J Kanitakis

..Past medical history included polydactylism of the feet and clinodactyly of the thumbs (both corrected surgically), respiratory tract infections, Wolf-Parkinson-White syndrome and refractive errors necessitating glasses...

..From a diagnostic point of view, the expression of CD10 appears to be an additional feature for the histological differential diagnosis between primary and metastatic melanomas...

..The diagnosis can be confirmed either by molecular analysis or by ultrastructural examination of the brain or more simply the skin...

..So far little or conflicting data exist concerning the expression of CD10 in normal and pathologic skin...

..We report herein the case of a benign naevus associating ossification and mummification; this case suggests that, similarly to pilomatricomas, osteoma formation within melanocytic naevi may develop as a result of mummification...

..This article reviews the main data concerning the anatomy, histology and immunohistochemistry of normal human skin...

..We report herein the ninth case of multiple eruptive dermato fibromas associated with HIV infection. The relevant literature is reviewed and the differences of these lesions from "ordinary" dermatofibromas are discussed...

..From a practical point of view, immunostaining for K15 seems to be an additional useful adjunct for the differential diagnosis between basal cell carcinoma and trichoepithelioma...

..Since recurring tumours are more likely to spread metastatically, our results upheld the contention that a higher expression of the Tn antigen is correlated with a more aggressive course of cutaneous squamous cell carcinomas...

..To study the immunohistochemical expression of the Thomsen-Friedenreich antigen (T) and its precursor, Tn, in the skin in various cancers...

..We conclude that antibodies to peripherin may be used for the demonstration of cutaneous neurons in normal and diseased skin; however their diagnostic usefulness appears limited, less than that of antibodies to neurofilaments...

..Radiotherapy should be reserved to limited cases. Prevention must be undertaken by a regular dermatological examination and sun protection...

..The expression of receptors for neuropeptides in the skin is modified in skin diseases...

..This finding, together with our previous biochemical studies, suggests that corneodesmosin may exert a protective function against proteolytic degradation of corneodesmosomes both in normal skin and in the pathological horny layer...

..On the basis of our results, we speculate that these cells could represent uncommitted mesenchymal cells, unique by virtue of CD34 antigen expression...

..Skin cancers were not encountered, but the risk of carcinomas in early adulthood should be considered...

..This case suggests that CPH can undergo malignant transformation, probably as a result of actinic damage. On this occasion, a complete literature review of CPH is presented...

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..We review here the main clinicopathological and therapeutic features of mammary and extramammary Paget's disease...

..We report a case of metastatic hepatocellular carcinoma to the skin that was confirmed immunohistochemically by the expression of a hepatomitochondria-specific antigen detectable on paraffin-embedded sections (Hep Par 1)...

..It further underscores the nosologic heterogeneity of LABD, which probably includes, apart from bullous pemphigoid, epidermolysis bullosa acquisita and cicatricial pemphigoid...

..We report the fifth case occurring in a child without Down syndrome. Milia-like idiopathic calcinosis cutis has long been regarded as a peculiar subtype of idiopathic calcinosis cutis. The pathogenesis of the disorder remains unclear...

..5 mg/kg/day, we favor the diagnosis of vulvar cicatricial pemphigoid. Only two such cases have been reported thus far. The diagnostic criteria and therapeutic modalities are discussed...

..We present herein a new typical case of this tumor that was studied immunohistochemically, and review the relevant literature in order to delineate its clinicopathological features...

..Prevention consists of regular use of a flea-control product in cats and prompt cleaning of scratches. Our cases highlight several original features of this rare condition, which could potentially improve the management of BA in OTR...

..The discovery of the Human Herpes virus 8 (HHV8) improved our knowledge of the pathogenesis of Kaposi's sarcoma. After organ transplantation, Kaposi's sarcoma exhibits distinctive features compared with other forms of the disease...

..Toxidermia is a well-known complication of antidepressor therapy, often related to photosensitization. The authors report an original case of amoxapine-related acute generalized exanthematous pustulosis which regressed at drug withdrawal...

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..Malignant transformation remains a rare, under-recognized and ominous, complication of leg ulcers, although its exact prevalence is unknown...

..The main tumours falling into this category and their associated syndromes are reviewed here...

..Reactivation of latent dermal melanocytes should explain the pathogenesis of acquired forms. Ultrastructural examinations show an extracellular sheath enclosing dermal melanocytes in all types of dermal melanocytosis...

..In these cases of CTA no signs of chronic graft rejection have been detected. However, the possibility that chronic rejection may develop in CTA exists, highlighting the necessity of close continuous follow-up of the patients...

..This case confirms that infections may be a possible cause of NEH and underlines the necessity to search for infective agents, especially in patients immunocompromised by haematopoietic malignancies and/or chemotherapeutic treatments...

..Moreover, LOX protein plays a role in the skin carcinomas and invasion but not through its enzymatic activity...

..The aim of this study was to compare the individual rate of subsequent skin cancers in kidney (KTR) and heart transplant recipients (HTR) after the first squamous cell carcinoma (SCC) and to assess risk factors for tumor multiplicity...

..These results suggest that p63 may be a useful adjunct in the diagnosis of skin carcinomas; however, contrary to what has been previously claimed, expression of p63 does not rule out the metastatic origin of a cutaneous carcinoma...

..The first human face allograft was performed in France on November 27, 2005. We report herein the clinicopathologic findings from the skin and oral mucosa of this allograft during the first eight months...

..Whereas skin is known to be highly immunogenic, grafts have been well accepted up to now. Therefore, here we investigated the putative presence of regulatory T cells in the graft...

..We describe the first case of trichilemmal carcinoma presenting with a misleading clinical aspect in a heart transplant recipient. We then briefly outline the salient clinicopathologic features of this malignancy...

..We performed the first human partial face allograft on November 27, 2005. Here we report outcomes up to 18 months after transplantation...

..We speculate that this lesion developed from pre-existing Bowen's disease extending to the hair follicles...

..No human leukocyte antigen alloantibodies were detected in any of the patients during the study period. These results suggest that humoral rejection occurs rarely, if at all, in the setting of human composite tissue allografts...

..Merkel cell carcinoma is an uncommon neuroendocrine skin tumor, of which 67 cases have been reported up till now, usually briefly, in organ transplant patients...

..Based on a review of the literature, the salient features of GBCC are discussed...

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..The first human hand allograft, performed in Lyon, France, on September 23, 1998, was removed during month 29 posttransplantation as the result of rejection because the patient did not comply with the immunosuppressive treatment...

..These findings further support the contention that cutaneous lesions of FDH may be progressive, and provide a physiopathologic basis for understanding the hyperpigmented lesions of FDH...

..Cytokines triggered in the course of organ transplantation include IL-10. This molecule may induce expression of HLA-G, which in turn may be implicated in tumor development in transplanted recipients...

..These biologicals have opened a new era for the management of this disease; they are reviewed in this article, based on data available in the literature...

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..To assess the clinicopathologic features of basal cell carcinomas developing in organ transplant recipients...

..No signs of graft-versus-host disease have been detected. This case of double hand transplantation shows that conventional immunosuppression is effective and safe to ensure survival and functional recovery of the grafted limb...

..This might contribute to the impairment of LC reconstitution in the skin of patients with GVHD...

..By analogy with melanoacanthoma, a tumor consisting of a combined proliferation of epidermal keratinocytes and melanocytes, we called this tumor "melanotrichoblastoma" and view it as a peculiar variant of (pigmented) TB...

..In conclusion, stem cells originating from a grafted kidney may migrate to the skin, differentiate, or fuse as keratinocytes that could, rarely, undergo cancer transformation...

..Hep Par 1 should be used with caution in the investigation of cutaneous metastases from an unknown primary site, preferably in conjunction with other markers of neoplastic hepatocytes...

..No association between TP53 arginine/arginine genotype and human papillomavirus status could be determined, however...

..Although several studies have been devoted to adult transplant patients, few data are available on the long-term skin malignancies following pediatric organ transplantation...

..The factors enhancing Kaposi's sarcoma associated with the HHV8 virus remain to be defined. The possibility of transmission of the infection through the graft must lead to the systematic search for this virus in the donors...

..This unique observation suggests that retransplantation of patients with previous posttransplantation KS is possible...

..These data suggest that cytotoxic activity occurs in situ in American cutaneous leishmaniasis and that both NK cells and activated CD8+ T cells are involved in this reaction...

..In addition, the unaffected, heterozygous carriers of the mutation indicate that the K10 peptide from one normal allele alone is sufficient for keratin network formation...

..Denial tended to lessen as the new grafted hands gained in sensitivity and motricity...

..The salient clinicopathological features of this disease are briefly reviewed...

..We report herein a new case of Grover's disease that developed in a renal transplant patient. To the best of our knowledge, this is the first observation of Grover's disease developing in the setting of solid organ transplantation...

..Subsequently, cutaneous changes resembling pseudoxanthoma elasticum (PXE) were observed in patients treated with DPA and were reported as pseudo-PXE...

..This may have important implications for the prevention of UV-induced skin cancers...