Harri Vainio

Summary

Affiliation: International Agency for Research on Cancer
Country: France

Publications

  1. ncbi Primary and secondary prevention in colorectal cancer
    Harri Vainio
    International Agency for Research on Cancer, Lyon, France
    Acta Oncol 42:809-15. 2003
  2. ncbi Targeting angiogenesis -- a novel mode in cancer chemoprevention
    Harri Vainio
    Unit of Chemoprevention, International Agency for Research on Cancer, Lyon, France
    Asian Pac J Cancer Prev 4:83-6. 2003
  3. ncbi The need for preventive drugs and vaccines in global cancer control: a challenge for public health and for industry
    Harri Vainio
    International Agency for Research on Cancer, Unit of Chemoprevention, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Toxicol Ind Health 18:84-90. 2002
  4. ncbi Weight control and physical activity in cancer prevention: international evaluation of the evidence
    Harri Vainio
    International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon, France
    Eur J Cancer Prev 11:S94-100. 2002
  5. ncbi The public health potential of aspirin
    Harri Vainio
    Unit of Chemoprevention, International Agency for Research on Cancer, Lyon, France
    Pharmacol Toxicol 91:49-50. 2002
  6. ncbi Hormone replacement therapy for symptoms but not for chemoprevention of chronic diseases
    Harri Vainio
    Unit of Chemoprevention, International Agency for Research on Cancer, Lyon, France
    Asian Pac J Cancer Prev 4:275-6. 2003
  7. ncbi Evaluation of cancer-preventive agents and strategies a new program at the International Agency for Research on Cancer
    H Vainio
    Unit of Chemoprevention, International Agency for Research on Cancer, Lyon, France
    Ann N Y Acad Sci 952:177-80. 2001
  8. ncbi Use of biomarkers in risk assessment
    H Vainio
    WHO, International Agency for Research on Cancer, Unit of Chemoprevention, 150 cours Albert Thomas, F 69372 Lyon, France
    Int J Hyg Environ Health 204:91-102. 2001
  9. ncbi Is COX-2 inhibition a panacea for cancer prevention?
    H Vainio
    Unit of Chemoprevention, International Agency for Research on Cancer, Lyon, France
    Int J Cancer 94:613-4. 2001
  10. ncbi An international evaluation of the cancer-preventive potential of nonsteroidal anti-inflammatory drugs
    H Vainio
    Unit of Chemoprevention, IARC, Lyon, France
    Cancer Epidemiol Biomarkers Prev 6:749-53. 1997

Collaborators

Detail Information

Publications42

  1. ncbi Primary and secondary prevention in colorectal cancer
    Harri Vainio
    International Agency for Research on Cancer, Lyon, France
    Acta Oncol 42:809-15. 2003
    ..Overall, primary and secondary prevention, chemoprevention and screening research and implementation of these prevention strategies are priorities for reduction of colorectal cancer incidence and mortality...
  2. ncbi Targeting angiogenesis -- a novel mode in cancer chemoprevention
    Harri Vainio
    Unit of Chemoprevention, International Agency for Research on Cancer, Lyon, France
    Asian Pac J Cancer Prev 4:83-6. 2003
    ..Development and use, alone or in combination with other agents with other mechanisms of action, of specific antiangiogenic agents is likely to open new possibilities in cancer chemoprevention...
  3. ncbi The need for preventive drugs and vaccines in global cancer control: a challenge for public health and for industry
    Harri Vainio
    International Agency for Research on Cancer, Unit of Chemoprevention, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Toxicol Ind Health 18:84-90. 2002
    ..Future enhanced efforts on an international basis are needed to guarantee access to these lifesaving drugs and vaccines. Putting prevention high on the agenda requires political courage and a long-term perspective...
  4. ncbi Weight control and physical activity in cancer prevention: international evaluation of the evidence
    Harri Vainio
    International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon, France
    Eur J Cancer Prev 11:S94-100. 2002
    ..Thus adiposity and physical inactivity appear to be the most important avoidable causes of these cancers...
  5. ncbi The public health potential of aspirin
    Harri Vainio
    Unit of Chemoprevention, International Agency for Research on Cancer, Lyon, France
    Pharmacol Toxicol 91:49-50. 2002
  6. ncbi Hormone replacement therapy for symptoms but not for chemoprevention of chronic diseases
    Harri Vainio
    Unit of Chemoprevention, International Agency for Research on Cancer, Lyon, France
    Asian Pac J Cancer Prev 4:275-6. 2003
    ..The WHI estrogen and progestin arm was prematurely stopped in July 2002 because the overall risks of the intervention outweighed the benefits (Women's Health Initiative Investigators, 2002)...
  7. ncbi Evaluation of cancer-preventive agents and strategies a new program at the International Agency for Research on Cancer
    H Vainio
    Unit of Chemoprevention, International Agency for Research on Cancer, Lyon, France
    Ann N Y Acad Sci 952:177-80. 2001
    ..Carotenoids, 3. Vitamin A, 4. Retinoids, and 5. Sunscreens--and volume 6 (Weight Control and Physical Activity) is in press. Future volumes will include evaluations of breast cancer screening (vol. 7) and fruits and vegetables (vol. 8)...
  8. ncbi Use of biomarkers in risk assessment
    H Vainio
    WHO, International Agency for Research on Cancer, Unit of Chemoprevention, 150 cours Albert Thomas, F 69372 Lyon, France
    Int J Hyg Environ Health 204:91-102. 2001
    ..Factors associated with a small differential risk, however theoretically or mechanistically important, offer only little practical use...
  9. ncbi Is COX-2 inhibition a panacea for cancer prevention?
    H Vainio
    Unit of Chemoprevention, International Agency for Research on Cancer, Lyon, France
    Int J Cancer 94:613-4. 2001
    ..Combinations of COX-2 inhibitors with other agents that target other pathways in carcinogenesis may be a more efficacious and a less toxic strategy in cancer chemoprevention...
  10. ncbi An international evaluation of the cancer-preventive potential of nonsteroidal anti-inflammatory drugs
    H Vainio
    Unit of Chemoprevention, IARC, Lyon, France
    Cancer Epidemiol Biomarkers Prev 6:749-53. 1997
    ..The results of the meeting, including recommendations for future research, will be published as Volume 1 of the IARC Handbooks of Cancer Prevention...
  11. ncbi Use of biomarkers--new frontiers in occupational toxicology and epidemiology
    H Vainio
    Unit of Chemoprevention, International Agency for Research on Cancer, Lyon, France
    Toxicol Lett 102:581-9. 1998
    ..Factors associated with a small differential risk, however theoretically or mechanistically important, offer only little practical use...
  12. ncbi Promise of molecular epidemiology--epidemiologic reasoning, biological rationale and risk assessment
    H Vainio
    Unit of Chemoprevention, International Agency for Research on Cancer, Lyon, France
    Scand J Work Environ Health 25:498-504. 1999
    ..As experience accumulates, there is new appreciation that attention to study design, infrastructure, and biomarker validation can improve the results...
  13. ncbi An international evaluation of the cancer-preventive potential of sunscreens
    H Vainio
    International Agency for Research on Cancer, Lyon Cedex, France
    Int J Cancer 88:838-42. 2000
    ..Such an extension may increase the risk for cutaneous melanoma. The working group warned against relying solely on sunscreens for protection from UV radiation...
  14. ncbi Non-steroidal anti-inflammatory drugs and chemoprevention of cancer
    H Vainio
    Unit of Chemoprevention, International Agency for Research on Cancer, Lyon, France
    Ann Chir Gynaecol 89:173-6. 2000
    ..Some of the NSAID induced gastric ulceration and bleeding will most likely be avoided by adopting the use of cyclooxygenase-2 (COX-2) selective NSAIDs, which will selectively inhibit COX-2 while sparing COX-1...
  15. ncbi Cancer-preventive effects of sunscreens are uncertain
    H Vainio
    Unit of Chemoprevention, International Agency for Research on Cancer, Lyon, France
    Scand J Work Environ Health 26:529-31. 2000
    ..Such an extension may increase the risk for cutaneous melanoma. The workshop warned against relying solely on sunscreens for protection from ultraviolet radiation...
  16. ncbi Prevention of disease with pharmaceuticals
    H Vainio
    Unit of Chemoprevention, International Agency for Research on Cancer, Lyon, France
    Pharmacol Toxicol 88:111-8. 2001
    ..Better understanding of the molecular steps critical to carcinogenesis should open new avenues for cancer chemoprevention...
  17. ncbi Diabetes mellitus and ovarian cancer (Sweden)
    Elisabete Weiderpass
    International Agency for Research on Cancer, Lyon, France
    Cancer Causes Control 13:759-64. 2002
    ..We present results from a large, population-based cohort study in Sweden, where we assessed ovarian cancer risk among patients hospitalized for diabetes mellitus...
  18. ncbi Weight control and physical activity in cancer prevention
    Franca Bianchini
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France
    Obes Rev 3:5-8. 2002
    ..In light of the beneficial effects of weight control and physical activity for cancer prevention, a healthy lifestyle, keeping a low body weight and exercising most days of the week, is recommended...
  19. ncbi Occupational exposures and gastrointestinal cancers among Finnish women
    Elisabete Weiderpass
    International Agency for Research on Cancer, Unit of Field and Intervention Studies, 150 cours Albert Thomas, F 69372 Lyon
    J Occup Environ Med 45:305-15. 2003
    ..Therefore, the associations observed should need to be confirmed in other studies...
  20. ncbi Overweight, obesity, and cancer risk
    France Bianchini
    Unit of Chemoprevention, International Agency for Research on Cancer IARC, Lyon, France
    Lancet Oncol 3:565-74. 2002
    ..Avoidance of weight gain thus seems to be an important factor for cancer prevention...
  21. ncbi Reduced risk of prostate cancer among patients with diabetes mellitus
    Elisabete Weiderpass
    Unit of Field and Intervention Studies, International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
    Int J Cancer 102:258-61. 2002
    ..We did find a small, but significantly decreased risk of prostate cancer among men who had been hospitalized for diabetes mellitus...
  22. ncbi Isothiocyanates in cancer prevention
    Franca Bianchini
    International Agency for Research on Cancer, Lyon, France
    Drug Metab Rev 36:655-67. 2004
    ..However, further research is needed to better clarify the importance of these polymorphisms in modulating the effect of isothiocyanates in cancer development...
  23. ncbi A prospective study of body size in different periods of life and risk of premenopausal breast cancer
    Elisabete Weiderpass
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 13:1121-7. 2004
    ..The decreased risk of premenopausal breast cancer was observed in overweight and obese women without, but not in those with, a family history of breast cancer...
  24. ncbi [Overweight and physical inactivity can increase the risk of cancer. Evident connection in the most common cancer types]
    Jennifer Terry
    General Clinical Research Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Lakartidningen 101:894-6. 2004
  25. ncbi Effect of glutathione-S-transferase polymorphisms on the cancer preventive potential of isothiocyanates: an epidemiological perspective
    Adeline Seow
    Department of Community, Occupational and Family Medicine, National University of Singapore, 16 Medical Drive, MD3, Singapore 117597, Singapore
    Mutat Res 592:58-67. 2005
    ....
  26. ncbi Fatty fish consumption lowers the risk of endometrial cancer: a nationwide case-control study in Sweden
    Paul Terry
    Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 11:143-5. 2002
    ..8-1.3; P-value for trend, 0.72). Total fish consumption was inversely associated with risk, although weakly. Our results suggest that the consumption of fatty fish, but not other types of fish, may decrease the risk of endometrial cancer...
  27. pmc Organochlorines in Swedish women: determinants of serum concentrations
    Anders Wicklund Glynn
    Swedish National Food Administration, Uppsala, Sweden
    Environ Health Perspect 111:349-55. 2003
    ..This shows that the studied organochlorines should not be treated as a homogeneous group of compounds in epidemiologic studies...
  28. ncbi Distribution of glutathione S-transferase M1, P1 and T1 genotypes in different age-groups of Finns without diagnosed cancer
    Anu Voho
    Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, 41 a A, FI 00250, Helsinki, Finland
    Cancer Detect Prev 30:144-51. 2006
    ..It can be postulated that if the at-risk genotypes of these genes were real risk factors for the environmental cancers, their prevalence would presumably decrease with age in cancer-free part of the population...
  29. ncbi Can health promotion at the workplace help prevent cancer?
    Harri Vainio
    Scand J Work Environ Health 28:137-9. 2002
  30. ncbi Fruit and vegetables in cancer prevention
    Harri Vainio
    Finnish Institute of Occupational Health, Helsinki, Finland
    Nutr Cancer 54:111-42. 2006
    ....
  31. ncbi From hazard identification to weighing the benefits and drawbacks of prevention
    Harri Vainio
    Finnish Institute of Occupational Health, Topeliuksenkatu 41 A, Helsinki, Finland
    Toxicol Appl Pharmacol 207:28-33. 2005
    ..We discuss in general terms ways of preventing cancer and of evaluating preventive strategies, giving as example mammography screening...
  32. ncbi EPHX1 gene polymorphisms and individual susceptibility to lung cancer
    Anu Voho
    Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN 00250 Helsinki, Finland
    Cancer Lett 237:102-8. 2006
    ..Neither was any difference seen in the prevalence of the EPHX1 Tyr113His genotypes or interpreted EPHX1 phenotypes in the different age groups...
  33. ncbi NAT2 slow acetylator genotype as an important modifier of breast cancer risk
    Pia Sillanpää
    Finnish Institute of Occupational Health, Helsinki, Finland
    Int J Cancer 114:579-84. 2005
    ..60; 95% CI, 1.07-2.39). Our results therefore suggest that NAT2 slow acetylator genotype may be an important modifier of environmentally induced breast cancer risk in Finnish women...
  34. ncbi Reporting, appraising, and integrating data on genotype prevalence and gene-disease associations
    Julian Little
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, Scotland
    Am J Epidemiol 156:300-10. 2002
    ....
  35. ncbi p53 autoantibodies predict subsequent development of cancer
    Yongliang Li
    Department of Environmental Health Sciences, Columbia University, New York, NY 10032, USA
    Int J Cancer 114:157-60. 2005
    ..8-10.9) with a positive predictive value of 0.76 and an average lead time to diagnosis of 3.5 years. p53 autoantibodies were also significantly associated with p53 alterations in the resultant tumors (kappa = 0.78, p = 0.01)...
  36. ncbi Building an evidence base for occupational health interventions
    Jos Verbeek
    Kuopio Regional Institute of Occupational Health, Department of Research and Development in Occupational Health, Finland
    Scand J Work Environ Health 30:164-70. 2004
    ..Occupational health could benefit considerably from greater awareness of the evidence for and against various types of intervention...
  37. ncbi Genetic biomarkers and occupational epidemiology--recollections, reflections and reconsiderations
    Harri Vainio
    Scand J Work Environ Health 30:1-3. 2004
  38. ncbi Combined COMT and GST genotypes and hormone replacement therapy associated breast cancer risk
    Katja Mitrunen
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland
    Pharmacogenetics 12:67-72. 2002
    ..84-45.0) of breast cancer in this study group. These results suggest that the use of HRT could substantially increase the risk of breast cancer among women with specific combinations of the at-risk genotypes of COMT and GST genes...
  39. ncbi Acrylamide in heat-processed foods--a carcinogen looking for human cancer?
    Harri Vainio
    Eur J Epidemiol 18:1105-6. 2003
  40. ncbi N-Acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk
    Harriet Wikman
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland
    Pharmacogenetics 12:227-33. 2002
    ..20, 95% CI 1.51 to 11.6). The results suggest for the first time that in addition to GSTs, the NATs play an important role in inception of asthmatic reactions related to occupational exposure to diisocyanates...
  41. ncbi Dietary factors in relation to endometrial cancer: a nationwide case-control study in Sweden
    Paul Terry
    Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden
    Nutr Cancer 42:25-32. 2002
    ..On the other hand, the use of iron supplements appeared to increase the risk (OR = 1.7, 95% CI = 0.9-3.3, P for trend = 0.03). The findings are discussed with respect to previous studies and the possible underlying mechanisms...
  42. ncbi CYP1A1 and CYP1B1 genetic polymorphisms, smoking and breast cancer risk in a Finnish Caucasian population
    Pia Sillanpää
    Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, Helsinki, Finland
    Breast Cancer Res Treat 104:287-97. 2007
    ..Our results suggest that the CYP1B1 polymorphism may be an important modifier of breast cancer risk in Finnish Caucasian women who have been exposed to tobacco smoke and/or carry the NAT2 slow acetylator genotype...