Research Topics
Species | L XerriSummaryAffiliation: Institut Paoli-Calmettes Country: France Publications
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Detail Information
Publications
Association of GATA3, P53, Ki67 status and vascular peritumoral invasion are strongly prognostic in luminal breast cancerJocelyne Jacquemier
Département d Oncologie Moléculaire Centre de Recherche en Cancérologie de Marseille, Institut Paoli Calmettes, UMR891 Inserm, IFR137, 232 Bd sainte Marguerite Marseille, France
Breast Cancer Res 11:R23. 2009..The aim of this study was to identify the best predictors of success of hormonal therapy...- FGFR1 and WT1 are markers of human prostate cancer progressionElizabeth Devilard
Centre de Recherche en Cancerologie de Marseille, Département d Oncologie Moléculaire, UMR599 Inserm et Institut Paoli Calmettes, Marseille, France
BMC Cancer 6:272. 2006..Androgen-independent prostate adenocarcinomas are responsible for about 6% of overall cancer deaths in men... - Markers of subtypes in inflammatory breast cancer studied by immunohistochemistry: prominent expression of P-cadherinAzza Ben Hamida
Centre de Recherche en Cancerologie de Marseille, Département d Oncologie Moléculaire, UMR599 Inserm, Marseille, France
BMC Cancer 8:28. 2008..The aim of this study was to determine the distribution of molecular subtypes in IBC and identify factors that may explain the poor prognosis of IBC... 
Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma/chronic lymphocytic leukemiaLuc Xerri
Department of Bio Pathology, Institut Paoli Calmettes, Marseille 13009, France
Hum Pathol 39:1050-8. 2008..Because the anti-PD-1.6.4 antibody works on paraffin sections, it represents a useful tool to differentiate SLL/CLL from other small B-cell lymphomas...
FADD expression and caspase activation in B-cell lymphomas resistant to Fas-mediated apoptosisL Xerri
Institut Paoli Calmettes, Marsielle, France
Br J Haematol 106:652-61. 1999..The dysfunction underlying NHL resistance to apoptosis must therefore lie upstream of caspase 8, or could alternatively be influenced by anti-apoptotic regulators of the Bcl-2 family...- [DNA-array analysis of the expression profile of apoptosis gene regulators in malignant lymphoma]L Xerri
Departement de Pathologie, INSERM U 119, Institut Paoli Calmettes, IFR 57 et Université de la Méditerranée, Marseille
Bull Acad Natl Med 185:963-74; discussion 974-5. 2001.... - Correlation between apoptosis microarray gene expression profiling and histopathological lymph node lesionsJ P Dales
INSERM U 119, Institut Paoli-Calmettes, , Marseille, France
Mol Pathol 54:17-23. 2001..CONCLUSIONS: Variations in array profiles of sorted cell populations can be associated with specific histological features, suggesting a possible diagnostic application of ready made apoptosis macroarrays in haematopathology... - Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signatureEmmanuelle Charafe-Jauffret
Centre de Recherche en Cancerologie de Marseille, Laboratoire d Oncologie Moleculaire, UMR891 Inserm Institut Paoli Calmettes, Universite de la Mediterranee, Marseille, France
Cancer Res 69:1302-13. 2009.... - Caspase 7 downregulation as an immunohistochemical marker of colonic carcinomaF Palmerini
INSERM U 119; Department of Pathology, Institut Paoli-Calmettes, , Marseille, France
Hum Pathol 32:461-7. 2001..Caspase 7 deficiency thus appears as a new immunohistochemical marker of colonic neoplasia; its correction represents a potential basis for new therapies... - Caspases: conductors of the cell death machinery in lymphoma cellsJ P Dales
, Marseille, France
Leuk Lymphoma 41:247-53. 2001..Inhibition of caspases activation appears as a potential mechanism to explain apoptotic defects of malignant B-cells, and thus may constitute the basis for new cancer therapies... - Role of induction chemotherapy and bone marrow transplantation in adult lymphoblastic lymphoma: a report on 62 patients from a single centerR Bouabdallah
Department of Hematology, Institut J Paoli I Calmettes, Marseille, France
Ann Oncol 9:619-25. 1998..To describe the outcome of an unselected large series of patients with lymphoblastic lymphoma (LBL) treated in a single institution... - Sensitivity to Fas-mediated apoptosis is null or weak in B-cell non-Hodgkin's lymphomas and is moderately increased by CD40 ligationL Xerri
Department of Hematopathology, Institut Paoli Calmettes, Marseilles, France
Br J Cancer 78:225-32. 1998..This may be an impediment to the development of Fas-based therapies for NHLs... - Correlated break at PARK2/FRA6E and loss of AF-6/Afadin protein expression are associated with poor outcome in breast cancerA Letessier
Centre de Recherche en Cancerologie de Marseille, Département d Oncologie Moléculaire, UMR599 Inserm et Institut Paoli Calmettes, Marseille, France
Oncogene 26:298-307. 2007..Loss of Afadin had prognostic impact, suggesting that AF-6 may be a TSG. Loss of Afadin was correlated with loss of FHIT expression, suggesting fragility of FRA6E and FRA3B in a certain proportion of breast tumors... - Gene expression profiling identifies molecular subgroups among nodal peripheral T-cell lymphomasB Ballester
TAGC, INSERM ERM206, Marseille, France
Oncogene 25:1560-70. 2006..These results suggest the existence of distinct subtypes of PTCL-U with specific molecular profiles, and thus provide a basis to improve their classification and to develop new therapeutic targets... - True histiocytic lymphoma following B-acute lymphoblastic leukaemia: case report with evidence for a common clonal origin in both neoplasmsR Bouabdallah
Department of Haematology, Cancer Centre Institut Paoli Calmettes, Universite de la Mediterranee, Marseille, France
Br J Haematol 113:1047-50. 2001..Genotypic study showed that both neoplasms contained the same immunoglobulin heavy gene rearrangement, which has not been reported previously... - Frequent nuclear localization of ICAD and cytoplasmic co-expression of caspase-8 and caspase-3 in human lymphomasL Xerri
Department of Pathology, Institut Paoli Calmettes, Marseille, France
J Pathol 192:194-202. 2000.... - Moesin expression is a marker of basal breast carcinomasEmmanuelle Charafe-Jauffret
Laboratory of Molecular Oncology, Marseille Cancer Research Institute, UMR599 Inserm Institut Paoli Calmettes, Marseille, France
Int J Cancer 121:1779-85. 2007..014). In multivariate analysis, Moesin expression was nearly an independent prognostic marker of poor outcome as shown by Cox proportional hazard model in patients without lymph node metastasis (p = 0.052, HR = 2.38, CI 95[0.99-5.69])... - Detection of different clonal EBV strains in Hodgkin lymphoma and nasopharyngeal carcinoma tissues from the same patientJ Rey
Department of Haematology, Pathology, Cancer Center Institute J Paoli I Calmettes, Marseille, France
Br J Haematol 142:79-81. 2008..Polymerase chain reaction was used to determine the LMP-1 gene sequence and demonstrate that the two tumours contained different clonal viral genomes, suggesting a central and specific role of EBV infection... - The C-class chemokine lymphotactin costimulates the apoptosis of human CD4(+) T cellsC Cerdan
National Institute of Health and Medical Research, University of Méditerranée and Department of Hematopathology, Institut Paoli Calmettes, Marseille, France
Blood 97:2205-12. 2001..This study demonstrates that the functional repertoire of Lptn in the regulation of human CD4(+) T-lymphocyte activation includes the ability to costimulate apoptosis... - Simultaneous occurrence of kaposi's sarcoma and chronic myelogenous leukemiaN Vey
Institut Paoli Calmettes, Centre Regional de Lutte Contre le Cancer, Universite de la Mediterranee, Marseille France
Leuk Lymphoma 41:425-8. 2001..Since no immune deficiency could be documented in the patient, this rare observation suggests that CML may have triggered the onset of SK through cytokine release... - T-cell/histiocyte-rich large B-cell lymphomas and classical diffuse large B-cell lymphomas have similar outcome after chemotherapy: a matched-control analysisR Bouabdallah
Cancer Center Institut Paoli Calmettes Université de la Méditerranée, Marseille
J Clin Oncol 21:1271-7. 2003.... - Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcomeBruno Chetaille
Department of Bio Pathology, Institut Paoli Calmettes and Université de la Mediterranée, Marseille, France
Blood 113:2765-3775. 2009..The observation of Th1/ antiviral response in EBV(+) cHL tissues provides a basis for novel treatment strategies... - Typical medullary breast carcinomas have a basal/myoepithelial phenotypeJocelyne Jacquemier
Marseille Cancer Institute, Molecular Oncology Department, UMR599 INSERM and Paoli Calmettes Institute, Marseille, France
J Pathol 207:260-8. 2005..In multivariate analysis with logistic regression, TMBC was defined by the association of P-cadherin (R=2.29), MIB1 > 50 (R=3.80), ERBB2 negativity (R=2.24) and p53 positivity (RR=1.45)... - Aldehyde dehydrogenase 1-positive cancer stem cells mediate metastasis and poor clinical outcome in inflammatory breast cancerEmmanuelle Charafe-Jauffret
Department of Molecular Oncology, Institut Paoli Calmettes UMR891 Institut National de la Sante et de la Recherche Medicale, Universite de la Mediterranee, Marseille Cancer Research Center, Marseille, France
Clin Cancer Res 16:45-55. 2010..To examine the role of cancer stem cells (CSC) in mediating metastasis in inflammatory breast cancer (IBC) and the association of these cells with patient outcome in this aggressive type of breast cancer... - Gene expression profiling of human melanoma cell lines with distinct metastatic potential identifies new progression markersFrancois Bertucci
Departments of Medical Oncology, UMR599 Inserm, Institut Paoli Calmettes, Marseille, France
Anticancer Res 27:3441-9. 2007..Identification of markers associated with melanoma progression is crucial to identify new prognostic and/or therapeutic targets... - [Prognostic value of gene expression profiling using cDNA arrays in lymphomas]Francois Bertucci
Departement d Oncologie Medicale, Institut Paoli Calmettes, IFR57, 232, boulevard de Sainte Marguerite, 13273 Marseille, France
Bull Cancer 89:661-5. 2002..Recent publications show the potential of DNA arrays to improve the prognostic classification of diffuse large B cell lymphomas and of Hodgkin's lymphoma, by identifying new tumour classes unrecognised by classical factors... - "Sugar" tumor of the pancreas: a rare entity that is diagnosable on preoperative fine-needle biopsiesOlivier Ramuz
Department of Pathology, Institut Paoli Calmettes, Marseille, France
Virchows Arch 446:555-9. 2005..This observation highlights that STs should be considered in preoperative differential diagnosis of pancreas tumors, since they may be treated by limited surgical resection... - Identification of TCL1A as an immunohistochemical marker of adverse outcome in diffuse large B-cell lymphomasOlivier Ramuz
Department of Pathology, Institut Paoli Calmettes, BP 156, 13273 Marseille Cedex 9, France
Int J Oncol 26:151-7. 2005..Our data suggest that TCL1A immunodetection is an independent marker of adverse outcome that could be used in routine settings for the management of DLCL patients... - Characterization of Hodgkin's lymphoma-like undifferentiated carcinoma of the nasopharyngeal type as a particular UCNT subtype mimicking Hodgkin's lymphomaEmmanuelle Charafe-Jauffret
Department of Pathology, Institut Paoli Calmettes, 232 Boulevard de Sainte Marguerite, BP 156, F 13273 Marseille cedex 9, France
Int J Oncol 23:97-103. 2003..These results show that UCNT morphologically resembling HL share also some specific phenotypical and molecular features with HL, and might deserve to be isolated as a particular UCNT subtype... - [The consortium of Biological Resource Centres (BRC) and tumour cell and tissue banks in the Marseilles metropolitan area]Christian Chabannon
Réseau des Centres de Ressources Biologiques et Tumorothèques de l Agglomération Marseillaise, Biothèque Tumorothèque, Institut Paoli Calmettes, Centre Regional de Lutte Contre le Cancer, Provence Alpes Cote d Azur, France
Med Sci (Paris) 22:26-31. 2006..Through these efforts, the ultimate goal is to adopt rules that define BRC, as defined by the Organization for Economic Co-operation and Development (OECD)... - [Inflammatory breast carcinoma: towards molecular characterization?]Emmanuelle Charafe-Jauffret
Département de biopathologie, Institut Paoli Calmettes, Marseille
Ann Pathol 23:564-9. 2003..It has been shown to be lost in IBC and could control tumor growth, invasion, and angiogenesis. This paper summarizes current knowledge on IBC and describes a new basis for a molecular definition of IBC... - Constitutive nuclear localization and initial cytoplasmic apoptotic activation of endogenous caspase-3 evidenced by confocal microscopyOlivier Ramuz
INSERM U119, Service d Anatomie et Cytologie Pathologiques, Laboratoire d Immunologie des Tumeurs, Institut Paoli Calmettes, IFR 57 and Université de la Méditerranée, Marseille, France
Int J Exp Pathol 84:75-81. 2003..These results provide new perspectives about the subcellular compartmentation and traffic of caspases during the apoptotic process... - A distinctive epitheliomesenchymal biphasic tumor in the duodenum: the first case of duodenoblastoma?F Poizat
Department of Biopathology, Paoli Calmettes Institut, 232 Bd Sainte Marguerite, 13009, Marseille, France
Virchows Arch 461:379-83. 2012..To our knowledge, this is the first reported case occurring primarily in the duodenum and might be the first case of "duodenoblastoma.".. - NM23 expression in metastasis of malignant melanoma is a predictive prognostic parameter correlated with survivalL Xerri
Department of Pathology, Institut Paoli Calmettes, Marseille, France
Br J Cancer 70:1224-8. 1994.... - Gene expression profiling of breast cell lines identifies potential new basal markersE Charafe-Jauffret
Marseille Cancer Institute, Laboratory of Molecular Oncology, Inserm/Institut Paoli-Calmettes, Marseille, France
Oncogene 25:2273-84. 2006.... - Cystic pancreatic endocrine tumors: an endoscopic ultrasound-guided fine-needle aspiration biopsy study with histologic correlationSlim Charfi
Department of Pathology, Paoli Calmettes Institute, Marseille, France
Cancer 117:203-10. 2009..The aim of this study was to evaluate the preoperative diagnostic strategy for these tumors and to assess the clinical and pathologic characteristics... - [Biochips and their applications in pathology]L Xerri
Institut Paoli Calmettes, Marseille
Ann Pathol . 2003 - [A typical case...]J Serratrice
, CHU Timone, Marseille, France
Rev Med Interne 26:S290-1. 2005 - Multicystic peritoneal mesothelioma: report of three casesS Charfi
Department biopathology, Paoli Calmettes Institute, 232 Bd St Marguerite, 13273, Marseille, Cedex 9, France
Pathologica 100:416-9. 2008..The clinical presentation, pathogenesis and pathologic features including differential diagnosis of multicystic peritoneal mesothelioma are discussed... - Dual lympho-myeloproliferative disorder in a patient with t(8;22) with BCR-FGFR1 gene fusionAnne Murati
Department of Molecular Oncology, Marseille Cancer Institute, UMR599 INSERM and Paoli-Calmettes Institute, Marseille, France
Int J Oncol 26:1485-92. 2005..Although the FGFR1-MPD is rare, its study provides interesting clues to the understanding of hematopoietic stem cell biology and oncogene activation... - Identification of new classes among acute myelogenous leukaemias with normal karyotype using gene expression profilingNorbert Vey
Department of Molecular Oncology, Institut Paoli-Calmettes-UMR599 Inserm, IFR137, Marseille Cancer Institute, Marseille, France
Oncogene 23:9381-91. 2004..Our results demonstrate the transcriptional heterogeneity of NC-AMLs, and suggest the existence of 'translocation-like' NC-AMLs and of a gene expression signature that may predict response to chemotherapy... - FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in miceGeraldine Guasch
Institut National de la Sante et de la Recherche Medicale INSERM, Marseille, France
Blood 103:309-12. 2004..Lymphoid symptoms, however, appeared when onset of the disease was delayed as the result of mutation of FOP-FGFR1 at tyrosine 511, the phospholipase C gamma (PLCgamma) binding site... - High expression of the inhibitory receptor BTLA in T-follicular helper cells and in B-cell small lymphocytic lymphoma/chronic lymphocytic leukemiaHasni M'Hidi
Departments of Bio pathology, Paoli Calmettes Institute, Marseille, France
Am J Clin Pathol 132:589-96. 2009..The specific high expression of BTLA in B-CLL/SLL represents a new potential diagnostic tool. The BTLA positivity of TFH cells may be a basis for designing future immunotherapies... - Inflammatory breast cancers in Tunisia and France show similar immunophenotypesEmmanuelle Charafe Jauffret
Institut de Cancérologie de Marseille, Département d Oncologie Moléculaire, Institut Paoli Calmettes et UMR599 Inserm, IFR137 Marseille, France
Breast 16:352-8. 2007..It is thought that IBC occurs with a high frequency in Tunisia. The aim of this study is to evaluate this signature on a Tunisian series... - Gene expression profiling defines molecular subtypes of classical Hodgkin's diseaseElisabeth Devilard
Department of Pathology, Institut Paoli-Calmettes, 232 Boulevard de Sainte-Marguerite, BP 156, 13273 Marseille Cedex, France
Oncogene 21:3095-102. 2002..Our results establish a molecular taxonomy of HD correlating with response to therapy and clinical outcome, thereby suggesting the possibility of improving the current prognostic classification... - Prognosis and gene expression profiling of 20q13-amplified breast cancersChristophe Ginestier
, , UMR599 Inserm, Marseilles, France
Clin Cancer Res 12:4533-44. 2006..CONCLUSIONS: Our results suggest that amplified tumors of types 1 and 2 are two distinct entities resulting from two different mechanisms and associated to different prognosis... - LAT regulates gammadelta T cell homeostasis and differentiationSelene Nunez-Cruz
Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique Université de la Méditerranée, Parc Scientifique de Luminy, Case 906, 13288 Marseille Cedex 9, France
Nat Immunol 4:999-1008. 2003..These effects are very similar to that triggered in the alphabeta lineage by a mutation involving a distinct LAT tyrosine. Thus, LAT is an essential regulator of T cell homeostasis and terminal differentiation... - Gene expression profiling in anaplastic large cell lymphoma and Hodgkin's diseasePascal Trempat
INSERM U563 Centre de Physiopathologie de Toulouse-Purpan, IFR31, Purpan Hospital, France
Leuk Lymphoma 45:2001-6. 2004..Interestingly, the present study identifies new genes which may be involved in the pathogenesis and/or clinical outcome of cHL and deserve further investigations... - [Misleading signet-ring cells...]Veronique Secq
Service d Anatomie et Cytologie Pathologiques, Département de biopathologie, Institut Paoli Calmettes, 232, boulevard Sainte Marguerite, 13273 Marseille Cedex 9, France
Ann Pathol 28:166-8. 2008 - [Plasmablastic lymphoma in a patient with HIV infection: an unusual case located in the skin]Jean Philippe Dales
Service d Anatomie et Cytologie Pathologiques, CHU Nord, Bd Pierre Dramard, 13916 Marseille 20
Ann Pathol 25:45-9. 2005..Despite one cycle chemotherapy the patient died four months after presentation. HIV-associated plasmablastic lymphoma is a poor prognosis malignancy that may resist typing due to the lack of expression of commonly used lymphoid markers... - Gene expression profiling identifies molecular subtypes of inflammatory breast cancerFrancois Bertucci
Institut de Cancérologie de Marseille, Laboratoire d Oncologie Moleculaire, Institut Paoli Calmettes and UMR599 Institut National de la Santé et de la Recherche Médicale, IFR137, France
Cancer Res 65:2170-8. 2005.... - The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cellsLaurence de Leval
Department of Pathology, Centre Hospitalo Universitaire Sart Tilman, Tour de Pathologie 1, University of Liege, 4000 Liege, Belgium
Blood 109:4952-63. 2007..Our findings strongly support that T(FH) cells represent the normal counterpart of AITL, and suggest that the AITL spectrum may be wider than suspected, as a subset of CD30(-) PTCLs-u may derive from or be related to AITL... - [A tumor-like lymphocytis mastitis]Sophie Giusiano
Service d Anatomie et Cytologie Pathologiques du Pr Colette Taranger Charpin, CHU Nord, chemin des Bourelly, 13915 Marseille Cedex 20
Ann Pathol 25:231-4. 2005..Although extremely rare, this particular form of lymphocytic mastitis, a diagnostic pitfall particularly during peroperative examination, should be recognized by pathologists... - High numbers of tumor-associated macrophages have an adverse prognostic value that can be circumvented by rituximab in patients with follicular lymphoma enrolled onto the GELA-GOELAMS FL-2000 trialDanielle Canioni
Department of Pathology, Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, Universite Paris Descartes, 149 rue de Sevres, 75015, Paris, France
J Clin Oncol 26:440-6. 2008..We tried to establish whether intratumoral macrophage count (MC) definitely is able to predict the outcome of FL patients in the rituximab era...