Dominique Langin

Summary

Country: France

Publications

  1. pmc Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity
    Corneliu Henegar
    INSERM, UMR S 872, Les Cordeliers, Eq, 7 Nutriomique and Eq, 13, Paris, F 75006 France
    Genome Biol 9:R14. 2008
  2. ncbi request reprint Control of fatty acid and glycerol release in adipose tissue lipolysis
    Dominique Langin
    Unité de Recherches sur les Obésités, INSERM UPS U586, Institut Louis Bugnard, Universite Paul Sabatier, CHU Rangueil, BP 84225, 31432 Toulouse Cedex 4, France
    C R Biol 329:598-607; discussion 653-5. 2006
  3. ncbi request reprint Adipocyte lipases and defect of lipolysis in human obesity
    Dominique Langin
    Obesity Research Unit, Institut National de la Sante et de la Recherche Medicale, Université Paul Sabatier UPS U586, Louis Bugnard Institute, Toulouse University Hospitals, Toulouse, France
    Diabetes 54:3190-7. 2005
  4. ncbi request reprint Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome
    Dominique Langin
    Obesity Research Unit Inserm UPS U586, Institut Louis Bugnard, Universite Paul Sabatier, CHU Rangueil, Toulouse, France
    Pharmacol Res 53:482-91. 2006
  5. ncbi request reprint Importance of TNFalpha and neutral lipases in human adipose tissue lipolysis
    Dominique Langin
    INSERM U586, Unité de Recherches sur les Obésités, F 31432 Toulouse, France
    Trends Endocrinol Metab 17:314-20. 2006
  6. doi request reprint High-fat diet-mediated lipotoxicity and insulin resistance is related to impaired lipase expression in mouse skeletal muscle
    Pierre Marie Badin
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche 1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, 31432 Toulouse Cedex 4, France
    Endocrinology 154:1444-53. 2013
  7. doi request reprint Peroxisome proliferator-activated receptor-alpha control of lipid and glucose metabolism in human white adipocytes
    Carole Ribet
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 858, 1 Avenue Jean Pouilhès, BP 84225, 31432 Toulouse Cedex 4, France
    Endocrinology 151:123-33. 2010
  8. pmc Determinants of human adipose tissue gene expression: impact of diet, sex, metabolic status, and cis genetic regulation
    Nathalie Viguerie
    INSERM, UMR1048, Obesity Research Laboratory, Team 4, I2MC, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France
    PLoS Genet 8:e1002959. 2012
  9. pmc Regulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58
    Pierre Marie Badin
    Inserm 1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Paul Sabatier University, Toulouse, France
    J Lipid Res 53:839-48. 2012
  10. doi request reprint Contribution of energy restriction and macronutrient composition to changes in adipose tissue gene expression during dietary weight-loss programs in obese women
    Frédéric Capel
    Laboratoire de recherches sur les obésités, Institut National de la Santé et de la Recherche Médicale Unit 858 I2MR, Equipe 4, IFR31, Institut Louis Bugnard, 1 avenue Jean Poulhes, BP 84225, 31432 Toulouse Cedex 4, France
    J Clin Endocrinol Metab 93:4315-22. 2008

Detail Information

Publications68

  1. pmc Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity
    Corneliu Henegar
    INSERM, UMR S 872, Les Cordeliers, Eq, 7 Nutriomique and Eq, 13, Paris, F 75006 France
    Genome Biol 9:R14. 2008
    ..However, the overall importance of these alterations, and their long-term impact on the metabolic functions of the WAT and on its morphology, remain unclear...
  2. ncbi request reprint Control of fatty acid and glycerol release in adipose tissue lipolysis
    Dominique Langin
    Unité de Recherches sur les Obésités, INSERM UPS U586, Institut Louis Bugnard, Universite Paul Sabatier, CHU Rangueil, BP 84225, 31432 Toulouse Cedex 4, France
    C R Biol 329:598-607; discussion 653-5. 2006
    ..The steps involved in the dysregulation of lipolysis observed in obesity have partly been identified...
  3. ncbi request reprint Adipocyte lipases and defect of lipolysis in human obesity
    Dominique Langin
    Obesity Research Unit, Institut National de la Sante et de la Recherche Medicale, Université Paul Sabatier UPS U586, Louis Bugnard Institute, Toulouse University Hospitals, Toulouse, France
    Diabetes 54:3190-7. 2005
    ..Decreased catecholamine-induced lipolysis and low HSL expression constitute a possibly primary defect in obesity...
  4. ncbi request reprint Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome
    Dominique Langin
    Obesity Research Unit Inserm UPS U586, Institut Louis Bugnard, Universite Paul Sabatier, CHU Rangueil, Toulouse, France
    Pharmacol Res 53:482-91. 2006
    ..A second approach is a chronic inhibition of lipolysis to diminish plasma fatty acid level which is a central feature of the metabolic syndrome...
  5. ncbi request reprint Importance of TNFalpha and neutral lipases in human adipose tissue lipolysis
    Dominique Langin
    INSERM U586, Unité de Recherches sur les Obésités, F 31432 Toulouse, France
    Trends Endocrinol Metab 17:314-20. 2006
    ..Characterization of the lipolytic pathways might provide novel strategies to decrease free fatty acid production and reverse insulin resistance and other obesity-related metabolic complications...
  6. doi request reprint High-fat diet-mediated lipotoxicity and insulin resistance is related to impaired lipase expression in mouse skeletal muscle
    Pierre Marie Badin
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche 1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, 31432 Toulouse Cedex 4, France
    Endocrinology 154:1444-53. 2013
    ..Together, these data suggest a pathophysiological link between altered skeletal muscle lipase expression and DAG-mediated insulin resistance in mice...
  7. doi request reprint Peroxisome proliferator-activated receptor-alpha control of lipid and glucose metabolism in human white adipocytes
    Carole Ribet
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 858, 1 Avenue Jean Pouilhès, BP 84225, 31432 Toulouse Cedex 4, France
    Endocrinology 151:123-33. 2010
    ..Rosiglitazone had no major impact on glycolysis and beta-oxidation. Altogether these results show that PPAR alpha can selectively up-regulate beta-oxidation and decrease glucose utilization in human white adipocytes...
  8. pmc Determinants of human adipose tissue gene expression: impact of diet, sex, metabolic status, and cis genetic regulation
    Nathalie Viguerie
    INSERM, UMR1048, Obesity Research Laboratory, Team 4, I2MC, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France
    PLoS Genet 8:e1002959. 2012
    ..These analyses help understanding the relative importance of environmental and individual factors that control the expression of human AT genes and therefore may foster strategies aimed at improving AT function in metabolic diseases...
  9. pmc Regulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58
    Pierre Marie Badin
    Inserm 1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Paul Sabatier University, Toulouse, France
    J Lipid Res 53:839-48. 2012
    ....
  10. doi request reprint Contribution of energy restriction and macronutrient composition to changes in adipose tissue gene expression during dietary weight-loss programs in obese women
    Frédéric Capel
    Laboratoire de recherches sur les obésités, Institut National de la Santé et de la Recherche Médicale Unit 858 I2MR, Equipe 4, IFR31, Institut Louis Bugnard, 1 avenue Jean Poulhes, BP 84225, 31432 Toulouse Cedex 4, France
    J Clin Endocrinol Metab 93:4315-22. 2008
    ..The molecular changes in adipose tissue associated with weight loss and specifically related to the dietary composition are poorly understood...
  11. doi request reprint Chronic TNFalpha and cAMP pre-treatment of human adipocytes alter HSL, ATGL and perilipin to regulate basal and stimulated lipolysis
    Veronic Bezaire
    Laboratoire de Recherches sur Obésités, INSERM U858, Toulouse, France
    FEBS Lett 583:3045-9. 2009
    ..Together, this resulted in a severely attenuated response to forskolin-stimulated lipolysis...
  12. pmc Contribution of adipose triglyceride lipase and hormone-sensitive lipase to lipolysis in hMADS adipocytes
    Veronic Bezaire
    INSERM U858, Laboratoire de recherches sur les obésités, F 31432 Toulouse, France
    J Biol Chem 284:18282-91. 2009
    ..Altogether, these results suggest that ATGL/CGI-58 acts independently of HSL and precedes its action in the sequential hydrolysis of triglycerides in human hMADS adipocytes...
  13. ncbi request reprint Acquirement of brown fat cell features by human white adipocytes
    Claire Tiraby
    Unité de Recherches sur les Obésités, Institut National de la Santé et de la Recherche Médicale Unité 586, Institut Louis Bugnard, Centre Hospitalier Universitaire de Toulouse, Universite Paul Sabatier, 31403 Toulouse, France
    J Biol Chem 278:33370-6. 2003
    ..UCP1 mRNA induction was shown in vivo by injection of the PGC-1 alpha adenovirus in mouse white fat. Alteration of energy balance through an increased utilization of fat in WAT may be a conceivable strategy for the treatment of obesity...
  14. ncbi request reprint Gene expression profiling of human skeletal muscle in response to stabilized weight loss
    Dominique Larrouy
    INSERM, U858, Obesity Research Laboratory, Institut de Medecine Moleculaire de Rangueil, Toulouse, France
    Am J Clin Nutr 88:125-32. 2008
    ..Whether this reduction remains after stabilized weight loss is still controversial, and the molecular mechanisms are unknown...
  15. doi request reprint Adipose tissue transcriptome reflects variations between subjects with continued weight loss and subjects regaining weight 6 mo after caloric restriction independent of energy intake
    Adriana Márquez-Quiñones
    Institut National de Sante et de Recherche Medicale INSERM, U858, Obesity Research Laboratory, Institut de Medecine Moleculaire de Rangueil, Toulouse, France
    Am J Clin Nutr 92:975-84. 2010
    ..The mechanisms underlying body weight evolution after diet-induced weight loss are poorly understood...
  16. ncbi request reprint Expression of human hormone-sensitive lipase in white adipose tissue of transgenic mice increases lipase activity but does not enhance in vitro lipolysis
    Stephanie Lucas
    INSERM U317, Institut Louis Bugnard, Centre Hospitalier Universitaire de Rangueil, Universite Paul Sabatier, 31403 Toulouse Cedex 4, France
    J Lipid Res 44:154-63. 2003
    ..However, transgenic mice became leaner than their wild-type (WT) littermates after a 4 day calorie restriction. The data show that overexpression of HSL, despite increased lipase activity, does not lead to enhanced lipolysis...
  17. pmc Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass
    Amandine Girousse
    INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France University of Toulouse, UMR1048, Paul Sabatier University, France
    PLoS Biol 11:e1001485. 2013
    ..Thus, reduction in WAT lipolysis reshapes FA fluxes without increase of fat mass and improves glucose metabolism through cell-autonomous induction of fat cell de novo lipogenesis, which contributes to improved insulin sensitivity...
  18. pmc Altered skeletal muscle lipase expression and activity contribute to insulin resistance in humans
    Pierre Marie Badin
    INSERM, U1048, Obesity Research Laboratory, Institute of Metabolicand Cardiovascular Diseases I2MC, Toulouse, France
    Diabetes 60:1734-42. 2011
    ..We hypothesized that an imbalance of ATGL relative to HSL (expression or activity) may contribute to DAG accumulation and insulin resistance...
  19. doi request reprint The transcriptional co-activator PGC-1alpha up regulates apelin in human and mouse adipocytes
    Anne Mazzucotelli
    Institut National de la Sante et de la Recherche Medicale, U858, Toulouse, France
    Regul Pept 150:33-7. 2008
    ..This is the first demonstration that PGC-1alpha is involved in the regulation of an adipokine gene expression and release...
  20. ncbi request reprint The transcriptional coactivator peroxisome proliferator activated receptor (PPAR)gamma coactivator-1 alpha and the nuclear receptor PPAR alpha control the expression of glycerol kinase and metabolism genes independently of PPAR gamma activation in human w
    Anne Mazzucotelli
    Institut national de la santé et de la recherche médicale INSERM U858, Obesity Research Laboratory, Toulouse, F 31432, France
    Diabetes 56:2467-75. 2007
    ....
  21. doi request reprint Adipose tissue lipolysis
    Catherine Ines Kolditz
    INSERM, Unité 858, Obesity Research Laboratory, Rangueil Institute of Molecular Medicine I2MR, IFR150, Toulouse, France
    Curr Opin Clin Nutr Metab Care 13:377-81. 2010
    ..This review aims at describing recent discoveries related to the lipolytic pathway and its regulatory mechanisms...
  22. doi request reprint Enhanced glucose metabolism is preserved in cultured primary myotubes from obese donors in response to exercise training
    Virginie Bourlier
    PhD, Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche 1048, Institut des Maladies Métaboliques et Cardiovasculaires, Centre Hospitalier Universitaire Rangueil, BP 84225, 1 avenue Jean Poulhes, 31432 Toulouse Cedex 4, France
    J Clin Endocrinol Metab 98:3739-47. 2013
    ..It can be hypothesized that skeletal muscle microenvironmental changes induced by endurance training lead to metabolic imprinting on myogenic progenitor cells. ..
  23. ncbi request reprint In vivo epinephrine-mediated regulation of gene expression in human skeletal muscle
    Nathalie Viguerie
    Unité de Recherches sur les Obésités, Institut National de la Sante et de la Recherche Medicale INSERM, Unité 586, Institut Louis Bugnard, Centre Hospitalier Universitaire de Toulouse, Universite Paul Sabatier, 31403 Toulouse, France
    J Clin Endocrinol Metab 89:2000-14. 2004
    ..They may contribute to the understanding of skeletal muscle alterations observed in pathological conditions characterized by sympathetic nervous system overdrive...
  24. doi request reprint Regulation of adipose tissue lipolysis revisited
    Veronic Bezaire
    INSERM U858, Laboratoire de recherches sur les obésités, F 31432 Toulouse, France
    Proc Nutr Soc 68:350-60. 2009
    ..Integration of these findings into whole adipose tissue metabolism and its systemic effects is also presented in the context of inflammation and insulin resistance...
  25. pmc Weight loss improves the adipogenic capacity of human preadipocytes and modulates their secretory profile
    Lenka Rossmeislova
    Franco Czech Laboratory for Clinical Research on Obesity, Third Faculty of Medicine, Prague, Czech Republic, and INSERM, Toulouse, France
    Diabetes 62:1990-5. 2013
    ..However, enhanced adipogenesis could also contribute to the unwanted weight regain after initial weight loss...
  26. ncbi request reprint [Fatty acid mobilization and their use in adipose tissue]
    Anne Mazzucotelli
    INSERM U586, Unité de Recherche sur les Obésités, Toulouse, F 31432 France
    J Soc Biol 200:83-91. 2006
    ..Targeting these key steps of lipid metabolism (adipose tissue lipolysis and fatty acid oxidation) constitutes a potential strategy for the treatment of obesity and associated metabolic disorders...
  27. doi request reprint Lipolysis and lipid mobilization in human adipose tissue
    Max Lafontan
    INSERM U, Institut de Medecine Moleculaire de Rangueil, IFR BMT, Toulouse, France
    Prog Lipid Res 48:275-97. 2009
    ..The manipulation of lipolysis has therapeutic potential in the metabolic disorders frequently associated with obesity and probably in several inborn errors of metabolism...
  28. ncbi request reprint Norepinephrine induces lipolysis in beta1/beta2/beta3-adrenoceptor knockout mice
    Geneviève Tavernier
    Unité de Recherches sur les Obésités, INSERM UPS U586, Institut Louis Bugnard IFR31, CHU Rangueil, Batiment L3, BP 84225, 31432 Toulouse Cedex 4, France
    Mol Pharmacol 68:793-9. 2005
    ..We conclude that the residual lipolytic effect observed in beta-less mice can be attributed to an unknown Gs-protein-coupled receptor with low affinity for catecholamines...
  29. ncbi request reprint Effect of thyroid hormone on gene expression
    Nathalie Viguerie
    French Institute of Health and Medical Research, Toulouse University Hospitals, Toulouse, France
    Curr Opin Clin Nutr Metab Care 6:377-81. 2003
    ..This review summarizes the recent advances in the characterization of target genes in different organs...
  30. ncbi request reprint Characterization of a novel testicular form of human hormone-sensitive lipase
    Aline Mairal
    INSERM Unit 317, Institut Louis Bugnard, Universite Paul Sabatier, Hopital Rangueil, Toulouse, France
    Biochem Biophys Res Commun 291:286-90. 2002
    ....
  31. ncbi request reprint Plasma levels and adipose tissue messenger ribonucleic acid expression of retinol-binding protein 4 are reduced during calorie restriction in obese subjects but are not related to diet-induced changes in insulin sensitivity
    Michaela Vitkova
    Institut National de la Santé et de la Recherche Médicale Université Paul Sabatier U858, IFR31, BP 84225, 31432 Toulouse Cedex 4, France
    J Clin Endocrinol Metab 92:2330-5. 2007
    ..Retinol-binding protein 4 (RBP4) may play a role in the development of insulin resistance...
  32. ncbi request reprint Conversion from white to brown adipocytes: a strategy for the control of fat mass?
    Claire Tiraby
    Unité de Recherches sur les Obésités, Institut National de la Santé et de la Recherche Médicale Inserm Unité 586, Institut Louis Bugnard, Centre Hospitalier Universitaire de Toulouse, Universite Paul Sabatier, Toulouse, France
    Trends Endocrinol Metab 14:439-41. 2003
    ..The changes in gene expression promote stimulation of fatty acid oxidation. There is now evidence to support the concept of an alteration in energy balance through a conversion of white to brown adipose tissue...
  33. ncbi request reprint beta3-Adrenergic stimulation produces a decrease of cardiac contractility ex vivo in mice overexpressing the human beta3-adrenergic receptor
    Geneviève Tavernier
    Unité de Recherches sur les Obésités, Institut National de la Santé et de la Recherche Médicale Unité 586, Institut Louis Bugnard, Centre Hospitalier Universitaire de Toulouse, Universite Paul Sabatier, Toulouse, France
    Cardiovasc Res 59:288-96. 2003
    ..Because of the lack of suitable animal models, we have generated transgenic mice with cardiac-specific expression of the human beta(3)-AR (TG beta(3) mice)...
  34. doi request reprint Adipose tissue lipolysis revisited (again!): lactate involvement in insulin antilipolytic action
    Dominique Langin
    INSERM U858, Obesity Research Laboratory, Rangueil Institute of Molecular Medicine, Toulouse F 31432, France
    Cell Metab 11:242-3. 2010
    ..In this issue of Cell Metabolism, Ahmed et al. (2010) show that the metabolite is involved in the antilipolytic effect of insulin, providing a new link between fat and carbohydrate metabolism...
  35. doi request reprint Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: decreased metabolism and increased immune response
    Eva Klimcakova
    Franco Czech Laboratory for Clinical Research on Obesity, Third Faculty of Medicine, Prague, Czech Republic
    J Clin Endocrinol Metab 96:E73-82. 2011
    ..It is not known whether biological differences reported between sc adipose tissue (SAT) and visceral adipose tissue (VAT) depots underlie the pathogenicity of visceral fat...
  36. ncbi request reprint Transcriptional regulation of adipocyte hormone-sensitive lipase by glucose
    Fatima Smih
    INSERM Unité 317, Institut Louis Bugnard, Centre Hospitalier Universitaire de Rangueil, Universite Paul Sabatier, Toulouse, France
    Diabetes 51:293-300. 2002
    ..Analogs and metabolites were used to determine the signal metabolite of the glucose response. The signal is generated downstream of glucose-6-phosphate in the glycolytic pathway before the triose phosphate step...
  37. ncbi request reprint Understanding adipose tissue development from transgenic animal models
    Philippe Valet
    INSERM Unit 317, Louis Bugnard Institute, Paul Sabatier University, Bldg L3, Rangueil University Hospital, 31403 Toulouse Cedex 4, France
    J Lipid Res 43:835-60. 2002
    ..However, lack of phenotypes also illustrates the capacity of animals to set up adaptive mechanisms...
  38. ncbi request reprint Regulation of human adipocyte gene expression by thyroid hormone
    Nathalie Viguerie
    INSERM Unit 317, Institut Louis Bugnard, Universite Paul Sabatier, Hopital Rangueil, 31403 Toulouse Cedex 4, France
    J Clin Endocrinol Metab 87:630-4. 2002
    ..Thus, these data suggest that T(3) modulates expression of genes with a wide range of function in human adipose tissue...
  39. ncbi request reprint The role of uncoupling protein 2 in the development of type 2 diabetes
    Dominique Langin
    Institut Louis Bugnard, Unite Recherches sur les Obesites INSERM U586, Toulouse, France
    Drugs Today (Barc) 39:287-95. 2003
    ..The role of UCP2 in the control of insulin secretion constitutes, to date, the most pertinent path to investigate in a therapeutic perspective...
  40. doi request reprint Recruitment of brown fat and conversion of white into brown adipocytes: strategies to fight the metabolic complications of obesity?
    Dominique Langin
    INSERM U858, Laboratoire de recherches sur les obésités, Toulouse, F 31432, France
    Biochim Biophys Acta 1801:372-6. 2010
    ..These data open up new opportunities for the development of drugs for obesity and its metabolic and cardiovascular complications...
  41. ncbi request reprint The presence of a catalytically inactive form of hormone-sensitive lipase is associated with decreased lipolysis in abdominal subcutaneous adipose tissue of obese subjects
    Hind Ray
    Institut National de la Santé et de la Recherche Medicale INSERM 499, Faculte de Medecine Laennec, Rue Paradin, 69372 Lyon, France
    Diabetes 52:1417-22. 2003
    ..05). These results suggest that the presence of the truncated HSL protein is associated with an impaired adipocyte lipolysis...
  42. pmc Adipose gene expression prior to weight loss can differentiate and weakly predict dietary responders
    David M Mutch
    INSERM, Nutriomique U872, Paris, France
    PLoS ONE 2:e1344. 2007
    ..Therefore, we asked whether it is possible to identify subjects who will lose weight during dietary intervention using only a single gene expression snapshot...
  43. pmc Transcriptional control of brown fat determination by PRDM16
    Patrick Seale
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Cell Metab 6:38-54. 2007
    ..PRDM16 activates brown fat cell identity at least in part by simultaneously activating PGC-1alpha and PGC-1beta through direct protein binding. These data indicate that PRDM16 can control the determination of brown fat fate...
  44. pmc In vivo regulation of human skeletal muscle gene expression by thyroid hormone
    Karine Clement
    Department of Pediatrics and Genetics, Howard Hughes Medical Institute, Beckman Center, Stanford University School of Medicine, Stanford, California 94305, USA
    Genome Res 12:281-91. 2002
    ..These results define molecular signatures that help to understand the physiology and pathophysiology of thyroid hormone action...
  45. ncbi request reprint Adiponutrin: A new gene regulated by energy balance in human adipose tissue
    Yong Ming Liu
    Equipe d Accueil 3502 and Institut National de la Santé et de la Recherche Médicale INSERM Avenir and Department de Nutrition, Paris VI University, Paris, France
    J Clin Endocrinol Metab 89:2684-9. 2004
    ..These results indicate that adiponutrin gene expression in humans is highly regulated by changes in energy balance...
  46. ncbi request reprint Effects of different hypocaloric diets on protein secretion from adipose tissue of obese women
    Elisabet Arvidsson
    Department of Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Diabetes 53:1966-71. 2004
    ....
  47. ncbi request reprint The testicular form of hormone-sensitive lipase HSLtes confers rescue of male infertility in HSL-deficient mice
    Virginie Vallet-Erdtmann
    Groupe d Etude de la Reproduction chez l Homme et les Mammifères INSERM U625 Teams 1 and 2, Campus de Beaulieu, Universite de Rennes I, 35042 Rennes Cedex, Bretagne, France
    J Biol Chem 279:42875-80. 2004
    ..Therefore, expression of HSLtes and cognate cholesteryl ester hydrolase activity leads to a rescue of the infertility observed in HSL-deficient male mice...
  48. ncbi request reprint Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects
    Karine Clement
    INSERM Avenir Paris 6 University, EA 3502, Nutrition Department, AP HP, Hotel Dieu, Paris, France
    FASEB J 18:1657-69. 2004
    ..The beneficial effect of weight loss on obesity-related complications may be associated with the modification of the inflammatory profile in adipose tissue...
  49. ncbi request reprint Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesis
    Soraya Taleb
    INSERM Avenir, Paris, France
    FASEB J 19:1540-2. 2005
    ..Since this enzyme has been implicated in the development of atherosclerotic lesions, we propose that cathepsin S represents a molecular link between obesity and atherosclerosis...
  50. ncbi request reprint A novel hormone-sensitive lipase isoform expressed in pancreatic beta-cells
    Håkan Lindvall
    Department of Cell and Molecular Biology, Lund University, Sweden
    J Biol Chem 279:3828-36. 2004
    ..The minimal promoter is present within 170 bp from the transcriptional start site and maximal glucose responsiveness is conferred by sequence within 850 bp from the transcriptional start site...
  51. ncbi request reprint Effects of 3 diets with various calcium contents on 24-h energy expenditure, fat oxidation, and adipose tissue message RNA expression of lipid metabolism-related proteins
    Niels Boon
    Nutrition and Toxicology Research Institute Maastricht, University of Maastricht, Maastricht, Netherlands
    Am J Clin Nutr 82:1244-52. 2005
    ..Evidence from molecular and animal research and epidemiologic investigations indicates that calcium intake may be inversely related to body weight, possibly through alterations in 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] metabolism...
  52. ncbi request reprint A "futile cycle" induced by thiazolidinediones in human adipose tissue?
    Garry D Tan
    Nat Med 9:811-2; author reply 812. 2003
  53. ncbi request reprint Effect of aerobic training on plasma levels and subcutaneous abdominal adipose tissue gene expression of adiponectin, leptin, interleukin 6, and tumor necrosis factor alpha in obese women
    Jan Polak
    Franco Czech Laboratory for Clinical Research on Obesity, Third Medical Faculty and INSERM Unite 586, Charles University, Prague, Czech Republic
    Metabolism 55:1375-81. 2006
    ....
  54. ncbi request reprint The effects of increasing serum calcitriol on energy and fat metabolism and gene expression
    Niels Boon
    Nutrition and Toxicology Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    Obesity (Silver Spring) 14:1739-46. 2006
    ....
  55. ncbi request reprint The role of neutral lipases in human adipose tissue lipolysis
    Peter Arner
    Karolinska Institute at the Department of Medicine, Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Curr Opin Lipidol 18:246-50. 2007
    ..The aim of this article is to describe the relative roles of hormone sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis...
  56. ncbi request reprint Impaired fat-induced thermogenesis in obese subjects: the NUGENOB study
    Ellen E Blaak
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht, The Netherlands
    Obesity (Silver Spring) 15:653-63. 2007
    ..To study energy expenditure before and 3 hours after a high-fat load in a large cohort of obese subjects (n = 701) and a lean reference group (n = 113)...
  57. ncbi request reprint Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state
    Johan W E Jocken
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    J Clin Endocrinol Metab 92:2292-9. 2007
    ..In addition, we investigated whether a possible impaired expression could be reversed by a period of weight reduction...
  58. ncbi request reprint Adiponectin gene expression and plasma values in obese women during very-low-calorie diet. Relationship with cardiovascular risk factors and insulin resistance
    Marta Garaulet
    Franco Czech Laboratory for Clinical Research on Obesity, French Institute of Health and Medical Research, Institut National de la Santé et d la Recherche Médicale U586 and 3rd Faculty of Medicine, Charles University, Prague, Czech Republic
    J Clin Endocrinol Metab 89:756-60. 2004
    ..The data suggest that adiponectin is related to the protection against the metabolic syndrome but is not involved in the regulation of VLCD-induced improvement of insulin sensitivity...
  59. ncbi request reprint Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis
    Mikael Ryden
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 141 86 Stockholm, Sweden
    Am J Physiol Endocrinol Metab 292:E1847-55. 2007
    ..However, both lipases regulate basal lipolysis in human adipocytes. ATGL expression, unlike HSL, is not influenced by obesity or PCOS...
  60. ncbi request reprint NF-kappaB is important for TNF-alpha-induced lipolysis in human adipocytes
    Jurga Laurencikiene
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
    J Lipid Res 48:1069-77. 2007
    ..We conclude that in the presence of NF-kappaB inhibition, TNF-alpha-mediated lipolysis is reduced, which suggests that NF-kappaB is essential for retained human fat cell lipolysis...
  61. ncbi request reprint Profiling of adipokines secreted from human subcutaneous adipose tissue in response to PPAR agonists
    Eva Klimcakova
    Franco Czech Laboratory for Clinical Research on Obesity, Inserm and 3rd Faculty of Medicine, Charles University, Prague CZ 100 00, Czech Republic
    Biochem Biophys Res Commun 358:897-902. 2007
    ..Our data show that PPAR agonists modulate secretion of bioactive molecules from the different cell types composing human adipose tissue...
  62. ncbi request reprint Adiponectin gene expression in subcutaneous adipose tissue of obese women in response to short-term very low calorie diet and refeeding
    Yong Ming Liu
    EA 3502 and Institut National de la Santé et de la Recherche Médicale INSERM Avenir and Paris VI University, Department of Nutrition, Hotel Dieu, 75004 Paris, France
    J Clin Endocrinol Metab 88:5881-6. 2003
    ..Both the levels of adiposity and insulin sensitivity may contribute to the variation in adiponectin gene expression in response to acute energy changes...
  63. ncbi request reprint Hormone-sensitive lipase is a cholesterol esterase of the intestinal mucosa
    Jacques Grober
    Laboratoire de Physiologie de la Nutrition, Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l Alimentation, FRE2328 CNRS Université de Bourgogne 1, Dijon 21000, France
    J Biol Chem 278:6510-5. 2003
    ..The results also reveal that the enzyme participates in acylglycerol hydrolysis in jejunal enterocytes and cholesteryl ester hydrolysis throughout the small intestine...
  64. ncbi request reprint Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss
    Raffaella Cancello
    INSERM Avenir, Paris 6 University EA3502 and Human Research Center on Nutrition CRNH, Hotel Dieu Hospital, AP HP, Paris, France
    Diabetes 54:2277-86. 2005
    ..We show that improvement of the inflammatory profile after weight loss is related to a reduced number of macrophages in scWAT. MCP-1, PLAUR, CSF-3, and HIF-1alpha may play roles in the attraction of macrophages in scWAT...
  65. ncbi request reprint Cdk4 promotes adipogenesis through PPARgamma activation
    Anna Abella
    INSERM U540, Equipe Avenir, F 34090 Montpellier, France
    Cell Metab 2:239-49. 2005
    ..We show that the effects of cdk4 are not limited to the control of differentiation; cdk4 also participates in adipocyte function through activation of PPARgamma...
  66. ncbi request reprint Fat oxidation before and after a high fat load in the obese insulin-resistant state
    Ellen E Blaak
    Department of Human Biology, Nutrition Research Centre, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 91:1462-9. 2006
    ..Obesity may be associated with a lowered use of fat as a fuel, which may contribute to the enlarged adipose tissue stores...
  67. doi request reprint Effects of TCF7L2 polymorphisms on obesity in European populations
    Stephane Cauchi
    Centre National de la Recherche Scientifique 8090, Institute of Biology, Pasteur Institute, Lille, France
    Obesity (Silver Spring) 16:476-82. 2008
    ..Furthermore, our data suggest that the rs7903146 T allele may be possibly functional and associated with a nominal decrease in TCF7L2 expression in adipose tissue of individuals under calorie restriction...
  68. ncbi request reprint Genotype-by-nutrient interactions assessed in European obese women. A case-only study
    Jose L Santos
    Dept of Physiology and Nutrition, University of Navarra, 31008, Pamplona, Spain
    Eur J Nutr 45:454-62. 2006
    ..Whereas changes in the environment appear to be responsible for the increasing prevalence of obesity, genetic factors interacting with environmental factors would contribute to explain obesity onset and severity...