Robert G Kelly

Summary

Country: France

Publications

  1. doi Signaling pathways controlling second heart field development
    Francesca Rochais
    Developmental Biology Institute of Marseilles Luminy, UMR 6216 Centre National de la Recherche Scientifique Université de laMéditerranée, Campus de Luminy, Marseille, France
    Circ Res 104:933-42. 2009
  2. ncbi Molecular inroads into the anterior heart field
    Robert G Kelly
    Developmental Biology Institute of Marseilles, Marseille, France
    Trends Cardiovasc Med 15:51-6. 2005
  3. pmc Decreased levels of embryonic retinoic acid synthesis accelerate recovery from arterial growth delay in a mouse model of DiGeorge syndrome
    Lucile Ryckebusch
    INSERM UMR S910, Universite de la Mediterranee, Faculte de Medecine, 27 Bd Jean Moulin, Marseille, France
    Circ Res 106:686-94. 2010
  4. doi Resolving cell lineage contributions to the ventricular conduction system with a Cx40-GFP allele: a dual contribution of the first and second heart fields
    Lucile Miquerol
    Aix Marseille University, CNRS UMR 7288, Developmental Biology Institute of Marseille, Marseille, France
    Dev Dyn 242:665-77. 2013
  5. doi Second heart field cardiac progenitor cells in the early mouse embryo
    Alexandre Francou
    Developmental Biology Institute of Marseille Luminy, Marseille, France
    Biochim Biophys Acta 1833:795-8. 2013
  6. pmc Identification of a Tbx1/Tbx2/Tbx3 genetic pathway governing pharyngeal and arterial pole morphogenesis
    Karim Mesbah
    Developmental Biology Institute of Marseille Luminy, Aix Marseille University, CNRS UMR6216, Marseille, France
    Hum Mol Genet 21:1217-29. 2012
  7. doi New developments in the second heart field
    Stephane Zaffran
    Aix Marseille University, Marseille, France
    Differentiation 84:17-24. 2012
  8. ncbi Visualization of outflow tract development in the absence of Tbx1 using an FgF10 enhancer trap transgene
    Robert G Kelly
    Department of Genetics and Development, Columbia University, New York, NY, USA
    Dev Dyn 236:821-8. 2007
  9. doi Core issues in craniofacial myogenesis
    Robert G Kelly
    Developmental Biology Institute of Marseilles Luminy, UMR 6216 CNRS, Universite de la Mediterranee, Campus de Luminy, Marseille Cedex 9, France
    Exp Cell Res 316:3034-41. 2010
  10. doi Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates
    Ramkumar Sambasivan
    Institut Pasteur, Stem Cells and Development, CNRS URA 2578, Universite de la Mediterranee, Campus de Luminy, Marseille, France
    Dev Cell 16:810-21. 2009

Collaborators

Detail Information

Publications31

  1. doi Signaling pathways controlling second heart field development
    Francesca Rochais
    Developmental Biology Institute of Marseilles Luminy, UMR 6216 Centre National de la Recherche Scientifique Université de laMéditerranée, Campus de Luminy, Marseille, France
    Circ Res 104:933-42. 2009
    ....
  2. ncbi Molecular inroads into the anterior heart field
    Robert G Kelly
    Developmental Biology Institute of Marseilles, Marseille, France
    Trends Cardiovasc Med 15:51-6. 2005
    ....
  3. pmc Decreased levels of embryonic retinoic acid synthesis accelerate recovery from arterial growth delay in a mouse model of DiGeorge syndrome
    Lucile Ryckebusch
    INSERM UMR S910, Universite de la Mediterranee, Faculte de Medecine, 27 Bd Jean Moulin, Marseille, France
    Circ Res 106:686-94. 2010
    ..Recent studies have shown that reduction of RA or loss of Tbx1 alters the contribution of second heart field (SHF) progenitor cells to the elongating heart tube...
  4. doi Resolving cell lineage contributions to the ventricular conduction system with a Cx40-GFP allele: a dual contribution of the first and second heart fields
    Lucile Miquerol
    Aix Marseille University, CNRS UMR 7288, Developmental Biology Institute of Marseille, Marseille, France
    Dev Dyn 242:665-77. 2013
    ..The lineage relationship between progenitor cells giving rise to different components of the VCS is unclear...
  5. doi Second heart field cardiac progenitor cells in the early mouse embryo
    Alexandre Francou
    Developmental Biology Institute of Marseille Luminy, Marseille, France
    Biochim Biophys Acta 1833:795-8. 2013
    ..This article is part of a Special Issue entitled: Cardiomyocyte Biology: Cardiac Pathways of Differentiation, Metabolism and Contraction...
  6. pmc Identification of a Tbx1/Tbx2/Tbx3 genetic pathway governing pharyngeal and arterial pole morphogenesis
    Karim Mesbah
    Developmental Biology Institute of Marseille Luminy, Aix Marseille University, CNRS UMR6216, Marseille, France
    Hum Mol Genet 21:1217-29. 2012
    ..2DS patients...
  7. doi New developments in the second heart field
    Stephane Zaffran
    Aix Marseille University, Marseille, France
    Differentiation 84:17-24. 2012
    ....
  8. ncbi Visualization of outflow tract development in the absence of Tbx1 using an FgF10 enhancer trap transgene
    Robert G Kelly
    Department of Genetics and Development, Columbia University, New York, NY, USA
    Dev Dyn 236:821-8. 2007
    ..Furthermore, although normal Fgf10 levels are dependent on Tbx1, loss of Fgf10 alleles does not significantly modify the cardiac phenotype of Tbx1 heterozygous or homozygous mutant embryos...
  9. doi Core issues in craniofacial myogenesis
    Robert G Kelly
    Developmental Biology Institute of Marseilles Luminy, UMR 6216 CNRS, Universite de la Mediterranee, Campus de Luminy, Marseille Cedex 9, France
    Exp Cell Res 316:3034-41. 2010
    ....
  10. doi Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates
    Ramkumar Sambasivan
    Institut Pasteur, Stem Cells and Development, CNRS URA 2578, Universite de la Mediterranee, Campus de Luminy, Marseille, France
    Dev Cell 16:810-21. 2009
    ..These findings identify novel genetic networks that may provide insights into myopathies which often affect only subsets of muscles...
  11. pmc Hes1 is expressed in the second heart field and is required for outflow tract development
    Francesca Rochais
    Developmental Biology Institute of Marseilles Luminy, UMR 6216 CNRS Université de la Méditerranée, Campus de Luminy, Marseille, France
    PLoS ONE 4:e6267. 2009
    ..In order to provide further insight into second heart field development we characterized the insertion site of a transgene expressed in the second heart field and outflow tract as the result of an integration site position effect...
  12. doi Properties of branchiomeric and somite-derived muscle development in Tbx1 mutant embryos
    Raphälle Grifone
    Inserm Avenir Group, Developmental Biology Institute of Marseilles Luminy, UMR CNRS 6216 Université de la Méditerranée, Campus de Luminy, Marseille, France
    Dev Dyn 237:3071-8. 2008
    ..The critical requirement for Tbx1 during muscle development is thus in the robust onset of myogenic specification in pharyngeal mesoderm...
  13. doi Biphasic development of the mammalian ventricular conduction system
    Lucile Miquerol
    Developmental Biology Institute of Marseilles Luminy IBDML, CNRS UMR6216 Université de la Méditerranée, Campus de Luminy, Marseille, France
    Circ Res 107:153-61. 2010
    ..How the mammalian ventricular conduction system is established during development remains controversial...
  14. pmc Tbx3 is required for outflow tract development
    Karim Mesbah
    Developmental Biology Institute of Marseilles Luminy, France
    Circ Res 103:743-50. 2008
    ....
  15. doi The del22q11.2 candidate gene Tbx1 controls regional outflow tract identity and coronary artery patterning
    Magali Théveniau-Ruissy
    Developmental Biology Institute of Marseilles Luminy, Inserm Avenir Group, UMR 6216 CNRS Université de la Méditerrané, Campus de Luminy, Marseille Cedex 9, France
    Circ Res 103:142-8. 2008
    ..Our results implicate second heart field development in coronary artery patterning and provide new insights into the association between conotruncal defects and coronary artery anomalies...
  16. ncbi Myocardium at the base of the aorta and pulmonary trunk is prefigured in the outflow tract of the heart and in subdomains of the second heart field
    Fanny Bajolle
    Department of Developmental Biology, URA 2578 CNRS, Pasteur Institute, 25 rue du Dr Roux, 75724 Paris, France
    Dev Biol 313:25-34. 2008
    ....
  17. ncbi Heartening news for head muscle development
    Raphaelle Grifone
    Developmental Biology Institute of Marseilles Luminy, Inserm Avenir Group, UMR 6216 CNRS Université de la Méditerranée, Campus de Luminy Case 907, 13288 Marseilles Cedex 9, France
    Trends Genet 23:365-9. 2007
    ..The divergent myogenic fates of adjacent progenitor cells revealed by these data provide a new framework for the study of craniofacial myogenesis...
  18. ncbi A retrospective clonal analysis of the myocardium reveals two phases of clonal growth in the developing mouse heart
    Sigolène M Meilhac
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Development 130:3877-89. 2003
    ..We discuss how the characteristics of myocardial cell growth, which we describe, underlie the formation of the heart tube and its subsequent regionalised expansion...
  19. ncbi Cell history determines the maintenance of transcriptional differences between left and right ventricular cardiomyocytes in the developing mouse heart
    Robert G Kelly
    CNRS URA 2578, Department of Developmental Biology, Pasteur Institute, 25 rue du Dr Roux, Paris 75015, France
    J Cell Sci 116:5005-13. 2003
    ..Epigenetic mechanisms may therefore be involved in maintaining patterning of the mammalian myocardium...
  20. ncbi The clonal origin of myocardial cells in different regions of the embryonic mouse heart
    Sigolène M Meilhac
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Dev Cell 6:685-98. 2004
    ..These results are not consistent with the prespecification of the cardiac tube as a segmented structure. They are discussed in the context of different heart fields and of the evolution of the heart...
  21. ncbi Analysis of Mlc-lacZ Met mutants highlights the essential function of Met for migratory precursors of hypaxial muscles and reveals a role for Met in the development of hyoid arch-derived facial muscles
    Chiara Prunotto
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Torino, Corso Massimo d Azeglio 52, 10126 Turin, Italy
    Dev Dyn 231:582-91. 2004
    ..Surprisingly, however, X-gal staining showed that, in this mutant, hyoid arch-derived facial muscles were either reduced or absent, thus revealing that Met also contributes to the development of muscles in the head...
  22. ncbi The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesis
    Robert G Kelly
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Hum Mol Genet 13:2829-40. 2004
    ..While no abnormalities in branchiomeric myogenesis were detected in Tbx1(+/-) mice, reduced TBX1 levels may contribute to pharyngeal hypotonia in del22q11.2 patients...
  23. ncbi Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development
    Zachary Harrelson
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Development 131:5041-52. 2004
    ....
  24. ncbi Left and right ventricular contributions to the formation of the interventricular septum in the mouse heart
    Diego Franco
    Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, 23071 Jaen, Spain
    Dev Biol 294:366-75. 2006
    ..Examination of the orientation as well as the distribution of labeled cells in clusters provides new insights into the morphogenesis of the septum...
  25. ncbi Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice
    Anita Marguerie
    Cancer Research UK, London Research Institute, 61 Lincoln s Inn Fields, London WC2A 3PX, UK
    Cardiovasc Res 71:50-60. 2006
    ..In order to define the role of fibroblast growth factor (FGF) signaling in this process we investigated whether Fgf10 or the major Fgf10 receptor Fgfr2-IIIb are required for normal heart development...
  26. ncbi The anterior heart-forming field: voyage to the arterial pole of the heart
    Robert G Kelly
    CNRS URA 1947, Dept of Developmental Biology, Pasteur Institute, 28 rue du Dr Roux, Paris, France
    Trends Genet 18:210-6. 2002
    ..Discovery of the anterior heart-forming field has important implications for the interpretation of cardiac defects in mouse mutants and for the study of human congenital heart disease...
  27. ncbi T-box genes in vertebrate development
    L A Naiche
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Annu Rev Genet 39:219-39. 2005
    ..The few downstream target genes that have been identified indicate a wide range of downstream effectors...
  28. ncbi Rotation of the myocardial wall of the outflow tract is implicated in the normal positioning of the great arteries
    Fanny Bajolle
    Department of Developmental Biology, CNRS URA 2578, Pasteur Institute, Paris, France
    Circ Res 98:421-8. 2006
    ..We propose that failure of normal rotation of OFT myocardium may underlie major forms of congenital heart disease...
  29. ncbi Right ventricular myocardium derives from the anterior heart field
    Stephane Zaffran
    Department of Developmental Biology, CNRS URA 2578, Pasteur Institute, 25 rue du Dr Roux, Paris, 75015, France
    Circ Res 95:261-8. 2004
    ..This study demonstrates the differences in the embryological origin of right and left ventricular myocardium, which has important implications for congenital heart disease...
  30. ncbi Building the right ventricle
    Robert G Kelly
    Circ Res 100:943-5. 2007
  31. ncbi Integration of embryonic and fetal skeletal myogenic programs at the myosin light chain 1f/3f locus
    Peter S Zammit
    Department of Developmental Biology, CNRS URA 2578, Pasteur Institute, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Dev Biol 313:420-33. 2008
    ..Together our observations provide insights into the regulation of fetal myogenesis and the mechanisms by which temporally distinct genetic programs are integrated at a single locus...