Roustem Khazipov

Summary

Country: France

Publications

  1. ncbi request reprint Early development of neuronal activity in the primate hippocampus in utero
    R Khazipov
    Institut de Neurobiologie de la Méditerranée Institut National de la Santé et de la Recherche Médicale INSERM U29, Luminy, 13273 Marseille, France
    J Neurosci 21:9770-81. 2001
  2. ncbi request reprint Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus
    Roustem Khazipov
    Section of Neurology, Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, New Hampshire, 03756, USA
    Eur J Neurosci 19:590-600. 2004
  3. ncbi request reprint Early patterns of electrical activity in the developing cerebral cortex of humans and rodents
    Rustem Khazipov
    INMED, INSERM U29, 163 Route de Luminy, 13273 Marseille, France
    Trends Neurosci 29:414-8. 2006
  4. ncbi request reprint Synchronization of kainate-induced epileptic activity via GABAergic inhibition in the superfused rat hippocampus in vivo
    Roustem Khazipov
    Section of Neurology, Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Neurosci 23:5337-41. 2003
  5. ncbi request reprint Network mechanisms of spindle-burst oscillations in the neonatal rat barrel cortex in vivo
    Marat Minlebaev
    The Mediterranean Institute of Neurobiology INSERM U29, 163 Avenue de Luminy, B P 13, 13273 Marseille, France
    J Neurophysiol 97:692-700. 2007
  6. ncbi request reprint Shunting and hyperpolarizing GABAergic inhibition in the high-potassium model of ictogenesis in the developing rat hippocampus
    Dmytro Isaev
    Section of Neurology, Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Hippocampus 17:210-9. 2007
  7. ncbi request reprint Correlated bursts of activity in the neonatal hippocampus in vivo
    Xavier Leinekugel
    INMED, Institut National de la Santé et de la Recherche Médicale INSERM U29, Avenue de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France
    Science 296:2049-52. 2002
  8. pmc Long-term suppression of GABAergic activity by neonatal seizures in rat somatosensory cortex
    Elena Isaeva
    Department of Neurology, Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, NH, USA
    Epilepsy Res 87:286-9. 2009
  9. ncbi request reprint Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery
    Roman Tyzio
    Institut de Neurobiologie de la Mediterranee, INSERM U29, Universite de la Mediterranee, Campus Scientifique de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France
    Science 314:1788-92. 2006
  10. ncbi request reprint Retinal waves trigger spindle bursts in the neonatal rat visual cortex
    Ileana L Hanganu
    Institut de Neurobiologie de la Méditeranée, Université de la Méditeranée, Institut National de la Santé et de la Recherche Médicale U29, 13273 Marseille, France
    J Neurosci 26:6728-36. 2006

Detail Information

Publications25

  1. ncbi request reprint Early development of neuronal activity in the primate hippocampus in utero
    R Khazipov
    Institut de Neurobiologie de la Méditerranée Institut National de la Santé et de la Recherche Médicale INSERM U29, Luminy, 13273 Marseille, France
    J Neurosci 21:9770-81. 2001
    ..Comparing the results obtained in primates and rodents, we conclude that the template of early hippocampal network development is conserved across the mammalian evolution but that it is shifted toward fetal life in primate...
  2. ncbi request reprint Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus
    Roustem Khazipov
    Section of Neurology, Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, New Hampshire, 03756, USA
    Eur J Neurosci 19:590-600. 2004
    ..These results suggest that, in the immature hippocampus, GABA exerts dual (both excitatory and inhibitory) actions and that the excitatory component in the action of GABA may contribute to increased excitability during early development...
  3. ncbi request reprint Early patterns of electrical activity in the developing cerebral cortex of humans and rodents
    Rustem Khazipov
    INMED, INSERM U29, 163 Route de Luminy, 13273 Marseille, France
    Trends Neurosci 29:414-8. 2006
    ..This review is part of the INMED/TINS special issue "Nature and nurture in brain development and neurological disorders", based on presentations at the annual INMED/TINS symposium (http://inmednet.com/)...
  4. ncbi request reprint Synchronization of kainate-induced epileptic activity via GABAergic inhibition in the superfused rat hippocampus in vivo
    Roustem Khazipov
    Section of Neurology, Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Neurosci 23:5337-41. 2003
    ..Thus, GABAergic inhibition is instrumental in synchronizing kainate-induced epileptiform rhythmic activity in the gamma frequency band in the intact hippocampus in vivo...
  5. ncbi request reprint Network mechanisms of spindle-burst oscillations in the neonatal rat barrel cortex in vivo
    Marat Minlebaev
    The Mediterranean Institute of Neurobiology INSERM U29, 163 Avenue de Luminy, B P 13, 13273 Marseille, France
    J Neurophysiol 97:692-700. 2007
    ..We propose that local spindle-burst oscillations, driven by glutamatergic synapses and spatially confined by GABAergic synapses, contribute to the development of barrel cortex during the critical period of developmental plasticity...
  6. ncbi request reprint Shunting and hyperpolarizing GABAergic inhibition in the high-potassium model of ictogenesis in the developing rat hippocampus
    Dmytro Isaev
    Section of Neurology, Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Hippocampus 17:210-9. 2007
    ..Although shunting GABA is already efficient in the young age group, a developmental increase in the hyperpolarizing GABA(A) driving force likely contributes to the increase in the GABAergic control of seizures upon maturation...
  7. ncbi request reprint Correlated bursts of activity in the neonatal hippocampus in vivo
    Xavier Leinekugel
    INMED, Institut National de la Santé et de la Recherche Médicale INSERM U29, Avenue de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France
    Science 296:2049-52. 2002
    ..This earliest pattern, which diversifies during the second postnatal week, could provide correlated activity for immature neurons and may underlie activity-dependent maturation of the hippocampal network...
  8. pmc Long-term suppression of GABAergic activity by neonatal seizures in rat somatosensory cortex
    Elena Isaeva
    Department of Neurology, Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, NH, USA
    Epilepsy Res 87:286-9. 2009
    ..These results indicate that decreasing the inhibitory synaptic strength following neonatal seizures in neocortical neurons is not due to a postsynaptic mechanism...
  9. ncbi request reprint Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery
    Roman Tyzio
    Institut de Neurobiologie de la Mediterranee, INSERM U29, Universite de la Mediterranee, Campus Scientifique de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France
    Science 314:1788-92. 2006
    ..Thus, maternal oxytocin inhibits fetal neurons and increases their resistance to insults during delivery...
  10. ncbi request reprint Retinal waves trigger spindle bursts in the neonatal rat visual cortex
    Ileana L Hanganu
    Institut de Neurobiologie de la Méditeranée, Université de la Méditeranée, Institut National de la Santé et de la Recherche Médicale U29, 13273 Marseille, France
    J Neurosci 26:6728-36. 2006
    ..We propose that the interaction between retinal waves and spindle bursts contributes to the development of visual pathways to the cortex...
  11. ncbi request reprint Selective impairment of GABAergic synaptic transmission in the flurothyl model of neonatal seizures
    Elena Isaeva
    Section of Neurology, Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, NH 03756, USA
    Eur J Neurosci 23:1559-66. 2006
    ..We suggest that the selective depression of the amplitude of GABAergic synaptic responses may contribute to the adverse neurological and behavioral consequences that occur following neonatal seizures...
  12. pmc "Slow activity transients" in infant rat visual cortex: a spreading synchronous oscillation patterned by retinal waves
    Matthew T Colonnese
    Institut de Neurobiology de la Méditérannée, INSERM, Unité 901, 13273 Marseille Cedex 09, France
    J Neurosci 30:4325-37. 2010
    ..We propose that the synchronous oscillations of SATs participate in the formation of visual circuitry...
  13. doi request reprint Postnatal changes in somatic gamma-aminobutyric acid signalling in the rat hippocampus
    Roman Tyzio
    INMED INSERM U901, Universite de la Mediterranee, 163, Avenue de Luminy, 13273 Marseille, France
    Eur J Neurosci 27:2515-28. 2008
    ..Apparent hyperpolarizing GABA responses previously reported in the soma of CA3 pyramidal cells are probably due to cell depolarization during intracellular or whole-cell recordings...
  14. ncbi request reprint GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations
    Yehezkel Ben-Ari
    Insititut de Neurobiologie de la Méditerranée, Institut National de la Santé et de la Recherche Médicale U 29, Marseille, France
    Physiol Rev 87:1215-84. 2007
    ..In conclusion, it is suggested that an evolutionary preserved role for excitatory GABA in immature cells provides an important mechanism in the formation of synapses and activity in neuronal networks...
  15. pmc A conserved switch in sensory processing prepares developing neocortex for vision
    Matthew T Colonnese
    INSERM, U901, INMED, Aix Marseille Universite, Faculte des Sciences, 13273 Marseille, France
    Neuron 67:480-98. 2010
    ..Thus, the early development of visual processing is governed by a conserved, intrinsic program that switches thalamocortical response properties in anticipation of patterned vision...
  16. ncbi request reprint Anticonvulsant action of GABA in the high potassium-low magnesium model of ictogenesis in the neonatal rat hippocampus in vivo and in vitro
    Dmytro Isaev
    Section of Neurology, Dartmouth Medical School, Dartmouth Hitchcock Medical School, Lebanon, NH 03756, USA
    J Neurophysiol 94:2987-92. 2005
    ..Thus in the model of high-K(+)/low Mg(2+)-induced seizures both in in vivo and in vitro conditions, GABA, acting via GABA(A) receptors, has an anticonvulsant effect during the critical developmental period of enhanced excitability...
  17. ncbi request reprint Cholinergic modulation of spindle bursts in the neonatal rat visual cortex in vivo
    Ileana L Hanganu
    Institut de Neurobiologie de la Mediterranee, Institut National de la Santé et de la Recherche Médicale U29, 13273 Marseille, France
    J Neurosci 27:5694-705. 2007
    ..Thus, the cholinergic input facilitates the neonatal V1 spindle bursts and may prime the developing cortex to operate specifically on relevant early (retinal waves) and later (visual input) stimuli...
  18. ncbi request reprint Early motor activity drives spindle bursts in the developing somatosensory cortex
    Rustem Khazipov
    INMED, INSERM U29, Avenue de Luminy, B P 13, 13273 Marseille, France
    Nature 432:758-61. 2004
    ..We suggest that the interaction between movement-triggered sensory feedback signals and self-organized spindle oscillations shapes the formation of cortical connections required for sensorimotor coordination...
  19. pmc Recurrent neonatal seizures result in long-term increases in neuronal network excitability in the rat neocortex
    Elena Isaeva
    Department of Neurology, Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, NH 03756, USA
    Eur J Neurosci 31:1446-55. 2010
    ..Taken together, our results suggest that recurrent seizures in infancy result in a persistent enhancement of neocortical excitability...
  20. ncbi request reprint Role of extracellular sialic acid in regulation of neuronal and network excitability in the rat hippocampus
    Dmytro Isaev
    Neuroscience Center at Dartmouth, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Neurosci 27:11587-94. 2007
    ..We propose that decreasing the amount of extracellular sialic acid residues can be a useful approach to reduce neuronal excitability and serve as a novel therapeutic approach in the treatment of seizures...
  21. ncbi request reprint New concepts in neonatal seizures
    Gregory L Holmes
    Department of Neurology, Harvard Medical School, Center for Research in Pediatric Epilepsy, Children s Hospital, Boston, MA 02115, USA
    Neuroreport 13:A3-8. 2002
    ..These results argue that neonatal seizures should no longer be considered as benign events...
  22. ncbi request reprint In vivo blockade of neural activity alters dendritic development of neonatal CA1 pyramidal cells
    Laurent Groc
    Institute of Physiology and Pharmacology, Department of Physiology, Goteborg University, Goteborg, Sweden
    Eur J Neurosci 16:1931-8. 2002
    ..The apical dendrite, the axons, or the soma grew normally during activity deprivation. Thus, the in vivo neural activity in the neonate hippocampus seems to promote neuronal growth by initiating novel branches...
  23. ncbi request reprint Compensatory dendritic growth of CA1 pyramidal cells following growth impairment in the neonatal period
    Laurent Groc
    Institute of Physiology and Pharmacology, Department of Physiology, Goteborg University, Goteborg, Sweden
    Eur J Neurosci 18:1332-6. 2003
    ..These results suggest that the early hippocampal activity controls the growth rate but is not necessary for the generation of an adult normal basal dendritic tree...
  24. ncbi request reprint Membrane potential of CA3 hippocampal pyramidal cells during postnatal development
    Roman Tyzio
    Institut de la Neurobiologie de la Méditterranée Institute National de la Santé et de la Recherche Médicale U29, Marseille, France
    J Neurophysiol 90:2964-72. 2003
    ..Thus the membrane potential of CA3 pyramidal cells appears to be strongly negative at birth and does not change during postnatal development...
  25. ncbi request reprint Timing of the developmental switch in GABA(A) mediated signaling from excitation to inhibition in CA3 rat hippocampus using gramicidin perforated patch and extracellular recordings
    Roman Tyzio
    INMED INSERM U29, 163, Marseille, France
    Epilepsia 48:96-105. 2007
    ..We propose that excitatory GABA contributes to enhanced excitability and ictogenesis in the neonatal rat hippocampus...