Brigitte L Kieffer

Summary

Country: France

Publications

  1. ncbi request reprint Exploring the opioid system by gene knockout
    Brigitte L Kieffer
    IGBMC UMR 7104, Parc d innovation 1, rue Laurent Fries, B P 163, 67404 Illkirch Cedex, France
    Prog Neurobiol 66:285-306. 2002
  2. ncbi request reprint Big dynorphin as a putative endogenous ligand for the kappa-opioid receptor
    Florence Merg
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, France
    J Neurochem 97:292-301. 2006
  3. ncbi request reprint Mu-opioid receptors are involved in the tolerance to nicotine antinociception
    Lola Galeote
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    J Neurochem 97:416-23. 2006
  4. pmc In vivo delta opioid receptor internalization controls behavioral effects of agonists
    Amynah A A Pradhan
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, France
    PLoS ONE 4:e5425. 2009
  5. pmc Enhanced spontaneous activity of the mu opioid receptor by cysteine mutations: characterization of a tool for inverse agonist screening
    Karl Brillet
    Département des Récepteurs et Protéines Membranaires, UPR 9050, Ecole Superieure de Biotechnologie de Strasbourg, F 67400 Illkirch Graffenstaden, France
    BMC Pharmacol 3:14. 2003
  6. ncbi request reprint Opioid tolerance-in search of the holy grail
    Brigitte L Kieffer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, 67400 Illkirch, France
    Cell 108:587-90. 2002
  7. pmc Opioid receptors: from binding sites to visible molecules in vivo
    Brigitte L Kieffer
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, Département Neurobiologie et Génétique, Illkirch, F 67400 France INSERM, U596, Illkirch F 67400, France CNRS, UMR7104, Illkirch F 67400, France
    Neuropharmacology 56:205-12. 2009
  8. pmc Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance
    Amynah A A Pradhan
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université de Strasbourg, 67404 Illkirch, France
    J Neurosci 30:16459-68. 2010
  9. pmc RSK2 signaling in medial habenula contributes to acute morphine analgesia
    Emmanuel Darcq
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université de Strasbourg, Illkirch, France
    Neuropsychopharmacology 37:1288-96. 2012
  10. pmc Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice
    Raphael Weibel
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, Translational Medicine and Neurogenetic Programme, UdS Université de Strasbourg, INSERM U964, CNRS UMR7104, Illkirch, France
    PLoS ONE 8:e74706. 2013

Collaborators

Detail Information

Publications86

  1. ncbi request reprint Exploring the opioid system by gene knockout
    Brigitte L Kieffer
    IGBMC UMR 7104, Parc d innovation 1, rue Laurent Fries, B P 163, 67404 Illkirch Cedex, France
    Prog Neurobiol 66:285-306. 2002
    ..Future studies should involve parallel behavioral analysis of mice lacking receptors and peptides and will benefit from more sophisticated gene targeting approaches, including site-directed and anatomically-restricted mutations...
  2. ncbi request reprint Big dynorphin as a putative endogenous ligand for the kappa-opioid receptor
    Florence Merg
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, France
    J Neurochem 97:292-301. 2006
    ..Collectively, the high potency and efficacy and the relative abundance suggest that Big Dyn may play a role in the KOR-mediated activation of G proteins...
  3. ncbi request reprint Mu-opioid receptors are involved in the tolerance to nicotine antinociception
    Lola Galeote
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    J Neurochem 97:416-23. 2006
    ..These results indicate that mu-opioid receptors play an important role in the development of tolerance to nicotine antinociceptive effects...
  4. pmc In vivo delta opioid receptor internalization controls behavioral effects of agonists
    Amynah A A Pradhan
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, France
    PLoS ONE 4:e5425. 2009
    ..In fact, the majority of studies have been performed in transfected cell systems, which do not adequately model physiological environments and the complexity of integrated responses observed in the whole animal...
  5. pmc Enhanced spontaneous activity of the mu opioid receptor by cysteine mutations: characterization of a tool for inverse agonist screening
    Karl Brillet
    Département des Récepteurs et Protéines Membranaires, UPR 9050, Ecole Superieure de Biotechnologie de Strasbourg, F 67400 Illkirch Graffenstaden, France
    BMC Pharmacol 3:14. 2003
    ....
  6. ncbi request reprint Opioid tolerance-in search of the holy grail
    Brigitte L Kieffer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, 67400 Illkirch, France
    Cell 108:587-90. 2002
    ..However, recent evidence presents an alternative hypothesis, suggesting that receptor internalization could in fact reduce tolerance in vivo...
  7. pmc Opioid receptors: from binding sites to visible molecules in vivo
    Brigitte L Kieffer
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, Département Neurobiologie et Génétique, Illkirch, F 67400 France INSERM, U596, Illkirch F 67400, France CNRS, UMR7104, Illkirch F 67400, France
    Neuropharmacology 56:205-12. 2009
    ..Importantly, we will identify a number of research directions that are likely to develop during the next decade...
  8. pmc Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance
    Amynah A A Pradhan
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université de Strasbourg, 67404 Illkirch, France
    J Neurosci 30:16459-68. 2010
    ..Hence, ligand-directed receptor trafficking of the δ-opioid receptor engages distinct adaptive responses, and this study reveals a novel aspect of biased agonism in vivo...
  9. pmc RSK2 signaling in medial habenula contributes to acute morphine analgesia
    Emmanuel Darcq
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université de Strasbourg, Illkirch, France
    Neuropsychopharmacology 37:1288-96. 2012
    ..This study opens novel perspectives for both our understanding of opioid analgesia, and the identification of signaling pathways operating in the habenular complex...
  10. pmc Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice
    Raphael Weibel
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, Translational Medicine and Neurogenetic Programme, UdS Université de Strasbourg, INSERM U964, CNRS UMR7104, Illkirch, France
    PLoS ONE 8:e74706. 2013
    ..Previous pharmacology suggests that peripheral opiates may be clinically useful, and our data further demonstrate that Nav1.8 neuron-associated mu opioid receptors are feasible targets to alleviate some forms of persistent pain. ..
  11. doi request reprint Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit
    Chihiro Nozaki
    Institut de Génétique et Biologie Moléculaire et Cellulaire, Illkirch, France
    Nat Neurosci 14:1017-22. 2011
    ..The study also potentially provides a molecular basis for the pain-relieving effects of dietary zinc supplementation...
  12. doi request reprint Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia
    Claire Gaveriaux-Ruff
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, Neurobiology and Genetic Department, Illkirch F 67400, France
    Pain 152:1238-48. 2011
    ..The conditional knockout of delta-opioid receptor in primary afferent Na(V)1.8 neurons augmented mechanical allodynia in persistent pain models and abolished delta opioid analgesia in these models...
  13. ncbi request reprint Mu-delta opioid receptor functional interaction: Insight using receptor-G protein fusions
    Laelie A Snook
    Unite Mixte de Recherche 7104, Institut de Génétique et Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, France
    J Pharmacol Exp Ther 318:683-90. 2006
    ..In addition, no binding competition was observed between delta and mu ligands. Together, the data point to mu-delta opioid receptor heterodimers formed by contact interactions between monomers that retain their structural integrity...
  14. pmc δ-Opioid mechanisms for ADL5747 and ADL5859 effects in mice: analgesia, locomotion, and receptor internalization
    Chihiro Nozaki
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    J Pharmacol Exp Ther 342:799-807. 2012
    ..8-positive neurons. The lack of in vivo receptor internalization and locomotor activation, typically induced by SNC80, suggests agonist-biased activity at the receptor for the two drugs...
  15. ncbi request reprint Inflammatory pain is enhanced in delta opioid receptor-knockout mice
    Claire Gaveriaux-Ruff
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, Département Neurobiologie et Génétique, Illkirch F 67400, France
    Eur J Neurosci 27:2558-67. 2008
    ..We have previously shown enhanced neuropathic pain in delta-receptor knockout mice. The delta receptor definitely represents a promising target for treating chronic pain conditions...
  16. pmc Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo
    Gregory Scherrer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM, Universite Louis Pasteur, 1 rue Laurent Fries, 67404 Illkirch, France
    Proc Natl Acad Sci U S A 103:9691-6. 2006
    ..Direct receptor visualization in mice is a unique approach to receptor biology and drug design...
  17. ncbi request reprint Morphine-induced analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, cdk5 and adenylate cyclase activity
    Candice Contet
    département de neurobiologie, IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM U596, CNRS UMR7104, Universite Louis Pasteur, 1 rue Laurent Fries, F 67400 Illkirch, France
    Neuropharmacology 54:475-86. 2008
    ....
  18. pmc Impaired hippocampus-dependent and facilitated striatum-dependent behaviors in mice lacking the δ opioid receptor
    Julie Le Merrer
    Département de Médecine Translationnelle et Neurogénétique, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Neuropsychopharmacology 38:1050-9. 2013
    ..These data suggest, for the first time, that delta receptor activity tonically inhibits striatal function, and demonstrate that delta opioid receptors modulate learning and memory performance by regulating the HPC/striatum balance...
  19. pmc Evaluation of cre recombinase delivery in mammalian cells using baculovirus infection
    Eric Erbs
    Department of Neurobiology and Translational Medicine, IGBMC, Illkirch, France
    J Biotechnol 166:182-6. 2013
    ..Our results indicate that baculovirus infection leads to functional cre-recombinase expression in non-neuronal and neuroblastoma cell lines but not in mouse primary neuronal cultures or brain. ..
  20. pmc Sequential and opposing alterations of 5-HT(1A) receptor function during withdrawal from chronic morphine
    Pierre Eric Lutz
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France
    Eur Neuropsychopharmacol 21:835-40. 2011
    ..These molecular adaptations could contribute to the development of emotional disorders experienced by former opiate addicts...
  21. doi request reprint Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network
    Julie Le Merrer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM and CNRS, Illkirch Graffenstaden, France
    Addict Biol 17:1-12. 2012
    ..This transcriptional signature may represent a hallmark of drug abstinence and a unitary adaptive molecular mechanism in substance abuse disorders...
  22. ncbi request reprint Dissociation of analgesic and hormonal responses to forced swim stress using opioid receptor knockout mice
    Candice Contet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, France
    Neuropsychopharmacology 31:1733-44. 2006
    ..This implies that brain circuits mediating analgesic and hormonal responses to stress can be dissociated...
  23. ncbi request reprint The delta agonists DPDPE and deltorphin II recruit predominantly mu receptors to produce thermal analgesia: a parallel study of mu, delta and combinatorial opioid receptor knockout mice
    Gregory Scherrer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, UMR7104, Parc d Innovation, 1 rue Laurent Fries BP 10142, 67404 Illkirch Cedex, Strasbourg, France
    Eur J Neurosci 19:2239-48. 2004
    ....
  24. pmc Opioid receptors: distinct roles in mood disorders
    Pierre Eric Lutz
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de Recherche Scientifique CNRS, Strasbourg, France
    Trends Neurosci 36:195-206. 2013
    ....
  25. doi request reprint The nociceptin orphanin FQ peptide receptor agonist, Ro64-6198, impairs recognition memory formation through interaction with glutamatergic but not cholinergic receptor antagonists
    David Reiss
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Département de Médecine Transrationnelle et Neurogénétique, Illkirch, France
    Neurobiol Learn Mem 98:254-60. 2012
    ..1 mg/kg) or scopolamine (0.1 mg/kg) was without any effect on recognition memory. These findings suggest that NOP receptor may modulate memory formation through a functional interaction with glutamatergic but not cholinergic receptors...
  26. ncbi request reprint No evidence for G-protein-coupled epsilon receptor in the brain of triple opioid receptor knockout mouse
    Candice Contet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP Parc d innovation, 1 rue Laurent Fries BP 10142, C U de Strasbourg, 67404 Illkirch Cedex, France
    Eur J Pharmacol 492:131-6. 2004
    ..We conclude that the brain epsilon site involves mu, delta and/or kappa receptors, possibly coupled to nonclassical G proteins...
  27. ncbi request reprint Identification of a novel family of G protein-coupled receptor associated sorting proteins
    Frederic Simonin
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, C U de Strasbourg, France
    J Neurochem 89:766-75. 2004
    ..Another member of the family, GASP-2, also interacts with the carboxyl-terminal tail of several GPCRs. Therefore, GASP proteins may represent an important protein family regulating GPCR physiology...
  28. pmc Activation of nociceptin/orphanin FQ peptide receptors disrupts visual but not auditory sensorimotor gating in BALB/cByJ mice: comparison to dopamine receptor agonists
    Aurelia Ces
    Mouse Clinical Institute, Illkirch, France
    Neuropsychopharmacology 37:378-89. 2012
    ..They further suggest that dysfunction of N/OFQ transmission may be implicated in the pathogenesis of psychotic manifestations...
  29. doi request reprint Influence of endogenous opioid systems on T lymphocytes as assessed by the knockout of mu, delta and kappa opioid receptors
    Ali G Karaji
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite de Strasbourg, 1 rue Laurent Fries, BP10142, 67404 Illkirch, France
    J Neuroimmune Pharmacol 6:608-16. 2011
    ..Together, our results indicate a shift from TH1 to TH2 cytokines in triple-opioid receptor knockout animals, suggesting that global endogenous opioid tone drives T lymphocytes toward a TH1 profile under non-pathological conditions...
  30. pmc RSK2 signaling in brain habenula contributes to place aversion learning
    Emmanuel Darcq
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université de Strasbourg, 67404 Illkirch, France
    Learn Mem 18:574-8. 2011
    ..RSK2 signaling in the habenula, therefore, is essential for this task. Our study reveals a novel role for RSK2 in cognitive processes and uncovers the critical implication of an intriguing brain structure in place aversion learning...
  31. ncbi request reprint Enhanced humoral response in kappa-opioid receptor knockout mice
    Claire Gaveriaux-Ruff
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP10142, 67404 Illkirch Cedex, C U de Strasbourg, France
    J Neuroimmunol 134:72-81. 2003
    ..These results show that endogenous activation of kappa-opioid receptors may exert a tonic inhibition of antibody (Ab) response...
  32. ncbi request reprint Conditional gene targeting in the mouse nervous system: Insights into brain function and diseases
    Claire Gaveriaux-Ruff
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, UMR7104, Illkirch, France
    Pharmacol Ther 113:619-34. 2007
    ..Among the many developing functional genomic approaches, conditional gene targeting in the mouse has become an excellent tool to elucidate the function of the approximately 5000 known or unknown genes that operate in the nervous system...
  33. doi request reprint Mouse δ opioid receptors are located on presynaptic afferents to hippocampal pyramidal cells
    Xavier Rezai
    Translational Medicine and Neurogenetics, Institut de Génétique et de Biologie Moléculaire et Cellulaire IGBMC CNRS INSERM UdS, Illkirch, France
    Cell Mol Neurobiol 32:509-16. 2012
    ..In the mouse hippocampus, expression of functional delta opioid receptors is therefore mostly associated with interneurons emphasizing a presynaptic modulatory effect on the pyramidal cell firing rate...
  34. pmc Impaired emotional-like behavior and serotonergic function during protracted abstinence from chronic morphine
    Celia Goeldner
    Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université de Strasbourg, Illkirch, France
    Biol Psychiatry 69:236-44. 2011
    ..At present, their relationship remains unclear and has been little studied in animal models. Here we investigated emotional alterations during protracted abstinence, in mice with a history of chronic morphine exposure...
  35. doi request reprint Effects of delta opioid receptors activation on a response inhibition task in rats
    Katia Befort
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Département Neurobiologie et Génétique, INSERM, CNRS, Universite de Strasbourg, Illkirch, France
    Psychopharmacology (Berl) 214:967-76. 2011
    ..Recently, we identified an opioidergic contribution to response inhibition by showing that deletion of mu or delta opioid receptors in mice alters motor impulsivity...
  36. doi request reprint Reward processing by the opioid system in the brain
    Julie Le Merrer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Département Neurobiologie et Génétique, Illkirch, France
    Physiol Rev 89:1379-412. 2009
    ....
  37. pmc The delta opioid receptor: an evolving target for the treatment of brain disorders
    Amynah A Pradhan
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France
    Trends Pharmacol Sci 32:581-90. 2011
    ..Finally, the recent demonstration of biased agonism at the delta opioid receptor in vivo opens novel perspectives towards targeting specific therapeutic effects through drug design...
  38. doi request reprint Deletion of the δ opioid receptor gene impairs place conditioning but preserves morphine reinforcement
    Julie Le Merrer
    Département de Neurobiologie et Génétique, Institut de Biologie Moleculaire et Cellulaire, Illkirch, France
    Biol Psychiatry 69:700-3. 2011
    ..In the present study, we investigated the impact of δ receptor gene knockout on reinforced conditioned learning under several experimental paradigms...
  39. ncbi request reprint Mu opioid receptor: a gateway to drug addiction
    Candice Contet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, UMR7104, Parc d Innovation, 1 rue Laurent Fries BP 10142, 67404 Illkirch Cedex, Strasbourg, France
    Curr Opin Neurobiol 14:370-8. 2004
    ..The targeting of effectors or regulatory proteins, beyond the mu receptor itself, might provide valuable strategies to treat addictive disorders...
  40. pmc Delta opioid receptors regulate temporoammonic-activated feedforward inhibition to the mouse CA1 hippocampus
    Xavier Rezai
    Department of Neurogenetics and Translational Medicine, IGBMC, Illkirch, France
    PLoS ONE 8:e79081. 2013
    ....
  41. pmc Delta opioid receptors in brain function and diseases
    Paul Chu Sin Chung
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR7104 CNRS Université de Strasbourg, U964 Inserm, Illkirch, France
    Pharmacol Ther 140:112-20. 2013
    ..Neuroprotective effects of DOR activity represent a forthcoming research area. Future developments in DOR research will benefit from in-depth investigations of DOR function at cellular and circuit levels. ..
  42. pmc RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia
    Frederic Simonin
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 103:466-71. 2006
    ..Our data indicate that NPFF receptors are part of a bona fide antiopioid system and that selective antagonists of these receptors could represent useful therapeutic agents for improving the efficacy of opioids in chronic pain treatment...
  43. ncbi request reprint Knockout mouse models in pain research
    Andree Dierich
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Methods Mol Med 99:269-99. 2004
    ..We finally provide a few examples of mouse phenotyping in pain behavioral assays...
  44. doi request reprint Nociceptin receptor impairs recognition memory via interaction with NMDA receptor-dependent mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in the hippocampus
    Celia Goeldner
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, 67404 Illkirch, France
    J Neurosci 28:2190-8. 2008
    ..This modulation may in part take place by inhibiting glutamatergic function at the NMDA receptor...
  45. ncbi request reprint Zinc dynamics and action at excitatory synapses
    Angela Maria Vergnano
    Ecole Normale Superieure, Institut de Biologie de l ENS IBENS, F 75005 Paris, France INSERM, U1024, F 75005 Paris, France CNRS, UMR 8197, F 75005 Paris, France
    Neuron 82:1101-14. 2014
    ..By specifically moderating GluN2A-NMDAR signaling, zinc acts as a widespread activity-dependent regulator of neuronal circuits. ..
  46. ncbi request reprint Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation
    Fabien M Décaillot
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, 67404 Illkirch, France
    Nat Struct Biol 10:629-36. 2003
    ..N- and C-terminal determinants also influence receptor activity. Findings for this therapeutically important receptor may apply to other GPCRs that respond to diffusible ligands...
  47. pmc 15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse
    Pauline Charbogne
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104 Inserm U964, Illkirch F 67404, France CNRS, UMR7104, Illkirch F 67404, France UdS Université de Strasbourg, CNRS UMR 7104 Inserm U964, Illkirch F 67404, France Inserm U964, Illkirch F 67404, France
    Neuropharmacology 76:204-17. 2014
    ..This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  48. ncbi request reprint Brain regional Fos expression elicited by the activation of mu- but not delta-opioid receptors of the ventral tegmental area: evidence for an implication of the ventral thalamus in opiate reward
    Vincent David
    Centre de Neurosciences Intégratives et Cognitives, CNRS UMR 5228 Universités de Bordeaux 1 et 2, Talence, France
    Neuropsychopharmacology 33:1746-59. 2008
    ..We conclude that (i) VTA MORs, but not DORs, are critical for morphine reward and (ii) the role of VTA-thalamic projections in opiate reward deserves to be further explored...
  49. ncbi request reprint Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones
    Miquel Martin
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    Eur J Neurosci 17:701-8. 2003
    ..Phenotypes of mutant mice were subtle, suggesting a low endogenous opioid tone in the regulation of physiological pain...
  50. ncbi request reprint Delta-opioid receptors are critical for tricyclic antidepressant treatment of neuropathic allodynia
    Malika Benbouzid
    Institut des Neurosciences Cellulaires et Integratives, Centre National de Recherche Scientifique Université Louis Pasteur, Strasbourg, France
    Biol Psychiatry 63:633-6. 2008
    ..A large body of clinical evidence indicates that antidepressant drugs can also be highly effective against chronic neuropathic pain. However, the mechanism by which these drugs alleviate pain is still unclear...
  51. ncbi request reprint Decreased motivation to eat in mu-opioid receptor-deficient mice
    Francesco Papaleo
    Laboratoire Homéostasie Allostasie Pathologie, EA 3666, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux, France
    Eur J Neurosci 25:3398-405. 2007
    ..The present findings strongly indicate that the MOR pathway mediates the motivational properties of food intake, but it is not essential for hedonic processing of ingestive behaviour...
  52. pmc The mu opioid receptor is involved in buprenorphine-induced locomotor stimulation and conditioned place preference
    Paul Marquez
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA
    Neuropharmacology 52:1336-41. 2007
    ..Together, the present results suggest that the ability of buprenorphine to increase motor activity and induce locomotor sensitization and CPP is mediated via the MOP...
  53. pmc Generation and characterization of Rgs4 mutant mice
    Nicolas Grillet
    CNRS UMR 8542, Department of Biology, Ecole Normale Superieure, 46 rue d Ulm, 75005, Paris, France
    Mol Cell Biol 25:4221-8. 2005
    ....
  54. ncbi request reprint The rewarding properties of MDMA are preserved in mice lacking mu-opioid receptors
    Patricia Robledo
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    Eur J Neurosci 20:853-8. 2004
    ..These differences could be due to distinct mechanisms controlling dopamine release in the nucleus accumbens and suggest that the effects of MDMA on dopaminergic neurons are independent of micro -opioid receptors...
  55. ncbi request reprint Deficit in attachment behavior in mice lacking the mu-opioid receptor gene
    Anna Moles
    Consiglio Nazionale delle Ricerche Institute of Neuroscience, Psychobiology and Psychopharmacology, Viale Marx 43, 00137 Roma, Italy
    Science 304:1983-6. 2004
    ..Results from this study may indicate a molecular mechanism for diseases characterized by deficits in attachment behavior, such as autism or reactive attachment disorder...
  56. ncbi request reprint Opposite alterations of NPFF1 and NPFF2 neuropeptide FF receptor density in the triple MOR/DOR/KOR-opioid receptor knockout mouse brains
    Christine Gouardères
    Institut de Pharmacologie et de Biologie Structurale, C N R S UMR 5089, 205 route de Narbonne, 31077 Toulouse Cedex, France
    J Chem Neuroanat 27:119-28. 2004
    ....
  57. ncbi request reprint Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors
    Sandy Ghozland
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    J Neurosci 22:1146-54. 2002
    ..Thus, an opposing activity of mu- and kappa-opioid receptors in modulating reward pathways forms the basis for the dual euphoric-dysphoric activity of THC...
  58. ncbi request reprint Basal and morphine-evoked dopaminergic neurotransmission in the nucleus accumbens of MOR- and DOR-knockout mice
    Vladimir I Chefer
    Integrative Neuroscience Section, DHHS NIH NIDA IRP BNRB INS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 18:1915-22. 2003
    ..Furthermore, they demonstrate that in contrast to the locomotor-activating effects of morphine, a small component of morphine-evoked DA release occurs independently of MOR activation...
  59. ncbi request reprint Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors
    Kabirullah Lutfy
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Neuropsychiatric Institute, Los Angeles, California 90024, USA
    J Neurosci 23:10331-7. 2003
    ..Our results indicate that the antinociceptive effect of buprenorphine in mice is micro-opioid receptor-mediated yet severely compromised by concomitant activation of ORL-1 receptors...
  60. ncbi request reprint Basal signaling activity of mu opioid receptor in mouse brain: role in narcotic dependence
    Danxin Wang
    Department of Biopharmaceutical Sciences and Pharmaceutical Chemistry, Wheeler Center for Neurobiology of Addiction, University of California San Francisco
    J Pharmacol Exp Ther 308:512-20. 2004
    ..These results demonstrate long-lasting regulation of basal MOR signaling as a potential factor in narcotic dependence...
  61. ncbi request reprint Regulation of delta-opioid receptor trafficking via mu-opioid receptor stimulation: evidence from mu-opioid receptor knock-out mice
    Anne Morinville
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada H3G 1Y6
    J Neurosci 23:4888-98. 2003
    ..These results demonstrate that selective activation of muOR is critical for morphine-induced targeting of deltaOR to neuronal membranes, but not for basal targeting of this receptor to the cell surface...
  62. pmc Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation
    David Philippe
    Equipe Mixte INSERM 0114 sur la Physiopathologie des Maladies Inflammatoires Intestinales, Centre Hospitalier Universitaire, Lille, France
    J Clin Invest 111:1329-38. 2003
    ..These data provide evidence that MOR plays a role in the control of gut inflammation and suggest that MOR agonists might be new therapeutic molecules in IBD...
  63. ncbi request reprint Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology
    George F Koob
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Recent Dev Alcohol 16:263-81. 2003
    ....
  64. ncbi request reprint Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in mu-opioid receptor knock-out mice
    Fernando Berrendero
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    J Neurosci 22:10935-40. 2002
    ..In summary, the present results show that mu-opioid receptors are involved in the rewarding responses induced by nicotine and participate in its antinociceptive responses and the expression of nicotine physical dependence...
  65. ncbi request reprint Probing opioid receptor interactions with azacycloalkane amino acids. Synthesis of a potent and selective ORL1 antagonist
    Liliane Halab
    Departement de Chimie, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    J Med Chem 45:5353-7. 2002
    ..Biological examination of peptides 10-13 showed two new antagonists (10 and 12) exhibiting increased selectivity for the ORL1 receptor...
  66. ncbi request reprint Deletion of the mu opioid receptor results in impaired acquisition of Pavlovian context fear
    Matthew J Sanders
    UCLA Psychology Department, Los Angeles, CA, USA
    Neurobiol Learn Mem 84:33-41. 2005
    ..The conditioning deficit seen in this line of mice may be related to impairment in hippocampus function...
  67. ncbi request reprint Lack of stimulant and anxiolytic-like effects of ethanol and accelerated development of ethanol dependence in mu-opioid receptor knockout mice
    Sandy Ghozland
    Department of Neuropharmacology SP 315, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropharmacology 49:493-501. 2005
    ....
  68. ncbi request reprint Circadian-dependent learning and memory enhancement in nociceptin receptor-deficient mice with a novel KUROBOX apparatus using stress-free positive cue task
    Jun Nagai
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Pharmacol Exp Ther 321:195-201. 2007
    ..In addition, this apparatus has an advantage that various physical and psychological parameters of movement activity affecting learning and memory behavior are also evaluated at the same time...
  69. ncbi request reprint Deletion of mu- and kappa-opioid receptors in mice changes epidermal hypertrophy, density of peripheral nerve endings, and itch behavior
    Mei Bigliardi-Qi
    Department of Dermatology, CHUV Hôpital Beaumont, Lausanne, Switzerland
    J Invest Dermatol 127:1479-88. 2007
    ..These results indicate that MOR and KOR are important in skin homeostasis, epidermal nerve fiber regulation, and pathophysiology of itching...
  70. ncbi request reprint Effects of nociceptin/orphanin FQ receptor (NOP) agonist, Ro64-6198, on reactivity to acute pain in mice: comparison to morphine
    David Reiss
    ICS, 1 rue Laurent Fries, BP 10142, 67404 Illkirch, France
    Eur J Pharmacol 579:141-8. 2008
    ..They also suggest that central NOP and mu receptors may inhibit reactivity to acute noxious stimuli via independent neural mechanisms...
  71. ncbi request reprint Effects of constitutive deletion of opioid receptors on the basal densities of Fas and Fas-associated protein with death domain (FADD) in the mouse brain: a delta-opioid tone inhibits FADD
    M Julia Garcia-Fuster
    Laboratori de Neurofarmacologia, Institut Universitari d Investigacio en Ciencies de la Salut IUNICS, Universitat de les Illes Balears, E 07122 Palma de Mallorca, Spain
    Eur Neuropsychopharmacol 17:366-74. 2007
    ..These data are in line with the acute opposite modulation of Fas and FADD induced by mu- and delta-opiate agonists, and strongly support the notion of an anti-apoptotic delta-opioid tone that restrains Fas signaling...
  72. ncbi request reprint Neuropathic pain is enhanced in delta-opioid receptor knockout mice
    Xavier Nadal
    Laboratori de Neurofarmacologia Facultat de Ciencies de la Salut i de la Vida Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    Eur J Neurosci 23:830-4. 2006
    ..These results reveal the involvement of DOR in the control of neuropathic pain and suggest a new potential therapeutic use of DOR agonists...
  73. ncbi request reprint Two faces for an opioid peptide--and more receptors for pain research
    Frederic Simonin
    Nat Neurosci 5:185-6. 2002
  74. ncbi request reprint Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons
    Wendy Walwyn
    Department of Psychiatry and Biobehavioral Sciences, Center for Health Sciences, University of California, Los Angeles, USA
    Mol Pharmacol 68:1688-98. 2005
    ..However, up-regulation of cell-surface delta receptors induces their coupling to Ca2+ channels. Pharmacological approaches that increase functional delta receptor expression may reveal a novel target for analgesic therapy...
  75. doi request reprint Molecular and biophysical mechanisms of arousal, alertness, and attention. Preface
    Donald W Pfaff
    The Rockefeller University, New York, NY, USA
    Ann N Y Acad Sci 1129:xi. 2008
  76. ncbi request reprint Lack of reward and locomotor stimulation induced by heroin in mu-opioid receptor-deficient mice
    Angelo Contarino
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Eur J Pharmacol 446:103-9. 2002
    ..These results support an essential role for the micro-opioid receptor in the rewarding and locomotor activating effects of heroin...
  77. ncbi request reprint Quantitative autoradiographic mapping of opioid receptors in the brain of delta-opioid receptor gene knockout mice
    Robin J Goody
    Pharmacology Group, School of Biomedical and Life Sciences, University of Surrey, Guilford, Surrey GU2 7XH, UK
    Brain Res 945:9-19. 2002
    ..The differences in [(3)H]CI-977 and [(3)H]bremazocine binding indicate these ligands show differential recognition of the kappa-receptor...
  78. pmc micro-Opioid receptor activation prevents acute hepatic inflammation and cell death
    Dania Chakass
    Institut National de la Santé et de la Recherche Médicale INSERM U795, University of Lille 2, Digestive Tract Diseases and Nutrition Department, 59037, Lille Cedex, France
    Gut 56:974-81. 2007
    ....
  79. ncbi request reprint Knock-in mice reveal nonsense-mediated mRNA decay in the brain
    Candice Contet
    Genesis 45:38-43. 2007
    ..These knock-in mouse lines will be valuable models to better understand and manipulate NMD in vivo...
  80. ncbi request reprint Cannabinoid withdrawal syndrome is reduced in double mu and delta opioid receptor knockout mice
    Anna Castañé
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Spain
    Eur J Neurosci 17:155-9. 2003
    ..Interestingly, the somatic manifestations of THC withdrawal were also significantly attenuated in mutant mice, suggesting that a cooperative action of MOR and DOR is required for the entire expression of THC dependence...
  81. ncbi request reprint Presynaptic delta opioid receptors regulate ethanol actions in central amygdala
    Maeng hee Kang-Park
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    J Pharmacol Exp Ther 320:917-25. 2007
    ..This result supports the hypothesis that endogenous opioid peptides modulate the ethanol-induced augmentation of GABA(A) receptor-dependent circuitry in CeA (Roberto et al., 2003)...
  82. doi request reprint Mechanisms for the regulation of state changes in the central nervous system: an introduction
    Donald W Pfaff
    Laboratory of Neurobiology and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Ann N Y Acad Sci 1129:1-7. 2008
    ..Here, we emphasize some of the central roles for opioid peptides. We also mention a few outstanding unanswered questions related to this area of neuroscience...
  83. ncbi request reprint Decreased oral self-administration of alcohol in kappa-opioid receptor knock-out mice
    Krisztina M Kovacs
    Laboratory of Neurobehavioral GeneticsNathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Alcohol Clin Exp Res 29:730-8. 2005
    ..Here we examined the effects of targeted disruption of kappa-opioid receptor (KOR) on oral alcohol self-administration and other behaviors...
  84. ncbi request reprint Cannabinoid receptor and WIN 55 212-2-stimulated [35S]-GTPgammaS binding in the brain of mu-, delta- and kappa-opioid receptor knockout mice
    Fernando Berrendero
    Laboratori de Neurofarmacologia, Facultat de Ciències de la Saluti i de la Vida, Univeristat Pompeu Fabra, c Doctor Aiguader 80, 08003 Barcelona, Spain
    Eur J Neurosci 18:2197-202. 2003
    ....
  85. ncbi request reprint Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene"
    Antoine Tabarin
    Laboratoire Homéostasie Allostasie Pathologie, EA 3666, University of Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux, France
    Diabetes 54:3510-6. 2005
    ....
  86. ncbi request reprint G-protein coupling of delta-opioid receptors in brains of mu-opioid receptor knockout mice
    Sarah M Oakley
    Pharmacology Group, School of Biomedical and Life Sciences, University of Surrey, Surrey GU2 7XH, Guildford, UK
    Eur J Pharmacol 466:91-8. 2003
    ..These findings suggest that in the majority of brain regions, G-protein coupling is unaltered in mu-opioid receptor knockout mice...

Research Grants4

  1. Opioid system /EtOH abuse: molecular genetic manipulat.
    Brigitte Kieffer; Fiscal Year: 2004
    ..abstract_text> ..
  2. Inactivation of mu opioid and CRF1 receptor genes in the extended amygdala
    Brigitte Kieffer; Fiscal Year: 2007
    ..Importantly, the WFS1-Cre transgenic mice generated in Specific Aim 1 will represent a unique tool for the conditional deletion of any other gene of interest in the extended amygdala, and will be generally useful in addiction research. ..