Herve Vaucheret

Summary

Affiliation: Institut National de la Recherche Agronomique
Country: France

Publications

  1. ncbi Post-transcriptional gene silencing in plants
    H Vaucheret
    Laboratoire de Biologie Cellulaire, INRA, Versailles 78026, France
    J Cell Sci 114:3083-91. 2001
  2. ncbi Post-transcriptional small RNA pathways in plants: mechanisms and regulations
    Herve Vaucheret
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, l Institut National de la Recherche Agronomique, 78026 Versailles Cedex, France
    Genes Dev 20:759-71. 2006
  3. ncbi The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development
    Herve Vaucheret
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, INRA, 78026 Versailles Cedex, France
    Genes Dev 18:1187-97. 2004
  4. ncbi AGO1 homeostasis entails coexpression of MIR168 and AGO1 and preferential stabilization of miR168 by AGO1
    Herve Vaucheret
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, INRA, 78026 Versailles Cedex, France
    Mol Cell 22:129-36. 2006
  5. ncbi AGO1 homeostasis involves differential production of 21-nt and 22-nt miR168 species by MIR168a and MIR168b
    Herve Vaucheret
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, INRA, Versailles, France
    PLoS ONE 4:e6442. 2009
  6. ncbi Plant ARGONAUTES
    Herve Vaucheret
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, Institut National de la Recherche Agronomique INRA, 78026 Versailles Cedex, France
    Trends Plant Sci 13:350-8. 2008
  7. ncbi MicroRNA-dependent trans-acting siRNA production
    Herve Vaucheret
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, INRA 78026 Versailles Cedex, France
    Sci STKE 2005:pe43. 2005
  8. ncbi Arabidopsis HEN1: a genetic link between endogenous miRNA controlling development and siRNA controlling transgene silencing and virus resistance
    Stéphanie Boutet
    Laboratoire de Biologie Cellulaire, INRA, 78026 Versailles Cedex, France
    Curr Biol 13:843-8. 2003
  9. ncbi Arabidopsis FIERY1, XRN2, and XRN3 are endogenous RNA silencing suppressors
    Isabelle Gy
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, Institut National de la Recherche Agronomique INRA, 78026 Versailles Cedex, France
    Plant Cell 19:3451-61. 2007
  10. ncbi DRB4-dependent TAS3 trans-acting siRNAs control leaf morphology through AGO7
    Xavier Adenot
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, Institut National de la Recherche Agronomique, 78026 Versailles Cedex, France
    Curr Biol 16:927-32. 2006

Collaborators

  • J C Palauqui
  • Taline Elmayan
  • Allison C Mallory
  • Franck Vazquez
  • Karin Ljung
  • Jun Liu
  • Xuemei Chen
  • Nicolas Bouche
  • C Beclin
  • Thomas Laux
  • J P Nap
  • Vincent Jauvion
  • Nathalie Bouteiller
  • Angel Emilio Martinez de Alba
  • Virginie Gasciolli
  • Jean Benoit Morel
  • Stéphanie Boutet
  • Philippe Mourrain
  • Jean Sébastien Parent
  • Ivan Le Masson
  • Maud Rivard
  • Nicolas Maunoury
  • Isabelle Gy
  • Dominique Lauressergues
  • Xavier Adenot
  • Céline Sorin
  • Florence Proux
  • Jean-Benoit Morel
  • J B Morel
  • P Mourrain
  • M Fagard
  • Rik van Blokland
  • Caroline Proux
  • Jan M Kooter
  • Julie Gombert
  • David P Bartel
  • Christophe Garcion
  • Gaia Geiss
  • Goran Sandberg
  • John D Bussell
  • Isabelle Camus
  • Mariusz Kowalczyk
  • Catherine Bellini
  • Heather McKhann
  • Ariane Gratias
  • Patrice Crété
  • Mathilde Fagard
  • Christian Godon
  • Frank Feuerbach
  • A M Lacombe
  • C Bellini
  • M Sanial
  • D Jouette
  • T A Vo
  • S Nikic
  • F Feuerbach
  • S Boutet
  • C Godon
  • N Picault
  • K Rémoué

Detail Information

Publications35

  1. ncbi Post-transcriptional gene silencing in plants
    H Vaucheret
    Laboratoire de Biologie Cellulaire, INRA, Versailles 78026, France
    J Cell Sci 114:3083-91. 2001
    ..Whether viruses can counteract RNAi in animals and whether endogenous suppressors of RNAi exist in animals is still unknown...
  2. ncbi Post-transcriptional small RNA pathways in plants: mechanisms and regulations
    Herve Vaucheret
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, l Institut National de la Recherche Agronomique, 78026 Versailles Cedex, France
    Genes Dev 20:759-71. 2006
    ..This review focuses on the various types of post-transcriptional small RNA-directed pathways in plants, describing their roles and their regulations...
  3. ncbi The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development
    Herve Vaucheret
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, INRA, 78026 Versailles Cedex, France
    Genes Dev 18:1187-97. 2004
    ....
  4. ncbi AGO1 homeostasis entails coexpression of MIR168 and AGO1 and preferential stabilization of miR168 by AGO1
    Herve Vaucheret
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, INRA, 78026 Versailles Cedex, France
    Mol Cell 22:129-36. 2006
    ..We suggest that miR168 stabilization occurs at the level of silencing-complex assembly and that modulating the efficiency of assembling miRNA-programmed silencing complexes will also be important in other contexts...
  5. ncbi AGO1 homeostasis involves differential production of 21-nt and 22-nt miR168 species by MIR168a and MIR168b
    Herve Vaucheret
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, INRA, Versailles, France
    PLoS ONE 4:e6442. 2009
    ..AGO1 homeostasis entails DCL1-dependent production of miR168 from MIR168a and MIR168b transcripts, post-transcriptional stabilization of miR168 by AGO1, and AGO1-catalyzed miR168-guided cleavage of AGO1 mRNA...
  6. ncbi Plant ARGONAUTES
    Herve Vaucheret
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, Institut National de la Recherche Agronomique INRA, 78026 Versailles Cedex, France
    Trends Plant Sci 13:350-8. 2008
    ....
  7. ncbi MicroRNA-dependent trans-acting siRNA production
    Herve Vaucheret
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, INRA 78026 Versailles Cedex, France
    Sci STKE 2005:pe43. 2005
    ..Some of the tasiRNA targets probably regulate the juvenile-to-adult phase transition, but the roles of other tasiRNA targets remain to be determined...
  8. ncbi Arabidopsis HEN1: a genetic link between endogenous miRNA controlling development and siRNA controlling transgene silencing and virus resistance
    Stéphanie Boutet
    Laboratoire de Biologie Cellulaire, INRA, 78026 Versailles Cedex, France
    Curr Biol 13:843-8. 2003
    ....
  9. ncbi Arabidopsis FIERY1, XRN2, and XRN3 are endogenous RNA silencing suppressors
    Isabelle Gy
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, Institut National de la Recherche Agronomique INRA, 78026 Versailles Cedex, France
    Plant Cell 19:3451-61. 2007
    ..We anticipate that screens incorporating partially compromised silencing components will uncover additional PTGS suppressors that may not be revealed using robust silencing systems...
  10. ncbi DRB4-dependent TAS3 trans-acting siRNAs control leaf morphology through AGO7
    Xavier Adenot
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, Institut National de la Recherche Agronomique, 78026 Versailles Cedex, France
    Curr Biol 16:927-32. 2006
    ....
  11. ncbi Redundant and specific roles of the ARGONAUTE proteins AGO1 and ZLL in development and small RNA-directed gene silencing
    Allison C Mallory
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, INRA, Versailles Cedex, France
    PLoS Genet 5:e1000646. 2009
    ....
  12. ncbi A branched pathway for transgene-induced RNA silencing in plants
    Christophe Beclin
    Laboratoire de Biologie Cellulaire, INRA, 78026 Cedex, Versailles, France
    Curr Biol 12:684-8. 2002
    ..Moreover, transgene methylation would result from production or action of dsRNA, since it does not require SGS2/SDE1, SGS3, and AGO1...
  13. ncbi An antagonistic function for Arabidopsis DCL2 in development and a new function for DCL4 in generating viral siRNAs
    Nicolas Bouche
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, INRA, Versailles, France
    EMBO J 25:3347-56. 2006
    ..Given the complexity of the small RNA repertoire in plants, the implication of each DCL, in particular DCL2, in the production of small RNAs that have no known function will constitute one of the next challenges...
  14. ncbi ARGONAUTE 1 homeostasis invokes the coordinate action of the microRNA and siRNA pathways
    Allison C Mallory
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, INRA, Route de Saint Cyr, 78026 Versailles, France
    EMBO Rep 10:521-6. 2009
    ....
  15. ncbi A neomorphic sgs3 allele stabilizing miRNA cleavage products reveals that SGS3 acts as a homodimer
    Taline Elmayan
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, INRA, Versaille, France
    FEBS J 276:835-44. 2009
    ....
  16. ncbi The nuclear dsRNA binding protein HYL1 is required for microRNA accumulation and plant development, but not posttranscriptional transgene silencing
    Franck Vazquez
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, INRA, 78026 Versailles Cedex, France
    Curr Biol 14:346-51. 2004
    ..elegans and Drosophila, respectively...
  17. ncbi Partially redundant functions of Arabidopsis DICER-like enzymes and a role for DCL4 in producing trans-acting siRNAs
    Virginie Gasciolli
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, Institut National de la Recherche Agronomique, 78026 Versailles Cedex, France
    Curr Biol 15:1494-500. 2005
    ....
  18. ncbi Arabidopsis RPA2: a genetic link among transcriptional gene silencing, DNA repair, and DNA replication
    Taline Elmayan
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, Institut National de la Recherche Agronomique, 78026 Versailles Cedex, France
    Curr Biol 15:1919-25. 2005
    ..These results suggest a coordination of the TGS machinery with DNA replication, repair, or recombination machinery at some loci, and they emphasize the diversification of the TGS pathway...
  19. ncbi AGO1 and AGO2 act redundantly in miR408-mediated Plantacyanin regulation
    Nicolas Maunoury
    Institut Jean Pierre Bourgin, INRA, Versailles, France
    PLoS ONE 6:e28729. 2011
    ..In contrast, AGO2 has only been implicated in antibacterial defense in association with miR393*, which has a 5'A. AGO2 also participates in antiviral defense in association with viral siRNAs...
  20. ncbi RDR2 partially antagonizes the production of RDR6-dependent siRNA in sense transgene-mediated PTGS
    Vincent Jauvion
    Institut Jean Pierre Bourgin, INRA, Versailles, France
    PLoS ONE 7:e29785. 2012
    ....
  21. ncbi The miRNA pathway limits AGO1 availability during siRNA-mediated PTGS defense against exogenous RNA
    Angel Emilio Martinez de Alba
    Institut Jean Pierre Bourgin, UMR1318, INRA, 78026 Versailles Cedex, France
    Nucleic Acids Res 39:9339-44. 2011
    ..We suggest that the miRNA pathway imposes an important limitation on PTGS efficiency, which could help protect endogenous mRNAs from being routinely targeted by PTGS...
  22. ncbi MicroRNA maturation and action--the expanding roles of ARGONAUTEs
    Allison C Mallory
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, INRA, 78026 Versailles Cedex, France
    Curr Opin Plant Biol 11:560-6. 2008
    ..Our expanding appreciation of miRNA-directed regulation during plant development and stress adaptations has placed miRNAs at the forefront of plant biology...
  23. ncbi A single transgene locus triggers both transcriptional and post-transcriptional silencing through double-stranded RNA production
    Philippe Mourrain
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, INRA, 78026, Versailles Cedex, France
    Planta 225:365-79. 2007
    ..In contrast, we contribute local and systemic trafficking of silencing signals and sensitivity to viruses to the cytoplasmic steps of PTGS and to amplification steps that require high levels of target mRNAs...
  24. ncbi Fertile hypomorphic ARGONAUTE (ago1) mutants impaired in post-transcriptional gene silencing and virus resistance
    Jean Benoit Morel
    Laboratoire de Biologie Cellulaire, Institut National de la Recherche Agronomique, 78026 Versailles Cedex, France
    Plant Cell 14:629-39. 2002
    ..Finally, we show that hypomorphic ago1 mutants are hypersensitive to virus infection, confirming the hypothesis that in plants PTGS is a mechanism of defense against viruses...
  25. ncbi The conserved RNA trafficking proteins HPR1 and TEX1 are involved in the production of endogenous and exogenous small interfering RNA in Arabidopsis
    Vincent Jauvion
    Institut Jean Pierre Bourgin, Institut National de la Recherche Agronomique, 78026 Versailles Cedex, France
    Plant Cell 22:2697-709. 2010
    ..We propose that both HPR1 and TEX1 participate in the trafficking of siRNA precursors to the ARGONAUTE catalytic center...
  26. ncbi Auxin and light control of adventitious rooting in Arabidopsis require ARGONAUTE1
    Céline Sorin
    Laboratoire de Biologie Cellulaire, Institut National de la Recherche Agronomique, 78026 Versailles Cedex, France
    Plant Cell 17:1343-59. 2005
    ..These results suggest that ARF17 could be a major regulator of adventitious rooting in Arabidopsis...
  27. ncbi Molecular cloning and characterisation of the two homologous genes coding for nitrate reductase in tobacco
    H Vaucheret
    Laboratoire de Biologie Cellulaire, INRA Centre de Versailles, France
    Mol Gen Genet 216:10-5. 1989
    ..The remaining N-terminal part of the protein should thus carry the catalytic site of nitrate reduction by the molybdenum cofactor...
  28. ncbi Mutations in the Arabidopsis H3K4me2/3 demethylase JMJ14 suppress posttranscriptional gene silencing by decreasing transgene transcription
    Ivan Le Masson
    Institut Jean Pierre Bourgin, Unité Mixte de Recherche 1318, Institut National de la Recherche Agronomique INRA, 78000 Versailles, France
    Plant Cell 24:3603-12. 2012
    ..Removing JMJ14 likely allows other H3K4 demethylases encoded by the Arabidopsis thaliana genome to act on transgenes and reduce transcription levels, thus preventing the triggering of S-PTGS...
  29. ncbi Transcriptional gene silencing in plants: targets, inducers and regulators
    H Vaucheret
    Laboratoire de Biologie Cellulaire, INRA, 78026, Versailles Cedex, France
    Trends Genet 17:29-35. 2001
    ..TGS and PTGS, therefore, appear to form two alternative pathways to control incoming, redundant and/or mobile nucleic acids...
  30. ncbi AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals
    M Fagard
    Laboratoire de Biologie Cellulaire, Institut National de la Recherche Agronomique, 78026 Versailles Cedex, France
    Proc Natl Acad Sci U S A 97:11650-4. 2000
    ..These results raise the possibility that PTGS, or at least some of its elements, could participate in the regulation of gene expression during development in plants...
  31. ncbi Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance
    P Mourrain
    Laboratoire de Biologie Cellulaire, Institut National de la Recherche Agronomique, Versailles, France
    Cell 101:533-42. 2000
    ..Both sgs2 and sgs3 mutants show enhanced susceptibility to virus, definitively proving that PTGS is an antiviral defense mechanism that can also target transgene RNA for degradation...
  32. ncbi Infection of tobacco or Arabidopsis plants by CMV counteracts systemic post-transcriptional silencing of nonviral (trans)genes
    C Beclin
    Laboratoire de Biologie Cellulaire, INRA Versailles, Versailles Cedex, 78026, France
    Virology 252:313-7. 1998
    ....
  33. ncbi Flank matrix attachment regions (MARs) from chicken, bean, yeast or tobacco do not prevent homology-dependent trans-silencing in transgenic tobacco plants
    H Vaucheret
    Laboratoire de Biologie Cellulaire, INRA, Versailles, France
    Mol Gen Genet 259:388-92. 1998
    ..These results therefore demonstrate that MARs are not able to protect transgene expression from strong silencing loci that act in trans...
  34. ncbi The origin and effect of small RNA signaling in plants
    Jean Sébastien Parent
    Institut Jean Pierre Bourgin, UMR1318, INRA Versailles, France
    Front Plant Sci 3:179. 2012
    ..We also review the various genetic requirements needed for production, movement and perception of the silencing signal...
  35. ncbi Form, function, and regulation of ARGONAUTE proteins
    Allison Mallory
    Institut Jean Pierre Bourgin, Unité Mixte de Recherche 1318, Institut National de la Recherche Agronomique, 78026 Versailles Cedex, France
    Plant Cell 22:3879-89. 2010
    ..In this review, we present general features of plant and animal AGO proteins and detail our knowledge on the 10 Arabidopsis thaliana AGOs...