Research Topics
Genomes and Genes | Nathalie JossoSummaryCountry: France Publications
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Publications
Testicular anti-Müllerian hormone: history, genetics, regulation and clinical applicationsNathalie Josso
Unite de Recherches sur l Endocrinologie et la Genetique de la Reproduction et du Developpment INSERM, Universite Paris XI, Clamart, France
Pediatr Endocrinol Rev 3:347-58. 2006..AMH is an excellent marker of prepubertal testicular function and has gained recognition as a valuable marker of follicular reserve in adult women...
AMH and AMH receptor defects in persistent Müllerian duct syndromeNathalie Josso
Unité de Recherches sur l Endocrinologie du Développement INSERM, Université Paris XI Clamart, France
Hum Reprod Update 11:351-6. 2005..In 15% of cases, the cause of the persistent Mullerian duct syndrome is unknown and could be related to complex malformations of the urogenital region, unrelated to AMH physiology...
Transduction pathway of anti-Müllerian hormone, a sex-specific member of the TGF-beta familyNathalie Josso
Unité de Recherches sur l Endocrinologie du Développement INSERM, Institut Paris Sud sur les Cytokines, 32 rue des Carnets, 92140 Clamart, France
Trends Endocrinol Metab 14:91-7. 2003....
The undervirilized male child: endocrine aspectsN Josso
, Institut de Recherches sur les Cytokines, Clamart, France
BJU Int 93:3-5. 2004
Processing of anti-mullerian hormone regulates receptor activation by a mechanism distinct from TGF-betaNathalie di Clemente
Institut National de la Santé et de la Recherche Médicale U782, 32 rue des Carnets, Clamart F 92140, France
Mol Endocrinol 24:2193-206. 2010..AMH thus exemplifies a new mechanism for receptor engagement in which interaction with the type II receptor promotes pro-region dissociation to generate mature ligand...
Role of type I receptors for anti-Müllerian hormone in the SMAT-1 Sertoli cell lineCorinne Belville
Institut National de la Sante et de la Recherche Medicale, Unité 493 sur l Endocrinologie du Développement, Universite Paris XI, 32 rue des Carnets, 92140 Clamart, France
Oncogene 24:4984-92. 2005..These results are a first step in understanding how AMH transduces its effects in immature Sertoli cells...
Natural mutations of the anti-Mullerian hormone type II receptor found in persistent Mullerian duct syndrome affect ligand binding, signal transduction and cellular transportCorinne Belville
INSERM U782, 32 rue des Carnets, Clamart F 92140, France
Hum Mol Genet 18:3002-13. 2009..This shows that the AMHRII signal sequence is defective and suggests that AMHRII uses its transmembrane domain instead of its signal sequence to translocate to the endoplasmic reticulum, a characteristic of type III membrane proteins...
Mutations of the anti-mullerian hormone gene in patients with persistent mullerian duct syndrome: biosynthesis, secretion, and processing of the abnormal proteins and analysis using a three-dimensional modelCorinne Belville
, Clamart, France
Mol Endocrinol 18:708-21. 2004..A molecular model of the AMH C-terminal domain provides insights into how some mutations could affect biosynthesis and function...
Testicular anti-Müllerian hormone: clinical applications in DSDNathalie Josso
INSERM U782, Universite Paris Sud, Clamart, France
Semin Reprod Med 30:364-73. 2012..Clinical and biological features of PMDS due to mutations in the genes coding for AMH or the AMH receptor, as well as genetic aspects and clinical management are discussed...
FSH and its second messenger cAMP stimulate the transcription of human anti-Müllerian hormone in cultured granulosa cellsJoelle Taieb
Institut National de la Sante et de la Recherche Medicale, Unité 782, 32 rue des Carnets, 92120 Clamart, France
Mol Endocrinol 25:645-55. 2011..The specific effect of gonadotropins upon granulosa cells may be obscured in vivo by the effect of FSH upon follicular maturation and by the presence of other hormones and growth factors, acting individually or in concert...
Follicle-stimulating hormone increases testicular Anti-Mullerian hormone (AMH) production through sertoli cell proliferation and a nonclassical cyclic adenosine 5'-monophosphate-mediated activation of the AMH GeneCéline Lukas-Croisier
Centro de Investigaciones Endocrinologicas, Hospital de Ninos, Gallo 1330, C1425EFD Buenos Aires, Argentina
Mol Endocrinol 17:550-61. 2003..We conclude that prepubertal testicular AMH production is increased by FSH stimulation through Sertoli cell proliferation and an enhancement of AMH gene transcription...
Jost's hormone inhibitrice comes of ageNathalie Josso
Unité de Recherches sur l Endocrinologie du Développement et Ecole Normale Supérieure, 1 rue Maurice Arnoux, 92120 Paris, France
Trends Endocrinol Metab 13:412-3. 2002..The First International Workshop on Anti-Müllerian hormone/Müllerian inhibiting substance was held in Aix-en-Provence, France, from 7-8 October 2002...
Aetiological diagnosis of male sex ambiguity: a collaborative studyYves Morel
, , Lyon, France
Eur J Pediatr 161:49-59. 2002..Sequencing of exons 2-8 of the androgen receptor after study of testosterone precursors following human chorionic gonadotrophin stimulation is recommended when gonadal dysgenesis and true hermaphroditism can be excluded...
Long-term surgical results and patient satisfaction with male pseudohermaphroditism or true hermaphroditism: a cohort of 63 patientsClaire Nihoul-Fekete
Department of Pediatric Surgery, Hopital des Enfants Malades, Paris, France
J Urol 175:1878-84. 2006..To improve treatment policy, we retrospectively evaluated the results of early corrective genital surgery in 63 sexually ambiguous patients 14 to 38 years old...
[Hermaphroditism pathology]Francis Jaubert
Service d'Anatomie et de Cytologie Pathologiques (UPRES EA 219, , Paris, France
Ann Pathol 24:499-509. 2004..Sex cord tumors are androgen insensitivity associated tumors, Leydig cells tumors and adrenal cell inclusion tumors. Sex reversion genes open new perspectives...
