Alan Kay

Summary

Country: France

Publications

  1. ncbi request reprint Hepatitis B virus genetic variability and evolution
    Alan Kay
    INSERM, U871, Physiopathologie moléculaire et nouveaux traitements des hépatites virales, 151 Cours A Thomas, Lyon F 69424, France
    Virus Res 127:164-76. 2007
  2. pmc Rolling circle amplification, a powerful tool for genetic and functional studies of complete hepatitis B virus genomes from low-level infections and for directly probing covalently closed circular DNA
    Séverine Margeridon
    INSERM, U871, Lyon, France
    Antimicrob Agents Chemother 52:3068-73. 2008
  3. ncbi request reprint A quasi-monoclonal anti-HBs response can lead to immune escape of 'wild-type' hepatitis B virus
    Séverine Margeridon
    INSERM U271, 151 Cours A Thomas, 69003 Lyon, France
    J Gen Virol 86:1687-93. 2005
  4. pmc HBVdb: a knowledge database for Hepatitis B Virus
    Juliette Hayer
    Unité Bases Moléculaires et Structurales des Systèmes Infectieux, Lyon, France
    Nucleic Acids Res 41:D566-70. 2013
  5. ncbi request reprint Characterization of two hepatitis B virus populations isolated from a hepatitis B surface antigen-negative patient
    Damien Jeantet
    U271 INSERM, 151 Cours Albert Thomas, Lyon Cedex 03, France
    Hepatology 35:1215-24. 2002
  6. ncbi request reprint Cloning and expression of surface antigens from occult chronic hepatitis B virus infections and their recognition by commercial detection assays
    Damien Jeantet
    U271 INSERM, Lyon, France
    J Med Virol 73:508-15. 2004
  7. ncbi request reprint What is really ongoing during occult HBV reactivation?
    Isabelle Chemin
    Hepatology 43:195; author reply 195-6. 2006
  8. ncbi request reprint HDV genotypes in the Western Brazilian Amazon region: A preliminary report
    Raymundo Parana
    Gonçalo Moniz Research Center, Salvador, Brazil INSERM Unit 271, Universite Claude Bernard Lyon 1, IFR 62, Lyon, France
    Am J Trop Med Hyg 75:475-9. 2006

Collaborators

  • Fabien Zoulim
  • Christian Trepo
  • I Chemin
  • Sebastião Viana
  • Séverine Margeridon
  • Damien Jeantet
  • Juliette Hayer
  • Raymundo Parana
  • Bernard Mandrand
  • Gilbert Deleage
  • Fanny Jadeau
  • Christophe Combet
  • Luc Barraud
  • Sandra Carrouée-Durantel
  • Juan Miguel Salcedo
  • Jose Tavares-Neto
  • Felix Molinet
  • Luciana Matteoni
  • Pedro Tauil
  • Argemiro D'Oliveira
  • Luciano Kalabric Silva
  • Márcio Rios-Leite
  • Cirley Lobato
  • Alain Lachaux
  • Philippe Merle
  • Albert Tran

Detail Information

Publications8

  1. ncbi request reprint Hepatitis B virus genetic variability and evolution
    Alan Kay
    INSERM, U871, Physiopathologie moléculaire et nouveaux traitements des hépatites virales, 151 Cours A Thomas, Lyon F 69424, France
    Virus Res 127:164-76. 2007
    ..Also, human intervention in the form of mass vaccination and antiviral treatment will reduce the burden of HBV-related liver disease but may also be accelerating evolution of the virus...
  2. pmc Rolling circle amplification, a powerful tool for genetic and functional studies of complete hepatitis B virus genomes from low-level infections and for directly probing covalently closed circular DNA
    Séverine Margeridon
    INSERM, U871, Lyon, France
    Antimicrob Agents Chemother 52:3068-73. 2008
    ..It can also be used to probe HBV cccDNA, the crucial intermediate in viral persistence and the archive of resistance mutations...
  3. ncbi request reprint A quasi-monoclonal anti-HBs response can lead to immune escape of 'wild-type' hepatitis B virus
    Séverine Margeridon
    INSERM U271, 151 Cours A Thomas, 69003 Lyon, France
    J Gen Virol 86:1687-93. 2005
    ..This study underlines the subtleties of virus-host interactions. Implications for HBV vaccination are discussed...
  4. pmc HBVdb: a knowledge database for Hepatitis B Virus
    Juliette Hayer
    Unité Bases Moléculaires et Structurales des Systèmes Infectieux, Lyon, France
    Nucleic Acids Res 41:D566-70. 2013
    ..The database can be accessed through a web interface that allows static and dynamic queries and offers integrated generic sequence analysis tools and specialized analysis tools (e.g. annotation, genotyping, drug resistance profiling)...
  5. ncbi request reprint Characterization of two hepatitis B virus populations isolated from a hepatitis B surface antigen-negative patient
    Damien Jeantet
    U271 INSERM, 151 Cours Albert Thomas, Lyon Cedex 03, France
    Hepatology 35:1215-24. 2002
    ..In conclusion, the cryptic nature of this double HBV infection is characterized by the predominance of the replication-deficient genotype D virus over the replication-competent genotype A virus...
  6. ncbi request reprint Cloning and expression of surface antigens from occult chronic hepatitis B virus infections and their recognition by commercial detection assays
    Damien Jeantet
    U271 INSERM, Lyon, France
    J Med Virol 73:508-15. 2004
    ..Most of the isolates fall into the second category. Mutations can therefore contribute to HBsAg seronegativity in occult HBV infections, but in most cases the explanation is probably the low level of viral replication...
  7. ncbi request reprint What is really ongoing during occult HBV reactivation?
    Isabelle Chemin
    Hepatology 43:195; author reply 195-6. 2006
  8. ncbi request reprint HDV genotypes in the Western Brazilian Amazon region: A preliminary report
    Raymundo Parana
    Gonçalo Moniz Research Center, Salvador, Brazil INSERM Unit 271, Universite Claude Bernard Lyon 1, IFR 62, Lyon, France
    Am J Trop Med Hyg 75:475-9. 2006
    ..Our preliminary results show that HDV genotypes I and III are present in Brazilian Amazonia and that HDV genotype III is not limited to the Amerindian population...