb-V-IX deficiency in thrombosis we generated mouse models of the disease by targeting the GPIb beta subunit...
  7. ncbi Synthesis of GPIb beta with novel transmembrane and cytoplasmic sequences in a Bernard-Soulier patient resulting in GPIb-defective signaling in CHO cells
    C Strassel
    INSERM U.311, , Alsace, Strasbourg, France
    J Thromb Haemost 4:217-28. 2006
    ....
  8. ncbi A novel monoclonal antibody against the extracellular domain of GPIbbeta modulates vWF mediated platelet adhesion
    C Perrault
    INSERM U 311, Etablissement Francais du Sang Alsace, Strasbourg, France
    Thromb Haemost 86:1238-48. 2001
    ..This study suggests a role of GPIbbeta in modulating the adhesive properties of GPIb/V/IX and describes a useful tool to analyze the exact functions of GPIbbeta...
  9. ncbi Arterial thrombosis: relevance of a model with two levels of severity assessed by histologic, ultrastructural and functional characterization
    B Hechler
    UMR S949 INSERM, Universite de Strasbourg, Etablissement Francais du Sang Alsace, Strasbourg, France
    J Thromb Haemost 8:173-84. 2010
    ..Both types of lesion were sensitive to platelet GPIIb-IIIa and P2Y(12) inhibition, whereas only deep injuries were sensitive to thrombin blockade...
  10. ncbi Identification of five novel 14-3-3 isoforms interacting with the GPIb-IX complex in platelets
    P H Mangin
    INSERM UMR_S 949, EFS Alsace, Universite de Strasbourg, Strasbourg, France
    J Thromb Haemost 7:1550-5. 2009
    ..Interaction of 14-3-3zeta with the intracytoplasmic domain of GPIb appears to be a major effector of this activation pathway...
  11. ncbi The platelet glycoprotein GPIbbeta intracellular domain participates in von Willebrand factor induced-filopodia formation independently of the Ser 166 phosphorylation site
    T David
    EFS Alsace, INSERM, UMR S949, Universite Louis Pasteur, Strasbourg, France
    J Thromb Haemost 8:1077-87. 2010
    ..This process, mediated by the GPIb-V-IX complex, is accompanied by specific intracellular signaling leading to reorganization of the platelet actin cytoskeleton and extension of filopodia...
  12. ncbi Biosynthesis and intracellular post-translational processing of normal and mutant platelet glycoprotein GPIb-IX
    P Ulsemer
    INSERM U.311, , 10 rue Spielmann, BP 36, , France
    Biochem J 358:295-303. 2001
    ..The present study has shown that transfer from the ER to the Golgi represents an important step for controlling post-translational processing and surface expression of normal GPIb-IX-V complex...
  13. ncbi [Mechanisms of platelet activation and development of antiplatelet agents]
    J P Cazenave
    INSERM U 311, Strasbourg
    Arch Mal Coeur Vaiss 89:1501-6. 1996
    ....
  14. ncbi A PLC gamma 2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha2beta1
    P Mangin
    INSERM U 311, Etablissement Francais du Sang Alsace, 10 rue Spielmann, BP 36, 67065 Strasbourg Cedex, France
    FEBS Lett 542:53-9. 2003
    ....
  15. ncbi The thienopyridine PCR 4099 selectively inhibits ADP-induced platelet aggregation and fibrinogen binding without modifying the membrane glycoprotein IIb-IIIa complex in rat and in man
    C Gachet
    INSERM U 311, , Strasbourg, France
    Biochem Pharmacol 40:229-38. 1990
    ..We conclude that PCR 4099 selectively inhibits the ADP aggregation pathway and that the inhibition of fibrinogen binding is probably not due to a direct modification of the GP IIb-IIIa complex...
  16. ncbi The P2Y1 receptor plays an essential role in the platelet shape change induced by collagen when TxA2 formation is prevented
    P Mangin
    INSERM U 311, Etablissement Francais du Sang Alsace, Strasbourg, France
    J Thromb Haemost 2:969-77. 2004
    ..In conclusion, this study provides evidence that collagen requires not only the TxA2 receptor Tpalpha, but also P2Y(1), to induce platelet shape change...
  17. ncbi Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice
    A Eckly
    UMR_S949 INSERM Université de Strasbourg, Etablissement Francais du Sang Alsace, Strasbourg, France
    J Thromb Haemost 8:2243-51. 2010
    ..Paradoxically, previous studies using in vitro differentiated megakaryocytes showed an increased capacity for proplatelet formation when myosin was absent or inhibited...
  18. ncbi Mechanisms underlying FeCl3-induced arterial thrombosis
    A Eckly
    UMR S949 Inserm Université de Strasbourg, Strasbourg, France
    J Thromb Haemost 9:779-89. 2011
    ..The FeCl(3)-induced vascular injury model is widely used to study thrombogenesis in vivo, but the processes leading to vascular injury and thrombosis are poorly defined...
  19. ncbi Differential effects of extra- and intracellular calcium chelation on human platelet function and glycoprotein IIb-IIIa complex stability
    F Lanza
    INSERM U311, , , Strasbourg, France
    Nouv Rev Fr Hematol 34:123-31. 1992
    ..This study adds evidence for the role of external Ca2+ to maintain the integrity of a non-dissociated GP IIb-IIIa complex and suggests that intracellular Ca2+ is not involved in the stabilization of the GP IIb-IIIa complex...
  20. ncbi Circulating procoagulant microparticles and soluble GPV in myocardial infarction treated by primary percutaneous transluminal coronary angioplasty. A possible role for GPIIb-IIIa antagonists
    O Morel
    , Strasbourg, France
    J Thromb Haemost 2:1118-26. 2004
    ..MP could constitute a relevant parameter for the follow-up of STEMI patients treated by GPIIb-IIIa antagonists...
  21. ncbi Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation
    S Moog
    INSERM U 311, Etablissement Francais du Sang Alsace, Strasbourg, France
    Blood 98:1038-46. 2001
    ..In conclusion, GPV binds to collagen and appears to be required for normal platelet responses to this agonist. (Blood. 2001;98:1038-1046)..
  22. ncbi Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry
    D Loew
    Laboratoire de Spectrometrie de Masse Bio Organique, Universite Louis Pasteur, Strasbourg, France
    Biochemistry 39:10812-22. 2000
    ..This strategy provides results which can be extended to the native receptor to predict its activation or inactivation, and it could likewise be used to study other PARs or protease-dependent processes...
  23. ncbi CD9 participates in endothelial cell migration during in vitro wound repair
    C Klein-Soyer
    INSERM U 311, Etablissement de Transfusion Sanguine de Strasbourg Strasbourg, France
    Arterioscler Thromb Vasc Biol 20:360-9. 2000
    ..As such, CD9 is a potential target to inhibit angiogenesis in metastatic and atherosclerotic processes...
  24. ncbi Platelet activation revealed by reduced serotonin content in various left ventricular hypertrophic states
    C M Brandt
    Service de cardiologie, , Strasbourg, France
    Acta Cardiol 47:271-4. 1992
    ..This is attributed to platelet activation induced by important flow disturbances related to the hemodynamic conditions...
  25. ncbi Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation
    F Lanza
    Centre Regional de Transfusion Sanguine, Institut National de la Santé et de la Recherche Médicale Unité 311, Strasbourg, France
    J Biol Chem 268:20801-7. 1993
    ....
  26. ncbi A three-base deletion removing a leucine residue in a leucine-rich repeat of platelet glycoprotein Ib alpha associated with a variant of Bernard-Soulier syndrome (Nancy I)
    C de la Salle
    INSERM U 311, Centre Regional de Transfusion Sanguine, Strasbourg, France
    Br J Haematol 89:386-96. 1995
    ....
  27. ncbi A new variant of Glanzmann's thrombasthenia (Strasbourg I). Platelets with functionally defective glycoprotein IIb-IIIa complexes and a glycoprotein IIIa 214Arg----214Trp mutation
    F Lanza
    Institut National de la Santé et de la Recherche Médicale Unité 311, Centre Regional de Transfusion Sanguine, Strasbourg, France
    J Clin Invest 89:1995-2004. 1992
    ..This substitution points to an essential amino acid in a region of GPIIIa involved in the binding of fibrinogen and influencing the Ca(2+)-dependent stability of the GPIIb-IIIa complex...