Nicolas Jonckheere

Summary

Country: France

Publications

  1. doi Membrane-bound mucin modular domains: From structure to function
    Nicolas Jonckheere
    INSERM, UMR837, Jean Pierre Aubert Research Center, Team 5 Mucins, epithelial differentiation and carcinogenesis, 1 rue Polonovski, 59045 Lille Cedex, France Université Lille Nord de France, 1 place de Verdun, 59045 Lille Cedex, France Centre Hospitalier Régional et Universitaire de Lille, Place de Verdun, 59037 Lille Cedex, France Electronic address
    Biochimie 95:1077-86. 2013
  2. doi GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells
    Nicolas Jonckheere
    Jean Pierre Aubert Research Center, Lille Cedex, France
    Biochim Biophys Acta 1819:869-76. 2012
  3. pmc The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways
    Nicolas Jonckheere
    INSERM, UMR837, Jean Pierre Aubert Research Center, Team 5 Mucins, epithelial differentiation and carcinogenesis, Lille, France
    PLoS ONE 7:e32232. 2012
  4. doi The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors
    Nicolas Jonckheere
    INSERM, U837, Jean Pierre Aubert Research Center, Lille, France
    FEBS J 278:282-94. 2011
  5. pmc The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells
    Valérie Fauquette
    Unité INSERM 560, Place de Verdun, 59045 Lille Cedex, France
    Biochem J 386:35-45. 2005
  6. ncbi The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells
    Nicolas Jonckheere
    INSERM, U560, Place de Verdun, Lille, F 59045, France
    J Biol Chem 282:22638-50. 2007
  7. pmc Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1alpha
    Guillaume Piessen
    Unité INSERM 560, Place de Verdun, 59045 Lille Cedex, France
    Biochem J 402:81-91. 2007
  8. ncbi A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-beta in pancreatic carcinogenesis
    Nicolas Jonckheere
    Unité INSERM 560, Place de Verdun, 59045 Lille Cedex, France
    Oncogene 23:5729-38. 2004
  9. doi The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties: Implication for S100A4 protein
    Emilie Bruyère
    INSERM, UMR837, Jean Pierre Aubert Research Center, Team 5 Mucins, epithelial differentiation and carcinogenesis, rue Polonovski, 59045 Lille Cedex, France
    Biochem Biophys Res Commun 413:325-9. 2011
  10. pmc Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway
    Christophe Mariette
    Unité INSERM 560, Place de Verdun, 59045 Lille Cedex, France
    Biochem J 377:701-8. 2004

Collaborators

Detail Information

Publications15

  1. doi Membrane-bound mucin modular domains: From structure to function
    Nicolas Jonckheere
    INSERM, UMR837, Jean Pierre Aubert Research Center, Team 5 Mucins, epithelial differentiation and carcinogenesis, 1 rue Polonovski, 59045 Lille Cedex, France Université Lille Nord de France, 1 place de Verdun, 59045 Lille Cedex, France Centre Hospitalier Régional et Universitaire de Lille, Place de Verdun, 59037 Lille Cedex, France Electronic address
    Biochimie 95:1077-86. 2013
    ..In this review, we show 3D structures of EGF and SEA domains. We also describe the functional features of the evolutionary conserved domains of membrane-bound mucins and discuss consequences of splice events...
  2. doi GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells
    Nicolas Jonckheere
    Jean Pierre Aubert Research Center, Lille Cedex, France
    Biochim Biophys Acta 1819:869-76. 2012
    ..This is thus in favor of an important role for these two transcription factors as regulators of expression of the Muc5ac mucin during stomach development and in epithelial cancer cells...
  3. pmc The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways
    Nicolas Jonckheere
    INSERM, UMR837, Jean Pierre Aubert Research Center, Team 5 Mucins, epithelial differentiation and carcinogenesis, Lille, France
    PLoS ONE 7:e32232. 2012
    ..Our results show that ErbB2 and MUC4, which interact physically, activate different intracellular signalling pathways to regulate biological properties of CAPAN-2 pancreatic cancer cells...
  4. doi The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors
    Nicolas Jonckheere
    INSERM, U837, Jean Pierre Aubert Research Center, Lille, France
    FEBS J 278:282-94. 2011
    ..The characterization of the structural and functional features of the Muc5b mucin gene will provide us with a strong base to develop studies in murine models aimed at the identification of its biological role in lung pathophysiology...
  5. pmc The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells
    Valérie Fauquette
    Unité INSERM 560, Place de Verdun, 59045 Lille Cedex, France
    Biochem J 386:35-45. 2005
    ..Thus, PEA3, by its capacity to up-regulate the epithelial marker MUC4 and to down-regulate the ErbB-2 oncogene, appears as a key regulator of the differentiation/proliferation balance in pancreatic cancer cells...
  6. ncbi The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells
    Nicolas Jonckheere
    INSERM, U560, Place de Verdun, Lille, F 59045, France
    J Biol Chem 282:22638-50. 2007
    ..Altogether, these results demonstrate that MUC4 is a target gene of endodermal TFs and thus point out an important role for these TFs in regulating MUC4 expression during epithelial differentiation during development, cancer, and repair...
  7. pmc Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1alpha
    Guillaume Piessen
    Unité INSERM 560, Place de Verdun, 59045 Lille Cedex, France
    Biochem J 402:81-91. 2007
    ..These results bring new insights into MUC4 up-regulation in oesophageal carcinoma associated with bile reflux...
  8. ncbi A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-beta in pancreatic carcinogenesis
    Nicolas Jonckheere
    Unité INSERM 560, Place de Verdun, 59045 Lille Cedex, France
    Oncogene 23:5729-38. 2004
    ....
  9. doi The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties: Implication for S100A4 protein
    Emilie Bruyère
    INSERM, UMR837, Jean Pierre Aubert Research Center, Team 5 Mucins, epithelial differentiation and carcinogenesis, rue Polonovski, 59045 Lille Cedex, France
    Biochem Biophys Res Commun 413:325-9. 2011
    ..MUC4 mucin appears thus as a good therapeutic target to slow-down esophageal tumor progression...
  10. pmc Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway
    Christophe Mariette
    Unité INSERM 560, Place de Verdun, 59045 Lille Cedex, France
    Biochem J 377:701-8. 2004
    ..This new mechanism of regulation of MUC4 mucin gene points out an important role for bile acids as key molecules in targeting MUC4 overexpression in early stages of oesophageal carcinogenesis...
  11. doi Autocrine induction of invasive and metastatic phenotypes by the MIF-CXCR4 axis in drug-resistant human colon cancer cells
    Anne Frédérique Dessein
    INSERM U837, Centre de Recherche Jean Pierre Aubert, Place de Verdun, Lille F 59045, France
    Cancer Res 70:4644-54. 2010
    ..Combination therapies targeting the CXCR4-MIF axis could potentially counteract the emergence of the invasive metastatic behavior in clonal derivatives of drug-resistant colon cancer cells...
  12. doi The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancers
    Nicolas Jonckheere
    INSERM, Jean Pierre Aubert Research Centre, Lille, France
    Biochimie 92:1-11. 2010
    ..We will discuss the mechanisms of regulation at the promoter level (including genetic and epigenetic modifications) that may be responsible for the mucin altered pattern of expression in epithelial cancers...
  13. pmc Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-beta/Smad4 signalling pathway is potentiated by Sp1
    Nicolas Jonckheere
    Unité INSERM U560, Place de Verdun, 59045 Lille Cedex, France
    Biochem J 377:797-808. 2004
    ..Altogether these results bring new insights into the molecular mechanisms of TGF-beta-mediated up-regulation of Muc5ac and enhance our understanding as to how Muc5ac is regulated in certain pathologies of the gastrointestinal tract...
  14. ncbi The membrane-bound mucins: how large O-glycoproteins play key roles in epithelial cancers and hold promise as biological tools for gene-based and immunotherapies
    Nicolas Jonckheere
    INSERM, U837, Centre de Recherche Jean Pierre Aubert, France
    Crit Rev Oncog 14:177-96. 2008
    ....
  15. ncbi Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida
    Emmanuel Rat
    Equipe d accueil EA2679, Faculte de Medecine, Lille Cedex, France
    Birth Defects Res A Clin Mol Teratol 76:491-8. 2006
    ..As RA is a critical regulator of gene expression during embryonic development, the imbalance between the synthesis and degradation of RA during embryogenesis could contribute to malformations and developmental defects...