Research Topics
Species | P LabruneSummaryCountry: France Publications
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Publications
Perioperative management of hemostasis for surgery of benign hepatic adenomas in patients with glycogen storage disease type iaAlix Mollet-Boudjemline
APHP, Centre de Référence Maladies Héréditaires du Métabolisme Hépatique, Service de Pediatrie, Hopital Antoine Beclere, 157 rue de la Porte de Trivaux, 92141, Clamart Cedex, France
JIMD Rep 1:97-106. 2011....
Glucose-6-phosphatase deficiencyRoseline Froissart
Centre de Référence Maladies Héréditaires du Métabolisme Hépatique, Service de Pediatrie, APHP, Clamart Cedex, France
Orphanet J Rare Dis 6:27. 2011..DISEASE NAME AND SYNONYMS: Glucose-6-phosphatase deficiency or G6P deficiency or glycogen storage disease type I or GSDI or type I glycogenosis or Von Gierke disease or Hepatorenal glycogenosis...
[Natural history of hepatic glycogen storage diseases]Philippe Labrune
Service de Pediatrie, Centre de référence des maladies héréditaires du métabolisme hépatique, AP HP, Hopital Antoine Beclere, F 92141 Clamart Cedex, France
Presse Med 37:1172-7. 2008..It is important to know the natural history and long-term outcome of these patients to improve their treatment during childhood. To reach this goal, collaboration between pediatric specialists and those who treat adults is essential...
[Hepatomegaly: diagnosis approach]P Labrune
, , , , BP 405, 157, rue de la Porte de Trivaux, 92141 Clamart Cedex, France
Arch Pediatr 14:573-5. 2007
Chromosomal breakpoints characterization of two supernumerary ring chromosomes 20N Guediche
Univ Paris Sud, Service d Histologie Embryologie et Cytogénétique, APHP, Hopital Antoine Beclere, Clamart, France
Am J Med Genet A 152:464-71. 2010..This report may be helpful for prediction of natural history and outcome, particularly in prenatal diagnosis...
Molecular cytogenetic characterization of a 4p15.1-pter duplication and a 4q35.1-qter deletion in a recombinant of chromosome 4 pericentric inversionM L Maurin
Service d Histologie Embryologie Cytogénétique, INSERM U782, Universite Paris Sud, Hopital Antoine Beclere, APHP, Clamart, France
Am J Med Genet A 149:226-31. 2009..This case and review of literature suggest that two genes ArgBP2 and PDLIM3, located at 4q35.1 and both involved in cardiac and muscle development, could be responsible for cardiac defects observed in terminal 4q35.1 deletions...
Pure and complete trisomy 18p due to a supernumerary marker chromosome associated with moderate mental retardationP Mabboux
Service d Histologie Embryologie Cytogénétique, INSERM U782, Hopital Antoine Beclere, APHP, Universite Paris Sud, Clamart, France
Am J Med Genet A 143:727-33. 2007..We report here the first case of a pure and complete trisomy 18p due to a SMC. This report and review of literature confirm that the main phenotypic anomaly associated with trisomy 18p is moderate mental retardation...
Perinatal acquisition of drug-resistant HIV-1 infection: mechanisms and long-term outcomeConstance Delaugerre
EA 3620 MRT, Descartes University, Paris, France
Retrovirology 6:85. 2009..Primary-HIV-1-infection in newborns that occurs under antiretroviral prophylaxis that is a high risk of drug-resistance acquisition. We examine the frequency and the mechanisms of resistance acquisition at the time of infection in newborns...
Inter-observer agreement between physicians, nurses, and respiratory therapists for respiratory clinical evaluation in bronchiolitisV Gajdos
Unité Inserm U 822, Le Kremlin Bicetre, France
Pediatr Pulmonol 44:754-62. 2009..Thus, once the validity of this test has been confirmed in a large population sample, it should be possible to use this test to monitor children hospitalized with bronchiolitis and as an endpoint in clinical trials...
[Factors predicting serious bacterial infections in febrile infants less than three months old: multivariate analysis]V Gajdos
Service de Pediatrie, Hopital Antoine Beclere, Assistance Publique Hopitaux de Paris, BP 405, 157 rue de la Porte de Trivaux, 92141 Clamart Cedex, France
Arch Pediatr 12:397-403. 2005..To identify predictive factors of the presence of a serious bacterial infection (SBI) in febrile infants less than three months old...
Unusual cerebral manifestations in hereditary fructose intoleranceP Labrune
Service de Pediatrie, Hopital Antoine Beclere, Clamart, France
Arch Neurol 47:1243-4. 1990..Neurological impairment is not classic in hereditary fructose intolerance, but its occurrence in the acute phase of the disease is possible and does not constitute an argument against the diagnosis...
Crigler-Najjar type II disease inheritance: a family studyP Labrune
, , Clamart, France
J Inherit Metab Dis 12:302-6. 1989..The second infant of this couple was affected by the same disease and was treated with success by phenobarbital...
[Construction and validation of an evaluation tool of sexual health using self-administered questionnaires for an application to metabolic diseases]F Petit
Laboratoire de génétique moléculaire des maladies métaboliques, Hopital Antoine Beclere, 157, rue de la Porte de Trivaux, 92141 Clamart Cedex, France
Prog Urol 23:210-8. 2013..To elaborate and validate in general population a survey built with self-administered questionnaires in French about evaluation of sexual health for an application to men and women with metabolic disease...
Jeune syndrome and liver disease: report of three cases treated with ursodeoxycholic acidP Labrune
Service de Pediatrie, Hopital Antoine Béclere AP HP, Clamart, France
Am J Med Genet 87:324-8. 1999..In the three patients, treatment with ursodeoxycholic acid appeared to control the progression of the hepatic dysfunction...
[Influenza vaccination coverage rate in children with underlying chronic disorders in 7 French pediatric wards]C Weil-Olivier
Service de Pediatrie, Hopital Louis Mourier, Assistance Publique Hopitaux de Paris, 178, rue des Renouillers, 92701 Colombes cedex 01, France
Arch Pediatr 13:1287-93. 2006..The national goal is to reach 75% influenza vaccination coverage by 2008, but data on coverage in high risk children are limited...
Allelic heterogeneity of glycogen storage disease type Ib in French patients: a study of 11 casesP Trioche
Service de Pédiatrie and UPRES EA 2705, Hopital Antoine Béclere AP HP, Clamart Cedex, France
J Inherit Metab Dis 27:621-3. 2004..Among these, one is a novel mutation of G6PT: 855T>C (L229P)...
[What evidence for chest physiotherapy in infants hospitalized for acute viral bronchiolitis?]S Bailleux
Service de Pediatrie Generale, Hopital Antoine Beclere, AP HP, 157, rue de Porte de Trivaux, 92141 Clamart Cedex, France
Arch Pediatr 18:472-5. 2011..Further trials are necessary for evaluating this technique in infants who are not hospitalized...
Terminal 14q32.33 deletion: genotype-phenotype correlationM L Maurin
Service d Histologie Embryologie Cytogénétique APHP, INSERM U782, Hopital Antoine Beclere, Clamart, France
Am J Med Genet A 140:2324-9. 2006..6 Mb of chromosome 14...
Fetal type IV glycogen storage disease: clinical, enzymatic, and genetic data of a pure muscular form with variable and early antenatal manifestations in the same familyA L'hermine-Coulomb
Service d Anatomie Pathologique, Hopital Antoine Beclere, Clamart, France
Am J Med Genet A 139:118-22. 2005..Genetic analysis of the GBE gene may help to shed some light on the puzzling diversity of GSD IV phenotypes...
Partial effect of bromocriptine on lactose and galactose synthesis in a pregnant woman heterozygous for galactosaemiaM Odievre
Service de Pediatrie, Hĵpital Antoine Béclère AP HP, Clamart, France
J Inherit Metab Dis 24:507-8. 2001....
Sweet syndrome as the presenting manifestation of chronic granulomatous disease in an infantD Sedel
, , Clamart, France
Pediatr Dermatol 11:237-40. 1994..The precise relationship between the conditions remains to be determined. Granulocyte function should be evaluated in any infant with Sweet syndrome...
Haemolytic uraemic syndrome and pulmonary hypertension in a patient with methionine synthase deficiencyP Labrune
Service de Pediatrie, Hopital Antoine Beclere, Clamart, France
Eur J Pediatr 158:734-9. 1999....
Pulmonary arterial hypertension and type-I glycogen-storage disease: the serotonin hypothesisM Humbert
Unité Propre de Recherche de l Enseignement Supérieur 2705, Centre des Maladies Vasculaires Pulmonaires, Hĵpital Antoine Béclère, Universite Paris Sud, Clamart, France
Eur Respir J 20:59-65. 2002..4 nmol x L(-1)). It is concluded that type-Ia glycogen-storage disease may be another condition in which abnormal handling of serotonin is one event in a multistep process leading to severe pulmonary arterial hypertension...
The Tunisian population history through the Crigler-Najjar type I syndromeFrançois M Petit
Department of Biochemistry, Antoine Beclere Hospital, Universite Paris Sud, UFR Kremlin Bicêtre, Clamart Cedex, France
Eur J Hum Genet 16:848-53. 2008..After population migration from east to west, this mutation was introduced into the Tunisian population, and then perpetuated, probably because of marriages in isolated communities...
Prenatal diagnosis of Crigler-Najjar syndrome type I by single-strand conformation polymorphism (SSCP)Jeanne Francoual
Laboratoire de Biochimie, , 92141 Clamart Cedex, France
Prenat Diagn 22:914-6. 2002..SSCP analysis of DNA prepared either from amniocytes or from chorionic villi is a simple, reliable and fast method for prenatal diagnosis...
Glycogen storage disease type I: indications for liver and/or kidney transplantationPhilippe Labrune
Service de Pédiatrie et Consultation de Génétique, Hopital Antoine Béclere AP HP, BP 405, 92141 Clamart Cedex, France
Eur J Pediatr 161:S53-5. 2002..CONCLUSION: organ (liver/kidney) transplantation in glycogen storage disease type I may be advantageous when long-term metabolic control has been attempted. Nevertheless, post-transplantat long-term complications may still develop...
Glycogen storage disease type I: diagnosis, management, clinical course and outcome. Results of the European Study on Glycogen Storage Disease Type I (ESGSD I)Jan Peter Rake
Department of Paediatrics, Beatrix Children s Hospital, University Hospital Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
Eur J Pediatr 161:S20-34. 2002..With ageing, more and more complications will develop of which progressive renal disease and the complications related to liver adenomas are likely to be two major causes of morbidity and mortality...
Recurring acute abdominal pains in an adolescent as the presenting manifestations of hereditary angioneurotic oedemaLaurence Weiss
Department of Paediatrics, , 92141 Clamart Cedex, France
Acta Paediatr 94:1158-61. 2005..CONCLUSIONS: Angioneurotic oedema is a rare condition, which should be suspected in children with recurring abdominal pains, especially when there is liquid within the peritoneal cavity...
[Challenges of genetic diseases. About a genetic disease: cystic fibrosis]Philippe Labrune
, , 92141 Clamart
Rev Prat 52:679-82. 2002
Crigler-Najjar syndrome type I in Tunisia may be associated with a founder effect related to the Q357R mutation within the UGT1 geneJeanne Francoual
Hum Mutat 19:570-1. 2002
Paternal isodisomy for chromosome 2 as the cause of Crigler-Najjar type I syndromeFrançois M Petit
Service de Biochimie et Hormonologie, Hopital Antoine Beclere, Clamart, France
Eur J Hum Genet 13:278-82. 2005..This report demonstrates that uniparental disomy may be at the origin of very rare diseases transmitted as autosomal recessive traits and emphasizes the need for parental DNA analysis in such cases...
Granulocyte colony-stimulating factor in glycogen storage disease type 1b. Results of the European Study on Glycogen Storage Disease Type 1Gepke Visser
Beatrix Children s Hospital, University Hospital, Groningen, The Netherlands
Eur J Pediatr 161:S83-7. 2002..In view of the uncertainty, prospective controlled trials seem warranted to clarify the indication for the use of granulocyte colony-stimulating factor in this disease...
Guidelines for management of glycogen storage disease type I - European Study on Glycogen Storage Disease Type I (ESGSD I)Jan Peter Rake
Department of Paediatrics, Beatrix Children s Hospital, University Hospital Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
Eur J Pediatr 161:S112-9. 2002..management of complications (directly) related to metabolic disturbances and complications which may develop with ageing and their follow-up. CONCLUSION: In this paper guidelines for the management of GSD I are presented...
Increased levels of hemostatic proteins are independent of inflammation in glycogen storage disease type IaAnne Marfaing-Koka
, , Clamart, France
J Pediatr Gastroenterol Nutr 37:566-70. 2003..CONCLUSIONS: These results suggest that the hyperproteinemia of GSD-Ia (including hemostatic proteins) is attributable to hepatocyte dysfunction and not related to an inflammatory process...
Absence of specific facial dysmorphy in glycogen storage disease type IIIPhilippe Labrune
Clin Dysmorphol 12:213. 2003
Glycogen storage disease type Ib without neutropenia generated by a novel splice-site mutation in the glucose-6-phosphate translocase geneCelia J Angaroni
Centro de Estudio de las Metabolopatias Congenitas, CEMECO, Hospital de Niños de la Santísima Trinidad, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba, Argentina
Mol Genet Metab 88:96-9. 2006..A PCR-based cDNA analysis showed that the c.985-1G>C mutation produced two abnormal spliced G6PT1 transcripts both encoding hypothetical truncated proteins...
Second-trimester diagnosis of mucopolysaccharidosis type IV a presenting as hydrops fetalisClaire Colmant
Prenat Diagn 26:750-2. 2006
Association of a homozygous (TA)8 promoter polymorphism and a N400D mutation of UGT1A1 in a child with Crigler-Najjar type II syndromePhilippe Labrune
Hum Mutat 20:399-401. 2002
Successful pregnancy in a Crigler-Najjar type I patient treated by phototherapy and semimonthly albumin infusionsVincent Gajdos
, , Clamart, France
Gastroenterology 131:921-4. 2006
Further evidence that the UGT1A1*28 allele is not associated with coronary heart disease: The ECTIM StudyVincent Gajdos
Clin Chem 52:2313-4. 2006
Consensus guidelines for management of glycogen storage disease type 1b - European Study on Glycogen Storage Disease Type 1Gepke Visser
Beatrix Children s Hospital, Groningen, The Netherlands
Eur J Pediatr 161:S120-3. 2002....
Comments on seven novel mutations of the UGT1A1 gene in patients with unconjugated hyperbilirubinemia by D'Apolito et alFrançois M Petit
Haematologica 92:e80. 2007
