H Ohgaki

Summary

Affiliation: International Agency for Research on Cancer
Country: France

Publications

  1. ncbi request reprint Effect of intragastric application of N-methylnitrosourea in p53 knockout mice
    H Ohgaki
    Unit of Molecular Pathology, International Agency for Research on Cancer, Lyon, France
    Mol Carcinog 28:97-101. 2000
  2. ncbi request reprint Genetic pathways to glioblastoma: a population-based study
    Hiroko Ohgaki
    International Agency for Research on Cancer, Lyon, France
    Cancer Res 64:6892-9. 2004
  3. ncbi request reprint Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas
    Hiroko Ohgaki
    Pathology Group, International Agency for Research on Cancer HO, F 69372, Lyon, France
    J Neuropathol Exp Neurol 64:479-89. 2005
  4. ncbi request reprint Correlation among pathology, genotype, and patient outcomes in glioblastoma
    Taku Homma
    Pathology Group, International Agency for Research on Cancer, Lyon, France
    J Neuropathol Exp Neurol 65:846-54. 2006
  5. pmc Molecular classification of low-grade diffuse gliomas
    Young Ho Kim
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Am J Pathol 177:2708-14. 2010
  6. doi request reprint The definition of primary and secondary glioblastoma
    Hiroko Ohgaki
    Molecular Pathology Section, International Agency for Research on Cancer, Lyon, France
    Clin Cancer Res 19:764-72. 2013
  7. pmc Alterations of BCCIP, a BRCA2 interacting protein, in astrocytomas
    Jingmei Liu
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    BMC Cancer 9:268. 2009
  8. ncbi request reprint Epidemiology and etiology of gliomas
    Hiroko Ohgaki
    International Agency for Research on Cancer, Lyon, France
    Acta Neuropathol 109:93-108. 2005
  9. ncbi request reprint Genetic pathways to glioblastomas
    Hiroko Ohgaki
    International Agency for Research on Cancer, Lyon, France
    Neuropathology 25:1-7. 2005
  10. ncbi request reprint APC mutations are infrequent but present in human lung cancer
    Hiroko Ohgaki
    Unit of Molecular Pathology, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon 69372, France
    Cancer Lett 207:197-203. 2004

Detail Information

Publications65

  1. ncbi request reprint Effect of intragastric application of N-methylnitrosourea in p53 knockout mice
    H Ohgaki
    Unit of Molecular Pathology, International Agency for Research on Cancer, Lyon, France
    Mol Carcinog 28:97-101. 2000
    ..004), suggesting a slightly higher susceptibility to gastric carcinogenesis induced by MNU in p53(+/-) mice. Mol. Carcinog. 28:97-101, 2000...
  2. ncbi request reprint Genetic pathways to glioblastoma: a population-based study
    Hiroko Ohgaki
    International Agency for Research on Cancer, Lyon, France
    Cancer Res 64:6892-9. 2004
    ..0208). This suggests that the acquisition of TP53 mutations in these glioblastoma subtypes occurs through different mechanisms...
  3. ncbi request reprint Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas
    Hiroko Ohgaki
    Pathology Group, International Agency for Research on Cancer HO, F 69372, Lyon, France
    J Neuropathol Exp Neurol 64:479-89. 2005
    ..G:C-->A:T mutations at CpG sites were more frequent in secondary than primary glioblastomas, suggesting that the acquisition of TP53 mutations in these glioblastoma subtypes may occur through different mechanisms...
  4. ncbi request reprint Correlation among pathology, genotype, and patient outcomes in glioblastoma
    Taku Homma
    Pathology Group, International Agency for Research on Cancer, Lyon, France
    J Neuropathol Exp Neurol 65:846-54. 2006
    ..These results suggest that some histologic features in glioblastomas are associated with specific genetic alterations and with clinical outcome...
  5. pmc Molecular classification of low-grade diffuse gliomas
    Young Ho Kim
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Am J Pathol 177:2708-14. 2010
    ..8737). The molecular classification on the basis of IDH1/2 mutation, TP53 mutation, and 1p/19q loss has power similar to histological classification and avoids the ambiguity inherent to the diagnosis of oligoastrocytoma...
  6. doi request reprint The definition of primary and secondary glioblastoma
    Hiroko Ohgaki
    Molecular Pathology Section, International Agency for Research on Cancer, Lyon, France
    Clin Cancer Res 19:764-72. 2013
    ..Despite a similar histologic appearance, primary and secondary glioblastomas are distinct tumor entities that originate from different precursor cells and may require different therapeutic approaches...
  7. pmc Alterations of BCCIP, a BRCA2 interacting protein, in astrocytomas
    Jingmei Liu
    Department of Radiation Oncology, The Cancer Institute of New Jersey, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    BMC Cancer 9:268. 2009
    ..In this study, we investigated whether BCCIP is altered in astrocytomas...
  8. ncbi request reprint Epidemiology and etiology of gliomas
    Hiroko Ohgaki
    International Agency for Research on Cancer, Lyon, France
    Acta Neuropathol 109:93-108. 2005
    ....
  9. ncbi request reprint Genetic pathways to glioblastomas
    Hiroko Ohgaki
    International Agency for Research on Cancer, Lyon, France
    Neuropathology 25:1-7. 2005
    ....
  10. ncbi request reprint APC mutations are infrequent but present in human lung cancer
    Hiroko Ohgaki
    Unit of Molecular Pathology, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon 69372, France
    Cancer Lett 207:197-203. 2004
    ..These results suggest that disruption of the Wnt pathway through APC mutations is infrequent, but may be involved in the pathogenesis of a small subset of human lung carcinomas...
  11. doi request reprint Genetic alterations and signaling pathways in the evolution of gliomas
    Hiroko Ohgaki
    International Agency for Research on Cancer, Lyon, France
    Cancer Sci 100:2235-41. 2009
    ..In this review, we summarize the current status of genetic alterations and signaling pathways operative in the evolution of astrocytic and oligodendroglial tumors...
  12. doi request reprint Nervous system tumors associated with familial tumor syndromes
    Hiroko Ohgaki
    International Agency for Research on Cancer IARC, Lyon, France
    Curr Opin Neurol 23:583-91. 2010
    ..In this review, we provide a brief overview of these syndromes...
  13. doi request reprint Genetic profile of astrocytic and oligodendroglial gliomas
    Hiroko Ohgaki
    Molecular Pathology Section, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France
    Brain Tumor Pathol 28:177-83. 2011
    ....
  14. ncbi request reprint Brain tumors in S100beta-v-erbB transgenic rats
    Hiroko Ohgaki
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    J Neuropathol Exp Neurol 65:1111-7. 2006
    ....
  15. pmc Genetic pathways to primary and secondary glioblastoma
    Hiroko Ohgaki
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Am J Pathol 170:1445-53. 2007
    ..This has significant implications, particularly for the development of novel, targeted therapies, as discussed in this review...
  16. ncbi request reprint Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas
    R M Reis
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France
    Acta Neuropathol 101:297-304. 2001
    ..These results suggest that mutations in these mitotic spindle checkpoint genes do not play a significant role in the causation of chromosomal instability in glioblastomas...
  17. ncbi request reprint p14ARF deletion and methylation in genetic pathways to glioblastomas
    M Nakamura
    International Agency for Research on Cancer, Lyon, France
    Brain Pathol 11:159-68. 2001
    ....
  18. ncbi request reprint Promoter hypermethylation and homozygous deletion of the p14ARF and p16INK4a genes in oligodendrogliomas
    T Watanabe
    Unit of Molecular Pathology, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France
    Acta Neuropathol 101:185-9. 2001
    ....
  19. ncbi request reprint Promoter hypermethylation of the RB1 gene in glioblastomas
    M Nakamura
    International Agency for Research on Cancer, Lyon, France
    Lab Invest 81:77-82. 2001
    ..These results indicate that promoter hypermethylation is a late event during astrocytoma progression and is the major mechanism underlying loss of RB1 expression in glioblastomas...
  20. ncbi request reprint Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C --> A:T mutations of the TP53 tumor suppressor gene
    M Nakamura
    International Agency for Research on Cancer, F-69372 Lyon, France
    Carcinogenesis 22:1715-9. 2001
    ....
  21. ncbi request reprint Reduced expression of the Aalpha subunit of protein phosphatase 2A in human gliomas in the absence of mutations in the Aalpha and Abeta subunit genes
    S Colella
    International Agency for Research on Cancer (IARC, Lyon, France
    Int J Cancer 93:798-804. 2001
    ..By comparison, the levels of the Balpha and Calpha subunits were mostly normal. Our data indicate that these tumors contain very low levels of core and holoenzyme and high amounts of unregulated catalytic C subunit...
  22. ncbi request reprint Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas
    Yoshikazu Okamoto
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon Cedex 08, France
    Acta Neuropathol 108:49-56. 2004
    ..Multivariate Cox's regression analysis indicates that only age and histological type, but not genetic alterations, are significant predictive factors...
  23. pmc IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas
    Takuya Watanabe
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France
    Am J Pathol 174:1149-53. 2009
    ....
  24. ncbi request reprint Phenotype vs genotype in the evolution of astrocytic brain tumors
    P Kleihues
    International Agency for Research on Cancer, World Health Organization, Lyon, France
    Toxicol Pathol 28:164-70. 2000
    ....
  25. ncbi request reprint Second primary glioblastoma
    R M Reis
    International Agency for Research on Cancer, Lyon, France
    J Neuropathol Exp Neurol 60:208-15. 2001
    ..The presence in these neoplasms of multiple mutations in tumor suppressor genes suggests the involvement of a novel disease mechanism but there was no indication of a DNA mismatch repair deficiency or of an inherited tumor syndrome...
  26. ncbi request reprint Concurrent inactivation of RB1 and TP53 pathways in anaplastic oligodendrogliomas
    T Watanabe
    International Agency for Research on Cancer, Lyon, France
    J Neuropathol Exp Neurol 60:1181-9. 2001
    ..Thus, simultaneous disruption of the RB1/CDK4/p16INK4a/p15INK4b and the TP53/p14ARF/MDM2 pathways occurs in 45% (9/20) of anaplastic oligodendrogliomas, suggesting that these phenomena contribute to their malignant phenotype...
  27. pmc APC mutations in sporadic medulloblastomas
    H Huang
    International Agency for Research on Cancer, Lyon, France
    Am J Pathol 156:433-7. 2000
    ..Although germline APC mutations are a well established cause of familial colon and brain tumors (Turcot syndrome), this study provides the first evidence that APC mutations are also operative in a subset of sporadic medulloblastomas...
  28. doi request reprint Mutational inactivation of the nijmegen breakage syndrome gene (NBS1) in glioblastomas is associated with multiple TP53 mutations
    Takuya Watanabe
    International Agency for Research on Cancer, Lyon, France
    J Neuropathol Exp Neurol 68:210-5. 2009
    ..These results suggest that multiple TP53 mutations in glioblastomas are due to deficient repair of DNA double-strand breaks caused by mutational inactivation of the NBS1 gene...
  29. doi request reprint Epidemiology of brain tumors
    Hiroko Ohgaki
    Pathology Group, International Agency for Research on Cancer, Lyon, France
    Methods Mol Biol 472:323-42. 2009
    ....
  30. doi request reprint Common polymorphisms in the MDM2 and TP53 genes and the relationship between TP53 mutations and patient outcomes in glioblastomas
    Izabela Zawlik
    International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France
    Brain Pathol 19:188-94. 2009
    ..07-1.71). Detailed analyses revealed that TP53 codon 72 Pro allele was significantly associated with shorter survival among patients with glioblastomas carrying a TP53 mutation, and among those treated with surgery plus radiotherapy...
  31. doi request reprint IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas
    Sumihito Nobusawa
    International Agency for Research on Cancer, Lyon, France
    Clin Cancer Res 15:6002-7. 2009
    ....
  32. ncbi request reprint Endogenous deoxyribonucleic Acid (DNA) damage in human tissues: a comparison of ethenobases with aldehydic DNA lesions
    Alain Barbin
    International Agency for Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 12:1241-7. 2003
    ..These data are in line with previous studies showing that brain tissues are more susceptible to oxidative stress and lipid peroxidation than other tissues...
  33. ncbi request reprint PTEN methylation and expression in glioblastomas
    Nathalie Baeza
    International Agency for Research on Cancer IARC, 69372, Lyon, France
    Acta Neuropathol 106:479-85. 2003
    ....
  34. ncbi request reprint Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosis
    Yoshihiro Edamoto
    Unit of Molecular Pathology, International Agency for Research on Cancer IARC, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Int J Cancer 106:334-41. 2003
    ..e., chronic liver injury and cirrhosis, but tumors associated with alcoholism had more frequent alterations in the RB1 and p53 pathways than those caused by HCV infection...
  35. ncbi request reprint Germline SDHD mutation in paraganglioma of the spinal cord
    J Masuoka
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, Cedex 08, France
    Oncogene 20:5084-6. 2001
    ..This is the first observation indicating that inherited SDHD mutations may occasionally cause the development of paragangliomas in the central nervous system...
  36. ncbi request reprint Genetic evidence of the neoplastic nature of gemistocytes in astrocytomas
    R M Reis
    Unit of Molecular Pathology, International Agency for Research on Cancer (IARC, Lyon, France
    Acta Neuropathol 102:422-5. 2001
    ..In all cases, identical TP53 mutations were identified in both cell types, indicating that gemistocytes are indeed neoplastic cells. Their lack of proliferative activity may indicate terminal differentiation...
  37. ncbi request reprint Altered expression of immune defense genes in pilocytic astrocytomas
    Herve Huang
    International Agency for Research on Cancer, Lyon, France, and Department of Neurosurgery, University of Zurich, Zurich, Switzerland
    J Neuropathol Exp Neurol 64:891-901. 2005
    ....
  38. pmc Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice
    Wei Min Tong
    International Agency for Research on Cancer IARC, Lyon, France
    Am J Pathol 162:343-52. 2003
    ..These PARP-1/p53 double null mice represent a novel model for the pathogenesis of human medulloblastomas...
  39. ncbi request reprint Phenotype versus genotype correlation in oligodendrogliomas and low-grade diffuse astrocytomas
    Takao Watanabe
    Unit of Molecular Pathology, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Acta Neuropathol 103:267-75. 2002
    ..There was no correlation with LOH on chromosomes 1p/19q, suggesting that MGMT may not be a prognostic marker for oligodendrogliomas...
  40. ncbi request reprint A population-based study of the incidence and survival rates in patients with pilocytic astrocytoma
    Christoph Burkhard
    International Agency for Research on Cancer, Lyon, France
    J Neurosurg 98:1170-4. 2003
    ..The incidence of pilocytic astrocytomas and the rate of patient survival were analyzed in a population-based study in the canton of Zürich, Switzerland...
  41. doi request reprint Age as a predictive factor in glioblastomas: population-based study
    Daisuke Kita
    International Agency for Research on Cancer, Lyon, France
    Neuroepidemiology 33:17-22. 2009
    ....
  42. doi request reprint Selective acquisition of IDH1 R132C mutations in astrocytomas associated with Li-Fraumeni syndrome
    Takuya Watanabe
    Pathology Group, International Agency for Research on Cancer, Lyon, France
    Acta Neuropathol 117:653-6. 2009
    ..This remarkably selective occurrence of R132C mutations may reflect differences in the sequence of genetic events, with a preference for R132C mutations in astrocytes or precursor cells that already carry a germline TP53 mutation...
  43. ncbi request reprint Methylation of the p73 gene in gliomas
    Takao Watanabe
    Unit of Molecular Pathology, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Acta Neuropathol 104:357-62. 2002
    ..Analysis of a polymorphic site in exon 2 further showed that p73 was mono-allelically expressed in 6 out of 7 primary gliomas with heterozygous GC/TA polymorphism...
  44. ncbi request reprint Lung fibre burden in lung cancer cases employed in the rock and slag wool industry
    K Soldan
    International Agency for Research on Cancer, Lyon, France
    Ann Occup Hyg 50:241-8. 2006
    ..To evaluate the relationship between estimated exposure to man-made vitreous fibres (MMVF) and to asbestos fibres and their concentration in the lung tissue of lung cancer cases amongst MMVF production workers...
  45. doi request reprint Intratumoral patterns of genomic imbalance in glioblastomas
    Sumihito Nobusawa
    International Agency for Research on Cancer, Lyon, France
    Brain Pathol 20:936-44. 2010
    ....
  46. ncbi request reprint TP53 promoter methylation in human gliomas
    Vishwa Jeet Amatya
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Cedex 08, Lyon, France
    Acta Neuropathol 110:178-84. 2005
    ....
  47. ncbi request reprint Beta-catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in CDF1 mice
    Herve Huang
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon 08, France
    Cancer Lett 198:29-35. 2003
    ....
  48. doi request reprint Promoter methylation and polymorphisms of the MGMT gene in glioblastomas: a population-based study
    Izabela Zawlik
    International Agency for Research on Cancer, Lyon, France
    Neuroepidemiology 32:21-9. 2009
    ..70; 95% CI 0.48-1.01). These results suggest that MGMT methylation may be associated with susceptibility to acquire TP53 G:C-->A:T mutations, and that MGMT polymorphisms may affect the risk and prognosis of glioblastomas...
  49. ncbi request reprint PIK3CA alterations in primary (de novo) and secondary glioblastomas
    Daisuke Kita
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon Cedex 08, France
    Acta Neuropathol 113:295-302. 2007
    ..These results suggest that the EGFR/PTEN/PI3K pathway is frequently altered in glioblastomas and is a promising target for therapy, in particular for primary glioblastomas...
  50. ncbi request reprint Oxidative and nitrative stress caused by subcutaneous implantation of a foreign body accelerates sarcoma development in Trp53+/- mice
    Hiroshi Tazawa
    International Agency for Research on Cancer, 150 Cours Albert Thomas 69008 Lyon, France
    Carcinogenesis 28:191-8. 2007
    ..Such implant-induced sarcoma development in Trp53+/- mice could be useful for studying molecular mechanisms and developing new strategies for chemoprevention in human carcinogenesis induced by chronic inflammation and/or foreign bodies...
  51. ncbi request reprint Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation
    Wei Min Tong
    International Agency for Research on Cancer IARC, 69008 Lyon, France
    Cancer Res 62:6990-6. 2002
    ....
  52. ncbi request reprint Li-Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype
    Magali Olivier
    IARC, Lyon, Cedex 8, France
    Cancer Res 63:6643-50. 2003
    ..004). These observations have clinical implications for genetic testing and tumor surveillance in LFS/LFL families...
  53. ncbi request reprint Genetic and expression profiles of cerebellar liponeurocytomas
    Sonja Horstmann
    International Agency for Research on Cancer, Lyon, France
    Brain Pathol 14:281-9. 2004
    ..Furthermore, the cDNA expression array data suggest a relationship to central neurocytomas, but the presence of TP53 mutations, which are absent in central neurocytomas, suggests that their genetic pathways are different...
  54. ncbi request reprint Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomas
    Wojciech Biernat
    International Agency for Research on Cancer, 150 cours Albert Thomas, 60372 Lyon, France
    Brain Pathol 14:131-6. 2004
    ....
  55. doi request reprint Mutations in the Nijmegen breakage syndrome gene in medulloblastomas
    Jian Huang
    IARC, Lyon, France
    Clin Cancer Res 14:4053-8. 2008
    ..There may be functional interactions between NBS1 and the TP53 pathways. The objective of the present study is to assess whether NBS1 mutations play a role in the pathogenesis of sporadic medulloblastomas...
  56. ncbi request reprint AXIN1 mutations but not deletions in cerebellar medulloblastomas
    Nathalie Baeza
    International Agency for Research on Cancer, Lyon, France
    Oncogene 22:632-6. 2003
    ..Since there are multiple complementary, inverted sequences present in the AXIN1 gene, these large deletions may represent RT-PCR errors due to stem-loop secondary structures...
  57. ncbi request reprint Genetic alterations in the PI3K pathway in prostate cancer
    Xiuju Sun
    International Agency for Research on Cancer, Lyon, France
    Anticancer Res 29:1739-43. 2009
    ..Glands of Gleason pattern 3 are genetically heterogeneous, some containing the same genetic alterations observed in glands of Gleason pattern 4...
  58. ncbi request reprint Suppression of thymic lymphomas and increased nonthymic lymphomagenesis in Trp53-deficient mice lacking inducible nitric oxide synthase gene
    Masayuki Tatemichi
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 111:819-28. 2004
    ..While iNOS may have protective effects against nonthymic lymphomagenesis, the regulation of cytokine production by iNOS may be involved in the underlying mechanism of antilymphomagenesis effects in the peripheral lymphoid organ...
  59. pmc Whole genome amplification for array comparative genomic hybridization using DNA extracted from formalin-fixed, paraffin-embedded histological sections
    Jian Huang
    International Agency for Research on Cancer, Lyon, France
    J Mol Diagn 11:109-16. 2009
    ..0001). These results suggest that genetic analyses are possible using WGA-DNA extracted from paraffin sections, but that they should be performed with a carefully optimized and controlled protocol...
  60. ncbi request reprint Gene expression profiling and subgroup identification of oligodendrogliomas
    Herve Huang
    International Agency for Research on Cancer IARC, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
    Oncogene 23:6012-22. 2004
    ..048). These results demonstrate that oligodendrogliomas and low-grade astrocytomas differ in their gene expression profiles, and that there are subgroups of oligodendroglioma with distinct expression profiles related to clinical outcome...
  61. ncbi request reprint Granular cell astrocytomas show a high frequency of allelic loss but are not a genetically defined subset
    Amilcar A Castellano-Sanchez
    Department of Pathology, Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Pathol 13:185-94. 2003
    ..Instead, it appears that granular cell change occurs across genetic subsets. The high frequency of allelic loss, especially on 9p and 10q, may confer aggressive growth potential and be related to their rapid clinical progression...
  62. ncbi request reprint Stratification of medulloblastoma on the basis of histopathological grading
    Felice Giangaspero
    Department of Experimental Medicine and Pathology, University of Rome La Sapienza, 00151, Rome, Italy
    Acta Neuropathol 112:5-12. 2006
    ..These findings indicate that degree of anaplasia is the most significant histologic feature predictive of the survival of medulloblastoma patients...
  63. ncbi request reprint Molecular pathogenesis of astrocytic tumours
    Koichi Ichimura
    Department of Pathology, University of Cambridge, Cambridge, UK
    J Neurooncol 70:137-60. 2004
    ....
  64. ncbi request reprint Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma
    Jörg Wischhusen
    Laboratories of Molecular Neuro Oncology, Institute for Cell Biology, University of Tubingen, 72076 Tubingen, Germany
    Cancer Res 62:2592-9. 2002
    ..Thus, induction of B-cell and T-cell apoptosis via interactions of CD70 expressed on glioma cells and CD27 expressed on B and T cells may be a novel way for the immune escape of malignant gliomas...
  65. ncbi request reprint Congenital glioblastoma: a clinicopathologic and genetic analysis
    Daniel J Brat
    Departments of Pathology and Laboratory Medicine and Winship Cancer Institute, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA
    Brain Pathol 17:276-81. 2007
    ..Nonetheless, the strong nuclear expression of p53 in these and other pediatric GBMs could indicate that p53 dysregulation is important to tumorigenesis...