L Kessler

Summary

Country: France

Publications

  1. ncbi request reprint Macrophage activation in type 1 diabetic patients with catheter obstruction during peritoneal insulin delivery with an implantable pump
    L Kessler
    Department of Endocrinology Diabetology, University Hospital, Strasbourg, France
    Diabetes Care 24:302-7. 2001
  2. ncbi request reprint Comparison of microbiological results of needle puncture vs. superficial swab in infected diabetic foot ulcer with osteomyelitis
    L Kessler
    Department of Endocrinology and Diabetology, University Hospital, Strasbourg, France
    Diabet Med 23:99-102. 2006
  3. ncbi request reprint Influence of islet transportation on pancreatic islet allotransplantation in type 1 diabetic patients within the Swiss-French GRAGIL network
    Laurence Kessler
    Department of Endocrinology, University Hospital, Strasbourg, France
    Transplantation 77:1301-4. 2004
  4. doi request reprint Evidence for humoral rejection of a pancreatic islet graft and rescue with rituximab and IV immunoglobulin therapy
    L Kessler
    Department of Endocrinology, University Hospital, Strasbourg, France
    Am J Transplant 9:1961-6. 2009
  5. ncbi request reprint Effect of insulin on von Willebrand factor release in normal and diabetic subjects: in vivo and in vitro studies
    L Kessler
    Department of Diabetology, University Hospital, Strasbourg, France
    Horm Metab Res 33:674-80. 2001
  6. ncbi request reprint Reduction of blood glucose variability in type 1 diabetic patients treated by pancreatic islet transplantation: interest of continuous glucose monitoring
    Laurence Kessler
    Department of Endocrinology, University Hospital, Strasbourg, France
    Diabetes Care 25:2256-62. 2002
  7. ncbi request reprint Hyperbaric oxygenation accelerates the healing rate of nonischemic chronic diabetic foot ulcers: a prospective randomized study
    Laurence Kessler
    Department of Endocrinology and Diabetology, University Hospital, Strasbourg, France
    Diabetes Care 26:2378-82. 2003
  8. ncbi request reprint Surface treatment of polycarbonate films aimed at biomedical application
    Laurence Kessler
    Centre Européen d Etude du Diabète, Faculte de Medecine, Service d Endocrinologie et de Diabetologie, Hopital Civil, 1, Place de l Hopital, 67 091 Strasbourg, France
    J Biomater Sci Polym Ed 14:1135-53. 2003
  9. ncbi request reprint Influence of VEGF on the viability of encapsulated pancreatic rat islets after transplantation in diabetic mice
    S Sigrist
    Centre Européen d Etude du Diabète, Faculte de Medecine, 11, rue Humann, 67 000, Strasbourg, France
    Cell Transplant 12:627-35. 2003
  10. doi request reprint Combined pancreatic islet-lung transplantation: a novel approach to the treatment of end-stage cystic fibrosis
    L Kessler
    Department of Diabetology, University Hospital, University of Strasbourg, France
    Am J Transplant 10:1707-12. 2010

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Macrophage activation in type 1 diabetic patients with catheter obstruction during peritoneal insulin delivery with an implantable pump
    L Kessler
    Department of Endocrinology Diabetology, University Hospital, Strasbourg, France
    Diabetes Care 24:302-7. 2001
    ..e., vial insltlin). Macrophage activation was studied in patients with and without cathcter obstruction and compared with activation in healthy subjects...
  2. ncbi request reprint Comparison of microbiological results of needle puncture vs. superficial swab in infected diabetic foot ulcer with osteomyelitis
    L Kessler
    Department of Endocrinology and Diabetology, University Hospital, Strasbourg, France
    Diabet Med 23:99-102. 2006
    ..To study prospectively two methods for the bacteriological diagnosis of osteomyelitis related to diabetic foot ulcer: needle puncture performed across normal skin surrounding the foot ulcer and superficial swabbing of the ulcer...
  3. ncbi request reprint Influence of islet transportation on pancreatic islet allotransplantation in type 1 diabetic patients within the Swiss-French GRAGIL network
    Laurence Kessler
    Department of Endocrinology, University Hospital, Strasbourg, France
    Transplantation 77:1301-4. 2004
    ..The influence of islet transportation on pancreatic islet allotransplantation in type 1 diabetic patients was evaluated within the GRAGIL network...
  4. doi request reprint Evidence for humoral rejection of a pancreatic islet graft and rescue with rituximab and IV immunoglobulin therapy
    L Kessler
    Department of Endocrinology, University Hospital, Strasbourg, France
    Am J Transplant 9:1961-6. 2009
    ..One month later, the search by ELISA for antibodies against HLA class II antigens became negative, the Luminex tests normalizing more gradually. As the result of an improvement in glucose control, the patient was again insulin-free...
  5. ncbi request reprint Effect of insulin on von Willebrand factor release in normal and diabetic subjects: in vivo and in vitro studies
    L Kessler
    Department of Diabetology, University Hospital, Strasbourg, France
    Horm Metab Res 33:674-80. 2001
    ..In conclusion, hyperinsulinemia had no adverse effect on circulating vWf in normal or diabetic subjects. Neither release nor intracellular vWf content in non-diabetic or diabetic endothelial cells was influenced by insulin in vitro...
  6. ncbi request reprint Reduction of blood glucose variability in type 1 diabetic patients treated by pancreatic islet transplantation: interest of continuous glucose monitoring
    Laurence Kessler
    Department of Endocrinology, University Hospital, Strasbourg, France
    Diabetes Care 25:2256-62. 2002
    ..To compare the glycemic profiles of patients with type 1 diabetes treated with either an implantable insulin pump or pancreas or islet transplantation by the means of the continuous glucose monitoring system (CGMS; Minimed, Sylmar, CA)...
  7. ncbi request reprint Hyperbaric oxygenation accelerates the healing rate of nonischemic chronic diabetic foot ulcers: a prospective randomized study
    Laurence Kessler
    Department of Endocrinology and Diabetology, University Hospital, Strasbourg, France
    Diabetes Care 26:2378-82. 2003
    ..To study the effect of systemic hyperbaric oxygenation (HBO) therapy on the healing course of nonischemic chronic diabetic foot ulcers...
  8. ncbi request reprint Surface treatment of polycarbonate films aimed at biomedical application
    Laurence Kessler
    Centre Européen d Etude du Diabète, Faculte de Medecine, Service d Endocrinologie et de Diabetologie, Hopital Civil, 1, Place de l Hopital, 67 091 Strasbourg, France
    J Biomater Sci Polym Ed 14:1135-53. 2003
    ..In conclusion, the present study provided sufficient information to establish a relationship between the physicochemical modifications of the PVP-plasma-treated polycarbonate membrane and the improvement in its permeability...
  9. ncbi request reprint Influence of VEGF on the viability of encapsulated pancreatic rat islets after transplantation in diabetic mice
    S Sigrist
    Centre Européen d Etude du Diabète, Faculte de Medecine, 11, rue Humann, 67 000, Strasbourg, France
    Cell Transplant 12:627-35. 2003
    ..Local adjunction of VEGF may therefore improve the clinical outcome of islet transplantation...
  10. doi request reprint Combined pancreatic islet-lung transplantation: a novel approach to the treatment of end-stage cystic fibrosis
    L Kessler
    Department of Diabetology, University Hospital, University of Strasbourg, France
    Am J Transplant 10:1707-12. 2010
    ..Pulmonary function remained satisfactory in all patients. In conclusion, our cases series shows that combined bilateral lung and pancreatic islet transplantation may be a viable therapeutic option for patients with end-stage CF and CFRD...
  11. ncbi request reprint Human islet transplantation network for the treatment of Type I diabetes: first data from the Swiss-French GRAGIL consortium (1999-2000). Groupe de Recherche Rhin Rhĵne Alpes Genève pour la transplantation d'Ilots de Langerhans
    P Y Benhamou
    Department of Endocrinology, University Hospital, Grenoble, France
    Diabetologia 44:859-64. 2001
    ..The goal of this study was to demonstrate the feasibility of a multicentre network for islet transplantation in Type I (insulin-dependent) diabetic patients...
  12. doi request reprint Influence of rapamycin on rat macrophage viability and chemotaxis toward allogenic pancreatic islet supernates
    S Danner
    Laboratoire de Thérapie Cellulaire et Génique du Diabète, Centre Européen d Etude du Diabète, Strasbourg, France
    Transplant Proc 40:470-2. 2008
    ..These results suggested that, besides its anti-proliferative effect on T cells, rapamycin reduced macrophage attraction to the graft site...
  13. ncbi request reprint Chemotactic activity of culture supernatants of free and encapsulated pancreatic rat islets towards peritoneal macrophages
    V Karsten
    , UPRES-ULP 2106, Strasbourg, France
    Horm Metab Res 31:448-54. 1999
    ..In conclusion, pancreatic islet stimulated macrophage migration by release of immunological specific proteins partly retained by macroencapsulation...
  14. ncbi request reprint In vitro and in vivo studies of the properties of an artificial membrane for pancreatic islet encapsulation
    L Kessler
    , Biologie Cellulaire et Physiopathologie Digestives, Strasbourg, France
    Horm Metab Res 23:312-7. 1991
    ..However the stability of this treatment seems to be an important factor in preserving the biocompatibility of the membrane...
  15. ncbi request reprint Cardio protective effect of glucose-insulin infusion on acute digoxin toxicity in rat
    R Oubaassine
    Laboratory of Cellular and Genetic Therapy, European Centre of Diabetes Study, Strasbourg, France
    Toxicology 224:238-43. 2006
    ..001). At the time of death, both volume of digoxin infusion and serum digoxin concentration were increased in GID group as compared to digoxin group: 5.7+/-1.6ml versus 3.3+/-0.4ml (p<0.001) and 10.7+/-8.3mg/l versus 8.5+/-4.6mg/l...
  16. ncbi request reprint Role of chemokine signaling pathways in pancreatic islet rejection during allo- and xenotransplantation
    S Sigrist
    Laboratoire de Recherche, Centre Européen d Etude du Diabète, Boulevard René Leriche, 67 200 Strasbourg, France
    Transplant Proc 37:3516-8. 2005
    ..Understanding the molecular mechanisms of islet rejection may improve graft survival...
  17. doi request reprint Improvement of rat islet viability during transplantation: validation of pharmacological approach to induce VEGF overexpression
    A Langlois
    Centre Européen d Etude du Diabète, Strasbourg, France
    Cell Transplant 20:1333-42. 2011
    ..The pharmacological approach is an interesting strategy for improving graft efficiency during transplantation, but this approach needs to be improved with drugs that are more specific...
  18. doi request reprint Combined pancreatic islets-lung transplantation in cystic fibrosis-related diabetes: case reports
    L Kessler
    Service d endocrinologie, diabète et maladies métaboliques, Hopital Civil, 1, Place de l Hopital, 67091 Strasbourg, France
    Transplant Proc 42:4338-40. 2010
    ..Eighteen months after the combined graft, the FEV was 52%; the plasma C-peptide reached 0.79 μg/L, the HbA(1c), 6% and the insulin requirements decreased to 55 U/d in the absence of hypoglycemic events...
  19. doi request reprint Continuous glucose monitoring in cystic fibrosis patients according to the glucose tolerance
    F Moreau
    Department of Endocrinology and Diabetology, University Hospital, Strasbourg, France
    Horm Metab Res 40:502-6. 2008
    ..CGMS could be a useful tool for the early detection of hyperglycemia in patients with CF...
  20. ncbi request reprint Induction of angiogenesis in omentum with vascular endothelial growth factor: influence on the viability of encapsulated rat pancreatic islets during transplantation
    S Sigrist
    Centre Européen d Etude du Diabète, Faculte de Medecine, Hopital de Hautepierre, Strasbourg, France
    J Vasc Res 40:359-67. 2003
    ..Stimulation of angiogenesis of omentum induced by VEGF is associated with preservation of islet viability. Local delivery of VEGF proved to be a relevant approach to ameliorate the outcome of islet transplantation...
  21. doi request reprint Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials
    P Y Benhamou
    Department of Endocrinology, Centre Hospitalier Universitaire de Grenoble, Pôle DigiDUNE, Clinique d Endocrinologie, BP 217X, Grenoble 38043, France
    Diabet Med 26:617-21. 2009
    ..Rigorous assessment of health-related quality of life (HRQL) is mandatory to establish the benefits of islet transplantation...
  22. ncbi request reprint [Diffuse uptake of brown fat on computed-tomography coupled positron emission tomoscintigraphy (PET-CT) for the exploration of extra-adrenal pheochromocytoma]
    C Ramacciotti
    Service d endocrinologie, diabète et maladies métaboliques, Hopital Civil, CHU Strasbourg, France
    Ann Endocrinol (Paris) 67:14-9. 2006
    ..Bilateral spread of the radiotracer uptake was probably due to brown adipose tissue activation by excessive sympathetic stimulation induced by catecholamines released by the tumor...
  23. ncbi request reprint Logistics and transplant coordination activity in the GRAGIL Swiss-French multicenter network of islet transplantation
    Marie Claude Kempf
    Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
    Transplantation 79:1200-5. 2005
    ..Some institutions have elected to associate in multicenter networks, such as the Swiss-French GRAGIL (Groupe Rhin-Rhône-Alpes-Genève pour la Transplantation d'Ilots de Langerhans) consortium...
  24. ncbi request reprint Expectations and strategies regarding islet transplantation: metabolic data from the GRAGIL 2 trial
    Lionel Badet
    Department of Urology, University Hospital, Lyon, France
    Transplantation 84:89-96. 2007
    ....
  25. ncbi request reprint Cost analysis of human islet transplantation for the treatment of type 1 diabetes in the Swiss-French Consortium GRAGIL
    Adrienne P Guignard
    Department of Medical Information, Hospices Civils, Lyon, France
    Diabetes Care 27:895-900. 2004
    ..To evaluate the cost of islet transplantation in type 1 diabetic patients with a functional renal graft in a multicenter network...
  26. doi request reprint Combined pancreatic islet-lung transplantation with islet percutaneous portal embolization in cystic fibrosis
    Laurence Kessler
    Transplantation 85:1670-1. 2008
  27. ncbi request reprint Tacrolimus-associated optic neuropathy after pancreatic islet transplantation using a sirolimus/tacrolimus immunosuppressive regimen
    Laurence Kessler
    Transplantation 81:636-7. 2006