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Genomes and Genes | Chloe JamesSummaryCountry: France Publications
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Publications
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia veraChloe James
INSERM U362, Institut Gustave Roussy, Paris XI University, PR1, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
Nature 434:1144-8. 2005..As this mutation is also found in other myeloproliferative disorders, this unique mutation will permit a new molecular classification of these disorders and novel therapeutical approaches...- A JAK2 mutation in myeloproliferative disorders: pathogenesis and therapeutic and scientific prospectsChloe James
INSERM U362, Institut Gustave Roussy, Paris XI University, PR1, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
Trends Mol Med 11:546-54. 2005..Such a recurrent and unique mutation leading to a tyrosine kinase deregulation would make a suitable target for the development of specific therapies... 
The hematopoietic stem cell compartment of JAK2V617F-positive myeloproliferative disorders is a reflection of disease heterogeneityChloe James
INSERM, U876, Bordeaux, France
Blood 112:2429-38. 2008..These experiments provide new insights into the pathogenesis of JAK2V617F MPD and demonstrate that a JAK2 inhibitor needs to target the HSC compartment for optimal disease control in classical MPD...- Mutation in TET2 in myeloid cancersFrancois Delhommeau
INSERM U790, Institut Gustave Roussy, Villejuif, France
N Engl J Med 360:2289-301. 2009..The myelodysplastic syndromes and myeloproliferative disorders are associated with deregulated production of myeloid cells. The mechanisms underlying these disorders are not well defined... - The JAK2 617V>F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia veraSabrina Dupont
INSERM Unité 790, Universite Paris Sud, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France
Blood 110:1013-21. 2007.... - Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosisRonan Chaligne
Institut National de la Sante et de la Recherche Medicale INSERM, U790, Universite Paris XI, Institut Gustave Roussy, Villejuif, France
Blood 110:3735-43. 2007..In contrast, erythroid progenitors remained EPO dependent. These results demonstrate that in PMF, the MPL W515L or K mutation induces a spontaneous megakaryocyte (MK) differentiation and occurs in a multipotent HSCs... - Constitutive activation of STAT5 and Bcl-xL overexpression can induce endogenous erythroid colony formation in human primary cellsLoic Garcon
Unité U 790 Institut National de la Santé et de la Recherche Médicale INSERM, Institut Gustave Roussy, Villejuif, France
Blood 108:1551-4. 2006.... - [A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera]Valerie Ugo
INSERM U 362, PR1, Institut Gustave Roussy, Villejuif, France
Med Sci (Paris) 21:669-70. 2005 - Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemiaDominique Bluteau
INSERM, U1009, Villejuif, France
Blood 118:6310-20. 2011..We propose that the down-regulation of NR4A3 in RUNX1-mutated hematopoietic progenitors leads to an increase in the pool of cells susceptible to be hit by secondary leukemic genetic events... - New insights into the pathogenesis of JAK2 V617F-positive myeloproliferative disorders and consequences for the management of patientsJean Luc Villeval
INSERM, U790, Institut Gustave Roussy, IGR, Villejuif, France
Semin Thromb Hemost 32:341-51. 2006....