- Genome adaptation to chemical stress: clues from comparative transcriptomics in Saccharomyces cerevisiae and Candida glabrataGaelle Lelandais
Equipe de Bioinformatique Genomique et Moleculaire, INSERM UMR S726, Universite Paris 7, INTS, 6 rue Alexandre Cabanel, 75015 Paris, France
Genome Biol 9:R164. 2008....
- Structure and properties of transcriptional networks driving selenite stress response in yeastsHélène Salin
Laboratoire de Genetique Moleculaire, ENS CNRS UMR 8541 46 rue d Ulm, 75005 Paris, France
BMC Genomics 9:333. 2008..We then used chromatin immunoprecipitation and knock-out experiments to investigate the role of some of these regulators and the regulatory connections between them...
- MiCoViTo: a tool for gene-centric comparison and visualization of yeast transcriptome statesGaelle Lelandais
Laboratoire de Génétique Moléculaire CNRS UMR8541, Ecole Normale Superieure, Paris, 75230 Cedex 05, France
BMC Bioinformatics 5:20. 2004..One of the challenging questions raised by the tremendous amount of microarray data is to identify groups of co-regulated genes and to understand their role in cell functions...
- The nucleotide sequence of Saccharomyces cerevisiae chromosome IVC Jacq
Laboratoire de Genetique Moleculaire, URA 1302 du CNRS, Ecole Normale Superieure, Paris, France
Nature 387:75-8. 1997..Chromosome IV shares with chromosomes II, V, XII, XIII and XV some long clustered duplications which partly explain its origin...
- In yeast, the 3' untranslated region or the presequence of ATM1 is required for the exclusive localization of its mRNA to the vicinity of mitochondriaM Corral-Debrinski
Laboratoire de Genetique Moleculaire, UMR CNRS 8541, Ecole Normale Superieure, 75230 Paris, France
Mol Cell Biol 20:7881-92. 2000..These data demonstrate that mRNA localization is one of the mechanisms used, in yeast, for segregating mitochondrial proteins...
- Clustered amino acid substitutions in the yeast transcription regulator Pdr3p increase pleiotropic drug resistance and identify a new central regulatory domainA Nourani
, CNRS URA1302, , Paris, France
Mol Gen Genet 256:397-405. 1997..Moreover, this hot spot for gain-of-function mutations overlaps two structural motifs, MI and MII, recently proposed to be conserved in the large family of Zn2Cys6 transcription factors...
- Pse1/Kap121-dependent nuclear localization of the major yeast multidrug resistance (MDR) transcription factor Pdr1A Delahodde
Laboratoire de Genetique Moleculaire, CNRS, UMR 8541, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
Mol Microbiol 39:304-12. 2001..Together, these new observations underscore the diversity of cellular processes that address to the nucleus two very similar transcription factors involved in the control of the same phenotype, thus securing their function in the cell...
- Analysis of a 23 kb region on the left arm of yeast chromosome IVT Delaveau
, CNRS URA 1302, , Paris, France
Yeast 12:1587-92. 1996..The sequence from cosmid IL10 was obtained entirely by a combined subcloning and walking primer strategy...
- An artificial transcription activator mimics the genome-wide properties of the yeast Pdr1 transcription factorF Devaux
, CNRS UMR 8541, , 46 rue d Ulm, Paris, France
EMBO Rep 2:493-8. 2001..We propose that this approach could be useful for the study of new transcription factors identified in silico from sequenced organisms. Complete data are available at www.biologie.ens.fr/yeast-publi.html...
- yMGV: a database for visualization and data mining of published genome-wide yeast expression dataP Marc
Laboratoire de Genetique Moleculaire, CNRS 8541, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
Nucleic Acids Res 29:E63-3. 2001..The yMGV interface is available at http://transcriptome.ens.fr/ymgv/...
- Multiple-drug-resistance phenomenon in the yeast Saccharomyces cerevisiae: involvement of two hexose transportersA Nourani
Laboratoire de Genetique Moleculaire, CNRS, URA1302, Ecole Normale Superieure, Paris, France
Mol Cell Biol 17:5453-60. 1997..We thus demonstrate the existence of genetic interactions between genes coding for two classes of transporters (ABC and MFS) to control the multidrug resistance process...
- Why are many mRNAs translated to the vicinity of mitochondria: a role in protein complex assembly?A Margeot
Laboratoire de Génétique Moléculaire CNRS, UMR 8541, Ecole Normale Superieure, 46 rue d Ulm 75230 Paris Cedex 05, France
Gene 354:64-71. 2005..In both cases this locus specific translation process might be connected to a correct complex assembly program and the cases of ATP synthase and cytochrome c oxidase complexes will be considered in this respect...
- I-Sce III an intron-encoded DNA endonuclease from yeast mitochondria. Asymmetrical DNA binding properties and cleavage reactionM Schapira
, CNRS URA1302, , Paris, France
Nucleic Acids Res 21:3683-9. 1993..These findings suggest that this intron-encoded DNA endonuclease may have role in the RNA splicing process of the intron...
- Early expression of yeast genes affected by chemical stressA Lucau-Danila
Laboratoire de Genetique Moleculaire, CNRS UMR 8541, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
Mol Cell Biol 25:1860-8. 2005..We proposed that Yap1 nuclear localization and DNA binding are necessary but not sufficient to elicit the specificity of the chemical stress response...
- Mitochondria-associated yeast mRNAs and the biogenesis of molecular complexesM Garcia
Laboratoire de Genetique Moleculaire, Centre National de la Recherche Scientifique Ecole Normale Supérieure, Paris, France
Mol Biol Cell 18:362-8. 2007..Site-specific translation loci, both outside and inside mitochondria, may coordinate the construction of molecular complexes composed of both nuclearly and mitochondrially encoded subunits...
- Transcriptomes, transcription activators and microarraysF Devaux
Laboratoire de Genetique Moleculaire, Ecole Normale Superieure, 46 rue d'Ulm, 75005, Paris, France
FEBS Lett 498:140-4. 2001..All the collected data are available through the on-line database yTAFNET (http://transcriptome.ens.fr/ytafnet/). yTAFNET is designed to help the characterization of connections between the different yeast regulatory networks...
- Positive autoregulation of the yeast transcription factor Pdr3p, which is involved in control of drug resistanceA Delahodde
Laboratoire de Génétique Moléculaire CNRS URA1302, Ecole Normale Superieure, Paris, France
Mol Cell Biol 15:4043-51. 1995..Finally, we provide evidence in the absence of PDR1 for a PDR3-controlled transcriptional induction of the drug pump by cycloheximide and propose a model for the mechanism governing the transcriptional autoregulation of Pdr3p...
- A new specific DNA endonuclease activity in yeast mitochondriaB Sargueil
, Paris, France
Mol Gen Genet 225:340-1. 1991..We have discovered in mitochondrial extracts from the yeast strain 777-3A a new DNA endonuclease activity which cleaves the fused exon A3-exon A4 junction sequence of the CO XI gene...
- The role of the 3' untranslated region in mRNA sorting to the vicinity of mitochondria is conserved from yeast to human cellsJ Sylvestre
Laboratoire de Genetique Moleculaire, Unité Mixte Recherche Centre National de la Recherche Scientifique 8541, Ecole Normale Superieure, Paris, France
Mol Biol Cell 14:3848-56. 2003..Therefore, it seems that the recognition mechanism of OXA1 3' UTR is conserved throughout evolution and is necessary for Oxa1p function...
- PDR3, a new yeast regulatory gene, is homologous to PDR1 and controls the multidrug resistance phenomenonT Delaveau
Laboratoire de Genetique Moleculaire, CNRS URA 1302, Paris, France
Mol Gen Genet 244:501-11. 1994..The fact that the absence of both PDR1 and PDR3 (simultaneous disruption of the two genes) enhances multidrug sensitivity strongly suggests that the two transcriptional factors have closely related functions...
- Two mutant forms of the S1/TPR-containing protein Rrp5p affect the 18S rRNA synthesis in Saccharomyces cerevisiaeC Torchet
Laboratoire de Genetique Moleculaire, Ecole Normale Superieure, URA C N R S 1302, Paris, France
RNA 4:1636-52. 1998..Furthermore, we show that suppression by the Rok1p putative RNA helicase rescues the 18S rRNA synthesis defect caused by the rrp5delta6 mutation...