M Krempf

Summary

Country: France

Publications

  1. ncbi request reprint Weight reduction and long-term maintenance after 18 months treatment with orlistat for obesity
    M Krempf
    CHU Hotel Dieu, Service d Endocrinologie Nutrition, Nantes, France
    Int J Obes Relat Metab Disord 27:591-7. 2003
  2. ncbi request reprint Postprandial changes in the distribution of apolipoprotein AIV between apolipoprotein B- and non apolipoprotein B-containing lipoproteins in obese women
    F Ferrer
    Laboratoire de Biochimie Fondamentale et Appliquée, UFR de Pharmacie, Nantes, France
    Metabolism 52:1537-41. 2003
  3. ncbi request reprint A new labeling approach using stable isotopes to study in vivo plasma cholesterol metabolism in humans
    K Ouguerram
    Centre de Recherche en Nutrition Humaine, INSERM U539, Nantes, France
    Metabolism 51:5-11. 2002
  4. ncbi request reprint [Pregnancy and weight]
    M Krempf
    Clinique d Endocrinologie, Maladies metaboliques et nutrition, Hotel Dieu, 44093 Nantes 1
    Ann Endocrinol (Paris) 64:332. 2003
  5. ncbi request reprint [Obesity and cardiovascular risk]
    M Krempf
    Clinique d Endocrinologie, Hotel Dieu, 44093 Nantes
    Ann Endocrinol (Paris) 62:S23-9. 2001
  6. ncbi request reprint Butyrate stimulates ApoA-IV-containing lipoprotein secretion in differentiated Caco-2 cells: role in cholesterol efflux
    H Nazih
    INSERM U 539 et Centre de Recherche en Nutrition Humaine, Hotel Dieu, Nantes, France
    J Cell Biochem 83:230-8. 2001
  7. ncbi request reprint Effect of n-3 fatty acids on metabolism of apoB100-containing lipoprotein in type 2 diabetic subjects
    K Ouguerram
    INSERM U539, Hotel Dieu, Nantes, France
    Br J Nutr 96:100-6. 2006
  8. ncbi request reprint Efficacy and safety of micronised fenofibrate in a randomised double-blind study comparing four doses from 200 mg to 400 mg daily with placebo in patients with hypercholesterolemia
    M Krempf
    Clinique d Endocrinologie et Nutrition, Hotel Dieu, 44093 Nantes Cedex 1, France
    Diabetes Metab 26:184-91. 2000
  9. ncbi request reprint Negative and independent influence of apolipoprotein E on C-reactive protein (CRP) concentration in obese adults. Potential anti-inflammatory role of apoE in vivo
    K Bach-Ngohou
    , UFR de Pharmacie, Nantes, France
    Int J Obes Relat Metab Disord 25:1752-8. 2001
  10. ncbi request reprint Apolipoprotein E kinetics: influence of insulin resistance and type 2 diabetes
    K Bach-Ngohou
    INSERM U539, Centre de Recherche en Nutrition Humaine, CHU Hotel Dieu, Nantes, France
    Int J Obes Relat Metab Disord 26:1451-8. 2002

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Weight reduction and long-term maintenance after 18 months treatment with orlistat for obesity
    M Krempf
    CHU Hotel Dieu, Service d Endocrinologie Nutrition, Nantes, France
    Int J Obes Relat Metab Disord 27:591-7. 2003
    ..To determine the effect of orlistat on weight reduction and the long-term maintenance of this weight loss when associated with a continuous mildly reduced energy diet...
  2. ncbi request reprint Postprandial changes in the distribution of apolipoprotein AIV between apolipoprotein B- and non apolipoprotein B-containing lipoproteins in obese women
    F Ferrer
    Laboratoire de Biochimie Fondamentale et Appliquée, UFR de Pharmacie, Nantes, France
    Metabolism 52:1537-41. 2003
    ..Changes in apo AIV concentrations in apo B- and non-apo B-containing Lp after a fat meal depend mainly on the degree of obesity rather than on insulin resistance. This effect is more obvious for Lp AIV non-Bf than for Lp B:AIVf...
  3. ncbi request reprint A new labeling approach using stable isotopes to study in vivo plasma cholesterol metabolism in humans
    K Ouguerram
    Centre de Recherche en Nutrition Humaine, INSERM U539, Nantes, France
    Metabolism 51:5-11. 2002
    ..We conclude that this protocol could be applied to study the modulation of these processes by nutrition, diseases, or pharmacologic treatments...
  4. ncbi request reprint [Pregnancy and weight]
    M Krempf
    Clinique d Endocrinologie, Maladies metaboliques et nutrition, Hotel Dieu, 44093 Nantes 1
    Ann Endocrinol (Paris) 64:332. 2003
  5. ncbi request reprint [Obesity and cardiovascular risk]
    M Krempf
    Clinique d Endocrinologie, Hotel Dieu, 44093 Nantes
    Ann Endocrinol (Paris) 62:S23-9. 2001
    ....
  6. ncbi request reprint Butyrate stimulates ApoA-IV-containing lipoprotein secretion in differentiated Caco-2 cells: role in cholesterol efflux
    H Nazih
    INSERM U 539 et Centre de Recherche en Nutrition Humaine, Hotel Dieu, Nantes, France
    J Cell Biochem 83:230-8. 2001
    ..We conclude that butyrate may regulate apoA-IV secretion and, therefore, modulate reverse cholesterol transport...
  7. ncbi request reprint Effect of n-3 fatty acids on metabolism of apoB100-containing lipoprotein in type 2 diabetic subjects
    K Ouguerram
    INSERM U539, Hotel Dieu, Nantes, France
    Br J Nutr 96:100-6. 2006
    ..05). In conclusion, the present study, conducted in the fasting state, showed that supplementation with n-3 fatty acids in type 2 diabetic patients induced beneficial changes in the metabolism of apoB100-containing lipoprotein...
  8. ncbi request reprint Efficacy and safety of micronised fenofibrate in a randomised double-blind study comparing four doses from 200 mg to 400 mg daily with placebo in patients with hypercholesterolemia
    M Krempf
    Clinique d Endocrinologie et Nutrition, Hotel Dieu, 44093 Nantes Cedex 1, France
    Diabetes Metab 26:184-91. 2000
    ..This study showed treatment for 3 months with micronised fenofibrate at doses up to 400 mg per day is effective and can reduce LDL-cholesterol up to 30% allowing further evaluation of these doses on longer trials...
  9. ncbi request reprint Negative and independent influence of apolipoprotein E on C-reactive protein (CRP) concentration in obese adults. Potential anti-inflammatory role of apoE in vivo
    K Bach-Ngohou
    , UFR de Pharmacie, Nantes, France
    Int J Obes Relat Metab Disord 25:1752-8. 2001
    ..CONCLUSION: ApoE is strongly correlated with CRP and could have an anti-inflammatory effect in vivo in obese subjects. This correlation could be limited to LpnonB lipoproteins, depending on their apoE and CIII relative content...
  10. ncbi request reprint Apolipoprotein E kinetics: influence of insulin resistance and type 2 diabetes
    K Bach-Ngohou
    INSERM U539, Centre de Recherche en Nutrition Humaine, CHU Hotel Dieu, Nantes, France
    Int J Obes Relat Metab Disord 26:1451-8. 2002
    ..The aim of this study was to explore apoE kinetics of obese subjects and to determine what parameters could influence its metabolism...
  11. ncbi request reprint Effect of low-density lipoproteins on apolipoprotein AI kinetics in heterozygous familial hypercholesterolemia
    R Frenais
    Centre de Recherche en Nutrition Humaine, Groupe Métabolisme, Hotel Dieu, Nantes, France
    Metabolism 50:635-9. 2001
    ..1 +/- 5.7 v 18.0 +/- 5.7 mg/kg/d, P <.05) after LDL-apheresis. These human kinetic data suggest that LDL do not play a major role on HDL production in heterozygous FH patients...
  12. ncbi request reprint New model for kinetic studies of HDL metabolism in humans
    M Chetiveaux
    CHU Hotel Dieu, Nantes, France
    Eur J Clin Invest 34:262-7. 2004
    ..The aim of the study was to develop a new model for kinetic studies of Apolipoprotein A-I of HDL (Apo A-I-HDL) labelled with stable isotope by using HDL subclasses isolated with fast protein liquid chromatography (FPLC)...
  13. ncbi request reprint Insulin effects on acetate metabolism
    H Piloquet
    Centre de Recherche en Nutrition Humaine, Institut National de la Santé et de la Recherche Médicale U539, Nantes, France
    Am J Physiol Endocrinol Metab 285:E561-5. 2003
    ..No correlation between glucose and acetate utilization was observed. Our results support the hypothesis that, like glucose metabolism, acetate metabolism is sensitive to insulin...
  14. ncbi request reprint Kinetics of prebeta1 HDL and alphaHDL in type II diabetic patients
    M Chetiveaux
    INSERM U539, Centre de Recherche en Nutrition Humaine, CHU Hotel Dieu, Nantes, France
    Eur J Clin Invest 36:29-34. 2006
    ..The aim of this study was to analyze the recycling of high density lipoprotein (HDL) in six type II diabetic patients compared with six control subjects by endogenous labelling of apolipoprotein A-I (Apo A-I) with stable isotope Apo A...
  15. ncbi request reprint Childhood obesity and insulin resistance in a Yucatan mini-piglet model: putative roles of IGF-1 and muscle PPARs in adipose tissue activity and development
    S P Sebert
    Unité des Fonctions Digestives et de Nutrition Humaine, Institut National de la Recherche Agronomique INRA, Nantes, France
    Int J Obes (Lond) 29:324-33. 2005
    ..To explore metabolic and cellular modifications induced during childhood obesity, in a novel animal model of obese mini-piglets...
  16. ncbi request reprint Effect of dietary omega-3 fatty acids on high-density lipoprotein apolipoprotein AI kinetics in type II diabetes mellitus
    R Frenais
    Centre de Recherche en Nutrition Humaine, Groupe Métabolisme, INSERM U539, Hotel Dieu, Nantes, France
    Atherosclerosis 157:131-5. 2001
    ..05, and 12.1+/-2.8 vs. 16.1+/-3.3 mg/kg per day, P<0.05). These findings showed an effect of maxEPA(R) on kinetics of apolipoprotein AI in type II diabetes mellitus, probably linked to changes in plasma triglyceride level...
  17. ncbi request reprint Colonic fermentation from lactulose inhibits lipolysis in overweight subjects
    V Ferchaud-Roucher
    Centre de Recherche en Nutrition Humaine, Institut National de la Santé et de la Recherche Médicale U539, Nantes, France
    Am J Physiol Endocrinol Metab 289:E716-20. 2005
    ..02). These results showed in overweight subjects a short-term decrease in FFA level and glycerol turnover after lactulose ingestion related to a decrease of lipolysis in close relationship with an increase of acetate production...
  18. ncbi request reprint Influence of remnant accumulation markers on plasma concentrations of two lipoprotein(a) subspecies (containing or free of apoE)
    K Bach-Ngohou
    , UFR de Pharmacie, Nantes, France
    Metabolism 50:277-82. 2001
    ....
  19. ncbi request reprint Metabolism of cholesterol ester of apolipoprotein B100-containing lipoproteins in dogs: evidence for disregarding cholesterol ester transfer
    E Bailhache
    Centre de Recherche en Nutrition Humaine, INSERM U539, CHU Nantes, France
    Eur J Clin Invest 34:527-34. 2004
    ..The aim of our study was to determine modalities of in vivo plasma cholesterol ester turnover in this species, using a kinetic approach with stable isotopes...
  20. ncbi request reprint Effect of low-density lipoprotein apheresis on kinetics of apolipoprotein B in heterozygous familial hypercholesterolemia
    C Maugeais
    Centre de Recherche en Nutrition Humaine, , 44093 Nantes Cedex 01, France
    J Clin Endocrinol Metab 86:1679-86. 2001
    ..21.9 +/- 1.6 mg/kg.day; P = 0.076) was observed. These results suggested that the marked decrease in plasma LDL obtained a short time after LDL-apheresis is able to stimulate LDL receptor activity and VLDL production in heterozygous FH...
  21. ncbi request reprint An insulin-resistant hypertriglyceridaemic normotensive obese dog model: assessment of insulin resistance by the euglycaemic hyperinsulinaemic clamp in combination with the stable isotope technique
    E Bailhache
    USC INRA de Nutrition et Endocrinologie, Ecole Nationale Veterinaire de Nantes, France
    J Anim Physiol Anim Nutr (Berl) 87:86-95. 2003
    ....
  22. doi request reprint Long-term effect of CB1 blockade with rimonabant on cardiometabolic risk factors: two year results from the RIO-Europe Study
    Luc F Van Gaal
    Department of Diabetology, Metabolism, and Clinical Nutrition, Antwerp University Hospital, Wilrijkstraat 10, B 2650 Edegem Antwerp, Belgium
    Eur Heart J 29:1761-71. 2008
    ..We report the 2 year efficacy and tolerability data of rimonabant...
  23. ncbi request reprint [Dietary recommendations for dyslipidemic individuals]
    M Krempf
    Clinique d'Endocrinologie, , , 44093 Nantes Cedex 1
    Ann Med Interne (Paris) 152:198-200. 2001
    ..Long-term education is needed to encourage the patient to comply with this type of diet. Psycho-behavioral strategies can be useful here...
  24. ncbi request reprint Metabolism of high density lipoprotein apolipoprotein A-I and cholesteryl ester in insulin resistant dog: a stable isotope study
    F Briand
    Diabetes Obes Metab 9:139-42. 2007
    ..HDL-CE selective uptake represents the main process for HDL-CE turnover in dog, a species lacking cholesteryl ester transfer protein activity. We therefore investigate the effects of diet induced insulin resistance on RCT...
  25. ncbi request reprint [MICROALB study: screening for microalbuminuria in type 2 diabetic hypertensive patients by general practitioners in France]
    P Sabouret
    Institut de coeur, Groupe Hospitalier La Pitié Salpêtrière, Paris
    Arch Mal Coeur Vaiss 99:712-7. 2006
    ..To determine the prevalence of microalbuminuria (MAU) detected by a specific urinary strip in type 2 diabetic hypertensive patients in metropolitan France...
  26. pmc A third major locus for autosomal dominant hypercholesterolemia maps to 1p34.1-p32
    M Varret
    Hopital Necker Enfants Malades, Institut National de la Sante et de la Recherche Medicale, Unit 383, Universite Rene Descartes, 75743 Paris Cedex 15, France
    Am J Hum Genet 64:1378-87. 1999
    ..Radiation hybrid mapping located four candidate genes at 1p34.1-p32, outside the critical region, showing no identity with FH3. Our results show that ADH is genetically more heterogeneous than conventionally accepted...
  27. ncbi request reprint Effects of atorvastatin on high-density lipoprotein apolipoprotein A-I metabolism in dogs
    F Briand
    Centre de Recherche en Nutrition Humaine, INSERM U539, CHU Nantes, France
    Eur J Clin Invest 36:224-30. 2006
    ..We investigated the effects of atorvastatin on HDL-apolipoprotein (apo) A-I metabolism in dogs, a species lacking cholesteryl ester transfer protein activity...
  28. ncbi request reprint [Plastic surgery and obesity: why, when, how?]
    M Chaouat
    Service de Chirurgie plastique reconstructrice et esthétique Pr M Mimoun, Hopital Rothschild, Paris, France
    Ann Endocrinol (Paris) 64:S16-21. 2003
    ..The management and follow-up should be maintained on the long term after the initial weight loss and the surgical procedure, in order to reinforce the benefit and to prevent a weight regain...
  29. ncbi request reprint In vivo evidence for the role of lipoprotein lipase activity in the regulation of apolipoprotein AI metabolism: a kinetic study in control subjects and patients with type II diabetes mellitus
    R Frenais
    Human Nutrition Research Center, INSERM, U 539, Hotel Dieu, 44093 Nantes Cedex 01, France
    J Clin Endocrinol Metab 86:1962-7. 2001
    ....
  30. ncbi request reprint Influence of atorvastatin on apolipoprotein E and AI kinetics in patients with type 2 diabetes
    K Bach-Ngohou
    Institut National de la Santé et de la Recherche Médicale U539, Centre de Recherche en Nutrition Humaine, CHU Hôtel Dieu Nantes, France
    J Pharmacol Exp Ther 315:363-9. 2005
    ..The increased number of apoE per VLDL particle suggests that atorvastatin could enhance the direct catabolism of triglyceride-rich VLDL through apoE receptor pathways...
  31. ncbi request reprint Familial ligand-defective apolipoprotein B-100: simultaneous detection of the ARG3500-->GLN and ARG3531-->CYS mutations in a French population
    J P Rabes
    INSERM U383, Hopital Necker Enfants Malades, Universite Rene Descartes, Paris, France
    Hum Mutat 10:160-3. 1997
    ..Additionally, the first two R3531C mutations were identified in French probands. Genotypes were consistent with a previously reported haplotype, suggesting that this is another mutation of European ancestry...