Jean Pierre Vartanian

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc Genetic editing of HBV DNA by monodomain human APOBEC3 cytidine deaminases and the recombinant nature of APOBEC3G
    Michel Henry
    Molecular Retrovirology Unit, CNRS URA 3015, Institut Pasteur, Paris, France
    PLoS ONE 4:e4277. 2009
  2. pmc Evolution of the primate APOBEC3A cytidine deaminase gene and identification of related coding regions
    Michel Henry
    Molecular Retrovirology Unit, Institut Pasteur, Paris, France
    PLoS ONE 7:e30036. 2012
  3. pmc Lethal mutagenesis of foot-and-mouth disease virus involves shifts in sequence space
    Celia Perales
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Consejo Superior de Investigaciones Cientificas, Campus de Cantoblanco, 28049 Madrid, Spain
    J Virol 85:12227-40. 2011
  4. pmc Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis
    Jean Pierre Vartanian
    Molecular Retrovirology Unit, Institut Pasteur, Paris, France
    PLoS Pathog 6:e1000928. 2010
  5. ncbi request reprint Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases
    Renaud Mahieux
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Gen Virol 86:2489-94. 2005
  6. pmc Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A
    Marie Ming Aynaud
    Molecular Retrovirology Unit, CNRS URA3015, Institut Pasteur, 28 rue du Dr Roux, F 75724 Paris Cedex 15, France
    J Biol Chem 287:39182-92. 2012
  7. pmc Double-stranded RNA adenosine deaminase ADAR-1-induced hypermutated genomes among inactivated seasonal influenza and live attenuated measles virus vaccines
    Rodolphe Suspène
    Molecular Retrovirology Unit, Institut Pasteur, Paris Cedex 15, France
    J Virol 85:2458-62. 2011
  8. pmc Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo
    Rodolphe Suspène
    Molecular Retrovirology Unit, Institut Pasteur, CNRS URA 3015, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Virol 85:7594-602. 2011
  9. ncbi request reprint Recovery of APOBEC3-edited human immunodeficiency virus G->A hypermutants by differential DNA denaturation PCR
    Rodolphe Suspène
    Unite de Retrovirologie Moleculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Gen Virol 86:125-9. 2005
  10. pmc Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism
    Rodolphe Suspène
    Institut Pasteur, Molecular Retrovirology Unit, Centre National de la Recherche Scientifique URA3015, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 108:4858-63. 2011

Collaborators

Detail Information

Publications31

  1. pmc Genetic editing of HBV DNA by monodomain human APOBEC3 cytidine deaminases and the recombinant nature of APOBEC3G
    Michel Henry
    Molecular Retrovirology Unit, CNRS URA 3015, Institut Pasteur, Paris, France
    PLoS ONE 4:e4277. 2009
    ..A phylogenic analysis of A3 exons revealed that A3G is in fact a chimera with the first two exons being derived from the A3F gene. This might allow co-expression of the two genes that are able to restrict HIV-1Deltavif efficiently...
  2. pmc Evolution of the primate APOBEC3A cytidine deaminase gene and identification of related coding regions
    Michel Henry
    Molecular Retrovirology Unit, Institut Pasteur, Paris, France
    PLoS ONE 7:e30036. 2012
    ..This qualitative and quantitative variation among primate A3A genes suggest that subtle differences in function might ensue as more light is shed on this increasingly important enzyme...
  3. pmc Lethal mutagenesis of foot-and-mouth disease virus involves shifts in sequence space
    Celia Perales
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Consejo Superior de Investigaciones Cientificas, Campus de Cantoblanco, 28049 Madrid, Spain
    J Virol 85:12227-40. 2011
    ..Thus, even nonmutagenized FMDV quasispecies include a deep, mutationally biased portion of sequence space, in support of the view that the virus replicates close to the error threshold for maintenance of genetic information...
  4. pmc Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis
    Jean Pierre Vartanian
    Molecular Retrovirology Unit, Institut Pasteur, Paris, France
    PLoS Pathog 6:e1000928. 2010
    ..Although the mutant spectrum resulting from A3 editing is highly deleterious, a very small part, notably the lightly edited genomes, might help the virus evolve and even escape immune responses...
  5. ncbi request reprint Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases
    Renaud Mahieux
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Gen Virol 86:2489-94. 2005
    ..Thus, although HTLV-1 DNA can indeed be edited by at least four APOBEC3 cytidine deaminases in vitro, they are conspicuously absent in vivo...
  6. pmc Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A
    Marie Ming Aynaud
    Molecular Retrovirology Unit, CNRS URA3015, Institut Pasteur, 28 rue du Dr Roux, F 75724 Paris Cedex 15, France
    J Biol Chem 287:39182-92. 2012
    ..TRIB3 has been linked to cancer and via its own interactors and links the A3A DNA mutators to the Rb-BRCA1-ATM network. TRIB3 emerges as an important guardian of genome integrity...
  7. pmc Double-stranded RNA adenosine deaminase ADAR-1-induced hypermutated genomes among inactivated seasonal influenza and live attenuated measles virus vaccines
    Rodolphe Suspène
    Molecular Retrovirology Unit, Institut Pasteur, Paris Cedex 15, France
    J Virol 85:2458-62. 2011
    ..The hyperedited mutant frequency, including genomes and antigenomes, was a log greater for influenza virus compared to measles virus, suggesting a greater sensitivity to restriction by ADAR-1...
  8. pmc Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo
    Rodolphe Suspène
    Molecular Retrovirology Unit, Institut Pasteur, CNRS URA 3015, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Virol 85:7594-602. 2011
    ..That the A3C gene is not induced by type I interferons begs the question whether some herpesviruses encode A3C antagonists...
  9. ncbi request reprint Recovery of APOBEC3-edited human immunodeficiency virus G->A hypermutants by differential DNA denaturation PCR
    Rodolphe Suspène
    Unite de Retrovirologie Moleculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Gen Virol 86:125-9. 2005
    ....
  10. pmc Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism
    Rodolphe Suspène
    Institut Pasteur, Molecular Retrovirology Unit, Centre National de la Recherche Scientifique URA3015, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 108:4858-63. 2011
    ..Nonetheless, hyper- and lightly mutated sequences went hand in hand, raising the hypothesis that recurrent low-level mutation by APOBEC3A could catalyze the transition from a healthy to a cancer genome...
  11. ncbi request reprint Death and the retrovirus
    Jean Pierre Vartanian
    Unite de Retrovirologie Moleculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Cedex 15, Paris, France
    Trends Mol Med 9:409-13. 2003
    ..This death mechanism is circumvented by the HIV viral infectivity factor protein, which prevents APOBEC3G from entering the virion...
  12. pmc Efficient deamination of 5-methylcytidine and 5-substituted cytidine residues in DNA by human APOBEC3A cytidine deaminase
    Rodolphe Suspène
    Molecular Retrovirology Unit, Institut Pasteur, Paris, France
    PLoS ONE 8:e63461. 2013
    ..As 5MeCpG deamination hotspots characterize many genes associated with cancer it is plausible that A3A is a major player in the onset of cancer. ..
  13. pmc APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase
    Rodolphe Suspène
    Unite de Retrovirologie Moleculaire, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Nucleic Acids Res 32:2421-9. 2004
    ..APOBEC3G deamination of dC or dCTP was not detected. In short, APOBEC3G is a single-stranded DNA cytidine deaminase capable of restricting retroviral replication...
  14. pmc Restriction of foamy viruses by APOBEC cytidine deaminases
    Frédéric Delebecque
    Virus and Immunity Group, URA CNRS 1930, Institut Pasteur, 75724 Paris Cedex 15, France
    J Virol 80:605-14. 2006
    ..In infected hosts, the persistence strategy employed by FV might be based on low levels of replication, as well as avoidance of cells expressing large amounts of active cytidine deaminases...
  15. doi request reprint APOBEC1 and APOBEC3 cytidine deaminases as restriction factors for hepadnaviral genomes in non-humans in vivo
    Myrtille Renard
    Molecular Retrovirology Unit, Institut Pasteur, CNRS URA 3015, 28 rue de Dr Roux, 75724 Paris Cedex 15, France
    J Mol Biol 400:323-34. 2010
    ..There seems to be more genetic editing in liver or cell-associated genomes than serum or culture supernatants, suggesting that too much editing of virion cDNA might impede completion of DNA synthesis...
  16. doi request reprint Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions
    Jean Pierre Vartanian
    Molecular Retrovirology Unit, Institut Pasteur, 28 Rue de Docteur Roux, 75724 Paris Cedex 15, France
    Science 320:230-3. 2008
    ..Thus, stochastic or transient overexpression of APOBEC3 genes may expose the genome to a broad spectrum of mutations that could influence the development of tumors...
  17. pmc Human APOBEC1 cytidine deaminase edits HBV DNA
    Minerva Cervantes Gonzalez
    Molecular Retrovirology Unit, Virology Department, Institut Pasteur, 28 rue du Dr Roux 75724 Paris Cedex 15, France
    Retrovirology 6:96. 2009
    ..Analysis of sequences derived from the serum of two chronic carriers, indicated that hA1 explained only a small fraction of edited HBV genomes. By contrast, several human APOBEC3 deaminases were active including hA3G...
  18. pmc Inversing the natural hydrogen bonding rule to selectively amplify GC-rich ADAR-edited RNAs
    Rodolphe Suspène
    Unite de Retrovirologie Moleculaire, CNRS URA 3015, Unité de Génétique Moléculaire des Bunyaviridés and Laboratoire de Génomique Virale et Vaccination, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15
    Nucleic Acids Res 36:e72. 2008
    ..The editing of Alu elements in cellular mRNAs was strongly enhanced by type I interferon induction indicating a novel link mRNA metabolism and innate immunity...
  19. pmc Twin gradients in APOBEC3 edited HIV-1 DNA reflect the dynamics of lentiviral replication
    Rodolphe Suspène
    Unite de Retrovirologie Moleculaire, CNRS URA1930, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nucleic Acids Res 34:4677-84. 2006
    ..The degree of hypermutation varied smoothly among genomes indicating that the number of APOBEC3 molecules packaged varied considerably...
  20. pmc Identification of a hepatitis B virus genome in wild chimpanzees (Pan troglodytes schweinfurthi) from East Africa indicates a wide geographical dispersion among equatorial African primates
    Jean Pierre Vartanian
    Unite de Retrovirologie Moleculaire, Institut Pasteur, Paris, France
    J Virol 76:11155-8. 2002
    ..An entire hepatitis B virus (HBV) genome was amplified and sequenced from samples taken from one animal. This indicates that HBV is distributed across the entire range of chimpanzee habitats...
  21. ncbi request reprint Sustained G-->A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome
    Jean Pierre Vartanian
    Unite de Retrovirologie Moleculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Gen Virol 83:801-5. 2002
    ..This indicates that the intracellular [dTTP]/[dCTP] bias conducive to G-->A hypermutation may be sustained throughout the synthesis of minus-strand DNA. In turn, this suggests the possibility of mutation of host sequences...
  22. doi request reprint Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo
    Vincent Petit
    Unite de Retrovirologie Moleculaire, CNRS URA, Institut Pasteur, Paris, France
    J Mol Biol 385:65-78. 2009
    ..In short, murine APOBEC1 is a hypermutator of both RNA and ssDNA in vivo, which could exert occasional side effects upon overexpression...
  23. ncbi request reprint Anti-termination by SIV Tat requires flexibility of the nascent TAR structure
    Peter Sommer
    Unite de Retrovirologie Moleculaire, Pasteur Institute, 28 rue du Dr Roux, 75724 Paris, France
    J Mol Biol 344:11-28. 2004
    ..These results show that HIV/SIV replication requires only a minimal set of cis-acting elements in the promoter and suggest a hitherto unrecognised requirement of flexibility for the nascent TAR structure to allow anti-termination by Tat...
  24. ncbi request reprint A universal primer set for PCR amplification of nuclear histone H4 genes from all animal species
    Pascal Pineau
    Unité d Organisation Nucléaire et Oncogénèse, INSERM U579, Institut Pasteur, Paris, France
    Mol Biol Evol 22:582-8. 2005
    ..The data indicate that the HIST2H4 amplimers are, thus, suitable for both DNA quality testing as well as species identification in the animal kingdom...
  25. pmc Analysis of a library of macaque nuclear mitochondrial sequences confirms macaque origin of divergent sequences from old oral polio vaccine samples
    Jean Pierre Vartanian
    Unite de Retrovirologie Moleculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 99:7566-9. 2002
    ..In the case of divergent mtDNA sequences from old oral polio vaccine samples [Blancou, P., et al. (2001) Nature (London) 410, 1045-1046], all were closely related to numts in the Chinese macaque library...
  26. doi request reprint Hyperediting of human T-cell leukemia virus type 2 and simian T-cell leukemia virus type 3 by the dsRNA adenosine deaminase ADAR-1
    Nga Ling Ko
    Epidemiology and Physiopathology of Oncogenic Viruses, Institut Pasteur, CNRS URA 3015, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Gen Virol 93:2646-51. 2012
    ..In conclusion, the present observations demonstrate that ADAR-1 massively edits HTLV-2 and STLV-3 retroviruses in vitro, but probably remains a rare phenomenon in vivo...
  27. pmc Induction of mutations in Drosophila melanogaster gypsy retroelements by modulation of intracellular deoxynucleoside triphosphate pools in vivo
    Christophe Terzian
    Unite de Retrovirologie Moleculaire, CNRS URA 3015, Institut Pasteur, 28 rue du Dr Roux, F 75724 Paris Cedex 15, France
    J Virol 81:4900-3. 2007
    ..Due to the lack of proofreading, these gypsy elements represent hypervariable loci within the Drosophila genome, suggesting that dNTP pool imbalances in vivo are mutagenic...
  28. ncbi request reprint Network analysis of human and simian immunodeficiency virus sequence sets reveals massive recombination resulting in shorter pathways
    Simon Wain-Hobson
    Unite de Retrovirologie Moleculaire, Institut Pasteur, F 75724 Paris Cedex 15, France
    J Gen Virol 84:885-95. 2003
    ..Hence, lineages are younger than anticipated previously, although not in proportion to the ratio of the intrinsic recombination/point mutation rate. Recombination also inflates codon polymorphisms...
  29. pmc Human APOBEC3A isoforms translocate to the nucleus and induce DNA double strand breaks leading to cell stress and death
    Bianka Mussil
    Molecular Retrovirology Unit, Institut Pasteur, Paris, France
    PLoS ONE 8:e73641. 2013
    ..As chronic inflammation underlies many diseases including numerous cancers, it is possible that APOBEC3A induction may generate many of the lesions typical of a cancer genome. ..
  30. pmc Powerful mutators lurking in the genome
    Vincent Petit
    Molecular Retrovirology Unit, CNRS URA 3015, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Philos Trans R Soc Lond B Biol Sci 364:705-15. 2009
    ..For the APOBEC3 genes, not only is their physiological function unknown, but also their role in the induction of cancer remains to be determined. Yet given the pace of research, all this is certain to change in the next few years...
  31. doi request reprint Orthologous mammalian APOBEC3A cytidine deaminases hypermutate nuclear DNA
    Vincent Caval
    Molecular Retrovirology Unit, Institut Pasteur, Paris, France
    Mol Biol Evol 31:330-40. 2014
    ..Hence, their singular role in DNA catabolism is a well-established mechanism probably outweighing any deleterious or pathological roles such as genomic instability and cancer formation. ..