P A Kelly

Summary

Country: France

Publications

  1. pmc Effects of deletion of the prolactin receptor on ovarian gene expression
    Isabelle Grosdemouge
    Molecular Endocrinology, INSERM U344 Faculté de Médecine Necker Enfants Malades, 75730 Paris Cedex 15, France
    Reprod Biol Endocrinol 1:12. 2003
  2. ncbi request reprint Implications of multiple phenotypes observed in prolactin receptor knockout mice
    P A Kelly
    INSERM Unité 344 Endocrinologie Moléculaire, Faculte de Medecine Necker, 156 rue de Vaugirard, Paris Cedex, 75730, France
    Front Neuroendocrinol 22:140-5. 2001
  3. ncbi request reprint The role of prolactin and growth hormone in mammary gland development
    Paul A Kelly
    INSERM Unit 344 Molecular Endocrinology, Faculty of Medicine Necker, Paris, France
    Mol Cell Endocrinol 197:127-31. 2002
  4. ncbi request reprint Prolactin receptor signal transduction pathways and actions determined in prolactin receptor knockout mice
    P A Kelly
    INSERM Unité 344 Endocrinologie Moléculaire, Faculte de Medecine Necker, 156 rue de Vaugirard, 75730 Paris Cedex, France
    Biochem Soc Trans 29:48-52. 2001
  5. ncbi request reprint Growth hormone receptor signalling and actions in bone growth
    P A Kelly
    INSERM Unité 344 Endocrinologie Moléculaire, Faculty of Medicine Necker, Paris, France
    Horm Res 55:14-7. 2001
  6. ncbi request reprint Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor
    F Dif
    Institut National de la Santé et la Recherche Médicale, Unite 344, Endocrinologie Moleculaire, Faculte de Medecine Necker, 75730 Paris, France
    Endocrinology 142:5286-93. 2001
  7. ncbi request reprint From the molecular biology of prolactin and its receptor to the lessons learned from knockout mice models
    V Goffin
    INSERM Unité 344 Endocrinologie Moléculaire, Faculte de Medecine Necker, Paris, France
    Genet Anal 15:189-201. 1999
  8. ncbi request reprint Convergence of signaling transduced by prolactin (PRL)/cytokine chimeric receptors on PRL-responsive gene transcription
    F Ferrag
    INSERM U 344, , Paris, France
    Mol Endocrinol 10:451-60. 1996
  9. ncbi request reprint Growth hormone (GH) induces the formation of protein complexes involving Stat5, Erk2, Shc and serine phosphorylated proteins
    H Dinerstein-Cali
    INSERM Unite 344, Endocrinologie Moleculaire, Faculte de Medecine Necker Enfants Malades, 156 rue de Vaugirard, 75015, Paris, France
    Mol Cell Endocrinol 166:89-99. 2000
  10. ncbi request reprint Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling
    A Pezet
    INSERM U344, Faculte de Medecine Necker, 156 rue de Vaugirard, 75730 Paris Cedex 15, France
    J Biol Chem 274:24497-502. 1999

Collaborators

Detail Information

Publications56

  1. pmc Effects of deletion of the prolactin receptor on ovarian gene expression
    Isabelle Grosdemouge
    Molecular Endocrinology, INSERM U344 Faculté de Médecine Necker Enfants Malades, 75730 Paris Cedex 15, France
    Reprod Biol Endocrinol 1:12. 2003
    ..These modifications lead to the decrease of LH receptor expression and consequently to a loss of the enzymatic cascades necessary to produce adequate levels of progesterone which are required for the maintenance of pregnancy...
  2. ncbi request reprint Implications of multiple phenotypes observed in prolactin receptor knockout mice
    P A Kelly
    INSERM Unité 344 Endocrinologie Moléculaire, Faculte de Medecine Necker, 156 rue de Vaugirard, Paris Cedex, 75730, France
    Front Neuroendocrinol 22:140-5. 2001
    ..Bone formation is reduced in young animals and adults (males and females). Recently, we noticed that older KO animals show a slight reduction in body weight which appears to be due to reduced abdominal fat deposition...
  3. ncbi request reprint The role of prolactin and growth hormone in mammary gland development
    Paul A Kelly
    INSERM Unit 344 Molecular Endocrinology, Faculty of Medicine Necker, Paris, France
    Mol Cell Endocrinol 197:127-31. 2002
    ..In summary, it is now established that GH and PRL activate Stat5 in separate compartments, reflecting their specific roles in ductal and alveolar development and differentiation...
  4. ncbi request reprint Prolactin receptor signal transduction pathways and actions determined in prolactin receptor knockout mice
    P A Kelly
    INSERM Unité 344 Endocrinologie Moléculaire, Faculte de Medecine Necker, 156 rue de Vaugirard, 75730 Paris Cedex, France
    Biochem Soc Trans 29:48-52. 2001
    ..Bone formation is reduced in young animals and in adults (males and females). Finally, older males and females show a slight reduction in body weight, which seems to be due to reduced abdominal fat deposition in the knockout animals...
  5. ncbi request reprint Growth hormone receptor signalling and actions in bone growth
    P A Kelly
    INSERM Unité 344 Endocrinologie Moléculaire, Faculty of Medicine Necker, Paris, France
    Horm Res 55:14-7. 2001
    ..Finally, the use of the GH receptor knock-out mouse model has allowed us to dissect the role of this hormone in post-natal body growth and homeostasis...
  6. ncbi request reprint Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor
    F Dif
    Institut National de la Santé et la Recherche Médicale, Unite 344, Endocrinologie Moleculaire, Faculte de Medecine Necker, 75730 Paris, France
    Endocrinology 142:5286-93. 2001
    ....
  7. ncbi request reprint From the molecular biology of prolactin and its receptor to the lessons learned from knockout mice models
    V Goffin
    INSERM Unité 344 Endocrinologie Moléculaire, Faculte de Medecine Necker, Paris, France
    Genet Anal 15:189-201. 1999
    ..The development of genetic models provides new opportunities to understand how PRL can participate to the development of pathologies throughout life, as for example the initiation and progression of breast cancer...
  8. ncbi request reprint Convergence of signaling transduced by prolactin (PRL)/cytokine chimeric receptors on PRL-responsive gene transcription
    F Ferrag
    INSERM U 344, , Paris, France
    Mol Endocrinol 10:451-60. 1996
    ..Our data strengthen previous observations that Stat5 activation is not dependent on the activation of a specific Jak kinase and also suggest that neither Jak3 nor gamma c have a specific role in this process...
  9. ncbi request reprint Growth hormone (GH) induces the formation of protein complexes involving Stat5, Erk2, Shc and serine phosphorylated proteins
    H Dinerstein-Cali
    INSERM Unite 344, Endocrinologie Moleculaire, Faculte de Medecine Necker Enfants Malades, 156 rue de Vaugirard, 75015, Paris, France
    Mol Cell Endocrinol 166:89-99. 2000
    ..Our results support the importance of serine phosphorylation cascades in GH signaling and open another pathway of GH signal transduction...
  10. ncbi request reprint Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling
    A Pezet
    INSERM U344, Faculte de Medecine Necker, 156 rue de Vaugirard, 75730 Paris Cedex 15, France
    J Biol Chem 274:24497-502. 1999
    ..We thus propose that the early expressed SOCS genes (SOCS-1 and SOCS-3) switch off PRL signaling and that the later expressed SOCS-2 gene can restore the sensitivity of cells to PRL, partly by suppressing the SOCS-1 inhibitory effect...
  11. pmc Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5
    N A Sims
    Institut Nationale de la Santé et de la Recherche Médicale INSERM, Unite 344, Endocrinologie Moleculaire, Faculte de Medecine Necker, Paris, France
    J Clin Invest 106:1095-103. 2000
    ..Whereas bone length was reduced in Stat5ab(-/-) mice, there was no reduction in trabecular bone remodeling or growth-plate width as observed in GHR(-/-) mice, indicating that the effects of GH in bone may not involve Stat5 activation...
  12. ncbi request reprint Rescue of preimplantatory egg development and embryo implantation in prolactin receptor-deficient mice after progesterone administration
    N Binart
    INSERM, U 344, Endocrinologie Moleculaire, Faculte de Medecine Necker, Paris, France
    Endocrinology 141:2691-7. 2000
    ..Our model establishes the PRL receptor as a key regulator of reproduction and provides novel insights into the function of lactogenic hormones and their receptor...
  13. ncbi request reprint Internalization of prolactin receptor and prolactin in transfected cells does not involve nuclear translocation
    M Perrot Applanat
    INSERM U 344, , Paris, France
    J Cell Sci 110:1123-32. 1997
    ..Activation of STATs transcription factors and MAP kinases, as well as translocation of these proteins to the nucleus following their phosphorylation, probably remains the intracellular mechanism coupling stimulation to nuclear events...
  14. ncbi request reprint Subcellular trafficking of growth hormone receptor and Jak2 under ligand exposure
    S Moulin
    INSERM Unit 584, Hormone Targets, Faculty of Medicine Necker, Paris, France
    Horm Metab Res 35:396-401. 2003
    ..Immunoblots of nuclear extracts confirm the Jak2 nuclear exclusion...
  15. ncbi request reprint Osteoblasts are a new target for prolactin: analysis of bone formation in prolactin receptor knockout mice
    P Clement-Lacroix
    INSERM U 344, Endocrinologie Moleculaire, Faculte de Medecine Necker, Paris, France
    Endocrinology 140:96-105. 1999
    ..Thus, the PRL receptor knockout mouse model provides a new tool to investigate the involvement of PRL in bone metabolism...
  16. ncbi request reprint Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice
    C Bole-Feysot
    INSERM Unité 344 Endocrinologie Moléculaire, Faculte de Medecine Necker, Paris, France
    Endocr Rev 19:225-68. 1998
    ..On the other hand, many of the effects reported in this review may be shared with other hormones, cytokines, or growth factors and thus will be more difficult to study. (ABSTRACT TRUNCATED)..
  17. ncbi request reprint N-glycosylation of the prolactin receptor is not required for activation of gene transcription but is crucial for its cell surface targeting
    H Buteau
    INSERM U344 Endocrinologie Moléculaire, Faculte de Medecine Necker, Paris, France
    Mol Endocrinol 12:544-55. 1998
    ..These studies demonstrate that the glycosylation on the asparagyl residues of the extracellular domain of the PRLR is crucial for its cell surface localization and may affect signal transduction, depending on the cell line...
  18. ncbi request reprint Low doses of EPO activate MAP kinases but not JAK2-STAT5 in rat vascular smooth muscle cells
    F Ammarguellat
    INSERM Unit 344, Molecular Endocrinology, , 156 rue de Vaugirard, Paris Cedex 15, 75730, France
    Biochem Biophys Res Commun 284:1031-8. 2001
    ..In contrast, a strong activation of MAP kinase pathway was detected with as low as 10 IU/ml Epo. We suggest that MAPK activation reflects a physiologically relevant effect of Epo on VSMCs that may be correlated to cell proliferation...
  19. ncbi request reprint Monkey growth hormone (GH) receptor gene expression. Evidence for two mechanisms for the generation of the GH binding protein
    J F Martini
    INSERM Unite 344, Endocrinologie Moleculaire, Faculte de Medecine Necker Enfants Malades, 156 rue de Vaugirard, 75730 Paris Cedex 15, France
    J Biol Chem 272:18951-8. 1997
    ....
  20. ncbi request reprint The human growth hormone antagonist B2036 does not interact with the prolactin receptor
    V Goffin
    INSERM Unit 344, Endocrinologie Moleculaire, Paris, France
    Endocrinology 140:3853-6. 1999
    ..These observations further demonstrate that the eight amino acid substitutions within binding site 1 provide binding specificity directed towards the human GH receptor...
  21. pmc Identification and functional activity of prolactin receptors in thymic epithelial cells
    M Dardenne
    Centre National de la Recherche Scientifique, , , Paris, France
    Proc Natl Acad Sci U S A 88:9700-4. 1991
    ..These data bring further support for the general concept of the neuroendocrine immune circuit and extend the notion for a pleiotropic role of PRL as an immunomodulatory hormone...
  22. ncbi request reprint Immune system development and function in prolactin receptor-deficient mice
    B Bouchard
    Institut National de la Santé et de la Recherche Médicale U 344, Endocrinologie Moleculaire, Faculte de Medecine Necker, Paris, France
    J Immunol 163:576-82. 1999
    ..Taken together, these results show that immune system development and function proceed normally in the absence of PRL-mediated signaling and suggest that PRLR pathways are not essential for immunomodulation in vivo...
  23. ncbi request reprint Growth hormone exerts antiapoptotic and proliferative effects through two different pathways involving nuclear factor-kappaB and phosphatidylinositol 3-kinase
    S Jeay
    INSERM, U 344, Endocrinologie Moleculaire, Faculte de Medecine Necker, 75730 Paris, France
    Endocrinology 142:147-56. 2001
    ..NF-kappaB, which has been shown to be responsible for the antiapoptotic effect of GH, could also participate in GH-induced proliferation, as c-myc expression is promoted by PI 3-kinase, in an NF-kappaB-dependent and -independent manner...
  24. ncbi request reprint Expression of prolactin receptors in murine lymphoid cells in normal and autoimmune situations
    M C Gagnerault
    CNRS URA 1461, , Paris, France
    J Immunol 150:5673-81. 1993
    ..In conclusion, our data provide a molecular basis for a better understanding on the mode of action of PRL within the immune system in physiologic and pathologic situations...
  25. ncbi request reprint Should prolactin be reconsidered as a therapeutic target in human breast cancer?
    V Goffin
    INSERM Unité 344 Endocrinologie Moléculaire, Faculte de Medecine Necker, Paris, France
    Mol Cell Endocrinol 151:79-87. 1999
    ..If true, our hypothesis would suggest that the enzymatic cleavage of PRL could represent a new molecular target in the search for alternative strategies in the treatment of breast cancer...
  26. ncbi request reprint Null mutation of the prolactin receptor gene produces a defect in maternal behavior
    B K Lucas
    Institut National de la Santé et de la Recherche Médicale Unit 344, Endocrinologie Moleculaire, Faculte de Medecine Necker, Paris, France
    Endocrinology 139:4102-7. 1998
    ..Olfactory function was tested in an aversive conditioning paradigm, results indicating that heterozygous and homozygous PRLR mutant mice are not anosmic. These studies clearly establish the PRLR as a regulator of maternal behavior...
  27. ncbi request reprint Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse
    C J Ormandy
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 344, Endocrinologie Moléculaire Faculté de Médecine Necker, Paris, France
    Genes Dev 11:167-78. 1997
    ..This work establishes the prolactin receptor as a key regulator of mammalian reproduction, and provides the first total ablation model to further study the role of the prolactin receptor and its ligands...
  28. ncbi request reprint S179D-human PRL, a pseudophosphorylated human PRL analog, is an agonist and not an antagonist
    S Bernichtein
    INSERM, U-344, Molecular Endocrinology, , 75730 Paris, France
    Endocrinology 142:3950-63. 2001
    ....
  29. ncbi request reprint Prolactin receptor expression in human hematopoietic tissues analyzed by flow cytofluorometry
    M Dardenne
    CNRS URA 1461, Hopital Necker, Paris, France
    Endocrinology 134:2108-14. 1994
    ..These data along with those showing that the PRL gene is specifically expressed in human T-cells suggest that lymphocyte PRL may act in a paracrine or autocrine fashion in both central and peripheral lymphoid organs...
  30. ncbi request reprint The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor
    A Pezet
    INSERM U344 Endocrinologie Moléculaire, Faculte de Medecine Necker Enfants Malades, Paris, France
    Mol Cell Endocrinol 129:199-208. 1997
    ..These results support the notion that the tyrosine kinase JAK2 is implicated in activation of downstream protein effectors such as Stat5, which are involved in transcription of PRL-responsive genes...
  31. ncbi request reprint Expression of short and long forms of prolactin receptor in murine lymphoid tissues
    P Touraine
    INSERM U 344, Fac Médecine Necker, Paris, France
    Mol Cell Endocrinol 104:183-90. 1994
    ..The ubiquitous presence of both forms of receptor transcripts in different lymphoid tissues points to an important role of the PRLR and suggests that such forms of the receptor may be involved in differential functions in lymphocytes...
  32. ncbi request reprint Cytokine receptor signalling through two novel families of transducer molecules: Janus kinases, and signal transducers and activators of transcription
    J Finidori
    INSERM Unite 344, Institut Necker, Faculte de Medecine Necker, Paris, France
    J Endocrinol 147:11-23. 1995
  33. ncbi request reprint The proliferative and antiapoptotic actions of growth hormone and insulin-like growth factor-1 are mediated through distinct signaling pathways in the Pro-B Ba/F3 cell line
    E Baixeras
    INSERM, U-344, , , 75730 Paris Cedex 15, France
    Endocrinology 142:2968-77. 2001
    ..Thus, GH and IGF-I are able to promote cell survival and proliferation through independent and different pathways in Ba/F3 cells...
  34. ncbi request reprint Prolactin signaling influences the timing mechanism of the hair follicle: analysis of hair growth cycles in prolactin receptor knockout mice
    A J Craven
    New Zealand Pastoral Agriculture Research Institute, Hamilton 2020, New Zealand
    Endocrinology 142:2533-9. 2001
    ..The pituitary PRL regulation of hair follicle cycles observed in seasonally responsive mammals may be a result of pituitary PRL interacting with a local regulatory mechanism...
  35. ncbi request reprint Cloning and expression of the rat prolactin receptor, a member of the growth hormone/prolactin receptor gene family
    J M Boutin
    Laboratory of Molecular Endocrinology, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada
    Cell 53:69-77. 1988
    ....
  36. ncbi request reprint Prolactin receptor expression in the epithelia and stroma of the rat mammary gland
    I G Camarillo
    Department of Biology, University of California, Santa Cruz, California 95064, USA
    J Endocrinol 171:85-95. 2001
    ..This finding suggests PRL may have a direct affect on the mammary stroma and by that route affect mammary gland development...
  37. pmc Identification and sequence analysis of a second form of prolactin receptor by molecular cloning of complementary DNA from rabbit mammary gland
    M Edery
    Unité d Endocrinologie Moléculaire, Institut National de la Recherche Agronomique, Jouy en Josas, France
    Proc Natl Acad Sci U S A 86:2112-6. 1989
    ..In addition, the sequence identity of this form of prolactin receptor with the growth hormone receptor is extended in the cytoplasmic domain...
  38. ncbi request reprint Investigation of the role of prolactin in the development and function of the lacrimal and harderian glands using genetically modified mice
    K A McClellan
    Department of Ophthalmology, University of Sydney, Sydney Eye Hospital, Australia
    Invest Ophthalmol Vis Sci 42:23-30. 2001
    ..To determine whether prolactin receptor is essential for normal development and function of the lacrimal gland and whether hyperprolactinemia can alter lacrimal development...
  39. ncbi request reprint Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects
    M I Gallego
    Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA
    Dev Biol 229:163-75. 2001
    ..Our findings demonstrate that GH, Prl, and EGF activate Stat5 in separate compartments, which in turn reflects their specific roles in ductal and alveolar development and differentiation...
  40. ncbi request reprint Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins
    S Moutoussamy
    Unite 344, Endocrinologie Moleculaire, Institut National de la Sante et de la Recherche Medicale, Faculte de Medecine Necker Enfants Malades, 75730 Paris Cedex 15, France
    J Biol Chem 273:15906-12. 1998
    ..Our results suggest that Grb10 is a new target for a member of the cytokine receptor family that down-regulates some GH signaling pathways downstream of Jak2 and independently of Stat5...
  41. ncbi request reprint Prolactin controls mammary gland development via direct and indirect mechanisms
    C Brisken
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142 1479, USA
    Dev Biol 210:96-106. 1999
    ....
  42. ncbi request reprint Identification of phenylalanine 346 in the rat growth hormone receptor as being critical for ligand-mediated internalization and down-regulation
    G Allevato
    Hagedorn Research Institute, Gentofte, Denmark
    J Biol Chem 270:17210-4. 1995
    ....
  43. ncbi request reprint Prolactin potentiates insulin-stimulated leptin expression and release from differentiated brown adipocytes
    S Viengchareun
    INSERM U478, Institut Fédératif de Recherche Claude Bernard, Faculte de Medecine Xavier Bichat, 16 rue Henri Huchard, 75018 Paris, France
    J Mol Endocrinol 33:679-91. 2004
    ..This study provides the first evidence for a functional link between PRL and energy balance via a cross-talk between insulin and PRL signaling pathways in brown adipocytes...
  44. ncbi request reprint Implantation and decidualization defects in prolactin receptor (PRLR)-deficient mice are mediated by ovarian but not uterine PRLR
    J Reese
    Department of Pediatrics, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7338, USA
    Endocrinology 141:1872-81. 2000
    ..The function of uterine PRLR remains unclear. However, the eventual loss of pregnancy in P4-treated PRLR-/- mice suggests that uterine PRLR may be essential for the support of late gestation...
  45. ncbi request reprint GH prevents apoptosis in cardiomyocytes cultured in vitro through a calcineurin-dependent mechanism
    J R Gonzalez-Juanatey
    Unidad de Cardiología celular y molecular, Laboratorio de Investigación 1, Planta Baja, Area de Investigación y Docencia, Hospital Clinico Universitario de Santiago de Compostela, Travesía Choupana s n, 15706 Santiago de Compostela, Spain
    J Endocrinol 180:325-35. 2004
    ..In summary, GH protects PC and HL-1 cells from apoptosis. This effect is not mediated by IGF-I and may involve MAPK p38 as well as calcineurin...
  46. ncbi request reprint Long and short forms of the ovine prolactin receptor: cDNA cloning and genomic analysis reveal that the two forms arise by different alternative splicing mechanisms in ruminants and in rodents
    C Bignon
    Unité d Endocrinologie Moléculaire, Institut National de la Recherche Agronomique, Jouy en Josas, France
    J Mol Endocrinol 19:109-20. 1997
    ..The same organization was found in bovine and caprine genomes, suggesting that this feature is general in ruminants and different from rodents, which use mutually exclusive exons to produce s-PR and l-PR...
  47. ncbi request reprint A prolactin-dependent immune cell line (Nb2) expresses a mutant form of prolactin receptor
    S Ali
    Laboratory of Molecular Endocrinology, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada
    J Biol Chem 266:20110-7. 1991
    ..The identification of a modified long form of PRL-R in the Nb2 cell line should help localize domains of the PRL-R involved in signal transduction and further the investigation of prolactin's role in immune cell proliferation...
  48. ncbi request reprint Neurosurgical treatment of Nelson's syndrome
    P A Kelly
    Department of Endocrinology, St Bartholomew s and The Royal London Hospitals, London EC 1A 7BE, United Kingdom
    J Clin Endocrinol Metab 87:5465-9. 2002
    ....
  49. ncbi request reprint The human prolactin receptor in the fetal membranes, decidua, and placenta
    R A Maaskant
    Pacific Biomedical Research Center, University of Hawaii, Honolulu 96822, USA
    J Clin Endocrinol Metab 81:396-405. 1996
    ..Its increased expression during labor and delivery in the chorion, decidua, and placenta supports an autocrine/paracrine role for decidual PRL in the peripartum...
  50. ncbi request reprint Expression of two forms of prolactin receptor in rat ovary and liver
    M Shirota
    Laboratory of Molecular Endocrinology, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada
    Mol Endocrinol 4:1136-43. 1990
    ..5-kb mRNA is obtained with the probe specific to the short form. The predicted size of the mature form of the long PRL receptor (PRL-R2) is 591 amino acid residues.(ABSTRACT TRUNCATED AT 250 WORDS)..
  51. ncbi request reprint Identification of ligand binding determinants of the prolactin receptor
    M Rozakis-Adcock
    Laboratory of Molecular Endocrinology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
    J Biol Chem 267:7428-33. 1992
    ....
  52. ncbi request reprint Prolactin receptors in human breast tumors
    L Turcot-Lemay
    J Natl Cancer Inst 68:381-3. 1982
    ..4%) in tumors possessing prolactin receptors was revealed when hPRL was used as the labeled ligand. Therefore, hPRL is the preferred ligand for the assessment of prolactin receptor levels in human breast cancer biopsy specimens...
  53. ncbi request reprint Differential expression of prolactin receptor (PRLR) in normal and tumorous adrenal tissues: separation of cellular endocrine compartments by laser capture microdissection (LCM)
    A Glasow
    Department of Internal Medicine III, University of Leipzig, Germany
    Endocr Res 24:857-62. 1998
    ..By WST-1 test, we could show that PRL (10(-7) M) decreased proliferation and viability of adrenal cells in primary cell culture suggesting that PRL is not a mitogenic factor of adrenocortical cells...
  54. ncbi request reprint Cloning, characterization, and tissue distribution of prolactin receptor in the sea bream (Sparus aurata)
    C R Santos
    Centre of Marine Sciences CCMAR, Universidade do Algarve, Campus de Gambelas, Faro, 8000 810, Portugal
    Gen Comp Endocrinol 121:32-47. 2001
    ....
  55. ncbi request reprint The receptors for prolactin and growth hormone are localized in the same region of human chromosome 5
    K C Arden
    Ludwig Institute for Cancer Research, Royal Victoria Hospital, Montreal, Quebec, Canada
    Cytogenet Cell Genet 53:161-5. 1990
    ..Thus, these proteins may be encoded by a cluster of related genes that evolved from a common ancestral gene, in a manner consonant with that of their ligands...
  56. ncbi request reprint Identification of a cDNA encoding a long form of prolactin receptor in human hepatoma and breast cancer cells
    J M Boutin
    Laboratory of Molecular Endocrinology, McGill University, Royal Victoria Hospital, Montreal, Canada
    Mol Endocrinol 3:1455-61. 1989
    ..This cDNA will be a valuable tool to better understand the role of PRL in the development and growth of human breast cancer...