Research Topics
Genomes and GenesSpecies | M HashibeSummaryAffiliation: International Agency for Research on Cancer Country: France Publications
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Publications
Dietary risk factors for hypopharyngeal cancer in IndiaJulia E Heck
International Agency for Research on Cancer, Lyon, France
Cancer Causes Control 19:1329-37. 2008..The Indian subcontinent has among the highest rates of hypopharyngeal cancer worldwide. The purpose of this study was to examine the associations between the Indian diet and hypopharyngeal cancer...
Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology ConsortiumMia Hashibe
IARC, Lifestyle, Environment and Cancer Group, Genetics and Epidemiology Cluster, Lyon, France
Cancer Epidemiol Biomarkers Prev 18:541-50. 2009..The magnitude of risk conferred by the interaction between tobacco and alcohol use on the risk of head and neck cancers is not clear because studies have used various methods to quantify the excess head and neck cancer burden...
Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology ConsortiumMia Hashibe
Gene Environment Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France
J Natl Cancer Inst 99:777-89. 2007....- Socioeconomic status, lifestyle factors and oral premalignant lesionsM Hashibe
International Agency for Research on Cancer, Unit of Environmental Cancer Epidemiology, 150, cours Albert Thomas, 69372 Cedex 08 Lyon, France
Oral Oncol 39:664-71. 2003..Though the mechanism for the association is not clear, higher SES index, education and income were associated with decreased risk of oral premalignant lesions in our study... - NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysisChun Chao
Gene Environment Epidemiology Group, IARC, 150, cours Albert Thomas, 69372 Lyon Cedex 08, France
Cancer Epidemiol Biomarkers Prev 15:979-87. 2006..Such effects of the NQO1 polymorphism seem to be modified by ethnicity and smoking status... - Dietary risk factors for squamous cell carcinoma of the upper aerodigestive tract in central and eastern EuropeA Sapkota
Lifestyle, Environment and Cancer Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France
Cancer Causes Control 19:1161-70. 2008..We investigated the relationship between diet and UADT cancers in these high risk areas... - Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancerMia Hashibe
International Agency for Research on Cancer, Lyon, France
Cancer Epidemiol Biomarkers Prev 12:1509-17. 2003.... - Multiple ADH genes are associated with upper aerodigestive cancersMia Hashibe
International Agency for Research on Cancer, Lyon, France
Nat Genet 40:707-9. 2008..0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology... - The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tractJanet Hall
International Agency for Research on Cancer, Lyon, France
Carcinogenesis 28:665-71. 2007..While some of these associations are consistent with previous studies, we cannot rule out the possibility of false-positive associations. The positive findings should be explored in another large-scale study on UADT cancers... - Indoor air pollution from solid fuels and risk of hypopharyngeal/laryngeal and lung cancers: a multicentric case-control study from IndiaAmir Sapkota
International Agency for Research on Cancer, Lyon, France
Int J Epidemiol 37:321-8. 2008..Although as much as 74% of the Indian population relies on solid fuels for cooking, very little information is available on cancer risk associated with these fuels in India... - Contribution of tobacco and alcohol to the high rates of squamous cell carcinoma of the supraglottis and glottis in Central EuropeMia Hashibe
International Agency for Research on Cancer, Lyon, France
Am J Epidemiol 165:814-20. 2007..Preventive efforts to encourage current smokers to quit are likely to be the most effective way to reduce the incidence of laryngeal cancer in this region... - Esophageal cancer in Central and Eastern Europe: tobacco and alcoholMia Hashibe
International Agency for Research on Cancer, Lyon, France
Int J Cancer 120:1518-22. 2007..A synergistic interaction between tobacco and alcohol was observed for the risk of esophageal SCC, highlighting the importance of both factors for esophageal cancers in Central and Eastern Europe... - Marijuana use and the risk of lung and upper aerodigestive tract cancers: results of a population-based case-control studyMia Hashibe
IARC, Lyon, France
Cancer Epidemiol Biomarkers Prev 15:1829-34. 2006.... - Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tractMia Hashibe
IARC, Lyons, France
Cancer Epidemiol Biomarkers Prev 15:696-703. 2006..9% (42.9-83.1%) for esophageal cancer. CONCLUSIONS: Polymorphisms in the ADH1B and ALDH2 genes are associated with upper aerodigestive tract cancer in Central European populations and interact substantially with alcohol consumption... - Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individualsEsther H Lips
International Agency for Research on Cancer IARC, Lyon, France
Int J Epidemiol 39:563-77. 2010.... - The burden of cancer attributable to alcohol drinkingPaolo Boffetta
International Agency for Research on Cancer, Lyon, France
Int J Cancer 119:884-7. 2006..Although our estimates are based on simplified assumptions, the burden of alcohol-associated cancer appears to be substantial and needs to be considered when making public health recommendations on alcohol drinking... - A sex-specific association between a 15q25 variant and upper aerodigestive tract cancersDan Chen
International Agency for Research on Cancer IARC, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
Cancer Epidemiol Biomarkers Prev 20:658-64. 2011..24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35)... - Involuntary smoking and head and neck cancer risk: pooled analysis in the International Head and Neck Cancer Epidemiology ConsortiumYuan Chin Amy Lee
Lifestyle, Environment and Cancer Group, IARC, 150 cours Albert Thomas, 69008 Lyon, France
Cancer Epidemiol Biomarkers Prev 17:1974-81. 2008..These results are consistent with those for active smoking and suggest that elimination of involuntary smoking exposure might reduce head and neck cancer risk among never smokers... - Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control studyPaul Brennan
International Agency for Research on Cancer IARC, Lyon, France
Hum Mol Genet 16:1794-801. 2007..g. by forcing nearby stem cells to divide before they have repaired their own DNA damage from tobacco smoke). If so, reducing the rate of apoptosis by reducing CHEK2 activity could be protective-although not smoking would be far more so... - Active and involuntary tobacco smoking and upper aerodigestive tract cancer risks in a multicenter case-control studyYuan Chin Amy Lee
IARC, Lyon, France
Cancer Epidemiol Biomarkers Prev 18:3353-61. 2009..Our aim was to examine these specific issues in a large-scale case-control study in Europe... - Folate-related genes and the risk of tobacco-related cancers in Central EuropeRayjean J Hung
International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372, 69008, Lyon Cedex 08, France
Carcinogenesis 28:1334-40. 2007..These results support an important role of folate in protecting against tobacco-related cancers... - Sequence variants of NAT1 and NAT2 and other xenometabolic genes and risk of lung and aerodigestive tract cancers in Central EuropeJames D McKay
Association for International Cancer Research, 150 cours Albert Thomas, Lyon Cedex 08, France
Cancer Epidemiol Biomarkers Prev 17:141-7. 2008..We therefore conclude that, of the genetic variation studied, NAT1 gene was the most likely candidate to influence the risk of developing a tobacco-related cancer... - Association between diabetes mellitus and pre-malignant oral diseases: a cross sectional study in Kerala, IndiaRajesh P Dikshit
Gene Environment Epidemiology Group, International Agency for Research on Cancer, Lyon, France
Int J Cancer 118:453-7. 2006..An association between diabetes mellitus and pre-malignant oral lesions among women has been observed in our study, although the underlying mechanisms are not clear. This needs to be further evaluated in other settings... - Marijuana smoking and the risk of head and neck cancer: pooled analysis in the INHANCE consortiumJulien Berthiller
Lifestyle, Environment and Cancer Group, IARC, 69008 Lyon, France
Cancer Epidemiol Biomarkers Prev 18:1544-51. 2009..Because tobacco is a major risk factor for HNC, large studies with substantial numbers of never tobacco users could help to clarify whether marijuana smoking is independently associated with HNC risk... - Alcohol and cancerPaolo Boffetta
International Agency for Research on Cancer, Lyon, France
Lancet Oncol 7:149-56. 2006..Alcohol consumption is increasing in many countries and is an important cause of cancer worldwide... - Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE reviewPaul Brennan
International Agency for Research on Cancer, Lyon, France
Am J Epidemiol 159:1-16. 2004..These considerations suggest the potential for the organization of a consortium of investigators conducting studies in this field... - Recent changes in the epidemiology of head and neck cancerMaria Paula Curado
International Agency for Research on Cancer, Biostatistics and Epidemiology Cluster, Descriptive Epidemiology Production Group, Lyon, France
Curr Opin Oncol 21:194-200. 2009..To review the most recent epidemiological studies on head and neck cancer and changes in knowledge about risk factors. The main review concerned the squamous cell carcinoma of the oral cavity, oropharynx, larynx and hypopharynx... - Smokeless tobacco and increased risk of hypopharyngeal and laryngeal cancers: a multicentric case-control study from IndiaAmir Sapkota
International Agency for Research on Cancer, Lyon, France
Int J Cancer 121:1793-8. 2007.... - Meta-analysis of epidemiologic studies on cigarette smoking and liver cancerYuan Chin Amy Lee
International Agency for Research on Cancer, Lyon, France
Int J Epidemiol 38:1497-511. 2009.... - Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancerSean V Tavtigian
International Agency for Research on Cancer, 69372 Lyon, France
Am J Hum Genet 85:427-46. 2009.... - Risk of second primary cancer among patients with head and neck cancers: A pooled analysis of 13 cancer registriesShu Chun Chuang
International Agency for Research on Cancer IARC, Lyon, France
Int J Cancer 123:2390-6. 2008..These patterns were consistent with the notion that the pattern of cancer in survivors of head and neck cancer is dominated by the effect of tobacco smoking and alcohol drinking... - N2-ethyldeoxyguanosine as a potential biomarker for assessing effects of alcohol consumption on DNASilvia Balbo
IARC, Cours Albert Thomas 150, 69008, Lyon, France
Cancer Epidemiol Biomarkers Prev 17:3026-32. 2008..These results show the feasibility of quantifying N2-ethyl-dGuo in small-volume blood samples and are consistent with the hypothesis that ethanol contributes to carcinogenesis through DNA adducts formation... - Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortiumJulia E Heck
Lifestyle, Environment, and Cancer Group, International Agency for Research on Cancer, Lyon, France
Int J Epidemiol 39:166-81. 2010..Sexual contact may be the means by which head and neck cancer patients are exposed to human papillomavirus (HPV)... - Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tractDaniele Campa
International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France
Cancer Causes Control 18:449-55. 2007..The purpose of this study was to investigate the role of polymorphisms of genes involved in inflammation in the risk of cancers of the upper aerodigestive tract (UADT)... - Radiotherapy for oral cancer as a risk factor for second primary cancersMia Hashibe
International Agency for Research on Cancer, Lyon, France
Cancer Lett 220:185-95. 2005..Further studies that account for chemotherapy and examine frequency and duration of radiotherapy would be of interest in confirming the observed association... - Epidemiologic review of marijuana use and cancer riskMia Hashibe
International Agency for Research on Cancer, 69008 Lyon, France
Alcohol 35:265-75. 2005..Despite the challenges, elucidation of the association between marijuana use and cancer risk is important in weighing the benefits and risks of medical marijuana use and to clarify the impact of marijuana use on public health... - Home and workplace smoking bans in Italy, Ireland, Sweden, France and the Czech RepublicJ E Heck
International Agency for Research on Cancer, Lyon, France
Eur Respir J 35:969-79. 2010..53, 95% CI 0.32-0.88) than among professional workers. Workplace smoking bans are in place for most workers in these countries. Having a home smoking ban was based on smoking behaviour, demographics, beliefs and personal preference... - Risks of second primary cancer among patients with major histological types of lung cancers in both men and womenS C Chuang
International Agency for Research on Cancer, Lyon, France
Br J Cancer 102:1190-5. 2010..Patterns of second primary cancers (SPCs) following first primary lung cancers (FPLCs) may provide aetiological insights into FPLC... - Interaction between cigarette smoking and hepatitis B and C virus infection on the risk of liver cancer: a meta-analysisShu Chun Chuang
IARC, International Prevention Research Institute, 95 cours Lafayette, 69006 Lyon, France
Cancer Epidemiol Biomarkers Prev 19:1261-8. 2010..We conducted a meta-analysis to evaluate the interaction of HBV and HCV infection and cigarette smoking on the risk of HCC... - Determinants of smoking initiation among women in five European countries: a cross-sectional surveyDebora L Oh
International Agency for Research on Cancer, Lyon, France
BMC Public Health 10:74. 2010.... - Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer riskManuela Marron
International Agency for Research on Cancer, Lyon, France
Int J Epidemiol 39:182-96. 2010..However, it is unclear how many years must pass following cessation of these habits before the risk is reduced, and whether the risk ultimately declines to the level of never smokers or never drinkers... - Risk of second primary cancer among esophageal cancer patients: a pooled analysis of 13 cancer registriesShu Chun Chuang
IARC, Lyon, France
Cancer Epidemiol Biomarkers Prev 17:1543-9. 2008..The objective of this study is to assess the risk of second primary cancers following a first primary esophageal cancer as well as the risk of esophageal cancer as a second primary, following first primary cancers of other sites... - Perspectives on the molecular epidemiology of aerodigestive tract cancersRayjean J Hung
Genetics and Epidemiology Cluster, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France
Mutat Res 592:102-18. 2005..Such collaborative efforts and integration across disciplines will be essential in contributing to the elucidation of genetic susceptibility to aerodigestive tract cancers... - The epidemiology of neuroblastoma: a reviewJulia E Heck
International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France
Paediatr Perinat Epidemiol 23:125-43. 2009..2, 0.4). The rarity of neuroblastoma makes this disease particularly challenging to study epidemiologically. We review the methodological limitations of prior research and make suggestions for further areas of study... - Sensitivity of the association between increased lung cancer risk and bitumen fume exposure to the assumptions in the assessment of exposureFrank de Vocht
Gene Environment Epidemiology Group, International Agency for Research on Cancer IARC, Lyon, France
Int Arch Occup Environ Health 82:723-33. 2009..Sensitivity analyses were conducted to assess whether these associations were robust to assumptions in the exposure assessment for which support could not be obtained due to lack of either measurements or direct observations... - A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25Rayjean J Hung
International Agency for Research on Cancer IARC, Lyon 69008, France
Nature 452:633-7. 2008..Our results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets... - Risk factors for multiple oral premalignant lesionsGigi Thomas
Regional Cancer Centre, Trivandrum, India
Int J Cancer 107:285-91. 2003..9, 95%CI=0.5-1.7). The results suggest that tobacco chewing was the most important risk factor for multiple oral premalignant lesions and may be a major source of field cancerization on the oral epithelium in the Indian population... - A case-control study of the association of the polymorphisms and haplotypes of DNA ligase I with lung and upper-aerodigestive-tract cancersYuan Chin Amy Lee
Department of Epidemiology, University of California at Los Angeles School of Public Health, Los Angeles, CA 90095 1772, USA
Int J Cancer 122:1630-8. 2008..We observed weaker associations between the LIG1 haplotypes and UADT cancers. Our findings suggest the LIG1 haplotypes may affect the risk of lung and UADT cancers... - Betel quid without tobacco as a risk factor for oral precancersBinu J Jacob
Regional Cancer Centre, Trivandrum 695011, India
Oral Oncol 40:697-704. 2004..In conclusion, our study supports the hypothesis that chewing betel quid without tobacco elevates the risks of various oral precancers... - Body mass index, tobacco chewing, alcohol drinking and the risk of oral submucous fibrosis in Kerala, IndiaMia Hashibe
Department of Epidemiology, UCLA School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095-1772, USA
Cancer Causes Control 13:55-64. 2002..Our results indicated that alcohol drinking might be a moderate risk factor and confirmed the previous observation that chewing tobacco was a strong risk factor for oral submucous fibrosis... - Socioeconomic inequalities and oral cancer risk: a systematic review and meta-analysis of case-control studiesDavid I Conway
Dental Public Health Unit, Dental School, Medical Faculty, University of Glasgow, Glasgow, United Kingdom
Int J Cancer 122:2811-9. 2008..Our results provide evidence to steer health policy which focus on lifestyles factors toward an integrated approach incorporating measures designed to tackle the root causes of disadvantage... - Marijuana smoking and head and neck cancerMia Hashibe
Department of Epidemiology, UCLA School of Public Health, Jonsson Comprehensive Cancer Center, 90095-1772, USA
J Clin Pharmacol 42:103S-107S. 2002..It will also be of interest to examine potential field cancerization of the upper aerodigestive tract by marijuana and to explore marijuana as a risk factor for oral premalignant lesions... - Survival rates of invasive breast cancer among ethnic Chinese women born in East Asia and the United StatesShu-Chun Chuang
Department of Epidemiology, UCLA School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095, USA
Asian Pac J Cancer Prev 7:221-6. 2006.... - A road map for efficient and reliable human genome epidemiologyJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina 45110, Greece
Nat Genet 38:3-5. 2006..Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews...
Research Grants
- Pooled Analyses of SNPs and Risk of Head & Neck CancerMia Hashibe; Fiscal Year: 2006..abstract_text> ..
- International Head and Neck Cancer ConsortiumMia Hashibe; Fiscal Year: 2005..We anticipate that the INHANCE consortium will be a major step toward improving our understanding of the causes and mechanisms of head & neck cancers and the beginning of a long-standing cooperation. ..