Jorgensen C, Apparailly F. Prospects for gene therapy in inflammatory arthritis. Best Pract Res Clin Rheumatol. 2010;24:541-52 pubmed publisher
..We also discuss the currently used gene therapy clinical trials and define optimal strategies for success. ..
Duroux Richard I, Cuenca J, Ponsolles C, PiÃ±eiro A, Gonzalez F, Roubert C, et al
. MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. Int J Mol Sci. 2015;16:16953-65 pubmed publisher
..Overall, the present work provided promising biomarkers in molecular diagnostics for disease severity as well as potential new targets for therapeutic intervention in SLE. ..
Pers Y, Jorgensen C. Mesenchymal Stromal Cells: Updates and Therapeutic Outlook in Rheumatic Diseases. J Clin Med. 2013;2:201-13 pubmed publisher
..To date, most of the available data have been obtained in preclinical models and clinical efficacy needs to be evaluated through controlled randomized double-blind trials. ..
Manferdini C, Maumus M, Gabusi E, Paolella F, Grassi F, Jorgensen C, et al
. Lack of anti-inflammatory and anti-catabolic effects on basal inflamed osteoarthritic chondrocytes or synoviocytes by adipose stem cell-conditioned medium. Osteoarthritis Cartilage. 2015;23:2045-57 pubmed publisher
..ASC-CM is not sufficient to recapitulate the beneficial effect demonstrated using ASC in co-culture with inflamed OA chondrocytes and synoviocytes and shows that their use in clinical trials is fundamental to counteract OA progression. ..
Unguryte A, Bernotiene E, Bagdonas E, Garberyte S, Porvaneckas N, Jorgensen C. Human articular chondrocytes with higher aldehyde dehydrogenase activity have stronger expression of COL2A1 and SOX9. Osteoarthritis Cartilage. 2016;24:873-82 pubmed publisher
..Coexpression of ALDH activity with chondrogenic markers suggests its association with collagen II producing chondrocyte phenotype. Isotypes ALDH1A2 and ALDH1A3 can be associated with the ALDH activity in these cells. ..
Pers Y, Rackwitz L, Ferreira R, Pullig O, Delfour C, Barry F, et al
. Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial. Stem Cells Transl Med. 2016;5:847-56 pubmed publisher
..Larger and controlled long-term studies are now mandatory to confirm whether this new strategy of cell therapy can improve pain and induce structural benefit in osteoarthritis. ..
Khalifa O, Pers Y, Ferreira R, Sénéchal A, Jorgensen C, Apparailly F, et al
. X-Linked miRNAs Associated with Gender Differences in Rheumatoid Arthritis. Int J Mol Sci. 2016;17: pubmed
..X-linked miRNAs, in the context of sex differences, might provide novel insight into new molecular mechanisms and potential therapeutic targets in RA for disease treatment and prevention. ..
Cosenza S, Ruiz M, Maumus M, Jorgensen C, Noel D. Pathogenic or Therapeutic Extracellular Vesicles in Rheumatic Diseases: Role of Mesenchymal Stem Cell-Derived Vesicles. Int J Mol Sci. 2017;18: pubmed publisher
..Special attention is given to MSCs and MSC-derived EVs for modulating OA and RA progression with the perspective of developing innovative therapeutic strategies. ..
Asnagli H, Martire D, Belmonte N, Quentin J, Bastian H, Boucard Jourdin M, et al
. Type 1 regulatory T cells specific for collagen type II as an efficient cell-based therapy in arthritis. Arthritis Res Ther. 2014;16:R115 pubmed publisher
..Our results demonstrate the therapeutic potential of Col-Treg cells in two models of RA, providing evidence that Col-Treg could be an efficient cell-based therapy for RA patients whose disease is refractory to current treatments. ..