P Krack

Summary

Country: France

Publications

  1. ncbi request reprint Force overflow and levodopa-induced dyskinesias in Parkinson's disease
    Roland Wenzelburger
    Department of Neurology of the Christian Albrechts Universität Kiel, Germany
    Brain 125:871-9. 2002
  2. ncbi request reprint [Deep brain stimulation in Parkinson disease]
    P Krack
    Unité des troubles du Mouvement, Pôle de Psychiatrie et de Neurologie, CHU, Grenoble
    Rev Neurol (Paris) 164:F89-93. 2008
  3. ncbi request reprint Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease
    Paul Krack
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    N Engl J Med 349:1925-34. 2003
  4. doi request reprint Deep brain stimulation: from neurology to psychiatry?
    Paul Krack
    Movement Disorders Unit, Department of Psychiatry and Neurology, University Hospital Grenoble, France
    Trends Neurosci 33:474-84. 2010
  5. doi request reprint Levodopa-resistant freezing of gait and executive dysfunction in Parkinson's disease
    M U Ferraye
    Universite J Fourier Grenoble 1, INSERM, U836, Grenoble Institut des Neurosciences, Grenoble, France
    Eur Neurol 69:281-8. 2013
  6. ncbi request reprint Bilateral subthalamic nucleus stimulation improves health-related quality of life in PD
    E Lagrange
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    Neurology 59:1976-8. 2002
  7. doi request reprint High frequency deep brain stimulation of the subthalamic nucleus versus continuous subcutaneous apomorphine infusion therapy: a review
    R Carron
    Department of Neurosurgery, University Hospital, Grenoble, France
    J Neural Transm 118:915-24. 2011
  8. pmc Long term effects of bilateral subthalamic nucleus stimulation on cognitive function, mood, and behaviour in Parkinson's disease
    A Funkiewiez
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    J Neurol Neurosurg Psychiatry 75:834-9. 2004
  9. ncbi request reprint Is there a role for physiotherapy during deep brain stimulation surgery in patients with Parkinson's disease?
    E Chevrier
    Department of Neurology, Movement Disorders Unit, Grenoble University Hospital, Grenoble, Cedex 09, France
    Eur J Neurol 13:496-8. 2006
  10. ncbi request reprint Pyramidal tract side effects induced by deep brain stimulation of the subthalamic nucleus
    G Tommasi
    Department of Neurology, University Hospital, Joseph Fourier University, Grenoble, France
    J Neurol Neurosurg Psychiatry 79:813-9. 2008

Detail Information

Publications55

  1. ncbi request reprint Force overflow and levodopa-induced dyskinesias in Parkinson's disease
    Roland Wenzelburger
    Department of Neurology of the Christian Albrechts Universität Kiel, Germany
    Brain 125:871-9. 2002
    ..A close relationship was seen between the overshooting of forces and dyskinesias in the ON-drug condition. We postulate that both LID and grip force excess share common pathophysiological mechanisms related to motor fluctuations...
  2. ncbi request reprint [Deep brain stimulation in Parkinson disease]
    P Krack
    Unité des troubles du Mouvement, Pôle de Psychiatrie et de Neurologie, CHU, Grenoble
    Rev Neurol (Paris) 164:F89-93. 2008
  3. ncbi request reprint Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease
    Paul Krack
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    N Engl J Med 349:1925-34. 2003
    ..Although the short-term benefits of bilateral stimulation of the subthalamic nucleus in patients with advanced Parkinson's disease have been well documented, the long-term outcomes of the procedure are unknown...
  4. doi request reprint Deep brain stimulation: from neurology to psychiatry?
    Paul Krack
    Movement Disorders Unit, Department of Psychiatry and Neurology, University Hospital Grenoble, France
    Trends Neurosci 33:474-84. 2010
    ..In this review, we discuss the concept that dysfunction of motor, limbic and associative cortico-basal ganglia-thalamocortical loops underlies these various disorders, which might now be amenable to DBS treatment...
  5. doi request reprint Levodopa-resistant freezing of gait and executive dysfunction in Parkinson's disease
    M U Ferraye
    Universite J Fourier Grenoble 1, INSERM, U836, Grenoble Institut des Neurosciences, Grenoble, France
    Eur Neurol 69:281-8. 2013
    ..However, since some patients develop L-FOG despite the preservation of executive functions, lesions or dysfunction of other neuronal structures are likely to be involved...
  6. ncbi request reprint Bilateral subthalamic nucleus stimulation improves health-related quality of life in PD
    E Lagrange
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    Neurology 59:1976-8. 2002
    ..All aspects of quality of life, including motor (+48%), systemic (+34%), emotional (+29%), and social (+63%) dimensions, significantly improved with long-term STN stimulation...
  7. doi request reprint High frequency deep brain stimulation of the subthalamic nucleus versus continuous subcutaneous apomorphine infusion therapy: a review
    R Carron
    Department of Neurosurgery, University Hospital, Grenoble, France
    J Neural Transm 118:915-24. 2011
    ....
  8. pmc Long term effects of bilateral subthalamic nucleus stimulation on cognitive function, mood, and behaviour in Parkinson's disease
    A Funkiewiez
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    J Neurol Neurosurg Psychiatry 75:834-9. 2004
    ..Long term effects of subthalamic nucleus (STN) stimulation on cognition, mood, and behaviour are unknown...
  9. ncbi request reprint Is there a role for physiotherapy during deep brain stimulation surgery in patients with Parkinson's disease?
    E Chevrier
    Department of Neurology, Movement Disorders Unit, Grenoble University Hospital, Grenoble, Cedex 09, France
    Eur J Neurol 13:496-8. 2006
    ..All patients except one experienced physical pain and psychological suffering, alleviated by physiotherapy. These preliminary results need to be confirmed in a prospective randomized study...
  10. ncbi request reprint Pyramidal tract side effects induced by deep brain stimulation of the subthalamic nucleus
    G Tommasi
    Department of Neurology, University Hospital, Joseph Fourier University, Grenoble, France
    J Neurol Neurosurg Psychiatry 79:813-9. 2008
    ..To study the pyramidal tract side effects (PTSEs) induced by the spread of current from the subthalamic nucleus (STN) to the pyramidal tract (PT), in patients with parkinsonism undergoing STN stimulation...
  11. ncbi request reprint Effect of bilateral subthalamic nucleus stimulation on parkinsonian gait
    J Xie
    Department of Clinical and Biological Neurosciences, Centre Hospitalier Universitaire de Grenoble, France
    J Neurol 248:1068-72. 2001
    ..The UPDRS motor score was significantly (p < 0.001) decreased after both stimulation and levodopa. In conclusion, STN stimulation is effective on parkinsonian gait...
  12. doi request reprint Subthalamic nucleus versus pedunculopontine nucleus stimulation in Parkinson disease: synergy or antagonism?
    M U Ferraye
    University J Fourier Grenoble 1, 38041, Grenoble, France
    J Neural Transm 118:1469-75. 2011
    ....
  13. ncbi request reprint Ineffective subthalamic nucleus stimulation in levodopa-resistant postischemic parkinsonism
    P Krack
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    Neurology 54:2182-4. 2000
    ..This case suggests that parkinsonian patients who do not have a good response to levodopa or in whom a postsynaptic dopaminergic lesion can be shown may not be good candidates for STN surgery...
  14. ncbi request reprint Mirthful laughter induced by subthalamic nucleus stimulation
    P Krack
    Neuroscience Department, University of Grenoble, Grenoble, France
    Mov Disord 16:867-75. 2001
    ..Our report suggests that the STN, with its sensorimotor, cognitive, and limbic parts is not only involved in motor, but also in psychomotor regulation...
  15. ncbi request reprint Intraoperative microrecordings of the subthalamic nucleus in Parkinson's disease
    Abdelhamid Benazzouz
    Department of Clinical and Biological Neurosciences, Institut National de la Santé et de la Recherche Médicale U 318, University Hospital A Michallon, Pavillon B, Grenoble, France
    Mov Disord 17:S145-9. 2002
    ..In conclusion, microelectrode recording of the subthalamic area improves the accuracy of targeting the STN...
  16. ncbi request reprint Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease
    Aurélie Funkiewiez
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    Mov Disord 18:524-30. 2003
    ....
  17. ncbi request reprint Effects of levodopa and subthalamic nucleus stimulation on cognitive and affective functioning in Parkinson's disease
    Aurélie Funkiewiez
    Department of Clinical and Biological Neurosciences, University Hospital of Grenoble, and INSERM U318, Joseph Fourier University of Grenoble, Grenoble, France
    Mov Disord 21:1656-62. 2006
    ..To conclude, there were significant but contrasting effects of levodopa and STN stimulation on cognition and affective functions...
  18. ncbi request reprint Functional neurosurgery: past, present, and future
    A L Benabid
    University Joseph Fourier, Grenoble, France
    Clin Neurosurg 52:265-70. 2005
  19. ncbi request reprint Off-period dystonia in Parkinson's disease but not generalized dystonia is improved by high-frequency stimulation of the subthalamic nucleus
    Olivier Detante
    Department of Biological and Clinical Neurosciences, INSERM, Joseph Fourier University, Department of Neurology, CHU Grenoble, Grenoble, France
    Adv Neurol 94:309-14. 2004
    ..Assuming that the mechanism of action of STN-HFS is similar regardless of the cause of dystonia, our findings suggest that the STN is not similarly involved in off-period dystonia of IPD and others dystonias...
  20. doi request reprint Improvement in Parkinson disease by subthalamic nucleus stimulation based on electrode placement: effects of reimplantation
    Mathieu Anheim
    Department of Neurology, University Hospital A Michallon, Grenoble, France
    Arch Neurol 65:612-6. 2008
    ..The misplacement of electrodes is a possible explanation for suboptimal response to bilateral subthalamic nucleus (STN) stimulation in patients with Parkinson disease...
  21. ncbi request reprint [Deep brain stimulation]
    V Fraix
    Departement de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble
    Rev Neurol (Paris) 160:511-21. 2004
    ..Such studies, including cost benefit studies would be useful to assess the respective value of these different techniques...
  22. doi request reprint Effects of subthalamic nucleus stimulation and levodopa on freezing of gait in Parkinson disease
    M U Ferraye
    Université de Grenoble, INSERM U836, CHU de Grenoble, Pavillon de Neurologie, BP 217, 38043 Grenoble Cedex 9, France
    Neurology 70:1431-7. 2008
    ..We studied the effects of subthalamic nucleus (STN) stimulation vs levodopa on freezing of gait (FOG) and gait impairments in a large consecutive series of patients with Parkinson disease with bilateral STN stimulation...
  23. ncbi request reprint Treatment results: Parkinson's disease
    Pierre Pollak
    Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, France
    Mov Disord 17:S75-83. 2002
    ..Intracranial electrode implantation can induce a hematoma or contusion. Most authors agree that the benefit to risk ratio of DBS is favorable...
  24. ncbi request reprint Surgery of the motor thalamus: problems with the present nomenclatures
    Paul Krack
    Neurology Department, University of Grenoble, Grenoble, France
    Mov Disord 17:S2-8. 2002
    ..There is a need to better define the limits of the sensory and cerebellar afferent receiving thalamic nuclei as well as those of the cerebellar and pallidal afferent receiving territories in humans...
  25. ncbi request reprint Intraoperative micro- and macrostimulation of the subthalamic nucleus in Parkinson's disease
    Pierre Pollak
    Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
    Mov Disord 17:S155-61. 2002
    ..New skills are needed to assess all stimulation-induced effects and interpret them in anatomo-functional terms...
  26. ncbi request reprint Glutamate measurement in Parkinson's disease using MRS at 3 T field strength
    Nils Kickler
    INSERM, U594, Neuroimagerie Fonctionnelle et Métabolique, Grenoble, France
    NMR Biomed 20:757-62. 2007
    ..Ten patients with Parkinson's disease and 10 healthy controls were examined. Compared with healthy controls, no significant differences in glutamate were measured in patients, but a trend to lower total creatine was observed...
  27. ncbi request reprint Therapeutic electrical stimulation of the central nervous system
    Alim Louis Benabid
    INSERM U318, Universite Joseph Fourier, CHU Albert Michallon, pavilion B, BP 217, 38043 Grenoble, France
    C R Biol 328:177-86. 2005
    ..The understanding of the mechanism has opened a new field of research, which will call for reappraisal of the basic effects of electricity on the living tissues...
  28. ncbi request reprint Changes induced by levodopa and subthalamic nucleus stimulation on parkinsonian speech
    Serge Pinto
    Neurosciences Précliniques, INSERM Unité 318, Grenoble, France
    Mov Disord 20:1507-15. 2005
    ..These hypotheses may be helpful for better understanding and management of STN stimulation effects on motor speech and skeleton-motor subsystems...
  29. ncbi request reprint Postoperative management of subthalamic nucleus stimulation for Parkinson's disease
    Paul Krack
    Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France
    Mov Disord 17:S188-97. 2002
    ..Neurosurgeons who perform DBS need to understand the principles that guide the postoperative adaptation of treatment. This article defines guidelines for setting stimulation parameters, adapting drugs and managing adverse effects...
  30. ncbi request reprint Pathological gambling in Parkinson's disease improves on chronic subthalamic nucleus stimulation
    Claire Ardouin
    Departement de Neurologie, CHU Grenoble, INSERM U318, Universite Joseph Fourier, Grenoble, France
    Mov Disord 21:1941-6. 2006
    ....
  31. ncbi request reprint [Parkinson disease: deep cerebral stimulation]
    P Krack
    Departement des Neurosciences Cliniques et Biologiques, Centre Hospitalier Universitaire, INSERM U 318, Universite Joseph Fourier, Grenoble, France
    Rev Neurol (Paris) 158:S135-41. 2002
    ..100 per implanted side. The patient selection, the precision of the surgery and the quality of the postoperative follow-up are the three main determinants of success...
  32. ncbi request reprint Predictors of effective bilateral subthalamic nucleus stimulation for PD
    P D Charles
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    Neurology 59:932-4. 2002
    ..Younger age and levodopa responsiveness predict a favorable response to bilateral STN stimulation. For individual PD symptoms, those that improve with a suprathreshold dose levodopa challenge are likely to improve with stimulation...
  33. ncbi request reprint Comparison of two techniques to postoperatively localize the electrode contacts used for subthalamic nucleus stimulation
    Serge Pinto
    Department of Neurology, Centre Hospitalier Universitaire de Grenoble, and INSERM U318, Neurosciences Précliniques, Grenoble, France
    Neurosurgery 60:285-92; discussion 292-4. 2007
    ..To our knowledge, this is the first study attempting to compare the "gold standard" of stereotactic accuracy (Vg) with the anatomic resolution provided by MRI scans...
  34. ncbi request reprint Lifetime of Itrel II pulse generators for subthalamic nucleus stimulation in Parkinson's disease
    Mathieu Anheim
    Department of Neurology, University Hospital A Michallon, Grenoble, France
    Mov Disord 22:2436-9. 2007
    ..A close monitoring of patients and an anticipation of IPG replacement in the case of a low-battery signal are recommended...
  35. ncbi request reprint Deep brain stimulation: what does it offer?
    Alim Louis Benabid
    Department of Clinical Neurosciences, University Joseph Fourier, Grenoble, France
    Adv Neurol 91:293-302. 2003
  36. doi request reprint Neurological pictures. Vascular hemiparkinsonism sensitive to levodopa
    O Veran
    Universite Joseph Fourier, Grenoble, France
    J Neurol Neurosurg Psychiatry 79:1244. 2008
  37. doi request reprint Non-motor dopamine withdrawal syndrome after surgery for Parkinson's disease: predictors and underlying mesolimbic denervation
    Stephane Thobois
    Universitée Lyon I, Hospices Civils de Lyon, Hopital Neurologique Pierre Wertheimer, Service de Neurologie C, Lyon, France
    Brain 133:1111-27. 2010
    ..A varying extent of mesolimbic dopaminergic denervation and differences in dopaminergic treatment largely determine mood, anxiety and motivation in patients with Parkinson's disease, contributing to different non-motor phenotypes...
  38. ncbi request reprint Two-year follow-up of subthalamic deep brain stimulation in Parkinson's disease
    Jan Herzog
    Department of Neurology, Christian Albrechts Universitat Kiel, Kiel, Germany
    Mov Disord 18:1332-7. 2003
    ..The current series demonstrates efficacy and safety of STN-DBS beyond the first year after surgical procedure. Complications of STN-DBS comprise a wide range of psychiatric adverse events which, however, were temporary...
  39. doi request reprint Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study
    Karsten Witt
    Christian Albrechts University, Kiel, Germany
    Lancet Neurol 7:605-14. 2008
    ..To assess the neuropsychiatric consequences of DBS in patients with PD we did an ancillary protocol as part of a randomised study that compared DBS with the best medical treatment...
  40. ncbi request reprint Subthalamic nucleus influences spatial orientation in extra-personal space
    Karsten Witt
    Department of Neurology, University Schleswig Holstein, Kiel, Germany
    Mov Disord 21:354-61. 2006
    ..These patterns of symptoms of neglect demonstrate the influence of the STN on the attentional system of the nondominant hemisphere...
  41. ncbi request reprint A quick and universal method for stereotactic visualization of the subthalamic nucleus before and after implantation of deep brain stimulation electrodes
    Marwan I Hariz
    Department of Neurosurgery, Umea, Sweden
    Stereotact Funct Neurosurg 80:96-101. 2003
    ..Postoperatively, the same imaging protocol permitted visualization of the target area and DBS electrodes with minimum artifacts. This imaging technique may contribute to a decrease in the number of electrode passes at surgery...
  42. ncbi request reprint Subthalamic nucleus stimulation for Parkinson's disease preferentially improves akinesia of proximal arm movements compared to finger movements
    Roland Wenzelburger
    Department of Neurology, Christian Albrechts Universitat Kiel, Kiel, Germany
    Mov Disord 18:1162-9. 2003
    ..Other akinesia items and the time for build-up of lifting force were equally improved in both conditions. This suggests that routine STN-DBS might not be equally effective on all aspects of fine motor functions...
  43. ncbi request reprint Manic episode with psychotic symptoms induced by subthalamic nucleus stimulation in a patient with Parkinson's disease
    Jan Herzog
    Department of Neurology, Christian Albrechts Universitat Kiel, Kiel, Germany
    Mov Disord 18:1382-4. 2003
    ..A manic episode with psychotic symptoms induced by STN-DBS occurred in a previously psychiatrically healthy patient, focusing on the role of STN-DBS in influencing not only motor but also emotional behaviour...
  44. doi request reprint Are parkin patients particularly suited for deep-brain stimulation?
    Ebba Lohmann
    INSERM, U679, Paris, France
    Mov Disord 23:740-3. 2008
    ..Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results...
  45. ncbi request reprint Results of deep brain stimulation for dystonia: a critical reappraisal
    Laurent Vercueil
    Neurological Department, Grenoble University Hospital, France
    Mov Disord 17:S89-93. 2002
    ..A careful assessment of the efficacy by using improved clinical scale is also warranted...
  46. ncbi request reprint A randomized trial of deep-brain stimulation for Parkinson's disease
    Gunther Deuschl
    Christian Albrechts University, Kiel, Germany
    N Engl J Med 355:896-908. 2006
    ..Neurostimulation of the subthalamic nucleus reduces levodopa-related motor complications in advanced Parkinson's disease. We compared this treatment plus medication with medical management...
  47. ncbi request reprint Electrophysiological mapping for the implantation of deep brain stimulators for Parkinson's disease and tremor
    Robert E Gross
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mov Disord 21:S259-83. 2006
    ..The increase in surgical risk of intracranial hemorrhage correlated to the number of microelectrode trajectories must be considered against the risk of suboptimal benefits related to omission of this technique...
  48. ncbi request reprint Deep brain stimulation: neuropsychological and neuropsychiatric issues
    Valerie Voon
    Department of Psychiatry, Toronto Western Hospital, Toronto, Canada
    Mov Disord 21:S305-27. 2006
    ..Outcome studies, methodological issues, pathophysiology, and preoperative and postoperative management of the cognitive and neuropsychiatric aspects and complications of DBS for PD are discussed...
  49. ncbi request reprint Dyskinesias and grip control in Parkinson's disease are normalized by chronic stimulation of the subthalamic nucleus
    Roland Wenzelburger
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Ann Neurol 52:240-3. 2002
    ..Grip force overflow is a promising parameter to study the desensitizing effect of chronic deep-brain stimulation on levodopa-induced dyskinesias...
  50. ncbi request reprint Contraversive eye deviation during stimulation of the subthalamic region
    Paul Sauleau
    Department of Neurophysiology, Universite de Rennes 1, CHU de Rennes, France
    Mov Disord 22:1810-3. 2007
    ..Interestingly, this report shows that CED may be corrected by bilateral stimulation and that CED may not necessarily implicate electrode repositioning...
  51. ncbi request reprint Deep brain stimulation of the subthalamic nucleus improves cognitive flexibility but impairs response inhibition in Parkinson disease
    Karsten Witt
    Department of Neurology, Christian Albrechts University Kiel, Kiel, Germany
    Arch Neurol 61:697-700. 2004
    ....
  52. ncbi request reprint Differential effects of L-dopa and subthalamic stimulation on depressive symptoms and hedonic tone in Parkinson's disease
    Karsten Witt
    Department of Neurology, University Schleswig Holstein, Kiel, Germany
    J Neuropsychiatry Clin Neurosci 18:397-401. 2006
    ..These results demonstrate a single dissociation of depressive symptoms and anhedonia in response to an acute L-dopa and STN-stimulation challenge...
  53. ncbi request reprint Contribution of Jules Froment to the study of parkinsonian rigidity
    Emmanuel Broussolle
    Universite de Lyon, Universite Claude Bernard Lyon I, Faculté de médecine Lyon Sud, Lyon, France
    Mov Disord 22:909-14. 2007
    ..In their number, breadth, and originality, Froment's contributions to the study of parkinsonian rigidity remain currently relevant to clinical and neurophysiological issues of PD...
  54. doi request reprint Subthalamic stimulation improves orienting gaze movements in Parkinson's disease
    Paul Sauleau
    Department of Neurophysiology, University Hospital of Rennes, University of Rennes 1, France
    Clin Neurophysiol 119:1857-63. 2008
    ..To determine the effect of subthalamic stimulation on visually triggered eye and head movements in patients with Parkinson's disease (PD)...
  55. ncbi request reprint Deep brain stimulation: preoperative issues
    Anthony E Lang
    Department of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 21:S171-96. 2006
    ..It outlines answers to a series of questions developed to address all aspects of deep brain stimulation preoperative decision-making...