Vincent Jullien

Summary

Country: France

Publications

  1. pmc Efficacy of artesunate-amodiaquine and artemether-lumefantrine fixed-dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria among children aged six to 59 months in Nimba County, Liberia: an open-label randomized non-inferiority
    Birgit Schramm
    Epicentre, 75011 Paris, France
    Malar J 12:251. 2013
  2. pmc Pharmacokinetics and diffusion into sputum of oseltamivir and oseltamivir carboxylate in adults with cystic fibrosis
    V Jullien
    Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris AP HP, Paris, France
    Antimicrob Agents Chemother 55:4183-7. 2011
  3. ncbi request reprint [Pharmacokinetics-pharmacodynamics of antifungal drugs. Consequences for therapeutic drug monitoring]
    Vincent Jullien
    Universite Paris Descartes, Faculte de Medecine, Paris, France
    Therapie 61:209-17. 2006
  4. pmc Population analysis of weight-, age-, and sex-related differences in the pharmacokinetics of lopinavir in children from birth to 18 years
    Vincent Jullien
    Service de Pharmacologie Clinique, Groupe Hospitalier Cochin Saint Vincent De Paul, 74 82 Avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    Antimicrob Agents Chemother 50:3548-55. 2006
  5. pmc Age-related differences in the pharmacokinetics of stavudine in 272 children from birth to 16 years: a population analysis
    V Jullien
    Université Paris Descartes Faculté de Médecine, France
    Br J Clin Pharmacol 64:105-9. 2007
  6. pmc Population pharmacokinetics of tenofovir in human immunodeficiency virus-infected patients taking highly active antiretroviral therapy
    Vincent Jullien
    Service de Pharmacologie Clinique, Hopital Cochin Saint Vincent de Paul, 74 82 Avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    Antimicrob Agents Chemother 49:3361-6. 2005
  7. doi request reprint [Pharmacokinetics and pharmacodynamics of antifungal drugs in children]
    V Jullien
    Universite Paris Descartes, Inserm U 663, Service de Pharmacologie Clinique, Hopital Saint Vincent de Paul, 74 82, avenue Denfert Rochereau, 75014 Paris, France
    Arch Pediatr 18:S42-7. 2011
  8. ncbi request reprint Change to a once-daily combination including boosted atazanavir in HIV-1-infected children
    Eugenia Macassa
    Unité d Immunologie Hématologie Pédiatrique, Paris, France
    Pediatr Infect Dis J 25:809-14. 2006
  9. ncbi request reprint Abacavir pharmacokinetics in human immunodeficiency virus-infected children ranging in age from 1 month to 16 years: a population analysis
    Vincent Jullien
    Pharmacologie Clinique, Universite Rene Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    J Clin Pharmacol 45:257-64. 2005
  10. pmc Pharmacokinetic modelling of the placental transfer of nelfinavir and its M8 metabolite: a population study using 75 maternal-cord plasma samples
    Deborah Hirt
    Pharmacologie Clinique, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Cochin Saint Vincent De Paul, Faculté de Médecine René Descartes, Universite Paris 5, Paris, France
    Br J Clin Pharmacol 64:634-44. 2007

Collaborators

Detail Information

Publications35

  1. pmc Efficacy of artesunate-amodiaquine and artemether-lumefantrine fixed-dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria among children aged six to 59 months in Nimba County, Liberia: an open-label randomized non-inferiority
    Birgit Schramm
    Epicentre, 75011 Paris, France
    Malar J 12:251. 2013
    ....
  2. pmc Pharmacokinetics and diffusion into sputum of oseltamivir and oseltamivir carboxylate in adults with cystic fibrosis
    V Jullien
    Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris AP HP, Paris, France
    Antimicrob Agents Chemother 55:4183-7. 2011
    ..This should nevertheless be confirmed by a controlled pharmacokinetic study performed on a larger number of patients...
  3. ncbi request reprint [Pharmacokinetics-pharmacodynamics of antifungal drugs. Consequences for therapeutic drug monitoring]
    Vincent Jullien
    Universite Paris Descartes, Faculte de Medecine, Paris, France
    Therapie 61:209-17. 2006
    ..The main causes explaining this lack of data are reviewed and the possible use in humans of the parameters obtained from animal models is discussed...
  4. pmc Population analysis of weight-, age-, and sex-related differences in the pharmacokinetics of lopinavir in children from birth to 18 years
    Vincent Jullien
    Service de Pharmacologie Clinique, Groupe Hospitalier Cochin Saint Vincent De Paul, 74 82 Avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    Antimicrob Agents Chemother 50:3548-55. 2006
    ..The consequences of these pharmacokinetic discrepancies and the necessity to modify the currently recommended dosage regimen should be further investigated...
  5. pmc Age-related differences in the pharmacokinetics of stavudine in 272 children from birth to 16 years: a population analysis
    V Jullien
    Université Paris Descartes Faculté de Médecine, France
    Br J Clin Pharmacol 64:105-9. 2007
    ..To develop a population pharmacokinetic model for stavudine in children and to investigate the consistency of the currently recommended dose based on adult target concentrations...
  6. pmc Population pharmacokinetics of tenofovir in human immunodeficiency virus-infected patients taking highly active antiretroviral therapy
    Vincent Jullien
    Service de Pharmacologie Clinique, Hopital Cochin Saint Vincent de Paul, 74 82 Avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    Antimicrob Agents Chemother 49:3361-6. 2005
    ..In patients without tubular dysfunction, AUC(0-24) values markedly decreased from 6.7 to 1.4 mg . h/liter for BW/S(CR) increasing from 0.44 to 1.73. The relevance of a dosage adjustment based on BW/S(CR) should be further evaluated...
  7. doi request reprint [Pharmacokinetics and pharmacodynamics of antifungal drugs in children]
    V Jullien
    Universite Paris Descartes, Inserm U 663, Service de Pharmacologie Clinique, Hopital Saint Vincent de Paul, 74 82, avenue Denfert Rochereau, 75014 Paris, France
    Arch Pediatr 18:S42-7. 2011
    ..This article reviews the pharmacokinetic profiles of these drugs in children, with a focus on the age-related changes. The concentration/efficacy relationships that were evidenced in children are also described...
  8. ncbi request reprint Change to a once-daily combination including boosted atazanavir in HIV-1-infected children
    Eugenia Macassa
    Unité d Immunologie Hématologie Pédiatrique, Paris, France
    Pediatr Infect Dis J 25:809-14. 2006
    ..Pediatric experience with atazanavir combined with antiretroviral drugs administered once daily is very limited...
  9. ncbi request reprint Abacavir pharmacokinetics in human immunodeficiency virus-infected children ranging in age from 1 month to 16 years: a population analysis
    Vincent Jullien
    Pharmacologie Clinique, Universite Rene Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    J Clin Pharmacol 45:257-64. 2005
    ..5 +/- 2.5 mg x h/L, which is slightly greater than the mean AUC value reported in adults. This study confirms the relevance of the current weight-based abacavir dosage regimen in pediatric patients...
  10. pmc Pharmacokinetic modelling of the placental transfer of nelfinavir and its M8 metabolite: a population study using 75 maternal-cord plasma samples
    Deborah Hirt
    Pharmacologie Clinique, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Cochin Saint Vincent De Paul, Faculté de Médecine René Descartes, Universite Paris 5, Paris, France
    Br J Clin Pharmacol 64:634-44. 2007
    ..A population pharmacokinetic model was developed to characterize the transfer of nelfinavir and its active metabolite M8 from maternal to cord plasma and amniotic fluid...
  11. pmc Pregnancy-related effects on nelfinavir-M8 pharmacokinetics: a population study with 133 women
    Deborah Hirt
    Pharmacologie Clinique, Hopital Saint Vincent de Paul, Paris, France
    Antimicrob Agents Chemother 50:2079-86. 2006
    ..The Bayesian individual pharmacokinetic estimates suggested that the dosage should not be changed in pregnant women but may be doubled on the day of delivery...
  12. doi request reprint A population analysis of weight-related differences in lopinavir pharmacokinetics and possible consequences for protease inhibitor-naive and -experienced patients
    Marion Bouillon-Pichault
    Universite Paris Descartes, Paris, France
    Antivir Ther 14:923-9. 2009
    ..However, the probability to achieve these target C(troughs) with the current 400 mg twice-daily or 800 mg once-daily doses of the new tablet form, and the influence of body weight on this probability are unknown...
  13. doi request reprint Therapeutic drug monitoring of voriconazole after intravenous administration in infants and children with primary immunodeficiency
    Magdalena Gerin
    Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Paris, France
    Ther Drug Monit 33:464-6. 2011
    ..The aim of this work was to describe the probability of not achieving this target concentration in infants and children receiving intravenous voriconazole...
  14. ncbi request reprint Predictive factors of virologic success in HIV-1-infected children treated with lopinavir/ritonavir
    Constance Delaugerre
    Service de Virologie EA 3620, Hopital Necker Enfants Malades, Paris, France
    J Acquir Immune Defic Syndr 37:1269-75. 2004
    ..In pretreated children, LPV plasma levels should be optimized in an attempt to achieve sufficient drug concentrations to overcome the resistance level...
  15. doi request reprint Population analysis of the pregnancy-related modifications in lopinavir pharmacokinetics and their possible consequences for dose adjustment
    Marion Bouillon-Pichault
    Universite Paris Descartes, France
    J Antimicrob Chemother 63:1223-32. 2009
    ..To investigate the possible necessity of an increase in lopinavir dose during pregnancy in order to achieve the concentrations previously defined as predictive of virological efficacy...
  16. pmc Therapeutic drug monitoring of posaconazole: a monocentric study with 54 adults
    David Lebeaux
    Universite Paris Descartes, Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Centre d Infectiologie Necker Pasteur, Paris, France
    Antimicrob Agents Chemother 53:5224-9. 2009
    ..Therapeutic drug monitoring of posaconazole is therefore mandatory for immunosuppressed adults, at least for those with gastrointestinal disorders...
  17. doi request reprint Population pharmacokinetics of levetiracetam and dosing recommendation in children with epilepsy
    Stephanie Chhun
    Universite Paris Descartes, AP HP, Service de Pharmacologie Clinique, Groupe Hospitalier Cochin Saint Vincent De Paul, Paris, France
    Epilepsia 50:1150-7. 2009
    ..To develop a population pharmacokinetic model to evaluate the demographic and physiologic determinants of levetiracetam (LEV) pharmacokinetics (PK) and to suggest recommended doses of LEV in children...
  18. ncbi request reprint Simultaneous quantification of voriconazole and posaconazole in human plasma by high-performance liquid chromatography with ultra-violet detection
    Stephanie Chhun
    Universite Paris V, Faculté de Médecine René Descartes, Assistance Publique Hopitaux de Paris, Service de Pharmacologie Clinique, Groupe Hospitalier Cochin Saint Vincent De Paul, 74 82 Avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    J Chromatogr B Analyt Technol Biomed Life Sci 852:223-8. 2007
    ..The mean recovery was 98% for voriconazole and 108% for posaconazole. This method provides a useful tool for therapeutic drug monitoring...
  19. pmc Maternal-fetal transfer and amniotic fluid accumulation of nucleoside analogue reverse transcriptase inhibitors in human immunodeficiency virus-infected pregnant women
    Helene Chappuy
    Pharmacology, Hopital Cochin Saint Vincent de Paul, 82, avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    Antimicrob Agents Chemother 48:4332-6. 2004
    ..The efficacy or toxicity of NRTIs may vary according to placental transfer...
  20. ncbi request reprint Increased beta-2 microglobulinuria in human immunodeficiency virus-1-infected children and adolescents treated with tenofovir
    Andrea Papaleo
    Unité d Immunologie Hématologie Pédiatriques, Hôpital Necker Enfants Malades Assistance Publique Hôpitaux de Paris APHP et Faculté de médecine René Descartes, EA 3620 Université Paris V, Paris, France
    Pediatr Infect Dis J 26:949-51. 2007
    ..In view of the very long duration of treatments for HIV infection, their possible consequences for the child's growing body should be carefully evaluated...
  21. ncbi request reprint Quantification of tipranavir in human plasma by high-performance liquid chromatography with UV detection
    Emmanuelle Giraud
    Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Cochin Saint Vincent De Paul, Pharmacologie Clinique, France
    J Chromatogr B Analyt Technol Biomed Life Sci 830:86-90. 2006
    ..The method was linear and has been validated over a concentration range of 2-80 mg/l. The mean precision and accuracy of the method were respectively, 10.5 and -9.1%. The mean recovery was 70.8%...
  22. doi request reprint Suboptimal ciprofloxacin dosing as a potential cause of decreased Pseudomonas aeruginosa susceptibility in children with cystic fibrosis
    Emmanuelle Guillot
    Universite Paris Descartes, Paris, France
    Pharmacotherapy 30:1252-8. 2010
    ..To assess the probability of achieving ciprofloxacin pharmacodynamic targets with currently recommended dosages in order to investigate the risk of ciprofloxacin underexposure in children with cystic fibrosis...
  23. doi request reprint Simultaneous determination of three carbapenem antibiotics in plasma by HPLC with ultraviolet detection
    Tiphaine Legrand
    Universite Paris Descartes, INSERM, U663, Service de Pharmacologie Clinique, Groupe Hospitalier Cochin Saint Vincent De Paul, AP HP, 75014 Paris, France
    J Chromatogr B Analyt Technol Biomed Life Sci 875:551-6. 2008
    ..5 and 8.1% and precision below 10.4%. Mean recoveries were 82.2, 90.8 and 87.7% for imipenem, meropenem and ertapenem, respectively. This method provides a useful tool for the therapeutic drug monitoring of carbapenems...
  24. doi request reprint Pharmacokinetic design optimization in children and estimation of maturation parameters: example of cytochrome P450 3A4
    Marion Bouillon-Pichault
    Universite Paris Descartes, Paris, France
    J Pharmacokinet Pharmacodyn 38:25-40. 2011
    ..First-pass effects, alternative elimination routes, and combined elimination pathways should also be investigated...
  25. pmc Population pharmacokinetics of clindamycin orally and intravenously administered in patients with osteomyelitis
    Naïm Bouazza
    EA 3620, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
    Br J Clin Pharmacol 74:971-7. 2012
    ....
  26. ncbi request reprint Determination of tenofovir in human plasma by high-performance liquid chromatography with spectrofluorimetric detection
    Vincent Jullien
    Service de Pharmacologie Clinique, Universite Rene Descartes, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique Hopitaux de Paris, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    J Chromatogr B Analyt Technol Biomed Life Sci 785:377-81. 2003
    ..The average coefficient of the limit of quantification (5 microg/l) was 5.38% and at this concentration, a signal-to-noise ratio of 500 was measured..
  27. doi request reprint Quantification of seven nucleoside/nucleotide reverse transcriptase inhibitors in human plasma by high-performance liquid chromatography with tandem mass-spectrometry
    Thomas Le Saux
    Universite Paris Descartes, Faculte de Medecine, Service de Pharmacologie Clinique, Groupe Hospitalier Cochin Saint Vincent De Paul, Assistance Publique, Hopitaux de Paris, France
    J Chromatogr B Analyt Technol Biomed Life Sci 865:81-90. 2008
    ..The method has been implemented to assess plasma concentrations of patients infected by HIV and was found suitable for therapeutic drug monitoring...
  28. ncbi request reprint Influence of burns on pharmacokinetics and pharmacodynamics of drugs used in the care of burn patients
    Benoit Blanchet
    Department of Pharmacy toxicology, GH Cochin Saint Vincent de Paul, Paris, France
    Clin Pharmacokinet 47:635-54. 2008
    ..Methods based only on individual data or on a surrogate marker for efficacy may be used to optimize the dosing regimen in this population...
  29. ncbi request reprint Pharmacokinetics of tenofovir in haemodialysis
    Hassane Izzedine
    Department of Nephrology, Pitie Salpetriere Hospital, Paris, France
    Nephrol Dial Transplant 18:1931-3. 2003
  30. doi request reprint A physiological model to evaluate drug kinetics in patients with hemorrhagic shock followed by fluid resuscitation. Application to amoxicillin-clavulanate
    Michel Tod
    Pharmacie Toxicologie, CHU Cochin Saint Vincent de Paul, AP HP, Paris, France
    Pharm Res 25:1431-9. 2008
    ....
  31. doi request reprint Topiramate pharmacokinetics in infants and young children: contribution of population analysis
    Marion Bouillon-Pichault
    INSERM, U663, Paris F 75015, France
    Epilepsy Res 93:208-11. 2011
    ..To determine the range of topiramate (TPM) concentrations obtained in children under 4 with the recommended dosage regimen (3-9 mg/kg/day) and to compare them to adult target ranges...
  32. pmc Evaluation of cefotaxime and desacetylcefotaxime concentrations in cord blood after intrapartum prophylaxis with cefotaxime
    Jacques Lepercq
    Universite Paris Descartes, and Service de Gynécologie Obstétrique, Groupe Hospitalier Cochin Saint Vincent De Paul, 82, avenue Denfert Rochereau, Paris 75014, FranceParis, France
    Antimicrob Agents Chemother 53:2342-5. 2009
    ..The effectiveness of this regimen for the prevention of neonatal sepsis needs to be evaluated with a larger population...
  33. ncbi request reprint Facilitation of drug evaluation in children by population methods and modelling
    Michel Tod
    Department of Pharmacy toxicology, Hopital Cochin Saint Vincent de Paul, Paris, FranceEA 3738, Universite Lyon 1, Universite de Lyon, Lyon, France
    Clin Pharmacokinet 47:231-43. 2008
    ..Finally, the related technique of clinical trial simulation and its applications are presented and discussed...
  34. pmc Age-related effects on nelfinavir and M8 pharmacokinetics: a population study with 182 children
    Deborah Hirt
    Pharmacologie Clinique, Assistance Publique Hôpitaux Paris, France
    Antimicrob Agents Chemother 50:910-6. 2006
    ..This assumption should be further evaluated...
  35. ncbi request reprint Quantification of darunavir (TMC114) in human plasma by high-performance liquid chromatography with ultra-violet detection
    Lauriane Goldwirt
    Universite Paris V, Faculté de Médecine René Descartes, Assistance Publique Hopitaux de Paris, France
    J Chromatogr B Analyt Technol Biomed Life Sci 857:327-31. 2007
    ..7 and -11.4%. The mean recovery was 75.7% for darunavir and 66.7% for methylclonazepam. This method provides a useful tool for therapeutic drug monitoring in HIV patients...