Research Topics
| H OhshimaSummaryAffiliation: International Agency for Research on Cancer Country: France Publications
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Detail Information
Publications
Chemical basis of inflammation-induced carcinogenesisHiroshi Ohshima
Unit of Endogenous Cancer Risk Factors, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
Arch Biochem Biophys 417:3-11. 2003..Appropriate treatment of inflammation should be explored further for chemoprevention of human cancers...- Prevention of human cancer by modulation of chronic inflammatory processesHiroshi Ohshima
International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
Mutat Res 591:110-22. 2005..Better understanding of the molecular mechanisms by which chronic inflammation increases cancer risk will lead to further development of new strategies for cancer prevention at many sites... - Antioxidant and pro-oxidant actions of flavonoids: effects on DNA damage induced by nitric oxide, peroxynitrite and nitroxyl anionH Ohshima
Unit of Endogenous Cancer Risk Factors, International Agency for Research on Cancer, Lyon, France
Free Radic Biol Med 25:1057-65. 1998..Our results indicate that flavonoids have antioxidant properties, but some act as pro-oxidants in the presence of NO... - Analysis of 3-nitrotyrosine in biological fluids and protein hydrolyzates by high-performance liquid chromatography using a postseparation, on-line reduction column and electrochemical detection: results with various nitrating agentsH Ohshima
Unit of Endogenous Cancer Risk Factors, International Agency for Research on Cancer, Lyon, France
Nitric Oxide 3:132-41. 1999..A simple purification method using a C18 Sep-Pak cartridge is also described for analysis of free NTYR in human plasma... - Induction of DNA strand breakage and base oxidation by nitroxyl anion through hydroxyl radical productionH Ohshima
Unit of Endogenous Cancer Risk Factors, International Agency for Research on Cancer, Lyon, France
Free Radic Biol Med 26:1305-13. 1999..Thus NO may play an important role as a cause of diverse pathophysiological conditions such as inflammation and neurodegenerative diseases... - Genetic and epigenetic damage induced by reactive nitrogen species: implications in carcinogenesisHiroshi Ohshima
International Agency for Research on Cancer, Unit of Endogenous Cancer Risk Factors, 150 cours Albert Thomas, 69372, Cedex 08, Lyon, France
Toxicol Lett 140:99-104. 2003..Appropriate treatment of inflammation should be further explored for chemoprevention of human cancers, especially those associated with chronic inflammation... - Oxidative DNA damage in human lymphocytes: correlations with plasma levels of alpha-tocopherol and carotenoidsF Bianchini
International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
Carcinogenesis 21:321-4. 2000..Further studies are warranted to better elucidate the role of antioxidants in the modulation of oxidative stress in vivo... - Formation of spiroiminodihydantoin nucleoside by reaction of 8-oxo-7,8-dihydro-2'-deoxyguanosine with hypochlorous acid or a myeloperoxidase-H(2)O(2)-Cl(-) systemT Suzuki
Unit of Endogenous Cancer Risk Factors, International Agency for Research on Cancer, 69372 Lyon, Cedex 08, France
Chem Res Toxicol 14:1163-9. 2001..Our results suggest that formation of dSph from 8-oxodGuo is mediated, possibly via an addition of Cl(+) to, or two-electron oxidation of 8-oxodGuo, with HOCl or the myeloperoxidase-H(2)O(2)-Cl(-) system... - Nitrated and oxidized plasma proteins in smokers and lung cancer patientsB Pignatelli
International Agency for Research on Cancer, Lyon, France
Cancer Res 61:778-84. 2001..Our results indicate that cigarette smoking increases oxidative stress and that during lung cancer development, formation of reactive nitrogen species results in nitration and oxidation of plasma proteins... - Endogenously formed N-nitroso compounds and nitrosating agents in human cancer etiologyH Bartsch
Unit of Environmental Carcinogens and Host Factors, International Agency for Research on Cancer, Lyon, France
Pharmacogenetics 2:272-7. 1992..Together these results support the role of NOC and other nitrite-derived mutagens in human cancer etiology, in particular when exposure starts early in life and persists over a long period.(ABSTRACT TRUNCATED AT 250 WORDS).. - Increased oxidative and nitrative stress in human stomach associated with cagA+ Helicobacter pylori infection and inflammationC Q Li
Unit of Endogenous Cancer and Risk Factors, International Agency for Research on Cancer, Lyon, France
Dig Dis Sci 46:836-44. 2001..These results indicate that infection with cagA+ H. pylori induces significant oxidative and nitrative stress in stomach mucosa, contributing to the pathogenesis of H. pylori-associated gastroduodenal diseases... - Inverse correlation between alcohol consumption and lymphocyte levels of 8-hydroxydeoxyguanosine in humansF Bianchini
International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, Cedex 08, France
Carcinogenesis 22:885-90. 2001..The finding of a relationship between alcohol consumption and 8-oxodGuo in lymphocytes was unexpected and not based on a prior hypothesis. This finding consequently requires confirmation from a randomized intervention study... - Helicobacter pylori eradication attenuates oxidative stress in human gastric mucosaB Pignatelli
International Agency for Research on Cancer, Lyon, France
Am J Gastroenterol 96:1758-66. 2001..Oxidative stress is reduced by bacterial eradication in the first stages of mild gastritis. Moderate-severe gastritis may be a step that is reversible for iNOS, but partly irreversible for NTYR and 8-hydroxy-2'-deoxyguanosine... - Nitrotyrosine as a new marker for endogenous nitrosation and nitration of proteinsH Ohshima
International Agency for Research on Cancer, Unit of Environmental Carcinogens and Host Factors, Lyon, France
Food Chem Toxicol 28:647-52. 1990..8 +/- 2.3 (n = 11) were detected (detection limit 0.2 micrograms/litre). NTYR in proteins or its metabolites in urine can be readily analysed by GC-TEA as a new/additional marker for endogenous nitrosation and nitration... - Analysis of oxidized and nitrated proteins in plasma and tissues as biomarkers for exposure to reactive oxygen and nitrogen speciesH Ohshima
International Agency for Research on Cancer, Lyon, France
IARC Sci Publ 156:393-4. 2002 - Chlorination of guanosine and other nucleosides by hypochlorous acid and myeloperoxidase of activated human neutrophils. Catalysis by nicotine and trimethylamineM Masuda
Unit of Endogenous Cancer Risk Factors, International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon Cedex 8, France
J Biol Chem 276:40486-96. 2001.... - Nitric oxide prevents gamma-radiation-induced cell cycle arrest by impairing p53 function in MCF-7 cellsL Chazotte-Aubert
Unit of Endogenous Cancer Risk Factors, Group of Molecular Carcinogenesis, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex 08, 69372, France
Biochem Biophys Res Commun 281:766-71. 2001..This Bax accumulation, however, was shown to occur via a p53-independent pathway... - 8-nitroguanine, a product of nitrative DNA damage caused by reactive nitrogen species: formation, occurrence, and implications in inflammation and carcinogenesisHiroshi Ohshima
International Agency for Research on Cancer, Lyon, France
Antioxid Redox Signal 8:1033-45. 2006..Further studies are warranted to establish the roles of 8-NO(2)-G in various pathophysiological conditions and inflammation-associated cancer... - Nitrative DNA damage in inflammation and its possible role in carcinogenesisTomohiro Sawa
International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France
Nitric Oxide 14:91-100. 2006..Better understanding of the mechanisms and role of such nitrative damage in chronic inflammation-associated human cancer is a necessary basis to develop new strategies for cancer prevention by modulating the process of inflammation... - Differences in oxidative stress dependence between gastric adenocarcinoma subtypesBrigitte Bancel
Hopital de la Croix Rousse, Department of Pathology, 103 Grande Rue de la Croix Rousse, 69004 Lyon, France
World J Gastroenterol 12:1005-12. 2006..To investigate the extent of oxidative stress in pre-neoplastic and neoplastic gastric mucosa in relation to their pathological criteria and histological subtypes... - Analysis of urinary 8-nitroguanine, a marker of nitrative nucleic acid damage, by high-performance liquid chromatography-electrochemical detection coupled with immunoaffinity purification: association with cigarette smokingTomohiro Sawa
International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
Free Radic Biol Med 40:711-20. 2006.... - Nitration and nitrosation of N-acetyl-L-tryptophan and tryptophan residues in proteins by various reactive nitrogen speciesToshinori Suzuki
International Agency for Research on Cancer, 69372 Lyon Cedex 08, France
Free Radic Biol Med 37:671-81. 2004..Levels of 6-nitro-L-tryptophan and 3-nitro-L-tyrosine were similar in the nitrated protein. 6-Nitro-L-tryptophan in proteins can be measured as an additional biomarker of protein nitration... - Xanthine oxidase converts nitric oxide to nitroxyl that inactivates the enzymeMohammad Saleem
International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
Biochem Biophys Res Commun 315:455-62. 2004..As both XO and NO* synthase are activated and/or induced in ischemia-reperfusion injury, HNO formed by XO may contribute to pathogenesis by exerting its potent oxidation activity against a variety of biological compounds... - Nitric oxide prevents UV-induced phosphorylation of the p53 tumor-suppressor protein at serine 46: a possible role in inhibition of apoptosisRika Fukunaga-Takenaka
International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
Biochem Biophys Res Commun 308:966-74. 2003..Our results suggest that NO-mediated protection of apoptosis is p53-dependent, occurring at least partly through NO-inhibition of phosphorylation of p53 on Ser-46... - Detection of peroxynitrite-induced protein and DNA modificationsScott Lorch
Stokes Research Institute, Children's Hospital of Philadelphia, Department of Biochemistry and Biophysics, University of Pennsylvania Medical Center, Philadelphia, PA, USA
Methods Mol Biol 196:247-75. 2002 - Nicotine-modulated formation of spiroiminodihydantoin nucleoside via 8-oxo-7,8-dihydro-2'-deoxyguanosine in 2'-deoxyguanosine-hypochlorous acid reactionToshinori Suzuki
Unit of Endogenous Cancer Risk Factors, International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Cedex 08, Lyon, France
FEBS Lett 516:67-70. 2002..Our results imply that nicotine may enhance genotoxicity and tissue damage caused by neutrophil activation. dS may also serve as a new biomarker for oxidative DNA damage induced by oxidants such as HOCl... - Oxidative and nitrative stress caused by subcutaneous implantation of a foreign body accelerates sarcoma development in Trp53+/- miceHiroshi Tazawa
International Agency for Research on Cancer, 150 Cours Albert Thomas 69008 Lyon, France
Carcinogenesis 28:191-8. 2007..Such implant-induced sarcoma development in Trp53+/- mice could be useful for studying molecular mechanisms and developing new strategies for chemoprevention in human carcinogenesis induced by chronic inflammation and/or foreign bodies...