RUDOLF J KAAKS

Summary

Affiliation: International Agency for Research on Cancer
Country: France

Publications

  1. pmc Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study
    F Canzian
    International Agency for Research on Cancer, Lyon, France
    Br J Cancer 94:299-307. 2006
  2. pmc Reliability of follicle-stimulating hormone measurements in serum
    Alan A Arslan
    New York University School of Medicine, New York, NY, USA
    Reprod Biol Endocrinol 1:49. 2003
  3. pmc Lung cancers attributable to environmental tobacco smoke and air pollution in non-smokers in different European countries: a prospective study
    Paolo Vineis
    Imperial College London, London UK
    Environ Health 6:7. 2007
  4. pmc A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 8:R54. 2006
  5. pmc Circulating soluble Fas levels and risk of ovarian cancer
    Arslan Akhmedkhanov
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY, USA
    BMC Cancer 3:33. 2003
  6. ncbi Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review
    Rudolf Kaaks
    Hormones and Cancer Group, International Agency for Research on Cancer, 69372 Lyon, France
    Cancer Epidemiol Biomarkers Prev 11:1531-43. 2002
  7. ncbi Uses and limitations of statistical accounting for random error correlations, in the validation of dietary questionnaire assessments
    Rudolf Kaaks
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Public Health Nutr 5:969-76. 2002
  8. ncbi Interrelationships between plasma testosterone, SHBG, IGF-I, insulin and leptin in prostate cancer cases and controls
    R Kaaks
    Hormones and Cancer Group, International Agency for Research on Cancer, 150, cours Albert Thomas, 69372 Lyon, Cedex 08, France
    Eur J Cancer Prev 12:309-15. 2003
  9. ncbi Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition
    R Kaaks
    International Agency for Research on Cancer IARC WHO, Lyon, France
    Endocr Relat Cancer 12:1071-82. 2005
  10. ncbi Effects of dietary intervention on IGF-I and IGF-binding proteins, and related alterations in sex steroid metabolism: the Diet and Androgens (DIANA) Randomised Trial
    R Kaaks
    Hormones and Cancer Group, International Agency for Research on Cancer, Lyon, France
    Eur J Clin Nutr 57:1079-88. 2003

Research Grants

Collaborators

Detail Information

Publications74

  1. pmc Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study
    F Canzian
    International Agency for Research on Cancer, Lyon, France
    Br J Cancer 94:299-307. 2006
    ..Common genetic variation in these candidate genes does not play a major role in altering breast cancer risk in Caucasians...
  2. pmc Reliability of follicle-stimulating hormone measurements in serum
    Alan A Arslan
    New York University School of Medicine, New York, NY, USA
    Reprod Biol Endocrinol 1:49. 2003
    ..The objective of this study was to assess the reliability of FSH measurement using stored sera from an ongoing prospective cohort--the NYU Women's Health Study...
  3. pmc Lung cancers attributable to environmental tobacco smoke and air pollution in non-smokers in different European countries: a prospective study
    Paolo Vineis
    Imperial College London, London UK
    Environ Health 6:7. 2007
    ..It is therefore useful to estimate the burden of disease associated with indoor and outdoor air pollution...
  4. pmc A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Breast Cancer Res 8:R54. 2006
    ..Here, we report on the results of a large and comprehensive study of the association between genetic variation in the AR gene and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)...
  5. pmc Circulating soluble Fas levels and risk of ovarian cancer
    Arslan Akhmedkhanov
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY, USA
    BMC Cancer 3:33. 2003
    ..The main objective of the present study was to evaluate serum sFas as a potential biomarker of ovarian cancer risk...
  6. ncbi Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review
    Rudolf Kaaks
    Hormones and Cancer Group, International Agency for Research on Cancer, 69372 Lyon, France
    Cancer Epidemiol Biomarkers Prev 11:1531-43. 2002
    ..The ovarian androgen excess may be because of an interaction between obesity-related, chronic hyperinsulinemia with genetic factors predisposing to the development of ovarian hyperandrogenism...
  7. ncbi Uses and limitations of statistical accounting for random error correlations, in the validation of dietary questionnaire assessments
    Rudolf Kaaks
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Public Health Nutr 5:969-76. 2002
    ..To examine statistical models that account for correlation between random errors of different dietary assessment methods, in dietary validation studies...
  8. ncbi Interrelationships between plasma testosterone, SHBG, IGF-I, insulin and leptin in prostate cancer cases and controls
    R Kaaks
    Hormones and Cancer Group, International Agency for Research on Cancer, 150, cours Albert Thomas, 69372 Lyon, Cedex 08, France
    Eur J Cancer Prev 12:309-15. 2003
    ....
  9. ncbi Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition
    R Kaaks
    International Agency for Research on Cancer IARC WHO, Lyon, France
    Endocr Relat Cancer 12:1071-82. 2005
    ..The results from this study caution against the use of DHEA(S), or other androgens, for postmenopausal androgen replacement therapy...
  10. ncbi Effects of dietary intervention on IGF-I and IGF-binding proteins, and related alterations in sex steroid metabolism: the Diet and Androgens (DIANA) Randomised Trial
    R Kaaks
    Hormones and Cancer Group, International Agency for Research on Cancer, Lyon, France
    Eur J Clin Nutr 57:1079-88. 2003
    ....
  11. ncbi Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Rudolf Kaaks
    Nutrition and Hormones Group, International Agency for Research on Cancer IARC WHO, Lyon, France
    J Natl Cancer Inst 97:755-65. 2005
    ..We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort to examine associations among premenopausal serum concentrations of sex steroids and subsequent breast cancer risk...
  12. ncbi Biochemical markers as additional measurements in studies of the accuracy of dietary questionnaire measurements: conceptual issues
    R J Kaaks
    International Agency for Research on Cancer, Lyon, France
    Am J Clin Nutr 65:1232S-1239S. 1997
    ..Thus, the inclusion of such markers in dietary validity studies can make it more likely that the criteria of independent errors, crucial in validity studies, are met...
  13. ncbi Dietary intake assessments in epidemiology: can we know what we are measuring?
    Rudolf Kaaks
    Nutrition and Hormones Group, International Agency for Research on Cancer, Lyon, France
    Ann Epidemiol 16:377-80. 2006
    ..We discuss fundamental assumptions required for the validation of dietary questionnaire assessments, using latent variable models...
  14. ncbi Energy balance and cancer: the role of insulin and insulin-like growth factor-I
    R Kaaks
    International Agency for Research on Cancer, Lyon, France
    Proc Nutr Soc 60:91-106. 2001
    ..For cancers of the endometrium, breast and prostate, these findings are discussed in the context of relationships between insulin and IGF-I and levels of bioavailable sex steroids...
  15. ncbi Prospective study of IGF-I, IGF-binding proteins, and breast cancer risk, in northern and southern Sweden
    Rudolf Kaaks
    Unit of Nutrition and Cancer, International Agency for Research on Cancer, Lyon, France
    Cancer Causes Control 13:307-16. 2002
    ..To examine the possible relationships of breast cancer risk to prediagnostic plasma levels of insulin; insulin-like growth factor-I (IGF-I); and IGF-binding proteins -1, -2, and -3...
  16. ncbi Effects of weight control and physical activity in cancer prevention: role of endogenous hormone metabolism
    Rudolf Kaaks
    International Agency for Research on Cancer, 69372 Lyon Cedex 08, France
    Ann N Y Acad Sci 963:268-81. 2002
    ....
  17. ncbi [Plasma insulin, IGF-I and breast cancer]
    R Kaaks
    Centre international de recherche sur le cancer, 150, cours Albert Thomas, 69372 Lyon, France
    Gynecol Obstet Fertil 29:185-91. 2001
    ....
  18. ncbi Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women
    R Kaaks
    International Agency for Research on Cancer, Lyon, France
    J Natl Cancer Inst 92:1592-600. 2000
    ..To test this hypothesis, we conducted a case-control study nested within a cohort of 14 275 women in New York...
  19. ncbi Breast-cancer incidence in relation to height, weight and body-fat distribution in the Dutch "DOM" cohort
    R Kaaks
    Unit of Nutrition and Cancer, International Agency for Research on Cancer, Lyon, France
    Int J Cancer 76:647-51. 1998
    ....
  20. ncbi The role of multi-centre cohort studies in studying the relation between diet and cancer
    R Kaaks
    Unit of Nutrition and Cancer, International Agency for Research on Cancer, Lyon, France
    Cancer Lett 114:263-70. 1997
    ....
  21. ncbi Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition cohort
    Anne E Cust
    Nutrition and Hormones Unit, International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 166:912-23. 2007
    ....
  22. doi Serum levels of IGF-I, IGFBP-3 and colorectal cancer risk: results from the EPIC cohort, plus a meta-analysis of prospective studies
    Sabina Rinaldi
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 126:1702-15. 2010
    ..07 [1.01-1.14] for 1 standard deviation increase in IGF-I). Overall, data from our present study and previous prospective studies combined indicate a relatively modest association of colorectal cancer risk with serum IGF-I...
  23. ncbi Serum C-peptide levels and breast cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Martijn Verheus
    International Agency for Research on Cancer IARC WHO, Lyon, France
    Int J Cancer 119:659-67. 2006
    ..Nevertheless, among older, postmenopausal women, hyperinsulinemia might contribute to increasing breast cancer risk...
  24. ncbi Insulin-like growth factor-I, IGF binding protein-3, and breast cancer in young women: a comparison of risk estimates using different peptide assays
    Sabina Rinaldi
    Nutrition and Hormones Group, IARC, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 14:48-52. 2005
    ..These results are consistent with an association of breast cancer risk in young women with elevated IGF-I and IGFBP-3, and show that for IGFBP-3, the strength of such an association could vary substantially depending on the assay used...
  25. ncbi Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nu
    Federico Canzian
    Hormones and Cancer Team, International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon, France
    Cancer Epidemiol Biomarkers Prev 14:2316-25. 2005
    ....
  26. ncbi IGF-I, IGFBP-3 and breast cancer in young women: a pooled re-analysis of three prospective studies
    Sabina Rinaldi
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, Cedex 08, France
    Eur J Cancer Prev 14:493-6. 2005
    ..98 [0.54-1.75], 1.06 [0.59-1.91], 1.04 [0.58-1.87] and 1.77 [0.97-3.24] for quintiles of IGFBP-3). Our results give only moderate support for an association of blood IGF-I with breast cancer risk in young women...
  27. ncbi C-peptide, IGF-I, sex-steroid hormones and adiposity: a cross-sectional study in healthy women within the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Irene D Bezemer
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon Cedex 08, France
    Cancer Causes Control 16:561-72. 2005
    ..Interrelationships between these hormones and the associations with adiposity were evaluated in healthy women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC)...
  28. pmc Meat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition
    Teresa Norat
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69 372 Lyon cedex 08, France
    J Natl Cancer Inst 97:906-16. 2005
    ..Current evidence suggests that high red meat intake is associated with increased colorectal cancer risk. High fish intake may be associated with a decreased risk, but the existing evidence is less convincing...
  29. ncbi Haplotype-based analysis of common variation in the acetyl-coA carboxylase alpha gene and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition
    Olga M Sinilnikova
    IARC, Lyon, France
    Cancer Epidemiol Biomarkers Prev 16:409-15. 2007
    ..However, they suggest a possible role of the ACC-alpha common sequence variants in susceptibility to breast cancer and encourage studies of other genes involved in fatty acid synthesis...
  30. ncbi Plasma and dietary vitamin C levels and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
    Mazda Jenab
    Nutrition and Hormones Group, IARC WHO Lyon, France
    Carcinogenesis 27:2250-7. 2006
    ....
  31. ncbi Risk of endometrial cancer in relationship to cigarette smoking: results from the EPIC study
    Mustafa Al-Zoughool
    Nutrition and Hormones Group, International Agency for Research on Cancer, Lyon, France
    Int J Cancer 121:2741-7. 2007
    ..The reduction of endometrial cancer risk observed among postmenopausal women does not have direct public health relevance since cigarette smoking is the main known risk factor for cancer...
  32. ncbi Prediagnostic levels of C-peptide, IGF-I, IGFBP -1, -2 and -3 and risk of endometrial cancer
    Annekatrin Lukanova
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 108:262-8. 2004
    ..Decrease in the prevalence of chronic hyperinsulinemia, through changes in lifestyle or medication, is expected to prevent endometrial cancer...
  33. ncbi Serum levels of C-peptide, IGFBP-1 and IGFBP-2 and endometrial cancer risk; results from the European prospective investigation into cancer and nutrition
    Anne E Cust
    Nutrition and Hormones Unit, International Agency for Research on Cancer, Lyon, France
    Int J Cancer 120:2656-64. 2007
    ..bottom quartile = 1.28 [95% CI 0.67-2.45], p(trend) = 0.42. Our results provide modest support to the hypothesis that hyperinsulinaemia is a risk factor for endometrial cancer...
  34. ncbi Circulating levels of sex steroid hormones and risk of endometrial cancer in postmenopausal women
    Annekatrin Lukanova
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 108:425-32. 2004
    ....
  35. pmc Methodological challenges in the application of the glycemic index in epidemiological studies using data from the European Prospective Investigation into Cancer and Nutrition
    Marit M E van Bakel
    Nutritional and Database Resource Team, International Agency for Research on Cancer, 63372 Lyon, France
    J Nutr 139:568-75. 2009
    ..80). A more consistent methodology to attribute GI values to foods and validated DQ is needed to derive meaningful GI/GL estimates for nutritional epidemiology...
  36. ncbi Endogenous androgens and risk of epithelial ovarian cancer: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Sabina Rinaldi
    IARC, Lyon, France
    Cancer Epidemiol Biomarkers Prev 16:23-9. 2007
    ..The heterogeneity of results on the associations of fT with ovarian cancer risk in postmenopausal women deserves further investigation...
  37. doi Genetic variation in the SST gene and its receptors in relation to circulating levels of insulin-like growth factor-I, IGFBP3, and prostate cancer risk
    Mattias Johansson
    International Agency for Research on Cancer, F 69372 Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 18:1644-50. 2009
    ..We have investigated if genetic variation in the SST and SSTR1-5 genes influences prostate cancer risk and/or circulating IGFI and IGFBP3 hormone levels...
  38. ncbi Physical activity and risk of colon and rectal cancers: the European prospective investigation into cancer and nutrition
    Christine Friedenreich
    Nutrition and Hormones Group, IARC, Lyon, France
    Cancer Epidemiol Biomarkers Prev 15:2398-407. 2006
    ..We found that physical activity reduced colon cancer risk, specifically for right-sided tumors and for lean participants, but not rectal cancer...
  39. ncbi Haplotype-based analysis of common variation in the growth hormone receptor gene and prostate cancer risk
    James D McKay
    International Agency for Research on Cancer, Lyons, France
    Cancer Epidemiol Biomarkers Prev 16:169-73. 2007
    ..These results suggest that whereas genetic variation in the GHR gene does not seem to play a major role in prostate cancer etiology, one haplotype in the 3' region may be potentially relevant to cases with later onset of prostate cancer...
  40. doi Cigar and pipe smoking and cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Valerie A McCormack
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 127:2402-11. 2010
    ..Cigar and pipe smoking is not a safe alternative to cigarette smoking. The lower cancer risk of cigar and pipe smokers as compared to cigarette smokers is explained by lesser degree of inhalation and lower smoking intensity...
  41. ncbi Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition
    Mazda Jenab
    Nutrition and Hormones Group, IARC WHO, Lyon, France
    Int J Cancer 121:368-76. 2007
    ..No clear colorectal cancer risk associations were observed for IGFBP-1 or -2. This large prospective study confirms that hyperinsulinemia, as determined by C-peptide levels, is associated with an increased colorectal cancer risk...
  42. ncbi Lifetime and baseline alcohol intake and risk of colon and rectal cancers in the European prospective investigation into cancer and nutrition (EPIC)
    Pietro Ferrari
    International Agency for Research on Cancer IARC WHO, Lyon, France
    Int J Cancer 121:2065-72. 2007
    ..03, 95%CI=0.98-1.09). In this large European cohort, both lifetime and baseline alcohol consumption increase colon and rectum cancer risk, with more apparent risk increases for alcohol intakes greater than 30 g/day...
  43. doi CDH1 gene polymorphisms, smoking, Helicobacter pylori infection and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
    Mazda Jenab
    International Agency for Research on Cancer IARC WHO, Lyon, France
    Eur J Cancer 44:774-80. 2008
    ..However, three CDH1 polymorphisms in the same haplotype block, including the CDH1-160C/A, interacted with smoking to increase GC risk in smokers but not in never smokers. These findings should be confirmed in larger independent studies...
  44. doi The evaluation of the diet/disease relation in the EPIC study: considerations for the calibration and the disease models
    Pietro Ferrari
    International Agency for Research on Cancer IARC WHO, Lyon, France
    Int J Epidemiol 37:368-78. 2008
    ..This requires considerable work to standardize dietary measurements at the food and the nutrient levels...
  45. doi Glycosylated hemoglobin and risk of colorectal cancer in men and women, the European prospective investigation into cancer and nutrition
    Sabina Rinaldi
    IARC, 150, cours Albert Thomas, Lyon, 69372 Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 17:3108-15. 2008
    ..The results of the current study suggest a mild implication of hyperglycemia in colorectal cancer, which seems more important in women than in men, and more for cancer of the rectum than of the colon...
  46. ncbi Genetic and plasma variation of insulin-like growth factor binding proteins in relation to prostate cancer incidence and survival
    Mattias Johansson
    International Agency for Research against Cancer, Lyon, France
    Prostate 69:1281-91. 2009
    ..We analyzed genetic variation within genes coding for IGF binding proteins in relation to prostate cancer incidence and survival. We also investigated if circulating IGFBP3 affects prostate cancer-specific survival...
  47. doi Vitamin D receptor and calcium sensing receptor polymorphisms and the risk of colorectal cancer in European populations
    Mazda Jenab
    Lifestyle and Cancer Group, IARC, 150 cours Albert Thomas, 69008, Lyon, France
    Cancer Epidemiol Biomarkers Prev 18:2485-91. 2009
    ..These results confirm a role for the BsmI polymorphism of the VDR gene in CRC risk, independent of serum 25OHD concentration and dietary calcium intake...
  48. pmc Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study
    Mazda Jenab
    International Agency for Research on Cancer IARC WHO, Lyon, France
    BMJ 340:b5500. 2010
    ..To examine the association between pre-diagnostic circulating vitamin D concentration, dietary intake of vitamin D and calcium, and the risk of colorectal cancer in European populations...
  49. ncbi Diabetes mellitus and ovarian cancer (Sweden)
    Elisabete Weiderpass
    International Agency for Research on Cancer, Lyon, France
    Cancer Causes Control 13:759-64. 2002
    ..We present results from a large, population-based cohort study in Sweden, where we assessed ovarian cancer risk among patients hospitalized for diabetes mellitus...
  50. ncbi Weight control and physical activity in cancer prevention: international evaluation of the evidence
    Harri Vainio
    International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon, France
    Eur J Cancer Prev 11:S94-100. 2002
    ..Thus adiposity and physical inactivity appear to be the most important avoidable causes of these cancers...
  51. ncbi Circulating levels of sex steroid hormones and risk of ovarian cancer
    Annekatrin Lukanova
    Hormones and Cancer Group, International Agency for Research on Cancer, Lyon, France
    Int J Cancer 104:636-42. 2003
    ....
  52. ncbi Reduced risk of prostate cancer among patients with diabetes mellitus
    Elisabete Weiderpass
    Unit of Field and Intervention Studies, International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
    Int J Cancer 102:258-61. 2002
    ..We did find a small, but significantly decreased risk of prostate cancer among men who had been hospitalized for diabetes mellitus...
  53. ncbi Validity of free testosterone and free estradiol determinations in serum samples from postmenopausal women by theoretical calculations
    Sabina Rinaldi
    IARC, Unit of Nutrition and Cancer, 69500 Lyon, France
    Cancer Epidemiol Biomarkers Prev 11:1065-71. 2002
    ....
  54. ncbi Breast cancer: occurrence, risk factors and hormone metabolism
    Annie J Sasco
    Unit of Epidemiology for Cancer Prevention, International Agency for Research on Cancer, Lyon, France
    Expert Rev Anticancer Ther 3:546-62. 2003
    ..This paper will review available evidence from all of these areas, exploring the occurrence of cancer, risk factors for occurrence and the hormonal milieu that underlies it...
  55. ncbi Circulating levels of insulin-like growth factor-I and risk of ovarian cancer
    Annekatrin Lukanova
    Hormones and Cancer Group, International Agency for Research on Cancer, Lyon, France
    Int J Cancer 101:549-54. 2002
    ..We found a strong direct relationship between circulating IGF-I levels and risk of developing ovarian cancer before age 55. Additional, larger studies of this association are needed to provide more precise estimates of effect...
  56. ncbi Plasma levels of six carotenoids in nine European countries: report from the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Wael K Al-Delaimy
    Unit of Nutrition and Cancer, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Public Health Nutr 7:713-22. 2004
    ..Few studies have compared levels of these carotenoids between countries in Europe...
  57. ncbi Within- and between-cohort variation in measured macronutrient intakes, taking account of measurement errors, in the European Prospective Investigation into Cancer and Nutrition study
    Pietro Ferrari
    Unit of Nutrition and Cancer, International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 160:814-22. 2004
    ..After calibration, the two components had a similar weight. This observation has important implications for the analysis of multicenter studies because the between-cohort component provides a large part of the overall heterogeneity...
  58. ncbi Association of nut and seed intake with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition
    Mazda Jenab
    Nutrition and Hormones Group, IARC WHO, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 13:1595-603. 2004
    ..80-0.98), with no associations in men. It is not evident from this data why there may be a stronger association in women or why it may be limited to the colon, suggesting that much further research is necessary...
  59. ncbi Insulin-like growth factor II and colorectal cancer risk in women
    Kelly J Hunt
    International Agency for Research on Cancer, 69372 Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 11:901-5. 2002
    ..Mechanisms that might cause the increase in IGF-II levels are unknown but may include loss of parental imprinting of the IGF-II gene...
  60. ncbi Overweight, obesity, and cancer risk
    France Bianchini
    Unit of Chemoprevention, International Agency for Research on Cancer IARC, Lyon, France
    Lancet Oncol 3:565-74. 2002
    ..Avoidance of weight gain thus seems to be an important factor for cancer prevention...
  61. ncbi Weight control and physical activity in cancer prevention
    Franca Bianchini
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France
    Obes Rev 3:5-8. 2002
    ..In light of the beneficial effects of weight control and physical activity for cancer prevention, a healthy lifestyle, keeping a low body weight and exercising most days of the week, is recommended...
  62. ncbi Anthropometric measures, endogenous sex steroids and breast cancer risk in postmenopausal women: a study within the EPIC cohort
    Sabina Rinaldi
    International Agency for Research on Cancer IARC WHO, Lyon, France
    Int J Cancer 118:2832-9. 2006
    ..Our data indicate that the relationship of adiposity with breast cancer in postmenopausal women could be partially explained by the increases in endogenous estrogens, and by a decrease in levels of SHBG...
  63. ncbi Nonlinear relationship of insulin-like growth factor (IGF)-I and IGF-I/IGF-binding protein-3 ratio with indices of adiposity and plasma insulin concentrations (Sweden)
    Annekatrin Lukanova
    Department of Nutrition and Cancer, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France
    Cancer Causes Control 13:509-16. 2002
    ..In this study we test the hypothesis of a nonlinear relationship of IGF-I with indices of body fat such as body mass index (BMI), insulin, and leptin...
  64. ncbi Body mass index in relation to ovarian cancer: a multi-centre nested case-control study
    Annekatrin Lukanova
    Department of Nutrition and Cancer, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France
    Int J Cancer 99:603-8. 2002
    ..02. There was some evidence of direct association of ovarian cancer with height, which was limited to cancers diagnosed before age 55. Our data suggest that increasing body weight may confer a protection against ovarian cancer...
  65. ncbi No association between progesterone receptor gene +331G/A polymorphism and endometrial cancer
    Laure Dossus
    IARC, Lyon, France
    Cancer Epidemiol Biomarkers Prev 15:1415-6. 2006
  66. ncbi Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Anne E Cust
    Nutrition and Hormones Unit, International Agency for Research on Cancer, Lyon, France
    Endocr Relat Cancer 14:755-67. 2007
    ..01). None of the associations differed significantly by fasting status. These findings suggest that metabolic abnormalities and obesity may act synergistically to increase endometrial cancer risk...
  67. ncbi Risk of ovarian cancer in relation to prediagnostic levels of C-peptide, insulin-like growth factor binding proteins-1 and -2 (USA, Sweden, Italy)
    Annekatrin Lukanova
    International Agency for Research on Cancer, Lyon, France
    Cancer Causes Control 14:285-92. 2003
    ....
  68. ncbi Plasma adiponectin levels and endometrial cancer risk in pre- and postmenopausal women
    Anne E Cust
    Nutrition and Hormones Unit, International Agency for Research on Cancer, 69372 Lyon, France
    J Clin Endocrinol Metab 92:255-63. 2007
    ..Adiponectin, an adipocytokine secreted by adipose tissue, is decreased in obesity, insulin resistance, type 2 diabetes, and polycystic ovary syndrome, all of which are well-established risk factors for endometrial cancer...
  69. ncbi Serum B vitamin levels and risk of lung cancer
    Mattias Johansson
    International Agency for Research on Cancer, Lyon, France
    JAMA 303:2377-85. 2010
    ..B vitamins and factors related to 1-carbon metabolism help to maintain DNA integrity and regulate gene expression and may affect cancer risk...
  70. ncbi Amount of DNA in plasma and cancer risk: a prospective study
    Emmanuelle Gormally
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 111:746-9. 2004
    ..e., a time elapsed between blood drawing and disease onset lower than 36 months. This was particularly true for COPD deaths (OR = 12.7; 95% CI = 1.57-103) and leukemia (OR = 2.37; 95% CI = 1.20-4.67)...
  71. ncbi Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence
    Rudolf Kaaks
    International Agencyfor Research on Cancer, Lyon, France
    Novartis Found Symp 262:247-60; discussion 260-68. 2004
    ..Nutritional energy balance, macronutrient composition of the diet and physical activity levels appear to be major determinants of IGF-1 bioactivity...
  72. pmc International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants
    Therese Truong
    International Agency for Research on Cancer, Lyon 69008, France
    Carcinogenesis 31:625-33. 2010
    ....
  73. ncbi Epidemiologic studies of nutrition and cancer: let us not throw out the baby with the bath water
    Rudolf Kaaks
    Hormones and Cancer Group, International Agency for the Research on Cancer, Lyon, France
    Int J Cancer 116:662-4. 2005
  74. ncbi TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: a prospective study
    Emmanuelle Gormally
    IARC, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Cancer Res 66:6871-6. 2006
    ..TP53 mutation may be associated with environmental exposures. These observations have implications for monitoring early steps of carcinogenesis...

Research Grants6

  1. INSULIN, IGF-1 & CANCERS OF BREAST, ENDOMETRIUM & OVARY
    Rudolf Kaaks; Fiscal Year: 2000
    ..All studies are based on the same underlying population, obtained by combining three prospective cohort studies that are currently ongoing in New York, Umea (Sweden) and Milan (Italy). ..
  2. INSULIN, IGF-1 & CANCERS OF BREAST, ENDOMETRIUM & OVARY
    Rudolf Kaaks; Fiscal Year: 2001
    ..All studies are based on the same underlying population, obtained by combining three prospective cohort studies that are currently ongoing in New York, Umea (Sweden) and Milan (Italy). ..
  3. Lifestyle, insulin, IGF-I and colorectal cancer
    Rudolf Kaaks; Fiscal Year: 2003
    ..This study seeks to increase understanding of etiologic mechanisms relating over nutrition to colon cancer development, which will eventually allow the in formulation of more precise nutritional guidelines for efficient prevention. ..
  4. Lifestyle, insulin, IGF-I and colorectal cancer
    Rudolf Kaaks; Fiscal Year: 2004
    ..This study seeks to increase understanding of etiologic mechanisms relating over nutrition to colon cancer development, which will eventually allow the in formulation of more precise nutritional guidelines for efficient prevention. ..
  5. Lifestyle, insulin, IGF-I and colorectal cancer
    Rudolf Kaaks; Fiscal Year: 2005
    ..This study seeks to increase understanding of etiologic mechanisms relating over nutrition to colon cancer development, which will eventually allow the in formulation of more precise nutritional guidelines for efficient prevention. ..