Brégnard C, Guerra J, Dejardin S, Passalacqua F, Benkirane M, Laguette N. Upregulated LINE-1 Activity in the Fanconi Anemia Cancer Susceptibility Syndrome Leads to Spontaneous Pro-inflammatory Cytokine Production. EBioMedicine. 2016;8:184-194 pubmed publisher
..Altogether, our data open perspectives in the prevention of adverse effects of chronic inflammation in tumorigenesis. ..
Laguette N, Sobhian B, Casartelli N, Ringeard M, Chable Bessia C, Segeral E, et al
. SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature. 2011;474:654-7 pubmed publisher
..Our results demonstrate that SAMHD1 is an antiretroviral protein expressed in cells of the myeloid lineage that inhibits an early step of the viral life cycle...
Laguette N, Brégnard C, Hue P, Basbous J, Yatim A, Larroque M, et al
. Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing. Cell. 2014;156:134-45 pubmed publisher
..Thus, our work not only reveals the identity of the cellular factors required for Vpr-mediated G2/M arrest but also identifies the SLX4com as a regulator of innate immunity. ..