M Lafontan

Summary

Country: France

Publications

  1. ncbi Role of adipokines in the control of energy metabolism: focus on adiponectin
    Max Lafontan
    IFR31 Institut Louis Bugnard, Hopital Rangueil, Institut National de le Santé et de la Recherche Médicale INSERM, Obesity Research Unit Inserm UPS U586, BP 84225, F 31432 Toulouse Cedex 4, France
    Curr Opin Pharmacol 6:580-5. 2006
  2. ncbi Impact of visceral adipose tissue on liver metabolism. Part I: heterogeneity of adipose tissue and functional properties of visceral adipose tissue
    M Lafontan
    INSERM U858, institut de médecine moléculaire Rangueil, IFR31 Institut Louis Bugnard, 1, avenue Jean Poulhes, B P 84225, 31432 Toulouse Cedex 4, France
    Diabetes Metab 34:317-27. 2008
  3. ncbi Fat cells: afferent and efferent messages define new approaches to treat obesity
    Max Lafontan
    Obesity Research Unit, French Institute of Health and Medical Research Inserm UPS Unit 586, Universite Paul Sabatier, Institut Louis Bugnard, Hopital Rangueil, TSA50032, 31059 Toulouse Cedex 9, France
    Annu Rev Pharmacol Toxicol 45:119-46. 2005
  4. ncbi An unsuspected metabolic role for atrial natriuretic peptides: the control of lipolysis, lipid mobilization, and systemic nonesterified fatty acids levels in humans
    Max Lafontan
    IFR 31, Institut Louis Bugnard, Hopital Rangueil, Institut National de la Sante et de la Recherche Medicale, INSERM U586, 31432 Toulouse Cedex 4, France
    Arterioscler Thromb Vasc Biol 25:2032-42. 2005
  5. ncbi Control of lipolysis by natriuretic peptides and cyclic GMP
    Max Lafontan
    Inserm Institut National de la Santé et de la Recherche Médicale U858, I2MR Institut de Médecine Moléculaire de Rangueil, BP 84225, Toulouse Cedex 4, France
    Trends Endocrinol Metab 19:130-7. 2008
  6. ncbi Do regional differences in adipocyte biology provide new pathophysiological insights?
    Max Lafontan
    Unité de Recherches sur les Obésités Unité INSERM 586, Institut Louis Bugnard, Universite Paul Sabatier, CHU Rangueil, 31403 Toulouse Cedex 4, France
    Trends Pharmacol Sci 24:276-83. 2003
  7. ncbi [Metabolic and secretory activities of adipocytes]
    M Lafontan
    Unité Inserm 317, Institut Louis Bugnard, Universite Paul Sabatier, CHU Rangueil, Batiment L3, 31403 Toulouse, France
    Pathol Biol (Paris) 51:238-40. 2003
  8. ncbi Coexistence of beta 1-, beta 2-, and beta 3-adrenoceptors in dog fat cells and their differential activation by catecholamines
    J Galitzky
    Institut National de la Sante et de la Recherche Medicale, Faculte de Medecine, Universite Paul Sabatier, Toulouse, France
    Am J Physiol 264:E403-12. 1993
  9. ncbi Beta 3-adrenoceptors in dog adipose tissue: studies on their involvement in the lipomobilizing effect of catecholamines
    J Galitzky
    Institut National de la Sante et de la Recherche Medicale Unite 317, Faculte de Medecine, Universite Paul Sabatier, France
    J Pharmacol Exp Ther 266:358-66. 1993
  10. ncbi Hamster adipocyte alpha 2-adrenoceptor changes during fat mass modifications are not directly dependent on adipose tissue norepinephrine content
    J S Saulnier-Blache
    Institut National de la Santé et de la Recherche Médicale I N S E R M U 317, Universite Paul Sabatier, Toulouse, France
    Endocrinology 126:2425-34. 1990

Collaborators

Detail Information

Publications64

  1. ncbi Role of adipokines in the control of energy metabolism: focus on adiponectin
    Max Lafontan
    IFR31 Institut Louis Bugnard, Hopital Rangueil, Institut National de le Santé et de la Recherche Médicale INSERM, Obesity Research Unit Inserm UPS U586, BP 84225, F 31432 Toulouse Cedex 4, France
    Curr Opin Pharmacol 6:580-5. 2006
    ..In addition, adiponectin signaling pathways have recently been clarified by the discovery of a protein that interacts with adiponectin receptors...
  2. ncbi Impact of visceral adipose tissue on liver metabolism. Part I: heterogeneity of adipose tissue and functional properties of visceral adipose tissue
    M Lafontan
    INSERM U858, institut de médecine moléculaire Rangueil, IFR31 Institut Louis Bugnard, 1, avenue Jean Poulhes, B P 84225, 31432 Toulouse Cedex 4, France
    Diabetes Metab 34:317-27. 2008
    ..The functional characteristics of visceral adipose tissue will be compared with subcutaneous adipose tissue to clarify the major mechanisms affecting free fatty acid metabolism and cytokine production...
  3. ncbi Fat cells: afferent and efferent messages define new approaches to treat obesity
    Max Lafontan
    Obesity Research Unit, French Institute of Health and Medical Research Inserm UPS Unit 586, Universite Paul Sabatier, Institut Louis Bugnard, Hopital Rangueil, TSA50032, 31059 Toulouse Cedex 9, France
    Annu Rev Pharmacol Toxicol 45:119-46. 2005
    ..It is unlikely that all the adipocyte's endocrine and paracrine signals have been identified. Putative pharmacological strategies aiming at modulation of afferent and efferent fat cell messages are reviewed and discussed...
  4. ncbi An unsuspected metabolic role for atrial natriuretic peptides: the control of lipolysis, lipid mobilization, and systemic nonesterified fatty acids levels in humans
    Max Lafontan
    IFR 31, Institut Louis Bugnard, Hopital Rangueil, Institut National de la Sante et de la Recherche Medicale, INSERM U586, 31432 Toulouse Cedex 4, France
    Arterioscler Thromb Vasc Biol 25:2032-42. 2005
    ..The potential influence of NPs on the development of lipid disorders, obesity-related cardiovascular events, and cardiac cachexia will be discussed in this review...
  5. ncbi Control of lipolysis by natriuretic peptides and cyclic GMP
    Max Lafontan
    Inserm Institut National de la Santé et de la Recherche Médicale U858, I2MR Institut de Médecine Moléculaire de Rangueil, BP 84225, Toulouse Cedex 4, France
    Trends Endocrinol Metab 19:130-7. 2008
    ..These findings have metabolic implications and point to potential problems when natriuretic peptide secretion is altered or during therapeutic use of recombinant BNP...
  6. ncbi Do regional differences in adipocyte biology provide new pathophysiological insights?
    Max Lafontan
    Unité de Recherches sur les Obésités Unité INSERM 586, Institut Louis Bugnard, Universite Paul Sabatier, CHU Rangueil, 31403 Toulouse Cedex 4, France
    Trends Pharmacol Sci 24:276-83. 2003
    ..Possible pharmacological approaches to the treatment of obesity and related diseases are also considered...
  7. ncbi [Metabolic and secretory activities of adipocytes]
    M Lafontan
    Unité Inserm 317, Institut Louis Bugnard, Universite Paul Sabatier, CHU Rangueil, Batiment L3, 31403 Toulouse, France
    Pathol Biol (Paris) 51:238-40. 2003
    ..Numerous molecules synthesized and released by adipocytes have been described but their precise roles have to be studied in vivo before their potential application in treatment of obesity or type II diabetes can be proposed...
  8. ncbi Coexistence of beta 1-, beta 2-, and beta 3-adrenoceptors in dog fat cells and their differential activation by catecholamines
    J Galitzky
    Institut National de la Sante et de la Recherche Medicale, Faculte de Medecine, Universite Paul Sabatier, Toulouse, France
    Am J Physiol 264:E403-12. 1993
    ....
  9. ncbi Beta 3-adrenoceptors in dog adipose tissue: studies on their involvement in the lipomobilizing effect of catecholamines
    J Galitzky
    Institut National de la Sante et de la Recherche Medicale Unite 317, Faculte de Medecine, Universite Paul Sabatier, France
    J Pharmacol Exp Ther 266:358-66. 1993
    ..However, endogenous catecholamines released after sympathetic nervous system activation could stimulate beta 3-ARs in adipocytes only if a high level of sympathetic nervous system activity is realized...
  10. ncbi Hamster adipocyte alpha 2-adrenoceptor changes during fat mass modifications are not directly dependent on adipose tissue norepinephrine content
    J S Saulnier-Blache
    Institut National de la Santé et de la Recherche Médicale I N S E R M U 317, Universite Paul Sabatier, Toulouse, France
    Endocrinology 126:2425-34. 1990
    ..Nevertheless, the sympathetic-dependent mobilization of the fat stores, after induction of caloric restriction, can indirectly modulate the alpha 2-adrenoceptor density in the adipocyte by promoting changes in white fat cell size...
  11. ncbi Beta-3 adrenoceptor-mediated increase in cutaneous blood flow in the dog
    M Berlan
    Laboratoire de Pharmacologie Medicale et Clinique, Institut National de la Sante et de la Recherche Medicale, Unité 317, Faculte de Medecine, Toulouse, France
    J Pharmacol Exp Ther 268:1444-51. 1994
    ..BRL 37344 (but not isoproterenol) increased cutaneous temperature in normal dogs. This study suggests that beta-3 adrenoceptors exist in canine cutaneous vascular smooth muscles and that their stimulation induces vasodilatation...
  12. ncbi Atrial natriuretic peptide inhibits the production of adipokines and cytokines linked to inflammation and insulin resistance in human subcutaneous adipose tissue
    C Moro
    INSERM, U586, Obesity Research Unit, Toulouse, France
    Diabetologia 50:1038-47. 2007
    ....
  13. ncbi Recent developments on lipolysis regulation in humans and discovery of a new lipolytic pathway
    M Lafontan
    Unité Inserm 317, Institut Louis Bugnard, Universite Paul Sabatier, Toulouse, France
    Int J Obes Relat Metab Disord 24:S47-52. 2000
    ..A potent lipolytic and lipomobilizing effect of atrial natriuretic peptide has recently been discovered; the mechanisms of action and physiological relevance will also be discussed...
  14. ncbi Endothelial differentiation gene-2 receptor is involved in lysophosphatidic acid-dependent control of 3T3F442A preadipocyte proliferation and spreading
    C Pages
    INSERM U317, Institut Louis Bugnard, , CHU Rangueil, Batiment L3, 31403, Toulouse cedex 04, France
    J Biol Chem 276:11599-605. 2001
    ..Results demonstrate the significant contribution of the EDG-2 receptor in the biological responses generated by LPA in 3T3F442A preadipocytes...
  15. ncbi Selective reduction of alpha 2-adrenergic responsiveness in hamster adipose tissue during prolonged starvation
    C Carpene
    Institut National de la Sante et de la Recherche Medicale, U 317, Toulouse, France
    Am J Physiol 259:E80-8. 1990
    ..In the adipocyte, the alpha 2-antilipolytic responses and the alpha 2-adrenoceptor levels are dependent on the extent of the adipose mass; they are particularly reduced in emaciated hamsters...
  16. ncbi [Lipid mobilization and energy metabolism: impact of molecular and cellular approaches on the treatment of obesity]
    M Lafontan
    Unité Inserm 317, Universite Paul Sabatier, Institut Louis Bugnard, CHU Rangueil, 31403 Toulouse Cedex 4
    Ann Endocrinol (Paris) 61:56-69. 2000
    ..These include major questions about putative utilization of beta(3)-agonists, alpha(2)-antagonists and beta-antagonists in pharmacotherapy and/or prevention of obesity in humans...
  17. ncbi Predominance of beta 3-adrenergic component in catecholamine activation of lipolysis in garden dormouse adipocytes
    C Carpene
    Institut National de la Sante et de la Recherche Medicale, Universite Paul Sabatier, France
    Am J Physiol 266:R896-904. 1994
    ..This order was modified at 20 nM, arguing for the beta-atypical nature of the low-affinity sites. Thus garden dormouse adipocytes possess beta 3-ARs, which are involved to an important degree in the adrenergic activation of lipolysis...
  18. ncbi Adrenaline but not noradrenaline is a determinant of exercise-induced lipid mobilization in human subcutaneous adipose tissue
    I de Glisezinski
    Institut National de la Sante et de la Recherche Medicale, Toulouse, France
    J Physiol 587:3393-404. 2009
    ..For the moment, it is unknown if results apply specifically to SCAT and exercise only or if conclusions could be extended to all forms of lipolysis in humans...
  19. ncbi A1 adenosine receptors in the human fat cell: tissue distribution and regulation of radioligand binding
    D Larrouy
    INSERM U 317, Institut de Physiologie, Universite Paul Sabatier, Toulouse, France
    Eur J Pharmacol 206:139-47. 1991
    ....
  20. ncbi Advances in adipose tissue metabolism
    M Lafontan
    INSERM U858, Institute of Molecular Medicine of Rangueil, BP84225, 31432 Toulouse Cedex 4, Toulouse, France
    Int J Obes (Lond) 32:S39-51. 2008
    ..In addition, the in vivo validation of catecholamine action and the discovery of the lipolytic effects of natriuretic peptides will also be covered...
  21. ncbi Selective activation of beta3-adrenoceptors by octopamine: comparative studies in mammalian fat cells
    C Carpene
    Institut National de la Sante et de la Recherche Medicale INSERM, Unité 317, Institut Fédératif de Recherches 31, CHU Rangueil, Toulouse, France
    Naunyn Schmiedebergs Arch Pharmacol 359:310-21. 1999
    ..These data suggest that, among the biogenic amines metabolically related to catecholamines, octopamine can be considered as the most selective for beta3-ARs...
  22. ncbi Millennium fat-cell lipolysis reveals unsuspected novel tracks
    D Langin
    INSERM Unit 317, Institut Louis Bugnard, H pital Rangueil, Universite Paul Sabatier, Toulouse, France
    Horm Metab Res 32:443-52. 2000
    ..Genetic studies show that beta2-adrenoceptor and hormone-sensitive lipase genes may participate in the polygenic background of obesity...
  23. ncbi Coupling of inhibitory receptors with Gi-proteins in hamster adipocytes: comparison between adenosine A1 receptor and alpha 2-adrenoceptor
    D Larrouy
    INSERM U317, Institut Louis Bugnard, Universite Paul Sabatier, CHU Rangueil, Toulouse, France
    Eur J Pharmacol 267:225-32. 1994
    ....
  24. ncbi Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes
    K Lolmede
    Unité de Recherche sur les Obésités, Institut National de la Santé et de la Recherche Médicale INSERM U586, Institut Louis Bugnard, Centre Hospitalier Universitaire de Toulouse, Universite Paul Sabatier, Toulouse, France
    Int J Obes Relat Metab Disord 27:1187-95. 2003
    ..The aim of the present study is to assess the influence of hypoxia on the expression and secretion of adipocyte-derived proangiogenic factors...
  25. ncbi Human alpha 2A-adrenergic receptor gene expressed in transgenic mouse adipose tissue under the control of its regulatory elements
    J Boucher
    INSERM U317, Institut Louis Bugnard, CHU Rangueil, 31403 Toulouse Cedex 4, France
    J Mol Endocrinol 29:251-64. 2002
    ..Thus, these transgenic mice constitute an original model of diet-induced obesity for in vivo physiological and pharmacological studies with respect to the alpha2/beta-AR balance in adipose tissue...
  26. ncbi Effects of CB1 antagonist on the control of metabolic functions in obese type 2 diabetic patients
    M Lafontan
    Institut Louis Bugnard IFR31, Institut de Médecine Moléculaire de Rangueil I2MR, INSERM UPS U858, BP 84225, 31432 Toulouse cedex 04, France
    Diabetes Metab 33:85-95. 2007
    ..The emerging concept of endocannabinoids acting as metabolic regulators is the more likely explanation of the success of rimonabant treatments in phase III studies...
  27. ncbi Atrial natriuretic peptide contribution to lipid mobilization and utilization during head-down bed rest in humans
    Cedric Moro
    Institut National de la Sante et de la Recherche Medicale, U858, Laboratoire de Recherche sur les Obésités, Toulouse, France
    Am J Physiol Regul Integr Comp Physiol 293:R612-7. 2007
    ..In this physiological setting, independent of increasing catecholamines, our study suggests that ANP contributes to lipid mobilization and oxidation in healthy young men...
  28. ncbi Culture of human adipose tissue explants leads to profound alteration of adipocyte gene expression
    S Gesta
    I N S E R M U317, Institut Louis Bugnard, Universite Paul Sabatier, CHU Rangueil, Batiment L3, Toulouse cedex 04, France
    Horm Metab Res 35:158-63. 2003
    ..These data show that primary culture of human adipose tissue explants dramatically alters adipocyte gene expression...
  29. ncbi Recent data on the regulation of lipolysis by catecholamines and natriuretic peptides
    M Lafontan
    , Institut Louis Bugnard, CHU Rangueil, , 31403, Toulouse, France
    Ann Endocrinol (Paris) 63:86-90. 2002
  30. ncbi Integrated physiology and pathophysiology of CB1-mediated effects of the endocannabinoid system
    P V Piazza
    INSERM Bordeaux Neuroscience Research Center U862, University of Bordeaux II, 146 rue Leo Saignat, 33077 Bordeaux, France
    Diabetes Metab 33:97-107. 2007
    ..Finally, in a pathophysiological context, introducing the new concept of "proactive evolution diseases", which can explain the current obesity epidemic and the role the ECS plays in it...
  31. ncbi Impact of visceral adipose tissue on liver metabolism and insulin resistance. Part II: Visceral adipose tissue production and liver metabolism
    J Girard
    Institut Cochin, INSERM U567, CNRS UMR 8104, Universite Paris Descartes, 22, Rue Mechain, 75014 Paris, France
    Diabetes Metab 34:439-45. 2008
    ....
  32. ncbi Norepinephrine induces lipolysis in beta1/beta2/beta3-adrenoceptor knockout mice
    Geneviève Tavernier
    Unité de Recherches sur les Obésités, INSERM UPS U586, Institut Louis Bugnard IFR31, CHU Rangueil, Batiment L3, BP 84225, 31432 Toulouse Cedex 4, France
    Mol Pharmacol 68:793-9. 2005
    ..We conclude that the residual lipolytic effect observed in beta-less mice can be attributed to an unknown Gs-protein-coupled receptor with low affinity for catecholamines...
  33. ncbi Lipolysis and lipid mobilization in human adipose tissue
    Max Lafontan
    INSERM U, Institut de Medecine Moleculaire de Rangueil, IFR BMT, Toulouse, France
    Prog Lipid Res 48:275-97. 2009
    ..The manipulation of lipolysis has therapeutic potential in the metabolic disorders frequently associated with obesity and probably in several inborn errors of metabolism...
  34. ncbi Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity
    Carine Duffaut
    Equipe AVENIR Institut National de la Santé et de la Recherche Médicale INSERM, U858, Hôpital Rangueil Bat L4, Toulouse, France
    Biochem Biophys Res Commun 384:482-5. 2009
    ..Moreover it appears that early AT lymphocyte infiltration could be considered a protective process to temper adipose tissue inflammation...
  35. ncbi Remodeling phenotype of human subcutaneous adipose tissue macrophages
    V Bourlier
    Equipe AVENIR INSERM U858, 1 avenue Jean Poulhes, BP 84225, 31432 Toulouse Cedex 4, France
    Circulation 117:806-15. 2008
    ..However, the phenotype and functions of human ATMs are still to be defined...
  36. ncbi Differential regulation of atrial natriuretic peptide- and adrenergic receptor-dependent lipolytic pathways in human adipose tissue
    Cedric Moro
    Unité de Recherches sur les Obésités Inserm U586, Institut Louis Bugnard, Center Hospitalier Universitaire de Toulouse, Universite Paul Sabatier, 31062 Toulouse, France
    Metabolism 54:122-31. 2005
    ..The ANP-dependent lipolytic pathway undergoes desensitization in vitro and in situ. Insulin had no inhibitory effect on either ANP- or alpha(2)-AR-dependent pathways, while it counteracted the beta-AR pathway...
  37. ncbi [Natriuretic peptides: a new lipolytic pathway in human fat cells]
    Coralie Sengenes
    , Inserm U.586, Institut Louis Bugnard, CHU de Toulouse, TSA50032, 31059 Toulouse Cedex 9, France
    Med Sci (Paris) 21:29-33. 2005
    ..These findings may have several implications whenever natriuretic peptide secretion is altered such as in subjects with left ventricular dysfunction, congestive heart failure and obesity...
  38. ncbi Imidazoline binding sites in fat cells. Localization and pharmacologic differentiation from alpha 2-adrenergic receptors
    M Lafontan
    INSERM Unit 317, Institut Louis Bugnard, , Toulouse, France
    Am J Hypertens 5:72S-79S. 1992
    ..There is no clear demonstration of an interaction between NAIBS and G-proteins, adenylate cyclase, or lipolytic function in fat cells. Further studies are required to define their putative role in fat cells...
  39. ncbi Training enhances ANP lipid-mobilizing action in adipose tissue of overweight men
    Cedric Moro
    Franco-Czech Laboratory for Clinical Research on Obesity, INSERM U586, Institut Louis Bugnard, Centre Hospitalier Universitaire de Toulouse, , Toulouse, France
    Med Sci Sports Exerc 37:1126-32. 2005
    ..The recovery of a higher lipolytic efficiency in adipose tissue is an important benefit of a training program in overweight subjects...
  40. ncbi Functional and pharmacological characterization of the natriuretic peptide-dependent lipolytic pathway in human fat cells
    Cedric Moro
    , , Universitaire Rangueil, Toulouse, France
    J Pharmacol Exp Ther 308:984-92. 2004
    ..They are unaffected by insulin pretreatments of fat cells but undergo desensitization. In the search of potent and specific natriuretic peptide receptor-A antagonist, in the human fat cell, A71915 was the only reliable one found...
  41. ncbi [Natriuretic peptides: a new lipolytic pathway in human fat cells]
    Coralie Sengenes
    , Inserm U.586, Institut Louis Bugnard, CHU de Toulouse, TSA50032, 31059 Toulouse Cedex 9, France
    Med Sci (Paris) 21:61-5. 2005
    ..These findings may have several implications whenever natriuretic peptide secretion is altered such as in subjects with left ventricular dysfunction, congestive heart failure and obesity...
  42. ncbi Transcriptional regulation of adipocyte hormone-sensitive lipase by glucose
    Fatima Smih
    INSERM Unité 317, Institut Louis Bugnard, Centre Hospitalier Universitaire de Rangueil, Universite Paul Sabatier, Toulouse, France
    Diabetes 51:293-300. 2002
    ..Analogs and metabolites were used to determine the signal metabolite of the glucose response. The signal is generated downstream of glucose-6-phosphate in the glycolytic pathway before the triose phosphate step...
  43. ncbi Adipose tissue endothelial cells from obese human subjects: differences among depots in angiogenic, metabolic, and inflammatory gene expression and cellular senescence
    Aurélie Villaret
    Institut National de la Sante et de la Recherche Medicale, U858, Institut de Medecine Moleculaire de Rangueil, Toulouse, France
    Diabetes 59:2755-63. 2010
    ..We defined the properties of endothelial cells (EC) isolated from subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) biopsied in parallel from obese subjects...
  44. ncbi Gbeta gamma-independent coupling of alpha2-adrenergic receptor to p21(rhoA) in preadipocytes
    S Betuing
    INSERM U317, Institut Louis Bugnard, Universite Paul Sabatier, CHU Rangueil, Batiment L3, 31403, Toulouse Cedex 4, France
    J Biol Chem 273:15804-10. 1998
    ..Conversely to the activation of the p21(ras)/mitogen-activated protein kinase pathway, the alpha2-adrenergic activation of p21(rhoA)-dependent pathways are independent of the beta gamma-subunits of heterotrimeric G proteins...
  45. ncbi Exercise-induced lipid mobilization in subcutaneous adipose tissue is mainly related to natriuretic peptides in overweight men
    Cedric Moro
    INSERM U858 I2MR, Institut de Medecine Moleculaire de Rangueil, 1 Ave Jean Poulhès, Toulouse Cedex 4, France
    Am J Physiol Endocrinol Metab 295:E505-13. 2008
    ..On the basis of correlation findings, it seems to be related to a concomitant exercise-induced rise in plasma ANP when exercise is performed under tertatolol intake and a decrease in plasma insulin...
  46. ncbi Evidence of in situ proliferation of adult adipose tissue-derived progenitor cells: influence of fat mass microenvironment and growth
    Marie Maumus
    Hôpital Rangueil Bat L4, BP 84225, 31432 Toulouse cedex 04, France
    J Clin Endocrinol Metab 93:4098-106. 2008
    ..The processes involved in the self-renewal of this cell population remain to be defined...
  47. ncbi Involvement of a cGMP-dependent pathway in the natriuretic peptide-mediated hormone-sensitive lipase phosphorylation in human adipocytes
    Coralie Sengenes
    Obesity Research Unit, INSERM U 586, Institut Louis Bugnard, Centre Hospitalier Universitaire Rangueil, Universite Paul Sabatier, Toulouse, France
    J Biol Chem 278:48617-26. 2003
    ..The present study shows that lipolysis in human adipocytes can be controlled by an independent cGKI-mediated signaling as well as by the classical cAMP/PKA pathway...
  48. ncbi [Development of nutritional obesity in transgenic mice with an adrenergic receptivity in adipose tissue comparable with that of humans]
    I Castan-Laurell
    INSERM U317, CHU Rangueil, Institut Louis Bugnard, , 31403 Toulouse Cedex 4, France
    Pathol Biol (Paris) 50:52-7. 2002
    ..These results underline the physiologic relevance of the interaction of the presence of alpha 2-adrenergic receptors with a high fat diet in the control of adipose tissue development...
  49. ncbi Inhibition of human preadipocyte proteasomal activity by HIV protease inhibitors or specific inhibitor lactacystin leads to a defect in adipogenesis, which involves matrix metalloproteinase-9
    Sandra De Barros
    Unité de Recherche sur les Obésités, Institut National de la Santé et de la Recherche Médical Unité 586, Institut Louis Bugnard, Hopital Rangueil, Universite Paul Sabatier, Toulouse, France
    J Pharmacol Exp Ther 320:291-9. 2007
    ..This study adds significantly to recent reports that have linked HIV-PI-related lipodystrophic syndrome with altered proteasome function, endoplasmic reticulum stress, and metabolic disorders...
  50. ncbi Secretion of a lysophospholipase D activity by adipocytes: involvement in lysophosphatidic acid synthesis
    Stephane Gesta
    INSERM U317, Institut Louis Bugnard, Universite Paul Sabatier, CHU Rangueil, Batiment L3, Toulouse cedex 04, France
    J Lipid Res 43:904-10. 2002
    ..In conclusion, our results reveal the existence of a secreted lyso-PLD activity regulated during adipocyte-differentiation and involved in extra cellular production of synthesis of LPA by adipocytes...
  51. ncbi Natriuretic peptide-dependent lipolysis in fat cells is a primate specificity
    Coralie Sengenes
    INSERM U317, Laboratory of Medical and Clinical Pharmacology, Division of Medicine, National Institute of Health and Medical Research, Unité 317, 37 Allees Jules Guesde, 31073 Toulouse Cedex, France
    Am J Physiol Regul Integr Comp Physiol 283:R257-65. 2002
    ..In conclusion, NP-induced lipolysis is a primate specificity, and adipocytes from ANP-nonresponsive species present a predominance of "clearance" receptors and very low expression of "biologically active" receptors...
  52. ncbi Activation of alpha2-adrenergic receptors blunts epinephrine-induced lipolysis in subcutaneous adipose tissue during a hyperinsulinemic euglycemic clamp in men
    Vladimir Stich
    Department of Sports Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic
    Am J Physiol Endocrinol Metab 285:E599-607. 2003
    ..The effect involves 1) reduction of lipolysis stimulation mediated by the beta-adrenergic pathway and 2) the antilipolytic component of epinephrine action mediated by alpha2-ARs...
  53. ncbi Effects of a longitudinal training program on responses to exercise in overweight men
    Francois Crampes
    Department of Adaptation to Exercise, Laboratory of Medical and Clinical Pharmacology, Faculty of Medicine, INSERM Unit 317, Toulouse, France
    Obes Res 11:247-56. 2003
    ..During exercise in overweight subjects, the fasting condition seems more suited to oxidizing fat and maintaining glucose homeostasis than a 3-hour wait after a standard meal...
  54. ncbi Lipid mobilization with physiological atrial natriuretic peptide concentrations in humans
    Andreas L Birkenfeld
    Franz-Volhard Clinical Research Center, Haus 129, , Wiltbergstrasse 50, 13125 Berlin, Germany
    J Clin Endocrinol Metab 90:3622-8. 2005
    ..Natriuretic-peptide induced lipid mobilization might contribute to cardiac cachexia. Drugs that interfere with the natriuretic peptide system should be evaluated for potential metabolic side effects...
  55. ncbi Atrial natriuretic peptide contributes to physiological control of lipid mobilization in humans
    Cedric Moro
    Unité de Recherches sur les Obésités, Institut National de la Santé et de la Recherche Médicale U586, Toulouse, France
    FASEB J 18:908-10. 2004
    ..Oral beta-adrenergic receptor blockade, which potentiates exercise-induced ANP release by the heart, may contribute to lipid mobilization in SCAT. The potential relevance of an ANP-related lipid-mobilizing pathway is discussed...
  56. ncbi Atrial natriuretic peptide stimulates lipid mobilization during repeated bouts of endurance exercise
    Cedric Moro
    Franco Czech Laboratory for Clinical Research on Obesity, French Institute of Health and Medical Research INSERM U586, Toulouse, France
    Am J Physiol Endocrinol Metab 290:E864-9. 2006
    ..The results suggest that ANP is involved in the control of lipolysis during exercise and that it contributes to stimulation of lipolysis during repeated bouts of exercise...
  57. ncbi Yohimbine administration prevents over-responsiveness to epinephrine induced by simulated microgravity
    Michel Berlan
    Pharmacologie Medical and Clinical Laboratory, INSERM U 317, Paul Sabatier University, Toulouse, France
    Aviat Space Environ Med 73:735-42. 2002
    ..These changes may explain the orthostatic intolerance experienced by astronauts returning from spaceflights...
  58. ncbi Sex differences in lipolysis-regulating mechanisms in overweight subjects: effect of exercise intensity
    Cedric Moro
    Institut National de la Santé et de la Recherche Médicale U858, Laboratoire de Pharmacologie Medicale et Clinique, Faculte de Medecine, 37 Allees Jules Guesde, 31073 Toulouse, France
    Obesity (Silver Spring) 15:2245-55. 2007
    ..To explore sex differences in the regulation of lipolysis during exercise, the lipid-mobilizing mechanisms in the subcutaneous adipose tissue (SCAT) of overweight men and women were studied using microdialysis...
  59. ncbi Acute exposure to long-chain fatty acids impairs {alpha}2-adrenergic receptor-mediated antilipolysis in human adipose tissue
    Jan Polak
    Franco Czech Laboratory for Clinical Research on Obesity, French Institute of Health and Medical Research Institut National de la Santé et de la Recherche Médicale U858, Charles University in Prague, Prague, Czech Republic
    J Lipid Res 48:2236-46. 2007
    ..LCFA-mediated suppression of antilipolytic pathways represents another mechanism whereby a high fat content in the diet might increase adipose tissue lipolysis...
  60. ncbi Beta-adrenergic and atrial natriuretic peptide interactions on human cardiovascular and metabolic regulation
    Andreas L Birkenfeld
    Franz Volhard Clinical Research Center, Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    J Clin Endocrinol Metab 91:5069-75. 2006
    ..Atrial natriuretic peptide (ANP) has well-known cardiovascular effects and modifies lipid and carbohydrate metabolism in humans...
  61. ncbi [Physiological and pathophysiological features of the control of lipolysis and lipid mobilization by natriuretic peptides]
    Cedric Moro
    INSERM, U586, Unité de Recherche sur les Obésités, F 31432 Toulouse
    J Soc Biol 200:67-76. 2006
    ..The molecular basis of this inverse correlation is not yet demonstrated from a functional standpoint. Further studies are needed to clearly define the pathophysiological role of NP in obesity and heart failure...
  62. ncbi High isoproterenol doses are required to activate beta3-adrenoceptor-mediated functions in dogs
    Michel Pelat
    , INSERM U317, , Toulouse Cedex, France
    J Pharmacol Exp Ther 304:246-53. 2003
    ..These results also argue for the lack of a beta3-AR involvement in the control of heart rate and glycogenolysis in dogs...
  63. ncbi Protease inhibitor treatments reveal specific involvement of matrix metalloproteinase-9 in human adipocyte differentiation
    Virginie Bourlier
    Institut National de la Santé et de la Recherche Médicale U586, 37 Allees Jules Guesde, 31073 Toulouse, France
    J Pharmacol Exp Ther 312:1272-9. 2005
    ....
  64. ncbi Endothelin-1 inhibits TNF alpha-induced iNOS expression in 3T3-F442A adipocytes
    Christelle Merial-Kieny
    Département Diabète et Maladies Métaboliques, Institut de Recherche Servier, Suresnes 92150, France
    Br J Pharmacol 139:935-44. 2003
    ..6. Thus, these results confirm that adipocytes are a target for circulating ET-1 and demonstrate that the activation of the ETA receptor subtype can prevent TNFalpha-induced iNOS expression...