Anatol Kontush

Summary

Country: France

Publications

  1. ncbi Apolipoprotein Abeta: black sheep in a good family
    Anatol Kontush
    INSERM Unité 551, Hopital de la Pitie, Pavilion Benjamin Delessert, 83, Bd de l Hopital, 75651 Paris Cedex 13, France
    Brain Pathol 14:433-47. 2004
  2. ncbi Why is HDL functionally deficient in type 2 diabetes?
    Anatol Kontush
    INSERM Unité 551, Pavillon Benjamin Delessert, Hôpital de Pitié, 83 Boulevard de l hopital, 75651 Paris Cedex 13, France
    Curr Diab Rep 8:51-9. 2008
  3. pmc Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes
    R A Gangani D Silva
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45237, USA
    Proc Natl Acad Sci U S A 105:12176-81. 2008
  4. doi HDL3-mediated inactivation of LDL-associated phospholipid hydroperoxides is determined by the redox status of apolipoprotein A-I and HDL particle surface lipid rigidity: relevance to inflammation and atherogenesis
    Amal Zerrad-Saadi
    Dyslipidemia and Atherosclerosis Research Unit UMRS 939, National Institute for Health and Medical Research INSERM, Hôpital de Pitié UPMC Paris 6, University Paris Descartes, France
    Arterioscler Thromb Vasc Biol 29:2169-75. 2009
  5. doi Antiatherogenic function of HDL particle subpopulations: focus on antioxidative activities
    Anatol Kontush
    National Institute for Health and Medical Research INSERM, Dyslipidemia, Inflammation and Atherosclerosis Research Unit UMR 939, Paris, France
    Curr Opin Lipidol 21:312-8. 2010
  6. ncbi A normotriglyceridemic, low HDL-cholesterol phenotype is characterised by elevated oxidative stress and HDL particles with attenuated antioxidative activity
    Anatol Kontush
    Dyslipoproteinemia and Atherosclerosis Research Unit U 551, National Institute for Health and Medical Research INSERM, Hopital de la Pitie, 83 Boulevard de l hopital, 75651 Paris Cedex 13, France
    Atherosclerosis 182:277-85. 2005
  7. ncbi Amyloid-beta: acute-phase apolipoprotein with metal-binding activity
    Anatol Kontush
    INSERM Unité 551, Hopital de la Pitie, Pavillon Benjamin Delessert, 83, Bd de l Hopital, 75651 Paris Cedex 13, France
    J Alzheimers Dis 8:129-37; discussion 209-15. 2005
  8. ncbi Antiatherogenic small, dense HDL--guardian angel of the arterial wall?
    Anatol Kontush
    National Institute for Health and Medical Research INSERM, Unité 551, Hopital de la Pitie, Paris, France
    Nat Clin Pract Cardiovasc Med 3:144-53. 2006
  9. ncbi Preferential sphingosine-1-phosphate enrichment and sphingomyelin depletion are key features of small dense HDL3 particles: relevance to antiapoptotic and antioxidative activities
    Anatol Kontush
    Universite Pierre et Marie Curie Paris 6, Paris, France
    Arterioscler Thromb Vasc Biol 27:1843-9. 2007
  10. ncbi Antioxidative activity of HDL particle subspecies is impaired in hyperalphalipoproteinemia: relevance of enzymatic and physicochemical properties
    Anatol Kontush
    Dyslipoproteinemia and Atherosclerosis Research Unit U 551, National Institute for Health and Medical Research, Hopital de la Pitie, Paris, France
    Arterioscler Thromb Vasc Biol 24:526-33. 2004

Collaborators

Detail Information

Publications42

  1. ncbi Apolipoprotein Abeta: black sheep in a good family
    Anatol Kontush
    INSERM Unité 551, Hopital de la Pitie, Pavilion Benjamin Delessert, 83, Bd de l Hopital, 75651 Paris Cedex 13, France
    Brain Pathol 14:433-47. 2004
    ..New studies are needed to shed further light on the physiological role of Abeta in lipid metabolism in the brain...
  2. ncbi Why is HDL functionally deficient in type 2 diabetes?
    Anatol Kontush
    INSERM Unité 551, Pavillon Benjamin Delessert, Hôpital de Pitié, 83 Boulevard de l hopital, 75651 Paris Cedex 13, France
    Curr Diab Rep 8:51-9. 2008
    ..Therapeutic options for correcting HDL functional deficiency should target hypertriglyceridemia by normalizing circulating levels of triglyceride-rich lipoproteins...
  3. pmc Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes
    R A Gangani D Silva
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45237, USA
    Proc Natl Acad Sci U S A 105:12176-81. 2008
    ..We propose the first experiment-based molecular model of apoA-I in spherical HDL particles. This model provides a new foundation for understanding how apoA-I structure modulates HDL function and metabolism...
  4. doi HDL3-mediated inactivation of LDL-associated phospholipid hydroperoxides is determined by the redox status of apolipoprotein A-I and HDL particle surface lipid rigidity: relevance to inflammation and atherogenesis
    Amal Zerrad-Saadi
    Dyslipidemia and Atherosclerosis Research Unit UMRS 939, National Institute for Health and Medical Research INSERM, Hôpital de Pitié UPMC Paris 6, University Paris Descartes, France
    Arterioscler Thromb Vasc Biol 29:2169-75. 2009
    ....
  5. doi Antiatherogenic function of HDL particle subpopulations: focus on antioxidative activities
    Anatol Kontush
    National Institute for Health and Medical Research INSERM, Dyslipidemia, Inflammation and Atherosclerosis Research Unit UMR 939, Paris, France
    Curr Opin Lipidol 21:312-8. 2010
    ....
  6. ncbi A normotriglyceridemic, low HDL-cholesterol phenotype is characterised by elevated oxidative stress and HDL particles with attenuated antioxidative activity
    Anatol Kontush
    Dyslipoproteinemia and Atherosclerosis Research Unit U 551, National Institute for Health and Medical Research INSERM, Hopital de la Pitie, 83 Boulevard de l hopital, 75651 Paris Cedex 13, France
    Atherosclerosis 182:277-85. 2005
    ..It is indeterminate as to whether high cardiovascular risk in low HDL-C subjects occurs concomitantly with elevated oxidative stress and/or with biologically dysfunctional HDL particles...
  7. ncbi Amyloid-beta: acute-phase apolipoprotein with metal-binding activity
    Anatol Kontush
    INSERM Unité 551, Hopital de la Pitie, Pavillon Benjamin Delessert, 83, Bd de l Hopital, 75651 Paris Cedex 13, France
    J Alzheimers Dis 8:129-37; discussion 209-15. 2005
    ..Such oligomerised Abeta may lose its normal biological functions and acquire deleterious activities. To be efficient, novel anti-AD therapies should target oligomeric forms of Abeta while preserving the monomeric form of the peptide...
  8. ncbi Antiatherogenic small, dense HDL--guardian angel of the arterial wall?
    Anatol Kontush
    National Institute for Health and Medical Research INSERM, Unité 551, Hopital de la Pitie, Paris, France
    Nat Clin Pract Cardiovasc Med 3:144-53. 2006
    ..Induction of selective increase in the circulating concentrations of small, dense HDL3 particles with increased antiatherogenic activity seems especially promising, particularly for therapy of atherogenic dyslipidemia...
  9. ncbi Preferential sphingosine-1-phosphate enrichment and sphingomyelin depletion are key features of small dense HDL3 particles: relevance to antiapoptotic and antioxidative activities
    Anatol Kontush
    Universite Pierre et Marie Curie Paris 6, Paris, France
    Arterioscler Thromb Vasc Biol 27:1843-9. 2007
    ....
  10. ncbi Antioxidative activity of HDL particle subspecies is impaired in hyperalphalipoproteinemia: relevance of enzymatic and physicochemical properties
    Anatol Kontush
    Dyslipoproteinemia and Atherosclerosis Research Unit U 551, National Institute for Health and Medical Research, Hopital de la Pitie, Paris, France
    Arterioscler Thromb Vasc Biol 24:526-33. 2004
    ..The impact of such modification on antioxidative activities of HDL subfractions is indeterminate...
  11. ncbi Small, dense HDL particles exert potent protection of atherogenic LDL against oxidative stress
    Anatol Kontush
    Dyslipoproteinemia and Atherosclerosis Research Unit U 551, National Institute for Health and Medical Research INSERM, Hopital de la Pitie, Paris, France
    Arterioscler Thromb Vasc Biol 23:1881-8. 2003
    ..The relationship of the structural and functional heterogeneity of HDL particles to protection of LDL against oxidative stress is indeterminate...
  12. ncbi Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis
    Anatol Kontush
    Dyslipoproteinemia and Atherosclerosis Research Unit, National Institute for Health and Medical Research, Hopital de la Pitie, 83 Boulevard de l hopital, 75651 Paris Cedex 13, France
    Pharmacol Rev 58:342-74. 2006
    ....
  13. ncbi Spotlight on HDL-raising therapies: insights from the torcetrapib trials
    Anatol Kontush
    INSERM, Unité 551, Pavillon Benjamin Delessert, Hopital de la Pitie, 83 Boulevard de l hopital, 75651 Paris Cedex 13, France
    Nat Clin Pract Cardiovasc Med 5:329-36. 2008
    ..Normalization of both defective HDL function and diminished HDL levels should, therefore, be the focus of pharmacological HDL raising in future studies...
  14. doi Lipidomics as a tool for the study of lipoprotein metabolism
    Anatol Kontush
    Universite Pierre et Marie Curie Paris 6, Paris, 75013, France
    Curr Atheroscler Rep 12:194-201. 2010
    ....
  15. ncbi Vitamin E in neurodegenerative disorders: Alzheimer's disease
    Kanatol Kontush
    INSERM Unité 551, Pavillon Benjamin Delessert, Hopital de la Pitie, 83 Boulevard de l hopital, 75651 Paris Cedex 13, France
    Ann N Y Acad Sci 1031:249-62. 2004
    ..Altogether, these data suggest that vitamin E may be effective against in vivo oxidation of CSF lipoproteins and brain lipids, and offer new perspectives in the treatment of AD and other neurodegenerative disorders...
  16. ncbi Metabolic syndrome features small, apolipoprotein A-I-poor, triglyceride-rich HDL3 particles with defective anti-apoptotic activity
    Juliana A de Souza
    Universite Pierre et Marie Curie Paris 6, Paris F 75013, France
    Atherosclerosis 197:84-94. 2008
    ....
  17. doi Small, dense HDL 3 particles attenuate apoptosis in endothelial cells: pivotal role of apolipoprotein A-I
    Juliana A de Souza
    Dyslipoproteinemia and Atherosclerosis Research Unit UMR939, National Institute for Health and Medical Research INSERM, Hopital de la Pitie, Paris, France
    J Cell Mol Med 14:608-20. 2010
    ..We conclude that small, dense, lipid-poor HDL 3 potently protects endothelial cells from primary apoptosis and intracellular ROS generation induced by mildly oxLDL, and that apoA-I is pivotal to such protection...
  18. doi Small, dense high-density lipoprotein-3 particles are enriched in negatively charged phospholipids: relevance to cellular cholesterol efflux, antioxidative, antithrombotic, anti-inflammatory, and antiapoptotic functionalities
    Laurent Camont
    From the National Institute for Health and Medical Research INSERM, Dyslipidemia, Inflammation and Atherosclerosis Research Unit UMR 939, Paris, France L C, M L, F R, W L G, M J C, A K Université Pierre et Marie Curie Paris 6, Paris, France L C, M L, F R, W L G, M J C, A K AP HP, Groupe Hospitalier Pitie Salpetriere, Paris, France L C, M L, F R, W L G, M J C, A K ICAN, Paris, France L C, M L, F R, W L G, M J C, A K Heart Institute InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Academic Hospital
    Arterioscler Thromb Vasc Biol 33:2715-23. 2013
    ..Because phospholipids represent a major bioactive lipid component of HDL, we characterized the phosphosphingolipidome of major normolipidemic HDL subpopulations and related it to HDL functionality...
  19. doi Blood pressure-lowering response to amlodipine as a determinant of the antioxidative activity of small, dense HDL3
    Boris Hansel
    Service d Endocrinologie Métabolisme, Hopital de la Pitie, Paris, France
    Am J Cardiovasc Drugs 11:317-25. 2011
    ..This study aimed to assess the effect of 1 month's treatment with amlodipine on HDL AOX in hypertensive subjects...
  20. ncbi Alterations in lipoprotein defense against oxidative stress in metabolic syndrome
    Boris Hansel
    Service d Endocrinologie Métabolisme, Pavillon Benjamin Delessert, Hopital de la Pitie, 83 Boulevard de l hopital, 75651 Paris Cedex 13, France
    Curr Atheroscler Rep 8:501-9. 2006
    ..Therapeutic normalization of the quantity and the quality of HDL particles may constitute a novel approach to attenuate atherosclerosis and cardiovascular risk in MetS...
  21. pmc LDL-apheresis depletes apoE-HDL and pre-β1-HDL in familial hypercholesterolemia: relevance to atheroprotection
    Alexina Orsoni
    INSERM UMR S939, Hopital de la Pitie Salpetriere, Paris, France
    J Lipid Res 52:2304-13. 2011
    ..In LDL-receptor (LDL-R) deficiency, LDL-apheresis may enhance flux through the reverse cholesterol transport pathway and equally attenuate potential biglycan-mediated deposition of apoE-HDL in the arterial matrix...
  22. pmc Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors
    M John Chapman
    INSERM, UMR S939, Dyslipidemia, Inflammation and Atherosclerosis Research Unit, University Pierre and Marie Curie Paris 6, Pavillon Benjamin Delessert, Hopital de la Pitie, 83 Boulevard de l hopital, Paris Cedex 13, France
    Eur Heart J 31:149-64. 2010
    ..Further studies of these CETP inhibitors, in particular in long-term, large-scale outcome trials, will provide essential information on their safety and efficacy in reducing residual cardiovascular risk...
  23. ncbi High-density lipoprotein as a key component in the prevention of premature atherosclerotic disease in the insulin resistance syndrome
    Boris Hansel
    Dyslipoproteinemia and Atherosclerosis Research Unit U 551, National Institute for Health and Medical Research INSERM Pitie Salpetriere Hospital, Paris, France
    Semin Vasc Med 4:215-23. 2004
    ..Consistent with these developments, new therapeutic strategies can be envisaged for IRS, including treatment with recombinant HDL particles and inhibitors of cholesteryl ester transfer protein...
  24. ncbi One third of the variability in HDL-cholesterol level in a large dyslipidaemic population is predicted by age, sex and triglyceridaemia: The Paris La Pitié Study
    Boris Hansel
    Service d Endocrinologie Métabolisme AP HP, Hopital de la Pitie, Paris, France
    Curr Med Res Opin 22:1149-60. 2006
    ....
  25. ncbi Metabolic syndrome is associated with elevated oxidative stress and dysfunctional dense high-density lipoprotein particles displaying impaired antioxidative activity
    Boris Hansel
    Dyslipoproteinemia and Atherosclerosis Research Unit, National Institute for Health and Medical Research, Institut National de la Sante et de la Recherche Medicale, Hopital de la Pitie, 75013 Paris, France
    J Clin Endocrinol Metab 89:4963-71. 2004
    ..Induction of selective increase in the circulating concentrations of dense HDL subfractions may represent an innovative therapeutic approach for the attenuation of high cardiovascular risk in MetS...
  26. ncbi Mildly oxidized LDL particle subspecies are distinct in their capacity to induce apoptosis in endothelial cells: role of lipid hydroperoxides
    Anatol Kontush
    INSERM U 551, Pavillon Benjamin Delessert, Hopital de la Pitie, 75651 Paris Cedex 13, France
    FASEB J 17:88-90. 2003
    ..These data are highly relevant to atherogenic hypercholesterolemia, in which the LDL phenotype is dominated by elevated concentrations of light LDL3...
  27. pmc High-density lipoprotein (HDL) particle subpopulations in heterozygous cholesteryl ester transfer protein (CETP) deficiency: maintenance of antioxidative activity
    Sandrine Chantepie
    INSERM UMRS 939, Pitie Salpetriere University Hospital, Paris, France
    PLoS ONE 7:e49336. 2012
    ..These findings support the contention that HDL functionality is maintained in heterozygous CETP deficiency despite modifications in lipid and protein composition...
  28. doi Biological activities of HDL subpopulations and their relevance to cardiovascular disease
    Laurent Camont
    National Institute for Health and Medical Research INSERM, Dyslipidemia, Inflammation and Atherosclerosis Research Unit UMR 939, Paris F 75013, France
    Trends Mol Med 17:594-603. 2011
    ....
  29. pmc Distinct HDL subclasses present similar intrinsic susceptibility to oxidation by HOCl
    Sandrine Chantepie
    Universite Pierre et Marie Curie Paris 6, UMR S939 Dyslipydemia, Inflammation and Atherosclerosis in Metabolic Diseases, F 75013 Paris, France
    Arch Biochem Biophys 487:28-35. 2009
    ..We conclude that structural and physicochemical differences between HDL subclasses do not influence their intrinsic susceptibility to oxidative attack by HOCl...
  30. ncbi VLDL-induced triglyceride accumulation in human macrophages is mediated by modulation of LPL lipolytic activity in the absence of change in LPL mass
    Dragana Milosavljevic
    National Institute for Health and Medical Research INSERM Unite 551, Hopital de la Pitie, 83, Boulevard de l Hopital, F 75651 Paris Cedex 13, France
    Biochim Biophys Acta 1631:51-60. 2003
    ....
  31. doi Is a cardioprotective action of alcohol a myth?
    Boris Hansel
    Service d Endocrinologie Métabolisme, AP HP, France
    Curr Opin Cardiol 27:550-5. 2012
    ..The purpose of this review is to discuss the potential CV benefit of alcohol consumption with a particular focus on the findings of publications appearing within the past 2 years...
  32. pmc Unraveling the complexities of the HDL lipidome
    Anatol Kontush
    Dyslipidemia, Inflammation and Atherosclerosis Research Unit UMR 939, National Institute for Health and Medical Research INSERM, Paris, France Université Pierre et Marie Curie 6, Paris, France Groupe Hospitalier Pitié Salpêtrière, AP HP, Paris, France Institute of Cardiometabolism and Nutrition ICAN, Paris, France
    J Lipid Res 54:2950-63. 2013
    ..With all technical questions resolved, quantitative analysis of the molecular components of the HDL lipidome will contribute to expand our knowledge of cardiovascular and metabolic diseases. ..
  33. ncbi Vitamin E is not deficient in human atherosclerotic plaques
    Anatol Kontush
    Arterioscler Thromb Vasc Biol 24:e139-40; author reply e141-2. 2004
  34. ncbi Lipid peroxidation in neurodegeneration: new insights into Alzheimer's disease
    Sönke Arlt
    Department of Molecular Cell Biology, Institute for Medical Biochemistry and Molecular Biology, University Hospital Hamburg Eppendorf, Germany
    Curr Opin Lipidol 13:289-94. 2002
    ....
  35. ncbi Plasma and CSF markers of oxidative stress are increased in Parkinson's disease and influenced by antiparkinsonian medication
    Carsten Buhmann
    Neurological Department, University Clinic Hamburg Eppendorf, D 20246 Hamburg, Germany
    Neurobiol Dis 15:160-70. 2004
    ..These data support the concept of oxidative stress as a factor in the pathogenesis of PD and might be an indicator of a potential prooxidative role of LD and a possible antioxidative effect of DA in PD treatment...
  36. ncbi Amyloid-beta: phylogenesis of a chameleon
    Anatol Kontush
    Brain Res Brain Res Rev 46:118-20. 2004
  37. ncbi Comparison of the effects of alpha-tocopherol, ubiquinone-10 and probucol at therapeutic doses on atherosclerosis in WHHL rabbits
    Jan Hinrich Bräsen
    HELIOS Klinikum Berlin, Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, Medical Faculty of the Charite, Humboldt University, Wiltbergstr 50, 13125 Berlin, Germany
    Atherosclerosis 163:249-59. 2002
    ....
  38. ncbi Increased lipid peroxidation in cerebrospinal fluid and plasma from patients with Creutzfeldt-Jakob disease
    Sönke Arlt
    Institute for Medical Biochemistry and Molecular Biology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Neurobiol Dis 10:150-6. 2002
    ..These results support the hypothesis that oxidative mechanisms are involved in the pathogenesis of CJD and provide a rationale for the use of antioxidants in the therapy of this disease...
  39. ncbi Decreased plasma and cerebrospinal fluid ascorbate levels in patients with septic encephalopathy
    Kay Voigt
    Neurological Clinic, University Hospital Hamburg Eppendorf, Hamburg, Germany Medical Clinic, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Free Radic Res 36:735-9. 2002
    ..Our findings suggest that the short-term oxidative stress may be an important factor in the development of septic encephalopathy, possibly through dysregulation of the blood-brain barrier...
  40. ncbi Neonatal blood plasma is less susceptible to oxidation than adult plasma owing to its higher content of bilirubin and lower content of oxidizable Fatty acids
    Marcel Wiedemann
    Klinik fur Kinder und Jugendmedizin, Universitatskrankenhaus Eppendorf, Martinistrabetae 52, 20246 Hamburg, Germany
    Pediatr Res 53:843-9. 2003
    ..These data indicate that plasma is better protected against oxidative stress in newborns than in adults, owing to its higher content of antioxidants like bilirubin and its lower content of oxidizable lipids...
  41. ncbi Adverse effects of nitroglycerin treatment on endothelial function, vascular nitrotyrosine levels and cGMP-dependent protein kinase activity in hyperlipidemic Watanabe rabbits
    Ascan Warnholtz
    Division of Cardiology, University Hospital Eppendorf, Hamburg, Germany
    J Am Coll Cardiol 40:1356-63. 2002
    ..With the present studies we sought to determine how treatment with nitroglycerin (NTG) affects endothelial function, oxidative stress and nitric oxide (NO)-downstream signaling in Watanabe heritable hyperlipidemic rabbits (WHHL)...
  42. ncbi HDL: close to our memories?
    Anatol Kontush
    Arterioscler Thromb Vasc Biol 28:1418-20. 2008