Cedric Jacqueline

Summary

Country: France

Publications

  1. doi request reprint Efficacy of the new cephalosporin ceftaroline in the treatment of experimental methicillin-resistant Staphylococcus aureus acute osteomyelitis
    Cedric Jacqueline
    Universite de Nantes, Faculte de Medecine, Therapeutiques Cliniques et Experimentales des Infections, EA3826, F 44000 Nantes, France
    J Antimicrob Chemother 65:1749-52. 2010
  2. doi request reprint Impact of bacterial biofilm on the treatment of prosthetic joint infections
    Cedric Jacqueline
    Universite de Nantes, Faculte de Medecine, UPRES EA 3826, 1 rue Gaston Veil, Nantes, F 44000 France
    J Antimicrob Chemother 69:i37-40. 2014
  3. doi request reprint Efficacy of ceftolozane in a murine model of Pseudomonas aeruginosa acute pneumonia: in vivo antimicrobial activity and impact on host inflammatory response
    Cedric Jacqueline
    Universite de Nantes, Faculte de Medecine, Therapeutiques Cliniques et Experimentales des Infections, EA 3826, F 44000 Nantes, France
    J Antimicrob Chemother 68:177-83. 2013
  4. doi request reprint Comparison of ceftaroline fosamil, daptomycin and tigecycline in an experimental rabbit endocarditis model caused by methicillin-susceptible, methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus
    Cedric Jacqueline
    Universite de Nantes, Nantes Atlantique Universites, Therapeutiques Cliniques et Experimentales des Infections, EA3826, F 44000 Nantes, France
    J Antimicrob Chemother 66:863-6. 2011
  5. pmc In vitro and in vivo synergistic activities of linezolid combined with subinhibitory concentrations of imipenem against methicillin-resistant Staphylococcus aureus
    Cedric Jacqueline
    Laboratoire d Antibiologie, UER de Medecine, 1 rue Gaston Veil, 44035 Nantes, Cedex 01, France
    Antimicrob Agents Chemother 49:45-51. 2005
  6. pmc In vivo efficacy of continuous infusion versus intermittent dosing of linezolid compared to vancomycin in a methicillin-resistant Staphylococcus aureus rabbit endocarditis model
    Cedric Jacqueline
    Laboratoire d Antibiologie UPRES EA 1156, Faculte de Medecine, 44035 Nantes, Cedex 01, France
    Antimicrob Agents Chemother 46:3706-11. 2002
  7. pmc In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model
    Cedric Jacqueline
    Universite de Nantes, Nantes Atlantique Universites, Therapeutiques Cliniques et Experimentales des Infections, EA3826, UFR Medecine, Nantes, France
    Antimicrob Agents Chemother 51:3397-400. 2007
  8. ncbi request reprint Comparison of in vivo intrinsic activity of cefepime and imipenem in a Pseudomonas aeruginosa rabbit endocarditis model: effect of combination with tobramycin simulating human serum pharmacokinetics
    Dominique Navas
    Laboratoire d Antibiologie UPRES EA 1156, UER de Medecine, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France
    J Antimicrob Chemother 54:767-71. 2004
  9. ncbi request reprint Efficacy of quinupristin/dalfopristin versus vancomycin, alone or in combination with rifampicin, against methicillin-resistant Staphylococcus aureus in a rabbit arthritis model
    Antoine Hamel
    Universite de Nantes, Nantes Atlantique Universites, Therapeutiques Cliniques et Experimentales des Infections, EA 3826, UFR Medecine, 1 rue G Veil, F 44000 Nantes, France
    Int J Antimicrob Agents 31:158-60. 2008
  10. ncbi request reprint In vivo efficacy of linezolid in combination with gentamicin for the treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus
    Cedric Jacqueline
    Laboratoire d Antibiologie UPRES EA 1156, UER de Medecine, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France
    Int J Antimicrob Agents 24:393-6. 2004

Collaborators

  • Eric Batard
  • Karim Asehnoune
  • Regis Josien
  • Yigong Ge
  • Pierre Yves Donnio
  • Olivier Patey
  • Cedric Arvieux
  • David Boutoille
  • G Potel
  • Lucia Grandiere-Perez
  • Jocelyne Caillon
  • Antoine Roquilly
  • Antoine Hamel
  • Alexis Broquet
  • Cédric Bretonnière
  • Denis Bugnon
  • Jean Pierre Segain
  • Dominique Navas
  • Mélanie Sicard
  • Frederic Altare
  • Christophe Guitton
  • Pierre de Coppet
  • Laetitia Gautreau
  • Anne Francoise Miegeville
  • Jean Michel Rogez
  • Virginie Le Mabecque
  • Olivier Grossi
  • Anne Marie Le Ray
  • Nathalie Asseray
  • Marie France Kergueris
  • Christele Gras-Le Guen
  • Laurent Dube
  • Christele Gras Le Guen
  • Guillaume Deslandes
  • Elise Launay
  • Arnaud Legrand
  • Jean Christophe Roze
  • Cyndie Desessard
  • Jose Villadangos
  • Cecile Braudeau
  • Christelle Retiere
  • Mickael Vourc'h
  • Damien Masson
  • Véronique Sébille
  • Daniel Villers
  • Corinne Lejus
  • Helene Gautier
  • Guy Daculsi
  • Christian Merle
  • Marie Katel Laty
  • Jean Claude Granry

Detail Information

Publications31

  1. doi request reprint Efficacy of the new cephalosporin ceftaroline in the treatment of experimental methicillin-resistant Staphylococcus aureus acute osteomyelitis
    Cedric Jacqueline
    Universite de Nantes, Faculte de Medecine, Therapeutiques Cliniques et Experimentales des Infections, EA3826, F 44000 Nantes, France
    J Antimicrob Chemother 65:1749-52. 2010
    ..aureus (GISA) strains...
  2. doi request reprint Impact of bacterial biofilm on the treatment of prosthetic joint infections
    Cedric Jacqueline
    Universite de Nantes, Faculte de Medecine, UPRES EA 3826, 1 rue Gaston Veil, Nantes, F 44000 France
    J Antimicrob Chemother 69:i37-40. 2014
    ....
  3. doi request reprint Efficacy of ceftolozane in a murine model of Pseudomonas aeruginosa acute pneumonia: in vivo antimicrobial activity and impact on host inflammatory response
    Cedric Jacqueline
    Universite de Nantes, Faculte de Medecine, Therapeutiques Cliniques et Experimentales des Infections, EA 3826, F 44000 Nantes, France
    J Antimicrob Chemother 68:177-83. 2013
    ..To assess the activity of ceftolozane, a novel oxyimino-cephalosporin, in comparison with ceftazidime and piperacillin/tazobactam against a multidrug-resistant Pseudomonas aeruginosa strain using a murine model of pneumonia...
  4. doi request reprint Comparison of ceftaroline fosamil, daptomycin and tigecycline in an experimental rabbit endocarditis model caused by methicillin-susceptible, methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus
    Cedric Jacqueline
    Universite de Nantes, Nantes Atlantique Universites, Therapeutiques Cliniques et Experimentales des Infections, EA3826, F 44000 Nantes, France
    J Antimicrob Chemother 66:863-6. 2011
    ..aureus (MRSA) and glycopeptide-intermediate S. aureus (GISA) strains in a rabbit model of endocarditis...
  5. pmc In vitro and in vivo synergistic activities of linezolid combined with subinhibitory concentrations of imipenem against methicillin-resistant Staphylococcus aureus
    Cedric Jacqueline
    Laboratoire d Antibiologie, UER de Medecine, 1 rue Gaston Veil, 44035 Nantes, Cedex 01, France
    Antimicrob Agents Chemother 49:45-51. 2005
    ..The combination of linezolid plus imipenem appears to be promising for the treatment of severe MRSA infections and merits further investigations to explore the mechanism underlying the synergy between the two drugs...
  6. pmc In vivo efficacy of continuous infusion versus intermittent dosing of linezolid compared to vancomycin in a methicillin-resistant Staphylococcus aureus rabbit endocarditis model
    Cedric Jacqueline
    Laboratoire d Antibiologie UPRES EA 1156, Faculte de Medecine, 44035 Nantes, Cedex 01, France
    Antimicrob Agents Chemother 46:3706-11. 2002
    ..These data suggest that continuous infusion of linezolid could be an appropriate alternative to the use of glycopeptides for the treatment of severe methicillin-resistant S. aureus infections...
  7. pmc In vivo efficacy of ceftaroline (PPI-0903), a new broad-spectrum cephalosporin, compared with linezolid and vancomycin against methicillin-resistant and vancomycin-intermediate Staphylococcus aureus in a rabbit endocarditis model
    Cedric Jacqueline
    Universite de Nantes, Nantes Atlantique Universites, Therapeutiques Cliniques et Experimentales des Infections, EA3826, UFR Medecine, Nantes, France
    Antimicrob Agents Chemother 51:3397-400. 2007
    ..After a 4-day treatment, ceftaroline exhibited superior bactericidal in vivo activity against resistant S. aureus strains and appeared to be the most effective drug against a heterogeneous glycopeptide-intermediate S. aureus strain...
  8. ncbi request reprint Comparison of in vivo intrinsic activity of cefepime and imipenem in a Pseudomonas aeruginosa rabbit endocarditis model: effect of combination with tobramycin simulating human serum pharmacokinetics
    Dominique Navas
    Laboratoire d Antibiologie UPRES EA 1156, UER de Medecine, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France
    J Antimicrob Chemother 54:767-71. 2004
    ..Secondly, we studied the effect of combining therapy with tobramycin...
  9. ncbi request reprint Efficacy of quinupristin/dalfopristin versus vancomycin, alone or in combination with rifampicin, against methicillin-resistant Staphylococcus aureus in a rabbit arthritis model
    Antoine Hamel
    Universite de Nantes, Nantes Atlantique Universites, Therapeutiques Cliniques et Experimentales des Infections, EA 3826, UFR Medecine, 1 rue G Veil, F 44000 Nantes, France
    Int J Antimicrob Agents 31:158-60. 2008
    ..Vancomycin, alone or in combination with rifampicin, and quinupristin/dalfopristin+rifampicin were significantly more effective than quinupristin/dalfopristin alone...
  10. ncbi request reprint In vivo efficacy of linezolid in combination with gentamicin for the treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus
    Cedric Jacqueline
    Laboratoire d Antibiologie UPRES EA 1156, UER de Medecine, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France
    Int J Antimicrob Agents 24:393-6. 2004
    ..These data suggest that linezolid plus gentamicin could be an appropriate combination for the treatment of severe MRSA infections...
  11. pmc In vivo activity of a novel anti-methicillin-resistant Staphylococcus aureus cephalosporin, ceftaroline, against vancomycin-susceptible and -resistant Enterococcus faecalis strains in a rabbit endocarditis model: a comparative study with linezolid and van
    Cedric Jacqueline
    Universite de Nantes, Nantes Atlantique Universites, Therapeutiques Cliniques et Experimentales des Infections, UFR Medecine, Nantes, France
    Antimicrob Agents Chemother 53:5300-2. 2009
    ..Ceftaroline was more active than either vancomycin or linezolid against vancomycin-sensitive and -resistant isolates of E. faecalis...
  12. pmc Activity of glycopeptides against Staphylococcus aureus infection in a rabbit endocarditis model: MICs do not predict in vivo efficacy
    Nathalie Asseray
    Laboratoire Antibiologie, UPRES EA 3826, Faculte de Medecine, 1 rue Gaston Veil, 44035 Nantes, France
    Antimicrob Agents Chemother 49:857-9. 2005
    ..Each treated group was compared with a control group infected with the same strain. Vancomycin and teicoplanin showed similar activities. Low MICs did not predict better in vivo results...
  13. pmc Simulation of human gentamicin pharmacokinetics in an experimental Enterococcus faecalis endocarditis model
    Laurent Dube
    Laboratoire d Antibiologie, Unité UPRES EA 1156, Faculte de Medecine, and Laboratoire de Pharmacologie et de Toxicologie, CHU Nantes, France
    Antimicrob Agents Chemother 47:3663-6. 2003
    ..The decrease in bacterial counts was greater with HPS than with a dose-equivalent regimen without HPS...
  14. doi request reprint Toll-like receptor-4 agonist in post-haemorrhage pneumonia: role of dendritic and natural killer cells
    Antoine Roquilly
    Faculte de Medecine, Universite de Nantes, Nantes
    Eur Respir J 42:1365-78. 2013
    ..Dendritic and natural killer cells are critically involved in the beneficial effects of monophosphoryl lipid A within post-haemorrhage pneumonia. ..
  15. ncbi request reprint In vitro activity of linezolid alone and in combination with gentamicin, vancomycin or rifampicin against methicillin-resistant Staphylococcus aureus by time-kill curve methods
    Cedric Jacqueline
    Laboratoire d Antibiologie UPRES EA 1156, UER de Medecine, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France
    J Antimicrob Chemother 51:857-64. 2003
    ..Linezolid plus rifampicin appeared to be the most active combination against methicillin-resistant S. aureus strains in time-kill experiments...
  16. pmc In vitro and in vivo bactericidal activities of vancomycin dispersed in porous biodegradable poly(epsilon-caprolactone) microparticles
    Anne Marie Le Ray
    Centre de Recherche sur les Matériaux d Intérêt Biologique, Equipe INSERM 99 03, UFR Odontologie, University of Nantes, 1 rue Gaston Veil, 44035 Nantes, France
    Antimicrob Agents Chemother 49:3025-7. 2005
    ..The activity of vancomycin encapsulated in microparticles was evaluated in vitro and in vivo on rabbit osteomyelitis and showed a good activity compared to intravenous administration...
  17. pmc In vivo efficacy of moxifloxacin compared with cloxacillin and vancomycin in a Staphylococcus aureus rabbit arthritis experimental model
    Olivier Grossi
    Universite de Nantes, Nantes Atlantique Universites, Therapeutiques Cliniques et Experimentales des Infections, EA3826, UFR Medecine, Nantes, France
    Antimicrob Agents Chemother 51:3401-3. 2007
    ..No significant difference between therapeutic regimens was observed after a 7-day treatment. Oral moxifloxacin could be a suitable alternative to standard parenteral therapy for S. aureus arthritis...
  18. doi request reprint Depletion of natural killer cells increases mice susceptibility in a Pseudomonas aeruginosa pneumonia model
    Alexis Broquet
    1Laboratoire UPRES EA3826, Therapeutiques Cliniques et Experimentales des Infections, Faculte de Medecine, Universite de Nantes, Nantes, France 2CHU Nantes, Pôle Anesthésie Réanimations, Service d Anesthésie Réanimation Chirurgicale, Hotel Dieu, Nantes, France
    Crit Care Med 42:e441-50. 2014
    ..In this setting, the role of natural killer cells remains controversial. We assessed the role of systemic natural killer cells in a Pseudomonas aeruginosa mouse pneumonia model...
  19. doi request reprint In vivo impact of the MexAB-OprM efflux system on beta-lactam efficacy in an experimental model of Pseudomonas aeruginosa infection
    David Boutoille
    Universite de Nantes, Nantes Atlantique Universites, Therapeutiques Cliniques et Experimentales des Infections, EA 3826, Faculte de Medecine, Nantes F 44000, France
    Int J Antimicrob Agents 33:417-20. 2009
    ..In the most difficult-to-treat infections due to P. aeruginosa exhibiting the efflux system MexAB-OprM, CFZ at high doses and by continuous infusion should be preferred to TIC and PIP/TAZ...
  20. pmc Influence of carbon dioxide on the MIC of telithromycin for Streptococcus pneumoniae: an in vitro-in vivo study
    Eric Batard
    Laboratoire d Antibiologie, UER de Medecine, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France
    Antimicrob Agents Chemother 49:464-6. 2005
    ..2% of 346 Streptococcus pneumoniae ermB-positive strains. An increased telithromycin MIC in CO(2) was not correlated with loss of its activity in the murine sepsis/peritonitis model...
  21. doi request reprint Efficacy of doripenem in the treatment of Pseudomonas aeruginosa experimental pneumonia versus imipenem and meropenem
    Cédric Bretonnière
    Universite de Nantes, Faculte de Medecine, UPRES EA 3826, 1 rue Gaston Veil, 44000 Nantes, France
    J Antimicrob Chemother 65:2423-7. 2010
    ..The aim of this study was to compare doripenem with imipenem and meropenem in an experimental rabbit model of Pseudomonas aeruginosa pneumonia and then to compare different doripenem doses and methods of intravenous administration...
  22. pmc Intermittent active motion versus immobilization in the treatment of Staphylococcus aureus-induced arthritis in a rabbit model
    Antoine Hamel
    Laboratoire d Antibiologie Clinique et Expérimentale UPRES EA 3826, Faculte de Medecine, Universite de Nantes, Nantes, France
    J Child Orthop 2:491-5. 2008
    ..This study has evaluated the effects of immobilization versus intermittent active motion on cartilage and on antibiotic efficacy in a rabbit septic arthritis model...
  23. pmc Combination of quinupristin-dalfopristin and gentamicin against methicillin-resistant Staphylococcus aureus: experimental rabbit endocarditis study
    Eric Batard
    Laboratoire d Antibiologie, Faculte de Medecine, Universite de Nantes, Nantes, France
    Antimicrob Agents Chemother 46:2174-8. 2002
    ..This experimental study found no additive benefit in combining Q-D and gentamicin against dalfopristin- and gentamicin-susceptible MRSA...
  24. doi request reprint In vivo efficacy of ceftolozane against Pseudomonas aeruginosa in a rabbit experimental model of pneumonia: comparison with ceftazidime, piperacillin/tazobactam and imipenem
    Cédric Bretonnière
    Universite de Nantes, Faculte de Medecine, UPRES EA 3826, 1 rue Gaston Veil, Nantes F 44035, France CHU de Nantes, pôle hospitalo universitaire 3, Service de réanimation médicale polyvalente, Place A Ricordeau, Nantes F 44093, France Electronic address
    Int J Antimicrob Agents 44:218-21. 2014
    ..i.d.). In conclusion, in this rabbit model of P. aeruginosa pneumonia, ceftolozane had an efficacy equivalent to that of comparator agents at a dose of 1g t.i.d. and had better efficacy at a higher dose (2g t.i.d.)...
  25. doi request reprint Hydrocortisone prevents immunosuppression by interleukin-10+ natural killer cells after trauma-hemorrhage
    Antoine Roquilly
    1Faculty of Medicine, UPRES EA 3826, Therapeutiques Cliniques et Experimentales des Infections, University of Nantes, Nantes, France 2Intensive Care Unit, Anesthesia and Critical Care Department, Hôtel Dieu HME, University Hospital of Nantes, Nantes, France 3Biochemistry Department, Hôtel Dieu University Hospital of Nantes, Nantes, France 4UMR PhAN 1280, Institut des Maladies de L appareil Digestif, University Hospital of Nantes, Nantes, France 5CHU Nantes, Laboratoire d Immunologie, Centre d Immunomonitorage Nantes Atlantique CIMNA, Nantes, France 6INSERM Center of Research in Transplantation and Immunology UMR 1064, Nantes, France 7INSERM, Unite 892, Institut de Recherche Therapeutique, Universite de Nantes, Nantes, France 8Etablissement Français du Sang, Universite de Nantes, Immunovirologie et Polymorphisme génétique, Nantes, France 9Department of Microbiology and Immunology at the Doherty Institute of Infection and Immunity, the University of Australia, Parkville, Victoria, Cleveland Clinic Health System
    Crit Care Med 42:e752-61. 2014
    ....
  26. doi request reprint Linezolid dampens neutrophil-mediated inflammation in methicillin-resistant Staphylococcus aureus-induced pneumonia and protects the lung of associated damages
    Cedric Jacqueline
    Universite de Nantes, Faculte de Medecine, Therapeutiques Cliniques et Experimentales des Infections, EA 3826
    J Infect Dis 210:814-23. 2014
    ..Clinical studies reported a potent survival advantage conferred by the oxazolidinone and called into question the use of glycopeptides as first-line therapy...
  27. ncbi request reprint Eagle effect in Corynebacterium diphtheriae
    Lucia Grandiere-Perez
    Laboratoire d Antibiologie, Faculte de Medecine, Nantes, France
    J Infect Dis 191:2118-20. 2005
    ..The low dosage (20 mg/kg/day) was significantly more effective than the high dosage (200 mg/kg/day) against both strains (P<.025), confirming the paradoxical bactericidal effect observed in vitro...
  28. pmc CpG-ODN and MPLA prevent mortality in a murine model of post-hemorrhage-Staphyloccocus aureus pneumonia
    Antoine Roquilly
    Laboratoire UPRES EA 3826 Thérapeutiques cliniques et expérimentales des infections, Faculte de Medecine, Universite de Nantes, Nantes, France
    PLoS ONE 5:e13228. 2010
    ..After hemorrhage, a preventive treatment with CpG-ODN or Monophosphoryl Lipid A increased transcriptional activity in DCs (TNF-α, IFN-β and IL-12p40) and decreased mortality of post-hemorrhage MSSA pneumonia...
  29. pmc Diffusion of ofloxacin in the endocarditis vegetation assessed with synchrotron radiation UV fluorescence microspectroscopy
    Eric Batard
    Universite de Nantes, EA3826 Thérapeutiques cliniques et expérimentales des infections, Nantes, France
    PLoS ONE 6:e19440. 2011
    ..Synchrotron radiation UV fluorescence microscopy is a new tool for assessment of antibiotic diffusion in the endocarditis vegetation bacterial masses...
  30. pmc Internal device decreases antibiotic's efficacy on experimental osteomyelitis
    Antoine Hamel
    Laboratoire de Thérapeutiques Cliniques et Expérimentales des Infections, EA 3826, Faculté de Médecine de Nantes, Universite de Nantes, Nantes Atlantique Universites, rue Gaston Veil, Nantes, 44000, France
    J Child Orthop 2:239-43. 2008
    ..We have evaluated the effect of internal and external osteosynthesis devices on the efficacy of vancomycin treatment in a rabbit model of methicillin-resistant Staphylococcus aureus (MRSA)-induced post-traumatic osteomyelitis...
  31. doi request reprint Pharmacokinetics of linezolid treatment using intravenous and oral administrations in extremely premature infants
    Mélanie Sicard
    Nantes University Hospital, Nantes, France
    Eur J Clin Pharmacol 71:611-5. 2015
    ..As linezolid is effective in Gram-positive cocci infection, and devoid of renal side-effects, it has been used in Nantes neonatal intensive care units and linezolid plasma concentrations were monitored...