Olivier Lambotte

Summary

Country: France

Publications

  1. ncbi request reprint Characteristics and long-term outcome of 15 episodes of systemic lupus erythematosus-associated hemophagocytic syndrome
    Olivier Lambotte
    Department of Internal Medicine, Bicetre University Hospital, AP HP, Le Kremlin Bicetre, France
    Medicine (Baltimore) 85:169-82. 2006
  2. ncbi request reprint Pegylated interferon alpha-2a-associated life-threatening Evans' syndrome in a patient with chronic hepatitis C
    Olivier Lambotte
    Department of Internal Medicine, Kremlin Bicetre Hospital, AP HP, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    J Infect 51:e113-5. 2005
  3. ncbi request reprint HIV controllers: a homogeneous group of HIV-1-infected patients with spontaneous control of viral replication
    Olivier Lambotte
    Inserm E 0109, Faculte de Medecine Paris Sud, Universite Paris XI, Service de Sante Publique, Bicetre, France
    Clin Infect Dis 41:1053-6. 2005
  4. ncbi request reprint Listeria monocytogenes skin infection with cerebritis and haemophagocytosis syndrome in a bone marrow transplant recipient
    O Lambotte
    Department of Haematology, Necker Hospital, Paris, France
    J Infect 50:356-8. 2005
  5. ncbi request reprint Failure of rituximab to treat a lupus flare-up with nephritis
    O Lambotte
    Department of Internal Medicine, CHU Bicêtre AP HP, Le Kremlin Bicetre, France
    Clin Nephrol 64:73-7. 2005
  6. pmc Both HLA-B*57 and plasma HIV RNA levels contribute to the HIV-specific CD8+ T cell response in HIV controllers
    Camille Lécuroux
    INSERM U1012, Le Kremlin Bicetre, France
    J Virol 88:176-87. 2014
  7. ncbi request reprint Persistence of replication-competent HIV in both memory and naive CD4 T cell subsets in patients on prolonged and effective HAART
    Olivier Lambotte
    Inserm E 0109, Faculte de Medecine Paris Sud, Hôpital du Kremlin Bicêtre, Le Kremlin Bicetre, France
    AIDS 16:2151-7. 2002
  8. ncbi request reprint The lymphocyte HIV reservoir in patients on long-term HAART is a memory of virus evolution
    Olivier Lambotte
    INSERM E 109, Faculté de Médecine de Bicêtre, Universite Paris XI, France
    AIDS 18:1147-58. 2004
  9. doi request reprint HIV infection impairs CCR7-dependent T-cell chemotaxis independent of CCR7 expression
    Santiago Perez-Patrigeon
    Institut Pasteur, Paris, France
    AIDS 23:1197-207. 2009
  10. ncbi request reprint The correlation between levels of IL-7Ralpha expression and responsiveness to IL-7 is lost in CD4 lymphocytes from HIV-infected patients
    Jean Hervé Colle
    Unité Immunogénétique Cellulaire, Département Infection et Epidémiologie, Institut Pasteur, Paris, France
    AIDS 21:101-3. 2007

Detail Information

Publications63

  1. ncbi request reprint Characteristics and long-term outcome of 15 episodes of systemic lupus erythematosus-associated hemophagocytic syndrome
    Olivier Lambotte
    Department of Internal Medicine, Bicetre University Hospital, AP HP, Le Kremlin Bicetre, France
    Medicine (Baltimore) 85:169-82. 2006
    ..In the long-term, SLE-associated HS seems to define a severe SLE form with frequent flares, possible HS recurrences, and the need for prolonged immunosuppression...
  2. ncbi request reprint Pegylated interferon alpha-2a-associated life-threatening Evans' syndrome in a patient with chronic hepatitis C
    Olivier Lambotte
    Department of Internal Medicine, Kremlin Bicetre Hospital, AP HP, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    J Infect 51:e113-5. 2005
    ..Outcome was favourable under immunosuppressive treatment. Treatment with PEG-IFN-alpha2a requires careful follow-up, as IFNalpha can induce or exacerbate autoimmune diseases...
  3. ncbi request reprint HIV controllers: a homogeneous group of HIV-1-infected patients with spontaneous control of viral replication
    Olivier Lambotte
    Inserm E 0109, Faculte de Medecine Paris Sud, Universite Paris XI, Service de Sante Publique, Bicetre, France
    Clin Infect Dis 41:1053-6. 2005
    ..These 15 patients, whom we have referred to as "HIV controllers," are characterized by a low HIV DNA load in peripheral blood mononuclear cells and by a strong HIV-specific immune response...
  4. ncbi request reprint Listeria monocytogenes skin infection with cerebritis and haemophagocytosis syndrome in a bone marrow transplant recipient
    O Lambotte
    Department of Haematology, Necker Hospital, Paris, France
    J Infect 50:356-8. 2005
    ..L. monocytogenes infection should be suspected in patients with cerebritis despite large spectrum antibiotherapy and this report underscores the usefulness of skin biopsies in febrile immunocompromised patients...
  5. ncbi request reprint Failure of rituximab to treat a lupus flare-up with nephritis
    O Lambotte
    Department of Internal Medicine, CHU Bicêtre AP HP, Le Kremlin Bicetre, France
    Clin Nephrol 64:73-7. 2005
    ..This observation suggests that rituximab alone may be insufficient to control severe SLE with glomerulonephritis and should therefore be used with caution in patients with this condition...
  6. pmc Both HLA-B*57 and plasma HIV RNA levels contribute to the HIV-specific CD8+ T cell response in HIV controllers
    Camille Lécuroux
    INSERM U1012, Le Kremlin Bicetre, France
    J Virol 88:176-87. 2014
    ..In conclusion, both HLA-B*57 and the amount of ultrasensitive viral load seem to play a role in HIV-specific CD8(+) T cell responses in HIC. ..
  7. ncbi request reprint Persistence of replication-competent HIV in both memory and naive CD4 T cell subsets in patients on prolonged and effective HAART
    Olivier Lambotte
    Inserm E 0109, Faculte de Medecine Paris Sud, Hôpital du Kremlin Bicêtre, Le Kremlin Bicetre, France
    AIDS 16:2151-7. 2002
    ..To investigate the phenotypic features of infected lymphocytes in patients on prolonged and effective highly active antiretroviral therapy (HAART)...
  8. ncbi request reprint The lymphocyte HIV reservoir in patients on long-term HAART is a memory of virus evolution
    Olivier Lambotte
    INSERM E 109, Faculté de Médecine de Bicêtre, Universite Paris XI, France
    AIDS 18:1147-58. 2004
    ..To investigate the dynamics of the lymphocyte HIV reservoir in patients on prolonged and effective highly active antiretroviral therapy (HAART)...
  9. doi request reprint HIV infection impairs CCR7-dependent T-cell chemotaxis independent of CCR7 expression
    Santiago Perez-Patrigeon
    Institut Pasteur, Paris, France
    AIDS 23:1197-207. 2009
    ..We investigated CCR7 expression and chemotactic function in patient T cells, to gain further insights into mechanisms of T-cell dysfunction in HIV infection...
  10. ncbi request reprint The correlation between levels of IL-7Ralpha expression and responsiveness to IL-7 is lost in CD4 lymphocytes from HIV-infected patients
    Jean Hervé Colle
    Unité Immunogénétique Cellulaire, Département Infection et Epidémiologie, Institut Pasteur, Paris, France
    AIDS 21:101-3. 2007
    ..IL-7 responsiveness is only partly restored by HAART...
  11. pmc HIV controllers maintain a population of highly efficient Th1 effector cells in contrast to patients treated in the long term
    Benoit Vingert
    Unité d Immunogénétique Cellulaire, Institut Pasteur, Paris, France
    J Virol 86:10661-74. 2012
    ..In conclusion, HIV controllers maintained a population of highly efficient Th1 effectors directed against Gag in spite of a persistently low antigenemia, while patients treated in the long term showed a loss of CD4 effector functions...
  12. doi request reprint Prolonged valproic acid treatment does not reduce the size of latent HIV reservoir
    Nathalie Sagot-Lerolle
    INSERM, U802, Bicetre, France
    AIDS 22:1125-9. 2008
    ..To investigate the impact of prolonged valproic acid treatment on the HIV reservoir in patients on highly active antiretroviral therapy...
  13. doi request reprint Antiretroviral therapy initiation during primary HIV infection enhances both CD127 expression and the proliferative capacity of HIV-specific CD8+ T cells
    Camille Lécuroux
    INSERM U 802, Universite Paris Sud XI, AP HP Hôpital Bicêtre, Le Kremlin Bicetre, France
    AIDS 23:1649-58. 2009
    ....
  14. pmc HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity
    Benoit Vingert
    Unité d Immunogénétique Cellulaire, Institut Pasteur, Paris, France
    PLoS Pathog 6:e1000780. 2010
    ..Thus, HIV controllers harbor a pool of memory CD4+ T cells with the intrinsic ability to recognize minimal amounts of Gag antigen, which may explain how they maintain an active antiviral response in the face of very low viremia...
  15. pmc CD4 dynamics over a 15 year-period among HIV controllers enrolled in the ANRS French observatory
    Faroudy Boufassa
    INSERM, CESP Centre for research in Epidemiology and Population Health, U1018, Epidemiology of HIV and STI Team, Le Kremlin Bicetre, France
    PLoS ONE 6:e18726. 2011
    ..There are few large published studies of HIV controllers with long-term undetectable viral load (VL). We describe the characteristics and outcomes of 81 French HIV controllers...
  16. doi request reprint Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gag-specific CD8 T cell responses
    Asier Saez-Cirion
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France
    J Immunol 182:7828-37. 2009
    ..These results, on the one hand, suggest the importance of Gag responses in the antiviral potency of CD8(+) T cells from HICs and, on the other hand, propose that other host mechanisms may contribute to restraining HIV infection in HICs...
  17. pmc Potential Role for HIV-Specific CD38-/HLA-DR+ CD8+ T Cells in Viral Suppression and Cytotoxicity in HIV Controllers
    Stéphane Hua
    INSERM U1012, Le Kremlin Bicetre, France Université Paris Sud 11, Le Kremlin Bicetre, France
    PLoS ONE 9:e101920. 2014
    ..HIV controllers (HIC) are rare HIV-1-infected patients who exhibit spontaneous viral control. HIC have high frequency of CD38-/HLA-DR+ HIV-specific CD8+ T cells. Here we examined the role of this subset in HIC status...
  18. doi request reprint HIV infection perturbs interleukin-7 signaling at the step of STAT5 nuclear relocalization
    Ivan Landires
    Pasteur Institute, Cellular Immunogenetics Unit, Paris, France
    AIDS 25:1843-53. 2011
    ..We set to investigate the nature of IL-7-dependent signaling defects in patients with progressive HIV-1 infection...
  19. pmc Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers
    Asier Saez-Cirion
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France
    Blood 118:955-64. 2011
    ..These results point to a contribution of intrinsic cell resistance to the control of infection and the containment of viral reservoir in HICs...
  20. doi request reprint Elevated IP10 levels are associated with immune activation and low CD4⁺ T-cell counts in HIV controller patients
    Nicolas Noel
    aINSERM U1012, Régulation de la réponse immune, infection VIH1 et autoimmunité, Université Paris Sud bAPHP, Service de Medecine Interne, Hôpitaux Universitaires Paris Sud cINSERM U1018, Centre de Recherche en Epidémiologie et Santé des Populations, Universite Paris Sud, Le Kremlin Bicêtre dInstitut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris eService de Microbiologie, CHU Carémeau fINSERM U1047, Centre National de Référence des Brucella L A, UFR de Médecine Université Montpellier 1, Nîmes gFaculté de Médecine Paris Sud XI, Le Kremlin Bicêtre hAPHP, Laboratoire de Virologie, CHU Necker, Paris, France
    AIDS 28:467-76. 2014
    ..The levels of inflammatory biomarkers in HICs and the biomarkers' relationships with immunologic and virologic status have yet to be fully characterized...
  21. ncbi request reprint Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study)
    Aurelia Lamine
    INSERM U802, Paris XI University, Bicetre, France
    AIDS 21:1043-5. 2007
    ..The vif and vpr genes were normal. Infection with HIV-1 variants with attenuated replicative capacity cannot be a general factor accounting for undetectable viraemia in HIV controllers...
  22. ncbi request reprint Plasmacytoid dendritic cells (pDCs) from HIV controllers produce interferon-α and differentiate into functional killer pDCs under HIV activation
    Lucie Barblu
    Centre National de Recherche Scientifique UMR 8147, Universite Paris Descartes, Paris, France
    J Infect Dis 206:790-801. 2012
    ..Simian models have shown that prolonged high levels of IFN-α production could be responsible for AIDS progression...
  23. doi request reprint Natural history of HIV-control since seroconversion
    Yoann Madec
    aInstitut Pasteur, Emerging Diseases Epidemiology Unit, Paris bINSERM U1018, Centre de Recherche en Epidémiologie et Santé des Populations, Le Kremlin Bicêtre cFaculté de Médecine Paris Sud, Universite Paris Sud, Paris dDepartment of Public Health, AP HP, Bicetre Hospital, Le Kremlin Bicetre, France eMedical Research Council, Clinical Trials Unit, London, UK fCluster Infectious Diseases, Department of Research, Center for Infection and Immunity Amsterdam CINIMA, Public Health Service, Amsterdam, The Netherlands gResearch Department of Infection and Population Health, UCL Medical School, London, UK hSan Paolo Hospital, Milan, Italy iInternational AIDS Vaccine Initiative, San Francisco, USA jRobert Koch Institut, Berlin, Germany kUlleval Hospital, Oslo, Norway lINSERM U1012, Le Kremlin Bicêtre mDepartment of Internal Medicine, AP HP, Bicetre Hospital, Le Kremlin Bicêtre nUniversité Paris Sud, Paris, France
    AIDS 27:2451-60. 2013
    ..HIV-controllers spontaneously maintain HIV viremia at an undetectable level. We aimed to describe the delay to control from seroconversion, the duration of control, and risk factors for losing control...
  24. doi request reprint MHC-driven HIV-1 control on the long run is not systematically determined at early times post-HIV-1 infection
    Guillemette Antoni
    Epidemiology and Public Health Service, APHP, Hôpital du Kremlin Bicêtre, Universite Paris Sud, Paris, France
    AIDS 27:1707-16. 2013
    ..This effect is observed early after infection. Clarification needs to be established concerning the moment of action for the other HLA-B or HLA-C alleles...
  25. ncbi request reprint Regulatory dysfunction of the interleukin-7 receptor in CD4 and CD8 lymphocytes from HIV-infected patients--effects of antiretroviral therapy
    Jean Hervé Colle
    Unité Immunogénétique Cellulaire, Département de Médecine Moléculaire, Institut Pasteur, Paris, France
    J Acquir Immune Defic Syndr 42:277-85. 2006
    ..This may be due to abnormal activation of the immune system in HIV-infected patients and may contribute to the reduced CD4 count and the altered function of the CD8 compartment...
  26. doi request reprint NKG2D expression on HIV-specific CD8+ T cells is reduced in viremic HIV-1-infected patients but maintained in HIV controllers
    Camille Lécuroux
    INSERM, U1012, Le Kremlin Bicetre, France
    J Acquir Immune Defic Syndr 62:17-20. 2013
    ..The maintenance of NKG2D expression on CD8 T cells in HIV controllers may contribute to better cell function...
  27. doi request reprint Study of anti-Müllerian hormone and its relation to the subsequent probability of pregnancy in 112 patients with systemic lupus erythematosus, exposed or not to cyclophosphamide
    Nathalie Morel
    University Pierre and Marie Curie UPMC, Universite Paris 6, Paris, France
    J Clin Endocrinol Metab 98:3785-92. 2013
    ..There are no data available about the relation between anti-Müllerian hormone (AMH) serum levels and the probability of subsequent pregnancy in SLE patients...
  28. pmc Pressure from TRIM5α contributes to control of HIV-1 replication by individuals expressing protective HLA-B alleles
    Clémence Granier
    INSERM U941, Paris, France
    J Virol 87:10368-80. 2013
    ....
  29. pmc Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study
    Asier Saez-Cirion
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France
    PLoS Pathog 9:e1003211. 2013
    ..Our results show that early and prolonged cART may allow some individuals with a rather unfavorable background to achieve long-term infection control and may have important implications in the search for a functional HIV cure...
  30. doi request reprint CD4⁺ recent thymic emigrants are infected by HIV in vivo, implication for pathogenesis
    Véronique Fabre-Mersseman
    Institut Cochin, Département Immunologie Hematologie, Paris, France
    AIDS 25:1153-62. 2011
    ....
  31. doi request reprint Reconstitution inflammatory syndrome related to histoplasmosis, with a hemophagocytic syndrome in HIV infection
    Marc de Lavaissiere
    Service de Medecine Interne, Hopital Bicetre, AP HP, Le Kremlin Bicetre, France
    J Infect 58:245-7. 2009
    ..The immune reconstitution inflammatory syndrome might be a risk factor for hemophagocytosis...
  32. doi request reprint Safety and efficacy of rituximab in systemic lupus erythematosus: results from 136 patients from the French AutoImmunity and Rituximab registry
    Benjamin Terrier
    Bicetre Hospital, Assistance Publique Hopitaux de Paris, and Paris 11 University, Le Kremlin Bicetre, France
    Arthritis Rheum 62:2458-66. 2010
    ..However, in 2 recent randomized controlled trials (RCTs) of RTX, the primary end points were not met. We undertook this study to evaluate the safety and efficacy of RTX in off-trial patients with SLE seen in regular clinical practice...
  33. ncbi request reprint Efficacy of rituximab in refractory polymyositis
    Olivier Lambotte
    Department of Internal Medicine, Bicetre Hospital, Le Kremlin Bicetre, Paris, France
    J Rheumatol 32:1369-70. 2005
    ..Rituximab was well tolerated, and its efficacy in inflammatory myositis should be evaluated...
  34. pmc Blunted response to combination antiretroviral therapy in HIV elite controllers: an international HIV controller collaboration
    Faroudy Boufassa
    INSERM, CESP Centre for research in Epidemiology and Population Health, Epidemiology of HIV and STI Team, Le Kremlin Bicetre, France Univ Paris Sud, Le Kremlin Bicetre, France
    PLoS ONE 9:e85516. 2014
    ..Here we studied the CD4 T-cell count dynamics after cART initiation among 34 ECs followed in U.S. and European cohorts, by comparison with chronically viremic patients (VIRs)...
  35. pmc High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers
    Olivier Lambotte
    INSERM, U1012, Bicetre, France AP HP, Department of Internal Medicine and Infectious Diseases, Bicetre Hospital, Bicetre, France University Paris Sud, Bicetre, France
    PLoS ONE 8:e74855. 2013
    ..0086). These data suggest a role for ADCC in immune control of HIV, especially in HLA B57 negative controllers. ..
  36. ncbi request reprint In patients on prolonged HAART, a significant pool of HIV infected CD4 T cells are HIV-specific
    Audrey Demoustier
    Inserm E 0109, Faculté de Médecine de Bicêtre, Universite Paris XI, Bicetre, France
    AIDS 16:1749-54. 2002
    ..To examine the antigen specificities of HIV reservoir CD4 T cells in patients on prolonged and effective highly active antiretroviral therapy (HAART)...
  37. pmc Diagnosis of autoimmune lymphoproliferative syndrome caused by FAS deficiency in adults
    Olivier Lambotte
    Service de Medecine Interne, Assistance Publique Hopitaux de Paris, Hôpital du Kremlin Bicêtre, Le Kremlin Bicetre, France
    Haematologica 98:389-92. 2013
    ..Autoimmune lymphoproliferative syndrome may well be diagnosed in adulthood. The occurrence of additional genetic events may account for the delayed disease onset...
  38. ncbi request reprint High ferritin and low glycosylated ferritin may also be a marker of excessive macrophage activation
    Olivier Lambotte
    Department of Internal Medicine, Groupe Hospitalier Pitié, Paris, France
    J Rheumatol 30:1027-8. 2003
    ..However, high ferritin levels are found during hemophagocytosis syndrome (HS). We investigated the ferritin level and the percentage of glycosylation in a HS series of various causes...
  39. doi request reprint A survey of 90 patients with autoimmune lymphoproliferative syndrome related to TNFRSF6 mutation
    Benedicte Neven
    Inserm U768, Hopital Necker Enfants Malades, Paris, France
    Blood 118:4798-807. 2011
    ..We also noted a significantly greater occurrence of disease-related symptoms in male than in female patients...
  40. pmc HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis
    Delphine Sauce
    INSERM UMR S 945, Infections and Immunity, Avenir Group, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    Blood 117:5142-51. 2011
    ..These findings highlight the importance of primary hematopoietic resources in HIV pathogenesis and the response to antiretroviral treatments...
  41. ncbi request reprint [Burkitt's lymphoma in a patient with systemic lupus erythematosus treated with immunosuppressive drugs. A case report]
    C Bellier
    Service de Medecine Interne, CHU Henri Mondor, APHP, Creteil, France
    Rev Med Interne 27:244-7. 2006
    ..However, the pathophysiological link between lymphoma and SLE is still a matter of debate. We report a new case of Burkitt's lymphoma occurring in a patient treated with immunosuppressive drugs for SLE...
  42. pmc A web-based delphi study for eliciting helpful criteria in the positive diagnosis of hemophagocytic syndrome in adult patients
    Gilles Hejblum
    INSERM, UMR_S 1136, Institut Pierre Louis d Epidémiologie et de Santé Publique, Paris, France Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d Epidémiologie et de Santé Publique, Paris, France AP HP, Hopital Saint Antoine, Unité de santé publique, Paris, France
    PLoS ONE 9:e94024. 2014
    ..The study constitutes the first initiative to date for defining international guidelines devoted to the positive diagnosis of the reactive form of hemophagocytic syndrome. ..
  43. ncbi request reprint Efficacy of mycophenolate mofetil in adult refractory auto-immune cytopenias: a single center preliminary study
    Rami Kotb
    Department of Internal Medicine, Hopital de Bicetre, AP HP, Faculte de Medecine Paris Sud, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Eur J Haematol 75:60-4. 2005
    ..Treatment of auto-immune cytopenia refractory to front line therapy with intravenous immunoglobulins and steroids is a matter of concern. We assessed the efficacy and safety of mycophenolate mofetil in a prospective open preliminary study...
  44. pmc B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells
    Matthieu Mahevas
    Faculte de Medecine, Site Necker Enfants Malades, INSERM U783 Développement du système immunitaire, Universite Paris Descartes, Paris, France
    J Clin Invest 123:432-42. 2013
    ..Surprisingly, long-lived PC were not detected in untreated ITP spleens. These results suggest that the milieu generated by B cell depletion promotes the differentiation and settlement of long-lived PC in the spleen...
  45. doi request reprint FAS-L, IL-10, and double-negative CD4- CD8- TCR alpha/beta+ T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function
    Aude Magerus-Chatinet
    Inserm U768, Paris, France
    Blood 113:3027-30. 2009
    ..Overall, we showed that determination of the FAS-L represents, together with the IL-10 concentration and the DNT cell percentage, a reliable tool for the diagnosis of ALPS...
  46. ncbi request reprint Auricular chondritis and thrombotic microangiopathy: an unusual combination revealing systemic lupus erythematosus
    Nathalia Bellon
    AP HP, Department of Internal Medicine, Bicêtre University Medical Center, 78, rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Joint Bone Spine 80:424-5. 2013
    ..We report here a case of polychondritis, which was the first manifestation of a lupus-associated thrombotic microangiopathy. ..
  47. pmc Decreased B cell activating factor receptor expression on peripheral lymphocytes associated with increased disease activity in primary Sjögren's syndrome and systemic lupus erythematosus
    Jeremie Sellam
    Service de Rhumatologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Ann Rheum Dis 66:790-7. 2007
    ..To analyse B cell activating factor (BAFF) receptor (BAFF-R) expression on peripheral lymphocytes from patients with primary Sjögren's syndrome (pSS) and systemic lupus erythematosus (SLE)...
  48. doi request reprint [HIV controllers: how these patients control viral replication?]
    Olivier Lambotte
    Service de Medecine Interne et Maladies Infectieuses, CHU de Bicetre, Le Kremlin Bicetre, Le Kremlin Bicetre, France
    Med Sci (Paris) 28:172-8. 2012
    ....
  49. ncbi request reprint Hemophagocytic syndrome as a presenting sign of transformation of smoldering to acute adult T-cell leukemia/lymphoma: efficacy of anti-retroviral and interferon therapy
    Achille Aouba
    Department of Haematology, Hopital Necker Enfants Malades, Paris, France
    Am J Hematol 76:187-9. 2004
    ..Thus, we propose that adult T-cell leukemia/lymphoma must be added to the spectrum of etiologies of hemophagocytic syndrome...
  50. doi request reprint Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus
    Fanny Menard
    Universite Paris Sud, F 94270, Paris, France
    Clin Infect Dis 47:531-4. 2008
    ..3:1), immunodeficiency-like histological features (lymphocyte depletion, 45% of cases; mixed cellularity Hodgkin lymphoma subtype, 40%), and strong association with Epstein-Barr virus (94%)...
  51. doi request reprint Low glycosylated ferritin, a good marker for the diagnosis of hemophagocytic syndrome
    Laurence Fardet
    Department of Internal Medicine, Hopital Saint Antoine, Paris, France
    Arthritis Rheum 58:1521-7. 2008
    ..We undertook this study to determine whether hemophagocytic syndrome outside the context of AOSD is also associated with a very low percentage of glycosylated ferritin...
  52. doi request reprint Glomerular lesions in patients with sickle cell disease
    Gwenola Maigne
    Internal Medicine Unit, APHP, Hôpital Kremlin Bicêtre, Université Paris 11, Le Kremlin Bicetre, France
    Medicine (Baltimore) 89:18-27. 2010
    ..Hypoxic state does not seem to play a key role in the progression of glomerular lesions, but its potential role at an early stage of glomerular injury requires further investigation...
  53. pmc Tolerance and short term efficacy of rituximab in 43 patients with systemic autoimmune diseases
    J E Gottenberg
    Service de Rhumatologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Ann Rheum Dis 64:913-20. 2005
    ..To assess the tolerance and efficacy of rituximab in patients with various autoimmune diseases seen in daily rheumatological practice...
  54. doi request reprint [Autoimmune myelofibrosis with dermatomyositis]
    S Sahali
    Service de Medecine Interne, CHU de Bicetre, AP HP, 78, rue du General Leclerc, 94275 Le Kremlin Bicetre, France
    Rev Med Interne 30:71-3. 2009
    ..We report a second observation of autoimmune myelofibrosis associated with an inflammatory myositis in a 30-year-old female. The links between myelofibrosis and autoimmunity are discussed...
  55. ncbi request reprint HIV controllers: how do they tame the virus?
    Asier Saez-Cirion
    Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 25 rue du Dr Roux, 75725 Paris Cedex 15, France
    Trends Immunol 28:532-40. 2007
    ..In this review, we examine recent findings from these studies...
  56. ncbi request reprint Persistence of replication-competent HIV in the central nervous system despite long-term effective highly active antiretroviral therapy
    Olivier Lambotte
    AIDS 19:217-8. 2005
  57. ncbi request reprint HIV-1 persistence, viral reservoir, and the central nervous system in the HAART era
    Olivier Lambotte
    Laboratoire Immunité antivirale systémique et cérébrale Equipe Mixte INSERM et Université Paris Sud N o 0109 et Hôpital Bicêtre Assistance Publique Hôpitaux de Paris, France
    Brain Pathol 13:95-103. 2003
    ..A similar viral integration in astrocytes and less likely in resting microglia is suggested by several studies, although it has yet to be demonstrated conclusively...
  58. pmc HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
    Asier Saez-Cirion
    Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 75725 Paris, France
    Proc Natl Acad Sci U S A 104:6776-81. 2007
    ..This constitutive antiviral capacity of CD8(+) T cells could account for the control of viral replication in HIC...
  59. ncbi request reprint Lack of evidence for prolonged double-long terminal repeat episomal HIV DNA stability in vivo
    Houria Hendel Chavez
    J Acquir Immune Defic Syndr 45:247-9. 2007
  60. ncbi request reprint [Fatal liver failure after hepatitis B reactivation following chemotherapy for lymphoma in a patient with only anti-HBc antibody and review of the literature]
    Anne Thirot-Bidault
    Service des maladies du foie et de l appareil digestif, Hopital de Bicetre, Le Kremlin Bicetre
    Gastroenterol Clin Biol 31:1028-31. 2007
    ..In the literature, only 13 cases of patients with positive anti body anti-HBc alone who developed an hepatitis B reactivation after chemotherapy have been reported...
  61. ncbi request reprint Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 12:1365-71. 2006
    ..These data establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection...
  62. ncbi request reprint The significance of distal bronchial samples with commensals in ventilator-associated pneumonia: colonizer or pathogen?
    Olivier Lambotte
    Réanimation Polyvalente, Hopital Saint Joseph, 46 rue Henri Huchard, 75018 Paris, France
    Chest 122:1389-99. 2002
    ..To investigate the role of oropharyngeal and cutaneous commensal microorganisms (OCCs) as a cause of ventilator-associated pneumonia (VAP)...
  63. pmc Preserved central memory and activated effector memory CD4+ T-cell subsets in human immunodeficiency virus controllers: an ANRS EP36 study
    Simon J Potter
    Unité d Immunogénétique Cellulaire, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Virol 81:13904-15. 2007
    ..These findings suggest the induction of an efficient, nondetrimental type of immune activation in patients who spontaneously control HIV...