Pierre Labauge

Summary

Country: France

Publications

  1. ncbi request reprint Genetics of cavernous angiomas
    Pierre Labauge
    INSERM, U740, Paris, France
    Lancet Neurol 6:237-44. 2007
  2. ncbi request reprint Familial, adult onset form of leukoencephalopathy with brain stem and spinal cord involvement: inconstant high brain lactate and very slow disease progression
    Pierre Labauge
    Eur Neurol 58:59-61. 2007
  3. doi request reprint Outcome in 53 patients with spinal cord cavernomas
    Pierre Labauge
    Service de Neurologie, CHU de Nimes, 30029 France
    Surg Neurol 70:176-81; discussion 181. 2008
  4. pmc A MANBA mutation resulting in residual beta-mannosidase activity associated with severe leukoencephalopathy: a possible pseudodeficiency variant
    Frédérique Sabourdy
    Laboratoire de Biochimie Maladies Métaboliques, Institut Fédératif de Biologie, CHU Purpan, Toulouse, France
    BMC Med Genet 10:84. 2009
  5. ncbi request reprint [Familial forms of central nervous system cavernomas: from recognition to gene therapy]
    P Labauge
    Service de Neurologie, CHU Caremeau, place du Professeur Robert Debré, 30029 Nimes cedex 09, France
    Neurochirurgie 53:152-5. 2007
  6. ncbi request reprint Magnetic resonance findings in leucodystrophies and MS
    P Labauge
    Department of Neurology, CHU Montpellier Nimes, 30 029 Nimes Cedex, France
    Int MS J 16:47-56. 2009
  7. doi request reprint [Genetic demyelinating diseases]
    Pierre Labauge
    Departement de Neurologie, CHU de Montpellier Nîmes, Place du Pr R Debré, 30029 Nimes Cedex, France
    Presse Med 39:363-70. 2010
  8. ncbi request reprint Dominant form of vanishing white matter-like leukoencephalopathy
    Pierre Labauge
    Service de Neurologie, CHU Montpellier Nimes, Hopital Caremeau, Nimes, France
    Ann Neurol 58:634-9. 2005
  9. ncbi request reprint Natural history of adult-onset eIF2B-related disorders: a multi-centric survey of 16 cases
    Pierre Labauge
    CHU Nimes, Service de Neurologie, Hopital Caremeau, place du Professeur Debré, 30029 Nîmes Cedex 4, France
    Brain 132:2161-9. 2009
  10. ncbi request reprint [CACH/VWM syndrome and leucodystrophies related to EIF2B mutations]
    P Labauge
    Service de Neurologie, CHU de Montpellier Nîmes, Hopital Caremeau, 30029 Nimes Cedex
    Rev Neurol (Paris) 163:793-9. 2007

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Genetics of cavernous angiomas
    Pierre Labauge
    INSERM, U740, Paris, France
    Lancet Neurol 6:237-44. 2007
    ..These recent developments in clinical and molecular genetics have given us useful information about clinical care and genetic counselling and have broadened our understanding of the mechanisms of this disorder...
  2. ncbi request reprint Familial, adult onset form of leukoencephalopathy with brain stem and spinal cord involvement: inconstant high brain lactate and very slow disease progression
    Pierre Labauge
    Eur Neurol 58:59-61. 2007
  3. doi request reprint Outcome in 53 patients with spinal cord cavernomas
    Pierre Labauge
    Service de Neurologie, CHU de Nimes, 30029 France
    Surg Neurol 70:176-81; discussion 181. 2008
    ..Prevalence of cerebral cavernomas in the general population is close to 0.5%. In contrast, SCCs are rare. The aim of this study was to determine the outcome of SCC in a large sample of patients...
  4. pmc A MANBA mutation resulting in residual beta-mannosidase activity associated with severe leukoencephalopathy: a possible pseudodeficiency variant
    Frédérique Sabourdy
    Laboratoire de Biochimie Maladies Métaboliques, Institut Fédératif de Biologie, CHU Purpan, Toulouse, France
    BMC Med Genet 10:84. 2009
    ..These are all null mutations or missense mutations that abolish beta-mannosidase activity. In this study, we characterized the molecular defect of a new case of beta-mannosidosis, presenting with a severe neurological disorder...
  5. ncbi request reprint [Familial forms of central nervous system cavernomas: from recognition to gene therapy]
    P Labauge
    Service de Neurologie, CHU Caremeau, place du Professeur Robert Debré, 30029 Nimes cedex 09, France
    Neurochirurgie 53:152-5. 2007
    ..Familial forms may be considered not only as a neurological but as a systemic disease for which global management with a genetic counseling should be considered. Gene therapy is not today available, but perhaps in the future...
  6. ncbi request reprint Magnetic resonance findings in leucodystrophies and MS
    P Labauge
    Department of Neurology, CHU Montpellier Nimes, 30 029 Nimes Cedex, France
    Int MS J 16:47-56. 2009
    ..The first part will focus on MR patterns of vascular and nonvascular adult leucoencephalopathies, the second part on MR findings in MS and MS-related diseases. Specific MR patterns in both diseases will be summarized and compared...
  7. doi request reprint [Genetic demyelinating diseases]
    Pierre Labauge
    Departement de Neurologie, CHU de Montpellier Nîmes, Place du Pr R Debré, 30029 Nimes Cedex, France
    Presse Med 39:363-70. 2010
    ..Damage tothe posterior spinal cord suggests leukoencephalopathy with damage to the brainstem and cord marrow and is accompanied by elevated lactate (LBSL)...
  8. ncbi request reprint Dominant form of vanishing white matter-like leukoencephalopathy
    Pierre Labauge
    Service de Neurologie, CHU Montpellier Nimes, Hopital Caremeau, Nimes, France
    Ann Neurol 58:634-9. 2005
    ....
  9. ncbi request reprint Natural history of adult-onset eIF2B-related disorders: a multi-centric survey of 16 cases
    Pierre Labauge
    CHU Nimes, Service de Neurologie, Hopital Caremeau, place du Professeur Debré, 30029 Nîmes Cedex 4, France
    Brain 132:2161-9. 2009
    ..Functional and/or cognitive prognosis remains severe. Molecular diagnosis is facilitated for these forms by the screening of the two recurrent p.Arg113His-eIF2Bepsilon and p.Glu213Gly-eIF2Bbeta mutations, positive in 86% of cases...
  10. ncbi request reprint [CACH/VWM syndrome and leucodystrophies related to EIF2B mutations]
    P Labauge
    Service de Neurologie, CHU de Montpellier Nîmes, Hopital Caremeau, 30029 Nimes Cedex
    Rev Neurol (Paris) 163:793-9. 2007
    ..No specific treatment exists except the "prevention" of cellular stress. Corticosteroids sometimes proved to be useful in acute phases. Prognosis seems to correlate with the age of onset, the earliest forms being more severe...
  11. ncbi request reprint Clinical and radiological characteristics in multiple sclerosis patients with large cavitary lesions
    Dimitri Renard
    Department of Neurology, Centre Hospitalier Universitaire, Nimes, France
    Eur Neurol 68:156-61. 2012
    ....
  12. ncbi request reprint Brain MRI findings in long-standing and disabling multiple sclerosis in 84 patients
    Dimitri Renard
    Department of Neurology, CHU Nimes, Hopital Caremeau, Place du Pr DEBRE, 30029 Nîmes Cedex 4, France
    Clin Neurol Neurosurg 112:286-90. 2010
    ..To look for cerebral white matter MRI changes in patients with long-standing and disabling MS...
  13. ncbi request reprint Cognitive functions in neuromyelitis optica
    Frederic Blanc
    Department of Neurology, Strasbourg University, Alsace, France
    Arch Neurol 65:84-8. 2008
    ..To date, cognitive functions have never been investigated in NMO...
  14. doi request reprint Optical coherence tomography in neuromyelitis optica
    Jerome De Seze
    Department of Neurology, Strasbourg University, Hopital Civil, 1 Place de l Hopital, BP 426, 67091 Strasbourg Cedex, France
    Arch Neurol 65:920-3. 2008
    ..This pathologic entity may induce severe disability, including visual loss and paraplegia. Other than clinical follow-up, there is no marker for severity of the disease...
  15. ncbi request reprint Radiation therapy-related ataxia associated with FDG-PET cerebellar hypometabolism
    Dimitri Renard
    Department of Neurology, CHU Nimes, Hopital Caremeau, Nîmes Cedex 4, France
    Acta Neurol Belg 110:100-2. 2010
    ..FDG-PET abnormalities seem to correlate better with clinical signs related to radiation-associated brain toxicity than MRI...
  16. ncbi request reprint Brain FDG-PET changes in ALS and ALS-FTD
    Dimitri Renard
    Department of Neurology, CHU Nimes, Hopital Caremeau, 30029 Nîmes Cedex 4, France
    Acta Neurol Belg 111:306-9. 2011
    ..In ALS-FTD, extensive temporal hypometabolism is seen in addition to severe diffuse frontal hypometabolism...
  17. doi request reprint Subacute combined degeneration of the spinal cord caused by nitrous oxide anaesthesia
    Dimitri Renard
    Department of Neurology, CHU Nimes, Hopital Caremeau, Place du Pr DEBRE, 30029 Nîmes Cedex 4, France
    Neurol Sci 30:75-6. 2009
    ..Subacute combined degeneration (SCD) of the spinal cord is characterised by degeneration of the posterior and lateral columns. We report a case of SCD associated with nitrous oxide anaesthesia...
  18. doi request reprint Long-term outcomes of CLIPPERS (chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) in a consecutive series of 12 patients
    Guillaume Taieb
    Department of Neurology, Centre Hospitalier Universitaire, Nimes, France
    Arch Neurol 69:847-55. 2012
    ..Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a central nervous system inflammatory disease...
  19. doi request reprint Ictal urge to defecate associated with a right-sided mesial temporal cavernoma
    Guillaume Taieb
    Department of Neurology, CHU Nimes, Hopital Caremeau, Place du Pr DEBRE, 30029 Nîmes Cedex 4, France
    Epilepsy Behav 24:272-3. 2012
    ..In our patient, the ictal urge to defecate seems to involve the non-dominant hemisphere and seems to probably be affecting the autonomic network...
  20. doi request reprint Rapid onset frontal leukodystrophy with decreased diffusion coefficient and neuroaxonal spheroids
    Elisabeth Maillart
    Federation of Nervous System Diseases, Hopital de la Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie Paris VI, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    J Neurol 256:1649-54. 2009
    ..We found similar cases in the literature and propose that they represent a distinct entity within the group of LNS. Further studies will be required to identify its molecular basis...
  21. ncbi request reprint [Myasthenia gravis in the elderly: diagnosis, comorbidity and course: 45 cases]
    Thibaut Fraisse
    Service de médecine interne gériatrique, Centre Hospitalier Universitaire Caremeau, Nimes
    Presse Med 36:9-14. 2007
    ..Analyze the clinical presentation, laboratory indicators, and outcome of patients with late-onset myasthenia gravis (after 60 years)...
  22. doi request reprint [Retinal atrophy using optical coherence tomography (OCT) in 15 patients with multiple sclerosis and comparison with healthy subjects]
    L Jeanjean
    Consultation de neuro ophtalmologie, CHU Caremeau, place du Professeur Debré, 30900 Nimes, France
    Rev Neurol (Paris) 164:927-34. 2008
    ..Retinal nerve fiber layer (RNFL) imaging by optical coherence tomography (OCT) seems to be a non-invasive way of detecting optical axonal loss following optic neuritis...
  23. pmc Inflammatory-like presentation of CADASIL: a diagnostic challenge
    Nicolas Collongues
    Department of Neurology, Strasbourg University Hospital, 1, Avenue Moliere, 67000, Strasbourg, France
    BMC Neurol 12:78. 2012
    ..From a national registry of 268 patients with adult-onset leukodystrophy, we identified two patients with an atypical presentation of CADASIL without co-occurrence of another systemic disease...
  24. doi request reprint Increased risk of multiple sclerosis relapse after in vitro fertilisation
    Laure Michel
    Service de Neurologie, Centre Hospitalier Universitaire de Nantes, Hopital Laennec, Nantes Cedex, France
    J Neurol Neurosurg Psychiatry 83:796-802. 2012
    ..The objective of this study was to determine if there was an increased risk of developing exacerbations in women with MS after in vitro fertilisation (IVF)...
  25. doi request reprint Fluorine 18-labeled fluorodeoxyglucose positron emission tomography in familial Creutzfeldt-Jakob disease
    Dimitri Renard
    Department of Neurology, CHU Nimes, Hopital Caremeau, Place du Pr DEBRE, 30029 Nîmes Cedex 4, France
    Arch Neurol 65:1390-1. 2008
  26. ncbi request reprint Acute fulminant demyelinating disease: a descriptive study of 60 patients
    Jerome De Seze
    Departement de Neurologie, Hopital Civil, 1 Place de l Hopital, BP 426, 67091 Strasbourg Cedex, France
    Arch Neurol 64:1426-32. 2007
    ..To date, no clear criteria exist for ADEM, and the risk of subsequent evolution to multiple sclerosis (MS) remains unknown...
  27. ncbi request reprint Polyarteritis nodosa associated with essential mixed cryglobulinemia revealed by subarachnoid hemorrhage
    Guillaume Taieb
    Department of Neurology, Nîmes University Medical Center, Caremeau Hospital, France
    Intern Med 50:2905-9. 2011
    ..A pathophysiological relationship between cryoglobulin and PAN can be suspected. Mixed cryoglobulinemia may trigger vasculitis with PAN features, possibly explaining the lack of treatment response...
  28. ncbi request reprint [Headache due to idiopathic intracranial hypotension. Three case reports]
    Giovanni Castelnovo
    Service de Neurologie, CHU de Montpellier, Hôpital de Gui de chauliac, 34295 Montpellier Cedex 5, France
    Ann Med Interne (Paris) 153:403-6. 2002
    ..Postural headache is related to intracranial hypotension, most often secondary to lumbar puncture. We report three observations where headache of unknown cause led to the diagnosis of spontaneous intracranial hypotension...
  29. doi request reprint Interest of CSF biomarker analysis in possible cerebral amyloid angiopathy cases defined by the modified Boston criteria
    Dimitri Renard
    Department of Neurology, CHU Nimes, Hopital Caremeau, Place du Pr DEBRE, 30029, Nimes Cedex 9, France
    J Neurol 259:2429-33. 2012
    ..Especially Aβ40 levels seem to be of clinical interest to differentiate CAA from AD. CSF biomarkers have to be analyzed in a larger number of CAA patients, and compared to patients with other disorders causing LH or SS...
  30. ncbi request reprint Distal myasthenia gravis
    Dimitri Renard
    Department of Neurology, CHU Nimes, Hopital Caremeau, Nîmes Cedex 4, France
    Acta Neurol Belg 108:107-8. 2008
    ..MG with predominant distal limb involvement is uncommon. We present a case of MG with distal, asymmetrical, upper limb involvement, seven years after disease onset...
  31. doi request reprint Cannabis-related myocardial infarction and cardioembolic stroke
    Dimitri Renard
    Department of Neurology, CHU Nimes, Hopital Caremeau, Nimes, France
    J Stroke Cerebrovasc Dis 21:82-3. 2012
    ..This is the first case of cannabis-associated stroke of probable cardioembolic origin...
  32. pmc Painful camptocormia: the relevance of shaking your patient's hand
    Arnaud Dupeyron
    Département de Médecine Physique et Réadaptation, Centre Hospitalo Universitaire de Montpellier Nîmes, CHU Caremeau, place du Pr Robert Debré, 30029 Nimes cedex 09, France
    Eur Spine J 19:S87-90. 2010
    ..Axial weakness and muscle atrophy, validated by CT-scan imaging, are discussed independent of the concomitant pathology (Parkinson, myopathy)...
  33. doi request reprint Styloid and hyoid bone proximity is a risk factor for cervical carotid artery dissection
    Dimitri Renard
    Department of Neurology, Hopital Caremeau, France
    Stroke 44:2475-9. 2013
    ..Carotid artery dissection (CAD) is more common with increased styloid process length. Our goal was to determine whether proximity of the styloid process and the hyoid bone to the internal carotid artery (ICA) was a risk factor for CAD...
  34. ncbi request reprint Diploic epidermoid cyst associated with focal brain pseudohypertrophy
    Dimitri Renard
    Department of Neurology, CHU Nimes, Hopital Caremeau, Nîmes Cedex 4, France
    Acta Neurol Belg 111:56-8. 2011
    ..e., retraction due to age-related brain atrophy). This aspect of focal brain pseudohypertrophy can potentially be seen in all chronic primary cranial bone lesions associated with meningeal involvement...
  35. ncbi request reprint Relapsing inflammatory optic neuritis: is it neuromyelitis optica?
    J de Seze
    Department of Neurology, Strasbourg University, France
    Neurology 70:2075-6. 2008
  36. doi request reprint Primary brain amyloidoma: long-term follow-up
    Dimitri Renard
    Department of Neurology, CHU Nimes, Hopital Caremeau, Place du Pr DEBRE, 30029 Nîmes Cedex 4, France
    Arch Neurol 65:979-80. 2008
  37. ncbi request reprint Alpha-fodrin autoantibodies in the differential diagnosis of MS and Sjögren syndrome
    J de Seze
    Department of Neurology, University of Lille, France
    Neurology 61:268-9. 2003
  38. ncbi request reprint Lingual atrophy and dolichoectatic artery
    G Castelnovo
    Department, Hopital Caremeau, CHU Nimes, 2 Av du prof Debrie, Nimes, France
    Neurology 61:1121. 2003
  39. ncbi request reprint [Paroxysmal kinesigenic dyskinesia: a channelopathy? Study of 19 cases]
    G Fourcade
    Service de Neurologie, CHU Caremeau, place du Professeur Robert Debré, 30029 Nimes Cedex, France
    Rev Neurol (Paris) 165:164-9. 2009
    ..The favorable natural history, the episodic nature of the symptoms and their sensitivity to anticonvulsant therapy suggest channelopathy as a mechanism of PKD...
  40. doi request reprint [Social handicap at the onset of the multiple sclerosis]
    A Creange
    Service de Neurologie, CHU Albert Chenevier Henri Mondor, AP HP, Université Paris XII et Réseau SINDEFI SEP, Creteil, France
    Rev Neurol (Paris) 165:S167-72. 2009
    ..Since the onset of the disease, social events are very frequent: jobless and decrease of salaries (50% of the cases), divorce (10%), daily help (12%)...
  41. ncbi request reprint [A retrospective study of six patients with late-onset Pompe disease]
    A Saux
    Service de neurologie et centre de références des maladies neuromusculaires, CHU Caremeau, 2, avenue Pr Debré, 30029 Nimes Cedex, France
    Rev Neurol (Paris) 164:336-42. 2008
    ..The diagnosis is based on a low level of GAA either in the muscle biopsy or in the leucocytes. We report six cases of late-onset Pompe's disease from the Languedoc-Roussillon district...
  42. ncbi request reprint Autosomal dominant leukodystrophy and childhood ataxia with central nervous system hypomyelination syndrome
    Pierre Labauge
    Ann Neurol 60:485; author reply 485-6. 2006
  43. ncbi request reprint Genes involved in leukodystrophies: a glance at glial functions
    Odile Boespflug-Tanguy
    GReD, INSERM U931 CNRS 6247, Faculte de Medecine, 28, Place Henri Dunant, 63000 Clermont Ferrand, France
    Curr Neurol Neurosci Rep 8:217-29. 2008
    ..It focuses particularly on the genes involved in the hypomyelinated and vacuolating leukodystrophies, which provide new insights into the understanding of myelin formation and WM homeostasis...
  44. ncbi request reprint OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes
    Patrizia Amati-Bonneau
    Département de Biochimie et Génétique, Centre Hospitalier Universitaire d Angers, Angers, France
    Brain 131:338-51. 2008
    ..Our results show that certain OPA1 mutations exert a dominant negative effect responsible for multi-systemic disease, closely related to classical mitochondrial cytopathies, by a mechanism involving mtDNA instability...
  45. ncbi request reprint Prevalence of dentatorubral-pallidoluysian atrophy in a large series of white patients with cerebellar ataxia
    Isabelle Le Ber
    Institut National de la Santé et de la Recherche Médicale U289, Federation de Neurologie, Hopital Salpetriere, Assistance Publique Hopitaux de Paris, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Arch Neurol 60:1097-9. 2003
    ..Its prevalence is low in other countries. Three phenotypes are described: choreoathetoid movements, cerebellar ataxia, and progressive myoclonic epilepsy...
  46. pmc Ovarian failure related to eukaryotic initiation factor 2B mutations
    Anne Fogli
    INSERM Unité Mixte de Recherche 384, Faculte de Medecine, Clermont Ferrand, France
    Am J Hum Genet 72:1544-50. 2003
    ..The correlation we observed between the age at onset of the neurological deterioration and the severity of OF suggests a common pathophysiological pathway...