D Tulasne

Summary

Affiliation: Institut de Biologie de Lille
Country: France

Publications

  1. pmc Caspase-generated fragment of the Met receptor favors apoptosis via the intrinsic pathway independently of its tyrosine kinase activity
    J Lefebvre
    CNRS UMR 8161, Institut de Biologie de Lille Institut Pasteur de Lille IFR 142 Université de Lille 1 Université de Lille 2, Lille, France
    Cell Death Dis 4:e871. 2013
  2. doi request reprint Met degradation: more than one stone to shoot a receptor down
    Jonathan Lefebvre
    CNRS UMR 8161, Institut de Biologie de Lille, Institut Pasteur de Lille, B P 447, 59021 Lille, France
    FASEB J 26:1387-99. 2012
  3. ncbi request reprint The shadow of death on the MET tyrosine kinase receptor
    D Tulasne
    CNRS UMR 8161, Institut de Biologie de Lille Institut Pasteur de Lille Université de Lille 1 Université de Lille 2, IFR142, B P 447, 59021 Lille Cedex, France
    Cell Death Differ 15:427-34. 2008
  4. pmc Proapoptotic function of the MET tyrosine kinase receptor through caspase cleavage
    David Tulasne
    CNRS UMR 8117, Institut de Biologie de Lille, Institut Pasteur de Lille, B P 447, 59021 Lille, France
    Mol Cell Biol 24:10328-39. 2004
  5. ncbi request reprint Amplification of apoptosis through sequential caspase cleavage of the MET tyrosine kinase receptor
    B Foveau
    1CNRS UMR 8161, Institut de Biologie de Lille, CNRS Institut Pasteur de Lille Université de Lille 1 Université de Lille 2, Lille Cedex, France
    Cell Death Differ 14:752-64. 2007
  6. ncbi request reprint The ETS1 transcription factor is expressed during epithelial-mesenchymal transitions in the chick embryo and is activated in scatter factor-stimulated MDCK epithelial cells
    V Fafeur
    Centre National de la Recherche Scientifique, Institut Pasteur de Lille, France
    Cell Growth Differ 8:655-65. 1997
  7. pmc Down-regulation of the met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis
    Bénédicte Foveau
    CNRS UMR 8161, Institut de Biologie de Lille Institut Pasteur de Lille Université de Lille 1 Université de Lille 2, 59021 Lille Cedex, France
    Mol Biol Cell 20:2495-507. 2009
  8. pmc The multisubstrate docking site of the MET receptor is dispensable for MET-mediated RAS signaling and cell scattering
    D Tulasne
    Centre National de la Recherche Scientifique EP 560, Institut de Biologie de Lille, Institut Pasteur de Lille, 59021 Lille, France
    Mol Biol Cell 10:551-65. 1999
  9. ncbi request reprint Regulation of the Ets-1 transcription factor by sumoylation and ubiquitinylation
    Z Ji
    UMR 8161, Institut de Biologie de Lille, CNRS, Institut Pasteur de Lille, Universite de Lille 1, Universite de Lille 2, Lille Cedex, France
    Oncogene 26:395-406. 2007
  10. doi request reprint Phosphorylation of the MET receptor on juxtamembrane tyrosine residue 1001 inhibits its caspase-dependent cleavage
    Julien Deheuninck
    CNRS UMR 8161, Institut de Biologie de Lille, Universite Lille Nord de France, Institut Pasteur de Lille, IFR142, Lille, France
    Cell Signal 21:1455-63. 2009

Collaborators

  • V Fafeur
  • Sylvie Reveneau
  • Flavio Maina
  • A Richard
  • J L Baert
  • D Stehelin
  • Silvia Giordano
  • P Mehlen
  • Katsue Suzuki-Inoue
  • Yutao Yan
  • Teresa Bori-Sanz
  • C Brenner
  • O Inoue
  • R K Andrews
  • Catherine Leroy
  • Bénédicte Foveau
  • Julien Deheuninck
  • Frédéric Ancot
  • C Leroy
  • Zongling Ji
  • Z Ji
  • B Foveau
  • J Lefebvre
  • Jonathan Lefebvre
  • Souhaila Choul-Li
  • Gautier Goormachtigh
  • J Deheuninck
  • Jerome Vicogne
  • Oscar Berlanga
  • Rejane Paumelle
  • G Ichim
  • S Tauszig-Delamasure
  • A Chotteau-Lelievre
  • Z Kherrouche
  • R Montagne
  • G Muharram
  • Arnaud Lemiere
  • Ghaffar Muharram
  • Clélia Laitem
  • Gabriel Leprivier
  • Marc Aumercier
  • Annalisa Petrelli
  • Karina Reiss
  • Valérie Vingtdeux
  • Vincent Villeret
  • C Degerny
  • N Vintonenko
  • J Coll
  • F Ancot
  • Jean Pierre Kerckaert
  • Céline Villenet
  • Sabine Quief
  • Colette Dissous
  • Jean Pierre Vilain
  • Jacques Trolet
  • Dominique Legrand
  • Edith Browaeys
  • Katia Cailliau
  • Stephanie Jung
  • Jonathan Frampton
  • Bernard Vandenbunder
  • Yoshiki Miura
  • Teresa Bori
  • David Tulashe
  • Steve P Watson
  • Serge Plaza
  • Daniel C Snell
  • Zoulika Kherrouche
  • Masaaki Moroi

Detail Information

Publications20

  1. pmc Caspase-generated fragment of the Met receptor favors apoptosis via the intrinsic pathway independently of its tyrosine kinase activity
    J Lefebvre
    CNRS UMR 8161, Institut de Biologie de Lille Institut Pasteur de Lille IFR 142 Université de Lille 1 Université de Lille 2, Lille, France
    Cell Death Dis 4:e871. 2013
    ....
  2. doi request reprint Met degradation: more than one stone to shoot a receptor down
    Jonathan Lefebvre
    CNRS UMR 8161, Institut de Biologie de Lille, Institut Pasteur de Lille, B P 447, 59021 Lille, France
    FASEB J 26:1387-99. 2012
    ..Conversely, forced degradation of Met through reinduction of one or more degradation pathways is a promising therapeutic strategy...
  3. ncbi request reprint The shadow of death on the MET tyrosine kinase receptor
    D Tulasne
    CNRS UMR 8161, Institut de Biologie de Lille Institut Pasteur de Lille Université de Lille 1 Université de Lille 2, IFR142, B P 447, 59021 Lille Cedex, France
    Cell Death Differ 15:427-34. 2008
    ....
  4. pmc Proapoptotic function of the MET tyrosine kinase receptor through caspase cleavage
    David Tulasne
    CNRS UMR 8117, Institut de Biologie de Lille, Institut Pasteur de Lille, B P 447, 59021 Lille, France
    Mol Cell Biol 24:10328-39. 2004
    ..Finally, HGF/SF treatment does not favor MET cleavage and apoptosis, confirming the known survival role of ligand-activated MET. Our results show that stress stimuli convert the MET survival receptor into a proapoptotic factor...
  5. ncbi request reprint Amplification of apoptosis through sequential caspase cleavage of the MET tyrosine kinase receptor
    B Foveau
    1CNRS UMR 8161, Institut de Biologie de Lille, CNRS Institut Pasteur de Lille Université de Lille 1 Université de Lille 2, Lille Cedex, France
    Cell Death Differ 14:752-64. 2007
    ..These results revealed a two-step caspase cleavage of MET resulting in the reshaping of this survival receptor to a proapoptotic factor...
  6. ncbi request reprint The ETS1 transcription factor is expressed during epithelial-mesenchymal transitions in the chick embryo and is activated in scatter factor-stimulated MDCK epithelial cells
    V Fafeur
    Centre National de la Recherche Scientifique, Institut Pasteur de Lille, France
    Cell Growth Differ 8:655-65. 1997
    ..Taken together, these data identify ETS1 as a molecular actor of epithelia cell dissociation...
  7. pmc Down-regulation of the met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis
    Bénédicte Foveau
    CNRS UMR 8161, Institut de Biologie de Lille Institut Pasteur de Lille Université de Lille 1 Université de Lille 2, 59021 Lille Cedex, France
    Mol Biol Cell 20:2495-507. 2009
    ..This demonstrates the original involvement of a proteolytic process in degradation of the Met receptor implicated in negative regulation of invasive growth...
  8. pmc The multisubstrate docking site of the MET receptor is dispensable for MET-mediated RAS signaling and cell scattering
    D Tulasne
    Centre National de la Recherche Scientifique EP 560, Institut de Biologie de Lille, Institut Pasteur de Lille, 59021 Lille, France
    Mol Biol Cell 10:551-65. 1999
    ..We propose that signal transduction by autophosphorylation of the C-terminal tyrosine residues is not the sole mechanism by which the activated MET receptor can transmit RAS signaling and cell scattering...
  9. ncbi request reprint Regulation of the Ets-1 transcription factor by sumoylation and ubiquitinylation
    Z Ji
    UMR 8161, Institut de Biologie de Lille, CNRS, Institut Pasteur de Lille, Universite de Lille 1, Universite de Lille 2, Lille Cedex, France
    Oncogene 26:395-406. 2007
    ..These data show that Ets-1 can be modified by sumoylation and/or ubiquitinylation, with sumoylation repressing transcriptional activity of Ets-1 and having no clear antagonistic action on the ubiquitin-proteasome degradation pathway...
  10. doi request reprint Phosphorylation of the MET receptor on juxtamembrane tyrosine residue 1001 inhibits its caspase-dependent cleavage
    Julien Deheuninck
    CNRS UMR 8161, Institut de Biologie de Lille, Universite Lille Nord de France, Institut Pasteur de Lille, IFR142, Lille, France
    Cell Signal 21:1455-63. 2009
    ..These data demonstrate a direct protection mechanism of an activated phosphorylated MET receptor, against its caspase-dependent cleavage...
  11. doi request reprint Caspase cleavage of the MET receptor generates an HGF interfering fragment
    Julien Deheuninck
    UMR 8161, Institut de Biologie de Lille, CNRS, Universite de Lille 1, Universite de Lille 2, Institut Pasteur de Lille, BP 447, F 59021 Lille cedex, France
    Biochem Biophys Res Commun 367:573-7. 2008
    ..This fragment is able to bind HGF/SF and to prevent HGF-dependent signaling downstream of full MET, demonstrating its function as a decoy receptor...
  12. pmc Caspase cleavage of viral proteins, another way for viruses to make the best of apoptosis
    A Richard
    Centre National de la Recherche Scientifique CNRS, Unité mixte de recherche UMR 8161, Institut de Biologie de Lille, Institut Pasteur de Lille, Universite Lille Nord de France, Institut fédératif de recherche IFR 142, Lille, France
    Cell Death Dis 3:e277. 2012
    ..The present review aims at discussing the characterization and relevance of this post-translational modification that adds a new complexity in the already intricate host-apoptosis-virus triangle...
  13. doi request reprint Caspase cleavage of Ets-1 p51 generates fragments with transcriptional dominant-negative function
    Souhaila Choul-Li
    CNRS UMR 8161, Institut de Biologie de Lille, Institut Pasteur de Lille, Universite Lille Nord de France, IFR 142, B P 447, 1 rue Calmette, 59021 Lille Cedex, France
    Biochem J 426:229-41. 2010
    ..Furthermore, our results establish that caspase cleavage generates a stable C-terminal fragment that acts as a natural dominant-negative form of the full-length Ets-1 p51 protein...
  14. ncbi request reprint Conservation of epidermal growth factor receptor function in the human parasitic helminth Schistosoma mansoni
    Jerome Vicogne
    Unité 547 INSERM, Institut Pasteur de Lille, 59019 Lille Cedex, France
    J Biol Chem 279:37407-14. 2004
    ..The possible role of SER as a receptor for host EGF peptides and its implication in host-parasite signaling and parasite development are discussed...
  15. ncbi request reprint Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway
    Rejane Paumelle
    CNRS FRE 2353, Institut de Biologie de Lille, Institut Pasteur de Lille, B P 447, 59021 Lille, France
    Oncogene 21:2309-19. 2002
    ..These data demonstrated that ETS1 is a downstream target of HGF/SF acting through a RAS-RAF-MEK-ERK pathway and provides a signaling pathway leading to the regulation of gene expression by HGF/SF...
  16. ncbi request reprint HGF/SF regulates expression of apoptotic genes in MCF-10A human mammary epithelial cells
    Catherine Leroy
    CNRS UMR 8161 Institut de Biologie de Lille, Institut Pasteur de Lille, B P 447, 59021 Lille Cedex, France
    Ann N Y Acad Sci 1090:188-202. 2006
    ..This study identified novel apoptotic genes regulated by HGF/SF, which can contribute to its survival effect...
  17. ncbi request reprint Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling
    Katsue Suzuki-Inoue
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom
    J Biol Chem 277:21561-6. 2002
    ..These findings demonstrate that the proline-rich domain of GPVI mediates the association with Fyn/Lyn via their SH3 domain and that this interaction initiates activation signals through GPVI...
  18. ncbi request reprint Delineation of the region in the glycoprotein VI tail required for association with the Fc receptor gamma-chain
    Teresa Bori-Sanz
    Division of Medical Sciences, The Medical School Edgbaston, Birmingham B15 2TT, United Kingdom
    J Biol Chem 278:35914-22. 2003
    ..Analysis of selective deletions in the GPVI tail supported this conclusion. In addition, we show that the proline-rich domain is required for optimal Ca2+ release, whereas it is dispensable for FcR gamma-chain association...
  19. ncbi request reprint Molecular cloning and characterisation of SmSLK, a novel Ste20-like kinase in Schistosoma mansoni
    Yutao Yan
    INSERM, U 547, Lille, France
    Int J Parasitol 37:1539-50. 2007
    ..Therefore, these results indicate that SmSLK is a new member of the GCK protein family that could participate in the regulation of MAPK cascade activation during host-parasite interactions...
  20. ncbi request reprint The Fc receptor gamma-chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C-type lectin, convulxin
    Oscar Berlanga
    Department of Pharmacology, University of Oxford, UK
    Eur J Biochem 269:2951-60. 2002
    ..These results demonstrate that reconstitution of the GPVI-FcR gamma-chain complex in cells expressing the necessary signalling network is sufficient to initiate signalling events in response to convulxin and collagen-related peptide...