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Affiliation: Institut Pasteur
Queval C, Song O, Carralot J, Saliou J, Bongiovanni A, Deloison G, et al. Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling. Cell Rep. 2017;20:3188-3198 pubmed publisher
..Consistently, we show that inhibition of CISH expression leads to reduced replication of M. tuberculosis in macrophages. Our findings further broaden the molecular understanding of mechanisms deployed by bacteria to survive. ..
Song O, Kim H, Jouny S, Ricard I, Vandeputte A, Deboosere N, et al. A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone. Toxins (Basel). 2017;9: pubmed publisher
..This result points towards novel ATâ‚‚R-dependent signaling pathways in DRG neurons underlying the analgesic effect of mycolactone, with the perspective for the development of new types of nature-inspired analgesics. ..