Affiliation: Institut de Biologie Structurale
Morlot C, Straume D, Peters K, Hegnar O, Simon N, Villard A, et al
. Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae. Nat Commun. 2018;9:3180 pubmed publisher
..GatD is a glutaminase providing ammonia that is likely channeled to the MurT active site through a cavity network. The structure and assay presented here constitute a knowledge base for future drug development studies. ..
Philippe J, Gallet B, Morlot C, Denapaite D, Hakenbeck R, Chen Y, et al
. Mechanism of Î²-lactam action in Streptococcus pneumoniae: the piperacillin paradox. Antimicrob Agents Chemother. 2015;59:609-21 pubmed publisher
Zapun A, Morlot C, Taha M. Resistance to ?-Lactams in Neisseria ssp Due to Chromosomally Encoded Penicillin-Binding Proteins. Antibiotics (Basel). 2016;5: pubmed
..The variety of penA alleles and resulting variant PBP2 enzymes is described and the important amino acid substitutions are presented and discussed in a structural context. ..
Calvez P, Breukink E, Roper D, Dib M, Contreras Martel C, Zapun A. Substitutions in PBP2b from Î²-Lactam-resistant Streptococcus pneumoniae Have Different Effects on Enzymatic Activity and Drug Reactivity. J Biol Chem. 2017;292:2854-2865 pubmed publisher
..This finding indicates that some of the numerous amino acid substitutions were selected to restore a viable level of enzymatic activity by a compensatory molecular mechanism. ..