Regis Josien

Summary

Country: France

Publications

  1. pmc Constitutive expression of TNF-related activation-induced cytokine (TRANCE)/receptor activating NF-κB ligand (RANK)-L by rat plasmacytoid dendritic cells
    Thomas Anjubault
    INSERM UMR 1064, Nantes, France
    PLoS ONE 7:e33713. 2012
  2. pmc Decreased numbers of blood dendritic cells and defective function of regulatory T cells in antineutrophil cytoplasmic antibody-associated vasculitis
    Marie Rimbert
    CHU Nantes, Laboratoire d Immunologie, Nantes, France
    PLoS ONE 6:e18734. 2011
  3. doi request reprint Mechanism and localization of CD8 regulatory T cells in a heart transplant model of tolerance
    Xian Liang Li
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche 643, Nantes, France
    J Immunol 185:823-33. 2010
  4. ncbi request reprint Immature CD4- CD103+ rat dendritic cells induce rapid caspase-independent apoptosis-like cell death in various tumor and nontumor cells and phagocytose their victims
    Benjamin Trinité
    Institut National de la Santé et de la Recherche Médicale Unité 643, Institut de Transplantation et de Recherche en Transplantation, Nantes University Hospital, Nantes, France
    J Immunol 175:2408-17. 2005
  5. ncbi request reprint Two phenotypically distinct subsets of spleen dendritic cells in rats exhibit different cytokine production and T cell stimulatory activity
    Cecile Voisine
    Institut National de la Sante et de la Recherche Medicale, Unite 437, Nantes, France
    J Immunol 169:2284-91. 2002
  6. doi request reprint Human blood mDC subsets exhibit distinct TLR repertoire and responsiveness
    Caroline Hémont
    Nantes CHU, quai Moncousu, Nantes, France
    J Leukoc Biol 93:599-609. 2013
  7. doi request reprint Altered innate function of plasmacytoid dendritic cells restored by enzyme replacement therapy in Gaucher disease
    Cecile Braudeau
    CHU Nantes, Laboratoire d Immunologie, Centre d Immunomonitorage Nantes Atlantique CIMNA, Nantes F 44000, France
    Blood Cells Mol Dis 50:281-8. 2013
  8. pmc Impaired blood dendritic cell numbers and functions after aneurysmal subarachnoid hemorrhage
    Antoine Roquilly
    Laboratoire UPRES EA 3826 Thérapeutiques cliniques et expérimentales des infections, Faculte de Medecine, Universite de Nantes, Nantes, France
    PLoS ONE 8:e71639. 2013
  9. doi request reprint Modulation of regulatory T cell-Th17 balance by plasmacytoid dendritic cells
    Laetitia Gautreau
    Institut National de la Sante et de la Recherche Medicale, UMR 643, Nantes, France
    J Leukoc Biol 90:521-7. 2011
  10. pmc CD40Ig treatment results in allograft acceptance mediated by CD8CD45RC T cells, IFN-gamma, and indoleamine 2,3-dioxygenase
    Carole Guillonneau
    INSERM U643, Centre Hopitalier Universitaire de Nantes, Institut de Transplantation et de Recherche en Transplantation ITERT, and Université de Nantes, Faculte de Medecine, Nantes, France
    J Clin Invest 117:1096-106. 2007

Collaborators

Detail Information

Publications17

  1. pmc Constitutive expression of TNF-related activation-induced cytokine (TRANCE)/receptor activating NF-κB ligand (RANK)-L by rat plasmacytoid dendritic cells
    Thomas Anjubault
    INSERM UMR 1064, Nantes, France
    PLoS ONE 7:e33713. 2012
    ..Despite this TRANCE/RANKL expression, we were unable to demonstrate in vitro osteoclastogenesis activity for rat pDC. Taken together, these data identifies pDC as novel source of TRANCE/RANKL in the immune system...
  2. pmc Decreased numbers of blood dendritic cells and defective function of regulatory T cells in antineutrophil cytoplasmic antibody-associated vasculitis
    Marie Rimbert
    CHU Nantes, Laboratoire d Immunologie, Nantes, France
    PLoS ONE 6:e18734. 2011
    ..In this study, we examined the frequency and phenotype of DC subsets, and the frequency and function of Treg from patients with ANCA-associated vasculitis (AAV)...
  3. doi request reprint Mechanism and localization of CD8 regulatory T cells in a heart transplant model of tolerance
    Xian Liang Li
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche 643, Nantes, France
    J Immunol 185:823-33. 2010
    ..In conclusion, CD8(+) Tregs and pDCs interactions were necessary for suppression of CD4(+) T cells and involved different mechanisms modulated by the presence of cell contact between CD8(+) Tregs, pDCs, and CD4(+) effector cells...
  4. ncbi request reprint Immature CD4- CD103+ rat dendritic cells induce rapid caspase-independent apoptosis-like cell death in various tumor and nontumor cells and phagocytose their victims
    Benjamin Trinité
    Institut National de la Santé et de la Recherche Médicale Unité 643, Institut de Transplantation et de Recherche en Transplantation, Nantes University Hospital, Nantes, France
    J Immunol 175:2408-17. 2005
    ..Taken together, these data indicate that rat immature CD4- CD103+ DC mediate an unusual cytotoxic activity and can use this function to efficiently acquire Ag from live cells...
  5. ncbi request reprint Two phenotypically distinct subsets of spleen dendritic cells in rats exhibit different cytokine production and T cell stimulatory activity
    Cecile Voisine
    Institut National de la Sante et de la Recherche Medicale, Unite 437, Nantes, France
    J Immunol 169:2284-91. 2002
    ..The fact that both the CD4(+) and CD4(-) DC subsets produced low amounts of IFN-alpha upon viral infection suggests that they are not related to plasmacytoid DC...
  6. doi request reprint Human blood mDC subsets exhibit distinct TLR repertoire and responsiveness
    Caroline Hémont
    Nantes CHU, quai Moncousu, Nantes, France
    J Leukoc Biol 93:599-609. 2013
    ..Taken together, these data confirmed functional differences between blood mDC subsets. The major response of CD141(+) mDCs to TLR3 ligand and their cytokine production pattern suggest a role for these cells in antiviral immunity...
  7. doi request reprint Altered innate function of plasmacytoid dendritic cells restored by enzyme replacement therapy in Gaucher disease
    Cecile Braudeau
    CHU Nantes, Laboratoire d Immunologie, Centre d Immunomonitorage Nantes Atlantique CIMNA, Nantes F 44000, France
    Blood Cells Mol Dis 50:281-8. 2013
    ..These analyses were performed for each patient without and under enzyme replacement therapy...
  8. pmc Impaired blood dendritic cell numbers and functions after aneurysmal subarachnoid hemorrhage
    Antoine Roquilly
    Laboratoire UPRES EA 3826 Thérapeutiques cliniques et expérimentales des infections, Faculte de Medecine, Universite de Nantes, Nantes, France
    PLoS ONE 8:e71639. 2013
    ..Portions of this study were presented at the Annual Congress of Société Française d'Anesthésie et de Réanimation in Paris, September 2012...
  9. doi request reprint Modulation of regulatory T cell-Th17 balance by plasmacytoid dendritic cells
    Laetitia Gautreau
    Institut National de la Sante et de la Recherche Medicale, UMR 643, Nantes, France
    J Leukoc Biol 90:521-7. 2011
    ..These data suggest an important role for pDCs in modulating or switching Treg function and allowing Th17 differentiation...
  10. pmc CD40Ig treatment results in allograft acceptance mediated by CD8CD45RC T cells, IFN-gamma, and indoleamine 2,3-dioxygenase
    Carole Guillonneau
    INSERM U643, Centre Hopitalier Universitaire de Nantes, Institut de Transplantation et de Recherche en Transplantation ITERT, and Université de Nantes, Faculte de Medecine, Nantes, France
    J Clin Invest 117:1096-106. 2007
    ..CD8(+)CD45RC(low) T cells act through IFN-gamma production, which in turn induces IDO expression by graft ECs. Thus, donor alloantigen-specific CD8(+) Tregs may promote local graft immune privilege through IDO expression...
  11. pmc CpG-ODN and MPLA prevent mortality in a murine model of post-hemorrhage-Staphyloccocus aureus pneumonia
    Antoine Roquilly
    Laboratoire UPRES EA 3826 Thérapeutiques cliniques et expérimentales des infections, Faculte de Medecine, Universite de Nantes, Nantes, France
    PLoS ONE 5:e13228. 2010
    ..After hemorrhage, a preventive treatment with CpG-ODN or Monophosphoryl Lipid A increased transcriptional activity in DCs (TNF-α, IFN-β and IL-12p40) and decreased mortality of post-hemorrhage MSSA pneumonia...
  12. ncbi request reprint IDO expands human CD4+CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells
    Marcelo Hill
    INSERM, U 643, Nantes, Cedex 1, France
    Eur J Immunol 37:3054-62. 2007
    ..In conclusion, we show that IDO constitutes an intermediate pathway in DC maturation leading to expansion of CD4(+)CD25(high) regulatory T cells...
  13. doi request reprint Killer dendritic cells link innate and adaptive immunity against established osteosarcoma in rats
    Camille Chauvin
    Institut National de la Sante et de la Recherche Medicale, U643, CHU Nantes, Institut de Transplantation et de Recherche en Transplantation Urologie Néphrologie, IUN, Universite de Nantes, Faculte de Medecine, France
    Cancer Res 68:9433-40. 2008
    ....
  14. ncbi request reprint Dendritic cells as killers: mechanistic aspects and potential roles
    Camille Chauvin
    Institut National de la Sante et de la Recherche Medicale INSERM, Unité 643, Nantes, France
    J Immunol 181:11-6. 2008
    ..e., cell-mediated cytotoxicity, mostly toward tumor cells. In this article, we will review the phenotypes of these so-called killer DC, their killing mechanism, and putative implication in the immune response...
  15. pmc Penicillin binding proteins as danger signals: meningococcal penicillin binding protein 2 activates dendritic cells through Toll-like receptor 4
    Marcelo Hill
    INSERM U643, Nantes, CHU de Nantes, IUN, Nantes, Universite de Nantes, UMR 643, Nantes, France
    PLoS ONE 6:e23995. 2011
    ....
  16. ncbi request reprint Differential control of T regulatory cell proliferation and suppressive activity by mature plasmacytoid versus conventional spleen dendritic cells
    Asmahan Ouabed
    INSERM Unite 643, Centre Hospitalier Universitaire de Nantes, Institut de Transplantation et de Recherche en Transplantation Urologie Néphrologie, Universite de Nantes, 30 Boulevard Jean Monnet, Nantes, France
    J Immunol 180:5862-70. 2008
    ..Taken together, these results suggest that anergy and the suppressive function of Treg are differentially controlled by DC subsets...
  17. ncbi request reprint The role of TNF-related activation-induced cytokine-receptor activating NF-kappa B interaction in acute allograft rejection and CD40L-independent chronic allograft rejection
    Carole Guillonneau
    Institut National de la Santé et de la Recherche Médicale Unit 437, and Institut de Transplantation et de Recherche en Transplantation, Nantes, France
    J Immunol 172:1619-29. 2004
    ..We conclude that TRANCE-RANK interactions play an important role during acute allograft rejection and that CD40L-independent allogeneic immune responses can be, at least in part, dependent on the TRANCE pathway of costimulation...