Bonnard B, Pieronne Deperrois M, Djerada Z, Elmoghrabi S, Kolkhof P, Ouvrard Pascaud A, et al
. Mineralocorticoid receptor antagonism improves diastolic dysfunction in chronic kidney disease in mice. J Mol Cell Cardiol. 2018;121:124-133 pubmed publisher
..The benefits of finerenone suggest that activation of MR is involved in the cardiac complication of renal failure and strengthen previous studies showing beneficial effects of MRA in patients with CKD. ..
Tarjus A, Amador C, Michea L, Jaisser F. Vascular mineralocorticoid receptor and blood pressure regulation. Curr Opin Pharmacol. 2015;21:138-44 pubmed publisher
..In this review, we focus on recent advances obtained using transgenic model with cell-specific modulation of the expression MR in endothelium or smooth muscle and their impact on blood pressure. ..
Tarjus A, MartÃnez MartÃnez E, Amador C, Latouche C, El Moghrabi S, Berger T, et al
. Neutrophil Gelatinase-Associated Lipocalin, a Novel Mineralocorticoid Biotarget, Mediates Vascular Profibrotic Effects of Mineralocorticoids. Hypertension. 2015;66:158-66 pubmed publisher
..The clinical data indicate that this may translate in human patients. Lcn2 is, therefore, a new biotarget in cardiovascular fibrosis induced by mineralocorticoid activation. ..
Buonafine M, Martínez Martínez E, Jaisser F. More than a simple biomarker: the role of NGAL in cardiovascular and renal diseases. Clin Sci (Lond). 2018;132:909-923 pubmed publisher
..In the present review, we summarize current knowledge concerning the involvement of NGAL in cardiovascular and renal diseases and discuss the various mechanisms underlying its pathological implications. ..
Jaisser F, Farman N. Emerging Roles of the Mineralocorticoid Receptor in Pathology: Toward New Paradigms in Clinical Pharmacology. Pharmacol Rev. 2016;68:49-75 pubmed publisher
Buonafine M, MartÃnez MartÃnez E, Amador C, Gravez B, Ibarrola J, FernÃ¡ndez Celis A, et al
. Neutrophil Gelatinase-Associated Lipocalin from immune cells is mandatory for aldosterone-induced cardiac remodeling and inflammation. J Mol Cell Cardiol. 2018;115:32-38 pubmed publisher
..Our data further stressed a pathogenic role of NGAL in cardiac damages, besides its relevance as a biomarker of renal injury. ..
Barrera Chimal J, Estrela G, Lechner S, Giraud S, El Moghrabi S, Kaaki S, et al
. The myeloid mineralocorticoid receptor controls inflammatory and fibrotic responses after renal injury via macrophage interleukin-4 receptor signaling. Kidney Int. 2018;93:1344-1355 pubmed publisher
..Thus, our studies support the rationale for using mineralocorticoid receptor antagonists in clinical practice to prevent transition of acute kidney injury to chronic kidney disease. ..
Urbanet R, Nguyen Dinh Cat A, Feraco A, Venteclef N, El Mogrhabi S, Sierra Ramos C, et al
. Adipocyte Mineralocorticoid Receptor Activation Leads to Metabolic Syndrome and Induction of Prostaglandin D2 Synthase. Hypertension. 2015;66:149-57 pubmed publisher
..Moreover, translational studies showed that expression of MR and prostaglandin D2 synthase is strongly correlated in adipose tissues from obese patients. ..
Barrera Chimal J, AndrÃ© GrÃ©goire G, Nguyen Dinh Cat A, Lechner S, Cau J, Prince S, et al
. Benefit of Mineralocorticoid Receptor Antagonism in AKI: Role of Vascular Smooth Muscle Rac1. J Am Soc Nephrol. 2017;28:1216-1226 pubmed publisher
..The benefits of MR antagonism in the pig provide a rational basis for future clinical trials assessing the benefits of this approach in patients with IR-mediated AKI. ..