Research Topics
Species | Carine KarachiSummaryCountry: France Publications
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Publications
Three-dimensional cartography of functional territories in the human striatopallidal complex by using calbindin immunoreactivityCarine Karachi
INSERM U289, Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, 75013 Paris, France
J Comp Neurol 450:122-34. 2002..This three-dimensional partitioning of the human striatopallidal complex could help to define functional targets for high-frequency stimulation with greater accuracy and help to identify new stimulation sites...
The pallidosubthalamic projection: an anatomical substrate for nonmotor functions of the subthalamic nucleus in primatesCarine Karachi
INSERM U289, Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, Paris, France
Mov Disord 20:172-80. 2005..These data provide a functional cartography of this structure in primates and suggest that behavioral disorders observed in stimulated parkinsonian patients could result from a dysfunction of the limbic part of the STN...
Dysfunction of the subthalamic nucleus induces behavioral and movement disorders in monkeysCarine Karachi
INSERM, UMR_S679, Neurology and Experimental Therapeutics, Paris, France
Mov Disord 24:1183-92. 2009..Our study supports the hypothesis that the anteromedial part of the STN is involved in behavioral control...
Normal and pathological gait: what we learn from Parkinson's diseaseDavid Grabli
Universite Pierre et Marie Curie Paris 6, CR Icm, UMR S975, Paris, France
J Neurol Neurosurg Psychiatry 83:979-85. 2012..In addition, we review recent evidence regarding functional neurosurgery for gait disorders in PD and propose new directions for future therapeutic research...
Thalamic stimulation for tremor: can target determination be improved?Eric Bardinet
Universite Pierre et Marie Curie PARIS6, Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, Paris, France
Mov Disord 26:307-12. 2011..In clinical practice, this means that microelectrode exploration during Vim surgery should include at least one trajectory more medial than the statistical target...
Does unilateral basal ganglia activity functionally influence the contralateral side? What we can learn from STN stimulation in patients with Parkinson's diseaseYohann Brun
1Centre de Recherche de l Institut du Cerveau et de la Moelle Épiniere, UMR S975, Paris, France
J Neurophysiol 108:1575-83. 2012....
Internal pallidum and substantia nigra control different parts of the mesopontine reticular formation in primateAnne Sophie Rolland
Universite Pierre et Marie Curie Paris 6, CR Icm, UMR S975, INSERM, U975, CNRS, UMR 7225, Assistance Publique Hopitaux de Paris, Groupe Pitié Salpêtrière, Paris, France
Mov Disord 26:1648-56. 2011..These findings support the functional hypothesis that the nigro-cuneiform nucleus pathway could control axial posture whereas the pallido-pedunculopontine nucleus pathway could modulate locomotion...
Evidence for a dopaminergic innervation of the pedunculopontine nucleus in monkeys, and its drastic reduction after MPTP intoxicationAnne Sophie Rolland
INSERM, UMR_S975, Experimental Therapeutics of Neurodegeneration, Paris, France
J Neurochem 110:1321-9. 2009....
Functional parcellation of the lateral mesencephalusCarine Karachi
Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, 75013 Paris, France
J Neurosci 32:9396-401. 2012....
Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson diseaseCarine Karachi
Universite Pierre et Marie Curie Paris 6, CR Icm, UMR S975, Paris, France
J Clin Invest 120:2745-54. 2010..Our data therefore reveal that the cholinergic neurons of the PPN play a central role in controlling gait and posture and represent a possible target for pharmacological treatment of gait disorders in PD...
A three-dimensional, histological and deformable atlas of the human basal ganglia. I. Atlas construction based on immunohistochemical and MRI dataJerome Yelnik
INSERM U679, Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, Universite Pierre et Marie Curie, Faculte de Medecine, Paris, France
Neuroimage 34:618-38. 2007..This latter aspect will be presented in a forthcoming paper...
Bilateral deep brain stimulation of the pallidum for myoclonus-dystonia due to ε-sarcoglycan mutations: a pilot studyJulie Azoulay-Zyss
Service de Neurologie, Groupe Hospitalier Paris Saint Joseph, Universite Paris 5, Paris, France
Arch Neurol 68:94-8. 2011..To assess the efficacy of bilateral deep brain stimulation of the internal pallidum in patients with myoclonus-dystonia due to genetically proved ε-sarcoglycan (SGCE-M-D) deficiency...
Critical roles for anterior insula and dorsal striatum in punishment-based avoidance learningStefano Palminteri
Motivation, Brain and Behavior MBB Team, Institut du Cerveau et de la Moëlle épinière ICM, Hopital de la Pitie Salpetriere, 75013 Paris, France
Neuron 76:998-1009. 2012....
Behavioural disorders induced by external globus pallidus dysfunction in primates II. Anatomical studyChantal Francois
Neurologie et Thérapeutique Expérimentale, INSERM U289, Hopital de la Salpetriere, Paris, France
Brain 127:2055-70. 2004..This study provides the basis for further researches with a therapeutical viewpoint...
High-frequency stimulation of the anterior subthalamic nucleus reduces stereotyped behaviors in primatesNicolas Baup
Departement de Psychiatrie, Centre Hospitalier Saint Anne, Paris F 75014, France
J Neurosci 28:8785-8. 2008..Electrode trajectories, reconstructed postmortem, confirmed that the effective contacts were in the anterior STN. DBS in the limbic STN might therefore provide relief from the severe stereotyped behaviors observed in OCD and TS...
Internal pallidal and thalamic stimulation in patients with Tourette syndromeMarie Laure Welter
National Institute of Health and Medical Research INSERM, Unit 679, Pierre et Marie Curie University Paris 6, France
Arch Neurol 65:952-7. 2008....
