- Environmental influence on the genetic basis of mosquito resistance to malaria parasitesLouis Lambrechts
CNRS UMR 7103, Université Pierre et Marie Curie Paris, Parasitologie Evolutive, CC 237, CP52, 7 quai St Bernard, 75252 Paris Cedex 05, France
Proc Biol Sci 273:1501-6. 2006..e. the lines responded similarly to environmental variation. Overall, these results indicate that environmental variation can significantly reduce the importance of genes in determining the resistance of mosquitoes to malaria infection...
- Genetic correlation between melanization and antibacterial immune responses in a natural population of the malaria vector Anopheles gambiaeLouis Lambrechts
Laboratoire de Parasitologie Evolutive, CNRS UMR 7103, Universite Pierre and Marie Curie, CC237, 7 quai St Bernard, 75252 Paris Cedex 05, France
Evolution 58:2377-81. 2004..Thus, our data do not support the idea of a trade-off among different outcomes of the invertebrate immune system, but rather that some families are overall immunologically superior to others...
- Host genotype by parasite genotype interactions underlying the resistance of anopheline mosquitoes to Plasmodium falciparumLouis Lambrechts
Laboratoire de Parasitologie Evolutive, CNRS UMR 7103, Université P, and M, Curie, CC 237, 7 quai St Bernard, 75252 Paris Cedex 05, France
Malar J 4:3. 2005..In such systems, certain hosts are resistant to one subset of the parasite's genotypes, while other hosts are resistant to a different subset...
- Coevolutionary interactions between host and parasite genotypesLouis Lambrechts
Laboratoire de Parasitologie Evolutive, CNRS UMR 7103, Universite Pierre et Marie Curie, CC 237, 7 quai St Bernard, 75252 Paris Cedex 05, France
Trends Parasitol 22:12-6. 2006..Moreover, not only the traits of the infection but also the genetic correlations among these and other traits that determine fitness might be controlled by interactions between host and parasite genotypes...
- Effect of infection by Plasmodium falciparum on the melanization immune response of Anopheles gambiaeLouis Lambrechts
Laboratoire de Parasitologie Evolutive, Centre National de la Recherche Scientifique Université Pierre et Marie Curie, Paris, France
Am J Trop Med Hyg 76:475-80. 2007..falciparum relies on immune evasion rather than immuno-suppression to avoid being melanized and confirms that natural malaria transmission systems differ from laboratory models of mosquito-Plasmodium interactions...
- Anopheles gambiae immune responses to Sephadex beads: involvement of anti-Plasmodium factors in regulating melanizationEmma Warr
W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205 2179, USA
Insect Biochem Mol Biol 36:769-78. 2006....
- Increased melanizing activity in Anopheles gambiae does not affect development of Plasmodium falciparumKristin Michel
Faculty of Natural Sciences, Section of Infection and Immunity, Imperial College London, London SW7 2AZ, United Kingdom
Proc Natl Acad Sci U S A 103:16858-63. 2006..falciparum. This study suggests immune evasion strategies of the human malaria parasite and emphasizes the need to study mosquito innate immune responses toward the pathogens they transmit in natural vector-parasite combinations...
- A major genetic locus controlling natural Plasmodium falciparum infection is shared by East and West African Anopheles gambiaeMichelle M Riehle
Microbial and Plant Genomics Institute and Department of Microbiology, University of Minnesota, St Paul, MN 55108, USA
Malar J 6:87. 2007..An important question is whether genetic variation with respect to Plasmodium-resistance exists across Africa, and if so whether the same or multiple geographically distinct resistance mechanisms are responsible for the trait...
- Can transgenic mosquitoes afford the fitness cost?Louis Lambrechts
Department of Entomology, University of California, One Shields Avenue, Davis, CA 95616, USA
Trends Parasitol 24:4-7. 2008..Indeed, for the spread of a resistance transgene in a natural situation, the transgene's fitness cost and the efficacy of the gene drive will be more crucial than any evolutionary advantage...