Bernard Iung

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..To evaluate temporal trends in percutaneous mitral commissurotomy (PMC) in terms of changes in patient characteristics and their impact on immediate results...

..To identify the characteristics, treatment, and outcomes of contemporary patients with valvular heart disease (VHD) in Europe, and to examine adherence to guidelines...

..5 cm2) and who do not have an advanced heart disease. When the conditions are favourable, percutaneous mitral commissurotomy can be considered in patients who have few symptoms, in particular in order to reduce the thromboembolic risk...

..We sought to evaluate the feasibility and immediate and late results of mitral valve repair (MVRep) for acute and healed endocarditis...

..In addition, PMC may reduce the thromboembolic risk related to mitral stenosis...

..In case of symptomatic aortic stenosis in the elderly, the decision to operate should take into account an evaluation of the individual risk to benefit ratio, and avoid to differ the decision until an advanced stage of the disease...

..Long-term follow-up after percutaneous mitral commissurotomy enables predictive factors of late results to be identified...

..The aim of this study was to assess prosthesis/annulus discongruence and its impact on the occurrence of significant aortic regurgitation (AR) immediately after transcatheter aortic valve implantation (TAVI)...

..We sought to describe the results of transfemoral aortic valve implantation using either the Sapien prosthesis or the CoreValve System...

..Transcatheter aortic valve implantation (TAVI) is an alternative to conventional surgery in high-risk patients with severe aortic stenosis (AS), but data regarding mitral regurgitation (MR) characteristics and changes after TAVI are sparse...

..For asymptomatic patients with severe mitral regurgitation, guidelines recommend surgery in selected patients. However, little is known on how the current practice fits with guidelines...

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..In conclusion, the present series suggests that transarterial Medtronic CoreValve implantation is feasible in selected patients with bicuspid aortic valve and may lead to short-term hemodynamic and clinical improvement...

..We sought to evaluate the prognostic value of the degree of commissural opening (CO) on outcome...

..To assess the results of percutaneous aortic balloon valvuloplasty (PABV) as a potential bridge to further intervention in patients referred for transcatheter aortic valve implantation (TAVI)...

..To identify the proportion and characteristics of patients with severe symptomatic mitral regurgitation (MR) who are denied surgery...

..To assess the results of transcatheter aortic valve implantation (TAVI) using the Medtronic CoreValve System (MCS), through the transarterial approach, in high-risk patients with degenerated surgically implanted aortic bioprostheses (SP)...

..Transcatheter aortic valve implantation (TAVI) has been shown to be successful in high risk subgroups of patients. Our goal is therefore to evaluate the impact of a history of CABG on the outcome of patients who undergo TAVI...

..Vascular complications remain the main limitation of transfemoral aortic valve implantation. Based on a single-centre experience, we aim to detail the type, management and impact of those vascular complications...

..We aimed at evaluating the determinants of RVol in both organic (OMR) and functional mitral regurgitation (FMR)...

..We describe the first report of an Edwards SAPIEN valve implanted in a tricuspid bioprosthesis from the femoral vein. We highlight the feasibility of this previously avoided approach and the techniques involved...

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..There was a better concordance between practice and guidelines concerning interventions in asymptomatic patients. These findings underline the need for better implementation of guidelines...

..Whether threshold values of AVC obtained with EBCT could be extrapolated to multislice computed tomography (MSCT) was unclear and AVC diagnostic value in patients with low ejection fraction (EF) has never been specifically evaluated...

..To describe the characteristics of coronary artery disease (CAD) in high-risk patients with aortic stenosis (AS), and its impact on indications for transcatheter aortic valve implantation (TAVI), and on outcomes...

..Doppler pressure half-time (PHT) is widely used for mitral valve area (MVA) assessment but its accuracy has not been fully evaluated before and after percutaneous mitral commissurotomy (PMC) in a large series of patients...

..We describe the results of transcatheter aortic valve implantation (TAVI) in high-risk patients with aortic stenosis. Transfemoral access was the first option, and if contraindicated, the transapical approach was used...

..Real-time three-dimensional transoesophageal echocardiography (3D-TEE, MVA3D) may overcome these limitations but its accuracy has never been evaluated...

..This method has the advantage of simplicity but has not been evaluated in a nonselected series of consecutive patients before and after percutaneous mitral commissurotomy (PMC)...

..We suggest a threshold of 60 ml/m(2), which has good sensitivity, albeit with low specificity...

..Intervention is advised in selected asymptomatic patients with aortic valve disease. However, little is known regarding their actual management...

..To analyse decision-making in elderly patients with severe, symptomatic aortic stenosis (AS)...

..No previous study has looked for an association between aortic dilatation and the clinical sequelae of patent foramen ovale (PFO), although a possible relationship has been identified in case reports...

..A multidisciplinary approach involving cardiologists, cardiac surgeons, and anesthesiologists is required for this purpose, especially in high-risk patients...

..The changes in demographics explain why new procedures, such as transcatheter aortic valve implantation and percutaneous mitral valve repair, are potentially attractive in patients with high risk or even contraindications for surgery...

..The aim of this study was to define the sensitivity and specificity of semiquantitative methods compared with the proximal isovelocity surface area method as a reference for the diagnostic of severe AR...

..Transesophageal echocardiography (TEE) is reputed to be more accurate than transthoracic echocardiography (TTE), but validation studies are rare. A safeguard for LVOTd measurements is thus desirable...

..In asymptomatic mitral stenosis (MS), the usefulness of peak exercise Doppler echocardiography (DE) values is acknowledged, but the role of values recorded during the first stage of DE remains unclear...

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..Hence, the study aim was to evaluate the impact of PMC on RV function, by using Doppler-echocardiography...

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..Today balloon commissurotomy is a substitute for surgical commissurotomy and a complement to valve replacement...

..The aim of this study was to assess how early combined cerebral and abdominal magnetic resonance imaging (MRI) affects the diagnosis and management of adults with endocarditis...

..Overall, the use of TAVI will undoubtedly increase over time, enabling a larger number of patients with severe aortic stenosis to be treated in an effective and safe way, in complement to surgical aortic valve replacement...

..CMBs have been reported in isolated cases of infective endocarditis (IE), but their frequency and the association of CMBs with IE have not yet been studied...

..We sought to describe the results of a strategy offering either transfemoral or transapical aortic valve implantation in high-risk patients with severe aortic stenosis...

..Three-dimensional TEE clearly demonstrated the functional nature of the regurgitation with a transient and sudden tenting of the mitral leaflets with a circular mitral annulus resulting in a total absence of leaflet coaptation...

..Our aim was to evaluate the additional diagnostic value of the use of NI-CWD and the right parasternal view for the evaluation of AS severity in the modern area...

..Thus, percutaneous interventions already play an important role in treatment of valvular heart disease, a role that seems set for future expansion...

..The aim of the present study was to evaluate if the use of a fixed angle could provide an acceptable MVA estimation...

..We aimed to evaluate the relationship among N-terminal fragment of proBNP (Nt-proBNP), AS severity, symptoms and outcome in a large cohort of elderly patients with AS...

..Endocarditis is an important etiology of valvular disease and is most commonly caused by Staphylococci. Rheumatic heart disease remains prevalent in developing countries...

..The aim of the present study was to evaluate the TEE feasibility and efficiency using Kalinox compared with the standard care using benzodiazepine...

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..Beyond that stage, the results were comparable with those of bioprostheses in a cohort of young patients...

..This study aimed to compare long-term outcomes after successful thrombolysis vs. systematic attempted rescue PTCA...

..In addition, superiority of RT3DE for the evaluation of commissural splitting after percutaneous mitral commissurotomy (PMC) is unknown...

..We report the case of a 58-year-old woman with severe radiation-induced mitral stenosis and discuss the potential additional value of three-dimensional transesophageal echocardiography...

..Despite marked global differences in the prevalence of rheumatic heart disease, little is known about geographic variations in the characteristics of patients with severe mitral stenosis...

..Neurologic complications of endocarditis can influence diagnosis, therapeutic plans, and prognosis...

..To explore the diagnostic performance of MRI for the diagnosis of acute myocarditis, using a comprehensive imaging approach...

..FNa PET imaging represents a promising imaging modality to evaluate osteoblastic activity inside calcified aortic valves...

..The diversity of cases highlights the need for appropriate evaluation of heart disease before pregnancy and close follow-up by specialized teams...

..These findings provide evidence of inflammatory injury more severe in AS than in AR and involvement of mesenchymal cell response...

..To explore the variations in the use of invasive coronary procedures after acute coronary syndromes...

..Our objective was to assess non-invasively the presence of non-clinical markers of myocardial involvement in acute rheumatic fever...

..The incidence of thromboembolic events (TE) in the early period following mitral valve repair (MV repair) is poorly documented. The aim of this prospective study was to evaluate it, and to determine predictive factors...

..Recommendations are therefore almost entirely based on non-randomized studies and relevant basic science...

..It also allows for the first time, sequential MVA assessment during diastole. Notwithstanding marked flow and velocities changes, MVA remained unchanged throughout diastole underscoring the lack of flow-related valvular reserve in MS...

..The purpose of the present study was to evaluate the prognostic implications of perioperative B-type natriuretic peptide (BNP) and cardiac troponin I concentrations in patients undergoing cardiopulmonary bypass for cardiac surgery...

..019] P = 0.04, for an increase of 1% in hematocrit and 1 min in duration of surgery, respectively). In conclusion, these data support the idea that BIMA graft slightly increases postoperative drainage but not transfusion requirement...