Nadine Laguette

Summary

Country: France

Publications

  1. pmc How SAMHD1 changes our view of viral restriction
    Nadine Laguette
    Laboratoire de Virologie Moleculaire, Institut de Genetique Humaine, CNRS UPR 1142, 141 rue de la Cardonille, 34296 Montpellier Cedex 5, France
    Trends Immunol 33:26-33. 2012
  2. doi request reprint Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing
    Nadine Laguette
    Institut de Genetique Humaine, Laboratoire de Virologie Moleculaire, CNRS UPR1142, Montpellier 34000, France Electronic address
    Cell 156:134-45. 2014
  3. pmc Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac
    Alberto Brandariz-Nuñez
    Department of Microbiology and Immunology, Albert Einstein College of Medicine Bronx, Bronx, NY 10461, USA
    Retrovirology 9:49. 2012
  4. pmc SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
    Nadine Laguette
    Institut de Genetique Humaine, Laboratoire de Virologie Moleculaire, CNRS UPR1142, Montpellier 34000, France
    Nature 474:654-7. 2011
  5. doi request reprint Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1
    Alexandra Cribier
    Institut de Genetique Humaine, CNRS UPR1142, Laboratoires de Virologie Moléculaire, Montpellier 34000, France
    Cell Rep 3:1036-43. 2013
  6. pmc SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells
    Benjamin Descours
    Institut de Genetique Humaine, CNRS UPR1142, Laboratoires de Virologie Moléculaire, Montpellier, France
    Retrovirology 9:87. 2012
  7. pmc HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP
    Bijan Sobhian
    Laboratoire de Virologie Moleculaire, Institut de Genetique Humaine, CNRS UPR1142, Montpellier, France
    Mol Cell 38:439-51. 2010
  8. pmc Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein
    Nadine Laguette
    Institut de Genetique Humaine, Centre National de la Recherche Scientifique, Unité Propre de Recherche 1142, Laboratoires de Virologie Moléculaire, 34000 Montpellier, France
    Cell Host Microbe 11:205-17. 2012

Detail Information

Publications8

  1. pmc How SAMHD1 changes our view of viral restriction
    Nadine Laguette
    Laboratoire de Virologie Moleculaire, Institut de Genetique Humaine, CNRS UPR 1142, 141 rue de la Cardonille, 34296 Montpellier Cedex 5, France
    Trends Immunol 33:26-33. 2012
    ....
  2. doi request reprint Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing
    Nadine Laguette
    Institut de Genetique Humaine, Laboratoire de Virologie Moleculaire, CNRS UPR1142, Montpellier 34000, France Electronic address
    Cell 156:134-45. 2014
    ..Thus, our work not only reveals the identity of the cellular factors required for Vpr-mediated G2/M arrest but also identifies the SLX4com as a regulator of innate immunity. ..
  3. pmc Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac
    Alberto Brandariz-Nuñez
    Department of Microbiology and Immunology, Albert Einstein College of Medicine Bronx, Bronx, NY 10461, USA
    Retrovirology 9:49. 2012
    ..The viral accessory protein Vpx overcomes the SAMHD1-mediated lentiviral block by inducing its proteasomal degradation...
  4. pmc SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
    Nadine Laguette
    Institut de Genetique Humaine, Laboratoire de Virologie Moleculaire, CNRS UPR1142, Montpellier 34000, France
    Nature 474:654-7. 2011
    ..Our results demonstrate that SAMHD1 is an antiretroviral protein expressed in cells of the myeloid lineage that inhibits an early step of the viral life cycle...
  5. doi request reprint Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1
    Alexandra Cribier
    Institut de Genetique Humaine, CNRS UPR1142, Laboratoires de Virologie Moléculaire, Montpellier 34000, France
    Cell Rep 3:1036-43. 2013
    ..Our results uncover the phosphorylation of SAMHD1 at Thr592 by cyclin A2/CDK1 as a key regulatory mechanism of its antiviral activity...
  6. pmc SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells
    Benjamin Descours
    Institut de Genetique Humaine, CNRS UPR1142, Laboratoires de Virologie Moléculaire, Montpellier, France
    Retrovirology 9:87. 2012
    ..Quiescent CD4+ T lymphocytes are highly refractory to HIV-1 infection due to a block at reverse transcription...
  7. pmc HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP
    Bijan Sobhian
    Laboratoire de Virologie Moleculaire, Institut de Genetique Humaine, CNRS UPR1142, Montpellier, France
    Mol Cell 38:439-51. 2010
    ....
  8. pmc Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein
    Nadine Laguette
    Institut de Genetique Humaine, Centre National de la Recherche Scientifique, Unité Propre de Recherche 1142, Laboratoires de Virologie Moléculaire, 34000 Montpellier, France
    Cell Host Microbe 11:205-17. 2012
    ..The distinct evolutionary signature of SAMHD1 sheds light on the development of its antiviral specificity...