Rayjean J Hung

Summary

Affiliation: International Agency for Research on Cancer
Country: France

Publications

  1. ncbi Using hierarchical modeling in genetic association studies with multiple markers: application to a case-control study of bladder cancer
    Rayjean J Hung
    Internal Agency for Research on Cancer Epidemiology, 150 cours Albert Thomas, 69008 Lyon, France
    Cancer Epidemiol Biomarkers Prev 13:1013-21. 2004
  2. ncbi Folate-related genes and the risk of tobacco-related cancers in Central Europe
    Rayjean J Hung
    International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372, 69008, Lyon Cedex 08, France
    Carcinogenesis 28:1334-40. 2007
  3. ncbi Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review
    Rayjean J Hung
    Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 162:925-42. 2005
  4. ncbi Family history and the risk of kidney cancer: a multicenter case-control study in Central Europe
    Rayjean J Hung
    IARC, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 16:1287-90. 2007
  5. ncbi Inherited predisposition of lung cancer: a hierarchical modeling approach to DNA repair and cell cycle control pathways
    Rayjean J Hung
    IARC, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 16:2736-44. 2007
  6. pmc Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium
    Therese Truong
    Genetic Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex 08, France
    J Natl Cancer Inst 102:959-71. 2010
  7. doi Sequence variants of NAT1 and NAT2 and other xenometabolic genes and risk of lung and aerodigestive tract cancers in Central Europe
    James D McKay
    Association for International Cancer Research, 150 cours Albert Thomas, Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 17:141-7. 2008
  8. pmc Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype
    Paul Brennan
    International Agency for Research on Cancer IARC, Genetic Epidemiology Group, Lyon, France
    Int J Epidemiol 38:971-5. 2009
  9. ncbi Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study
    Paul Brennan
    International Agency for Research on Cancer IARC, Lyon, France
    Hum Mol Genet 16:1794-801. 2007
  10. ncbi The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract
    Janet Hall
    International Agency for Research on Cancer, Lyon, France
    Carcinogenesis 28:665-71. 2007

Detail Information

Publications41

  1. ncbi Using hierarchical modeling in genetic association studies with multiple markers: application to a case-control study of bladder cancer
    Rayjean J Hung
    Internal Agency for Research on Cancer Epidemiology, 150 cours Albert Thomas, 69008 Lyon, France
    Cancer Epidemiol Biomarkers Prev 13:1013-21. 2004
    ..Using data from a case-control study of bladder cancer, we showed how to use hierarchical modeling in genetic epidemiologic studies with multiple markers to control overestimation of effects and potential false-positive associations...
  2. ncbi Folate-related genes and the risk of tobacco-related cancers in Central Europe
    Rayjean J Hung
    International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372, 69008, Lyon Cedex 08, France
    Carcinogenesis 28:1334-40. 2007
    ..These results support an important role of folate in protecting against tobacco-related cancers...
  3. ncbi Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review
    Rayjean J Hung
    Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 162:925-42. 2005
    ..Recommendations for future studies include pooling of individual data to facilitate evaluation of multigenic effects and detailed analysis of effect modification by environmental exposure...
  4. ncbi Family history and the risk of kidney cancer: a multicenter case-control study in Central Europe
    Rayjean J Hung
    IARC, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 16:1287-90. 2007
    ....
  5. ncbi Inherited predisposition of lung cancer: a hierarchical modeling approach to DNA repair and cell cycle control pathways
    Rayjean J Hung
    IARC, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 16:2736-44. 2007
    ..In particular, further investigation of OGG1, MGMT, and CHEK2 focusing on the genetic regions where the present markers are located or the haplotype blocks tightly linked with these markers might be warranted...
  6. pmc Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium
    Therese Truong
    Genetic Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex 08, France
    J Natl Cancer Inst 102:959-71. 2010
    ....
  7. doi Sequence variants of NAT1 and NAT2 and other xenometabolic genes and risk of lung and aerodigestive tract cancers in Central Europe
    James D McKay
    Association for International Cancer Research, 150 cours Albert Thomas, Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 17:141-7. 2008
    ..We therefore conclude that, of the genetic variation studied, NAT1 gene was the most likely candidate to influence the risk of developing a tobacco-related cancer...
  8. pmc Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype
    Paul Brennan
    International Agency for Research on Cancer IARC, Genetic Epidemiology Group, Lyon, France
    Int J Epidemiol 38:971-5. 2009
    ..Obesity is a risk factor for several cancers although appears to have an inverse association with cancers strongly related to tobacco. Studying obesity is difficult due to numerous biases and confounding...
  9. ncbi Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study
    Paul Brennan
    International Agency for Research on Cancer IARC, Lyon, France
    Hum Mol Genet 16:1794-801. 2007
    ..g. by forcing nearby stem cells to divide before they have repaired their own DNA damage from tobacco smoke). If so, reducing the rate of apoptosis by reducing CHEK2 activity could be protective-although not smoking would be far more so...
  10. ncbi The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract
    Janet Hall
    International Agency for Research on Cancer, Lyon, France
    Carcinogenesis 28:665-71. 2007
    ..While some of these associations are consistent with previous studies, we cannot rule out the possibility of false-positive associations. The positive findings should be explored in another large-scale study on UADT cancers...
  11. ncbi Large-scale investigation of base excision repair genetic polymorphisms and lung cancer risk in a multicenter study
    Rayjean J Hung
    International Agency for Research on Cancer, Lyon, France
    J Natl Cancer Inst 97:567-76. 2005
    ..We examined associations among four well-characterized polymorphisms of BER genes (OGG1 Ser326Cys, XRCC1 Arg194Trp, XRCC1 Arg280His, and XRCC1 Arg399Gln) and lung cancer risk...
  12. ncbi Sequence variants in cell cycle control pathway, X-ray exposure, and lung cancer risk: a multicenter case-control study in Central Europe
    Rayjean J Hung
    IARC, Lyon, France
    Cancer Res 66:8280-6. 2006
    ..However, a definite conclusion can only be drawn on replication by different studies among individuals who are highly exposed to IR...
  13. ncbi Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract
    Daniele Campa
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France
    Cancer Causes Control 18:449-55. 2007
    ..The purpose of this study was to investigate the role of polymorphisms of genes involved in inflammation in the risk of cancers of the upper aerodigestive tract (UADT)...
  14. pmc Lung cancer susceptibility locus at 5p15.33
    James D McKay
    International Agency for Research on Cancer IARC, Lyon, France
    Nat Genet 40:1404-6. 2008
    ..016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology...
  15. pmc A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium
    James D McKay
    International Agency for Research on Cancer IARC, Lyon, France
    PLoS Genet 7:e1001333. 2011
    ..02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility...
  16. ncbi Lack of association between -251 T>A polymorphism of IL8 and lung cancer risk
    Daniele Campa
    IARC, Lyon, France
    Cancer Epidemiol Biomarkers Prev 14:2457-8. 2005
  17. ncbi Polymorphisms of the DNA repair genes XRCC1, XRCC3, XPD, interaction with environmental exposures, and bladder cancer risk in a case-control study in northern Italy
    Min Shen
    International Agency for Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 12:1234-40. 2003
    ..Similarly, the XRCC1 codon 399 polymorphism also had a protective effect on bladder cancer among heavy smokers. The XPD polymorphism was not, however, associated with bladder cancer risk...
  18. pmc Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls
    Darren R Brenner
    International Agency for Research on Cancer, Lyon, France
    Hum Genet 132:579-89. 2013
    ..HM allows for prior knowledge such as from bioinformatic sources to be incorporated into the analysis systematically, and it represents a complementary analytical approach to the conventional GWAS analysis...
  19. pmc Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals
    Esther H Lips
    International Agency for Research on Cancer IARC, Lyon, France
    Int J Epidemiol 39:563-77. 2010
    ....
  20. ncbi Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history
    Mounia Mounawar
    IARC, Lyon, France
    Cancer Res 67:5667-72. 2007
    ....
  21. ncbi GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk population
    Rayjean J Hung
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 110:598-604. 2004
    ..26 (95% CI = 1.06-9.95). SULT1A1 Arg213His polymorphism showed a marginal protective effect. These findings suggest that individual susceptibility to bladder cancer may be modulated by GSTM1, GSTT1 and NAT2 polymorphisms...
  22. pmc International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways
    Rayjean J Hung
    IARC, 150 cours Albert Thomas, 69008 Lyon, France
    Cancer Epidemiol Biomarkers Prev 17:3081-9. 2008
    ..To clarify the role of DNA repair genes in lung cancer susceptibility, we conducted a pooled analysis of genetic variants in DNA repair pathways, whose associations have been investigated by at least 3 individual studies...
  23. ncbi Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach
    Paul Brennan
    International Agency for Research on Cancer, Lyon, France
    Lancet 366:1558-60. 2005
    ..These data provide strong evidence for a substantial protective effect of cruciferous vegetable consumption on lung cancer...
  24. pmc Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors
    Thomas Vaissière
    Epigenetics Group, IARC, 150 cours Albert Thomas, Lyon Cedex 08, France
    Cancer Res 69:243-52. 2009
    ..Together, this study identifies aberrant DNA methylation patterns in lung cancer and thus exemplifies the mechanism by which environmental factors may interact with key genes involved in tumor suppression and contribute to lung cancer...
  25. ncbi Lack of association between polymorphisms in inflammatory genes and lung cancer risk
    Daniele Campa
    IARC, 150 cours Albert Thomas, F 69372 Lyon 08, France
    Cancer Epidemiol Biomarkers Prev 14:538-9. 2005
  26. doi Multiple ADH genes are associated with upper aerodigestive cancers
    Mia Hashibe
    International Agency for Research on Cancer, Lyon, France
    Nat Genet 40:707-9. 2008
    ..0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology...
  27. ncbi CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: a pooled analysis
    Rayjean J Hung
    Unit of Environmental Cancer Epidemiology, International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
    Carcinogenesis 24:875-82. 2003
    ..Our study therefore suggests that the CYP1A1 Ile(462)Val variant allele might play a role in lung carcinogenesis among non-smokers, possibly in combination with the GSTM1 null genotype...
  28. pmc Bayesian mixture modeling of gene-environment and gene-gene interactions
    Jon Wakefield
    International Agency for Research on Cancer, Lyon, France
    Genet Epidemiol 34:16-25. 2010
    ..We illustrate the methods first using simulation, and then on data from a case-control study of lung cancer in Central and Eastern Europe...
  29. pmc Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls
    Maria N Timofeeva
    International Agency for Research on Cancer, Lyon, France
    Hum Mol Genet 21:4980-95. 2012
    ..3 × 10(-8)). This large analysis provides additional evidence for the role of inherited genetic susceptibility to lung cancer and insight into biological differences in the development of the different histological types of lung cancer...
  30. pmc International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants
    Therese Truong
    International Agency for Research on Cancer, Lyon 69008, France
    Carcinogenesis 31:625-33. 2010
    ....
  31. pmc Aspirin and NSAID use and lung cancer risk: a pooled analysis in the International Lung Cancer Consortium (ILCCO)
    Valerie A McCormack
    Section of Environment and Radiation, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France
    Cancer Causes Control 22:1709-20. 2011
    ..To investigate the hypothesis that non-steroidal anti-inflammatory drugs (NSAIDs) lower lung cancer risk...
  32. ncbi Perspectives on the molecular epidemiology of aerodigestive tract cancers
    Rayjean J Hung
    Genetics and Epidemiology Cluster, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France
    Mutat Res 592:102-18. 2005
    ..Such collaborative efforts and integration across disciplines will be essential in contributing to the elucidation of genetic susceptibility to aerodigestive tract cancers...
  33. ncbi TP53 and KRAS mutation load and types in lung cancers in relation to tobacco smoke: distinct patterns in never, former, and current smokers
    Florence Le Calvez
    IARC, Lyon, France
    Cancer Res 65:5076-83. 2005
    ..6-50). These results support the notion that lung tumorigenesis proceeds through different molecular mechanisms according to smoking status. In never smokers, accumulation of N-Tyr suggests an etiology involving severe inflammation...
  34. doi The epidemiology of neuroblastoma: a review
    Julia E Heck
    International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France
    Paediatr Perinat Epidemiol 23:125-43. 2009
    ..2, 0.4). The rarity of neuroblastoma makes this disease particularly challenging to study epidemiologically. We review the methodological limitations of prior research and make suggestions for further areas of study...
  35. ncbi Genetic polymorphisms of MPO, COMT, MnSOD, NQO1, interactions with environmental exposures and bladder cancer risk
    Rayjean J Hung
    International Agency of Research on Cancer, Lyon 69008, France
    Carcinogenesis 25:973-8. 2004
    ....
  36. ncbi Pooled analysis and meta-analysis of the glutathione S-transferase P1 Ile 105Val polymorphism and bladder cancer: a HuGE-GSEC review
    Eliane Kellen
    Department of General Practice, Katholieke Universiteit Leuven, Comprehensive Cancer Institute Limburg, Limburg, Belgium
    Am J Epidemiol 165:1221-30. 2007
    ..Case-only analyses did not detect an interaction between the GSTP1 genotype and smoking status (never/ever). GSTP1 Ile 105Val appears to be associated with a modest increase in the risk of bladder cancer...
  37. ncbi Tobacco smoking and chewing, alcohol drinking and lung cancer risk among men in southern India
    Vendhan Gajalakshmi
    Epidemiological Research Center, Chennai, India
    Int J Cancer 107:441-7. 2003
    ..67, 95%CI=1.02-7.02). Bidi smoking seems to have a stronger carcinogenic effect than cigarette smoking: this difference holds no matter which aspect of smoking was considered...
  38. doi A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
    Rayjean J Hung
    International Agency for Research on Cancer IARC, Lyon 69008, France
    Nature 452:633-7. 2008
    ..Our results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets...
  39. ncbi Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes
    Federica Gemignani
    Genetics, Department of Biology, University of Pisa, Pisa, Italy
    Carcinogenesis 28:1287-93. 2007
    ..Finally, extensive EPHX1 metabolizers showed an increased risk as compared with the poor metabolizers...
  40. ncbi DNA repair and cell cycle control genes and the risk of young-onset lung cancer
    Stefano Landi
    Dip Biologia Genetics, University of Pisa, Pisa, Italy
    Cancer Res 66:11062-9. 2006
    ..38). Consideration of the relatively large number of markers assessed diminishes the significance of these findings; thus, these SNPs should be considered promising candidates for further investigation in other independent populations...
  41. ncbi Protective effects of plasma carotenoids on the risk of bladder cancer
    Rayjean J Hung
    Department of Epidemiology, University of California Los Angeles, Los Angeles, CA, USA
    J Urol 176:1192-7. 2006
    ..We examined the associations between plasma micronutrients and bladder cancer risk, and evaluated the combined effects of carotenoid and cigarette smoke...