Gordon C Tucker

Summary

Affiliation: Institut de Recherches Servier
Country: France

Publications

  1. pmc Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells
    Bérengère Marty
    Département de Transfert, Institut Curie, 26 Rue d Ulm, 75005 Paris, France
    Breast Cancer Res 10:R101. 2008
  2. ncbi request reprint Integrins: molecular targets in cancer therapy
    Gordon C Tucker
    Institut de Recherches Servier, Cancer Drug Discovery, 125 Chemin de Ronde, 78290 Croissy sur Seine, France
    Curr Oncol Rep 8:96-103. 2006
  3. ncbi request reprint Inhibitors of integrins
    Gordon C Tucker
    Institut de Recherches Servier, 11 rue des Moulineaux, 92150, Suresnes, France
    Curr Opin Pharmacol 2:394-402. 2002
  4. ncbi request reprint Alpha v integrin inhibitors and cancer therapy
    Gordon C Tucker
    Institut de Recherches Servier, Cancer Research Division, 125 Chemin de Ronde, 78290 Croissy sur Seine, France
    Curr Opin Investig Drugs 4:722-31. 2003
  5. ncbi request reprint Synthesis of N,N'-disubstituted 3-aminobenzo[c] and [d]azepin-2-ones as potent and specific farnesyl transferase inhibitors
    Thierry Le Diguarher
    Department of Medicinal Chemistry, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, France
    Bioorg Med Chem Lett 14:767-71. 2004
  6. ncbi request reprint Stereospecific synthesis of 5-substituted 2-bisarylthiocyclopentane carboxylic acids as specific matrix metalloproteinase inhibitors
    Thierry Le Diguarher
    Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, France, and Technologie Servier, 25 27 rue E Vignat, 45007 Orléans, France
    J Med Chem 46:3840-52. 2003
  7. ncbi request reprint Decrease in survival threshold of quiescent colon carcinoma cells in the presence of a small molecule integrin antagonist
    Mike F Burbridge
    Cancer Research Division, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Mol Pharmacol 63:1281-8. 2003
  8. ncbi request reprint Parallel liquid synthesis of N,N'-Disubstituted 3-amino azepin-2-ones as potent and specific farnesyl transferase inhibitors
    Thierry Le Diguarher
    Department of Medicinal Chemistry, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, France
    Bioorg Med Chem 11:3193-204. 2003
  9. doi request reprint S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool
    Gilles Ferry
    Pharmacologie Moléculaire et Cellulaire, Institut de Recherches Servier, Croissy sur Seine, France
    J Pharmacol Exp Ther 327:809-19. 2008
  10. ncbi request reprint Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists
    Francoise Perron-Sierra
    Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, France
    Bioorg Med Chem Lett 12:3291-6. 2002

Collaborators

  • John A Hickman
  • Jean Sébastien Saulnier-Blache
  • M F Burbridge
  • Pascal Fender
  • Thierry Le Diguarher
  • Marc Bertrand
  • Patrick J Casara
  • Francoise Perron-Sierra
  • Nicolas Guilbaud
  • Alain Pierre
  • Gilles Ferry
  • Bérengère Marty
  • Sylvie Maubant
  • Alex Cordi
  • Annie Genton
  • Stephane Biltresse
  • Jean Claude Ortuno
  • Jean Luc Fauchère
  • Eric Raimbaud
  • David Shanks
  • Patrick Casara
  • Eleonore Gravier
  • Jean A Boutin
  • Emmanuel Barillot
  • Philippe Hupe
  • Thierry Dubois
  • Pierre Gestraud
  • Marc Henri Stern
  • Jean Paul Thiery
  • Ingrid Lebigot
  • Jean Philippe Pradere
  • Michel Lonchampt
  • Monique Beucher-Gaudin
  • Audrey Tourdès
  • Adeline Giganti
  • Fathia Djelti
  • Natacha Moulharat
  • Anne Vincent-Salomon
  • Anne Try
  • Virginie Maire
  • Marion Kappler
  • Guillem Rigaill
  • Francisco Cruzalegui
  • Patrice Desos
  • Morgane Boutillon
  • Ellen Van Obberghen-Schilling
  • Dominique Saint-Dizier
  • Georges Dive
  • Mireille Attolini
  • Jacqueline Marchand-Brynaert
  • Philippe Hennig
  • Massimo Sabatini
  • Gilbert Dorey
  • Anne Marie Chollet
  • Dominique Saint Dizier

Detail Information

Publications13

  1. pmc Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells
    Bérengère Marty
    Département de Transfert, Institut Curie, 26 Rue d Ulm, 75005 Paris, France
    Breast Cancer Res 10:R101. 2008
    ..In contrast to HER2+ carcinomas, no targeted therapy is currently available for the treatment of patients with BLCs. In order to discover potential therapeutic targets, we aimed to discover deregulated signalling pathways in human BLCs...
  2. ncbi request reprint Integrins: molecular targets in cancer therapy
    Gordon C Tucker
    Institut de Recherches Servier, Cancer Drug Discovery, 125 Chemin de Ronde, 78290 Croissy sur Seine, France
    Curr Oncol Rep 8:96-103. 2006
    ..Possible reasons for this are discussed in this review. The parallel development of integrin antagonists as imaging tools for patient selection may accelerate the discovery of new avenues for their use...
  3. ncbi request reprint Inhibitors of integrins
    Gordon C Tucker
    Institut de Recherches Servier, 11 rue des Moulineaux, 92150, Suresnes, France
    Curr Opin Pharmacol 2:394-402. 2002
    ..Accumulating data on the role of integrins and the mechanism of action of pharmacological antagonists will help to develop and apply an efficient anti-integrin therapy in cancer...
  4. ncbi request reprint Alpha v integrin inhibitors and cancer therapy
    Gordon C Tucker
    Institut de Recherches Servier, Cancer Research Division, 125 Chemin de Ronde, 78290 Croissy sur Seine, France
    Curr Opin Investig Drugs 4:722-31. 2003
    ....
  5. ncbi request reprint Synthesis of N,N'-disubstituted 3-aminobenzo[c] and [d]azepin-2-ones as potent and specific farnesyl transferase inhibitors
    Thierry Le Diguarher
    Department of Medicinal Chemistry, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, France
    Bioorg Med Chem Lett 14:767-71. 2004
    ..A structure-activity study was performed by synthesis on N,N'-disubstitution of 3-aminobenzo[c] and [d]azepin-2-one 2 and 3 to afford potent and specific farnesyl transferase inhibitors with low nM enzymatic and cellular activities...
  6. ncbi request reprint Stereospecific synthesis of 5-substituted 2-bisarylthiocyclopentane carboxylic acids as specific matrix metalloproteinase inhibitors
    Thierry Le Diguarher
    Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, France, and Technologie Servier, 25 27 rue E Vignat, 45007 Orléans, France
    J Med Chem 46:3840-52. 2003
    ..Compounds 2a and 2e are active in the mouse B16-F10 metastasis model and display very good pharmacokinetic parameters...
  7. ncbi request reprint Decrease in survival threshold of quiescent colon carcinoma cells in the presence of a small molecule integrin antagonist
    Mike F Burbridge
    Cancer Research Division, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, Paris, France
    Mol Pharmacol 63:1281-8. 2003
    ..Together, these observations could guide the use of combination therapy with integrin antagonists in the clinic...
  8. ncbi request reprint Parallel liquid synthesis of N,N'-Disubstituted 3-amino azepin-2-ones as potent and specific farnesyl transferase inhibitors
    Thierry Le Diguarher
    Department of Medicinal Chemistry, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, France
    Bioorg Med Chem 11:3193-204. 2003
    ..The activities of the selected compounds were validated in vivo, and compounds 41a and 44a presented significant antitumour activity...
  9. doi request reprint S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool
    Gilles Ferry
    Pharmacologie Moléculaire et Cellulaire, Institut de Recherches Servier, Croissy sur Seine, France
    J Pharmacol Exp Ther 327:809-19. 2008
    ..S32826 is the first reported inhibitor of autotaxin with an IC(50) in the nanomolar range that can be used to validate the role of autotaxin in various pathologies in cellular models...
  10. ncbi request reprint Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists
    Francoise Perron-Sierra
    Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, France
    Bioorg Med Chem Lett 12:3291-6. 2002
    ..The preferred compounds 1-2, 1-3 and 1-8, showed nano- to subnanomolar IC(50) values on alpha(v)beta(3) and alpha(v)beta(5) integrins, with favorable pharmacokinetics...
  11. ncbi request reprint Blockade of alpha v beta3 and alpha v beta5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cells
    Sylvie Maubant
    Centre National de Recherche Scientifique, Unité Mixte de Recherche CNRS UMR 6543, Centre Antoine Lacassagne, Nice, France
    Blood 108:3035-44. 2006
    ..Altogether, these findings have important implications for the development of this class of antiangiogenics...
  12. ncbi request reprint Novel RGD-like molecules based on the tyrosine template: design, synthesis, and biological evaluation on isolated integrins alphaVbeta3/alphaIIbbeta3 and in cellular adhesion tests
    Stephane Biltresse
    Unite de Chimie Organique et Medicinale, Universite Catholique de Louvain, Batiment Lavoisier, Place Louis Pasteur, 1, B 1348 Louvain la Neuve, Belgium
    Bioorg Med Chem 12:5379-93. 2004
    ..A modeling study at the ab initio level in MINI-1' basis allowed to compare the various synthetic ligands of integrins and to propose novel pharmacophore structures...
  13. ncbi request reprint Adenovirus dodecahedron cell attachment and entry are mediated by heparan sulfate and integrins and vary along the cell cycle
    Pascal Fender
    CNRS, CEA, UJF Institut de Biologie Structurale, 41 rue Jules Horowitz 38027 Grenoble, France
    Virology 371:155-64. 2008
    ..This provides new clues for the use of this adenovirus nanoparticle as a delivery vector and sheds light on the integrin and HSPGs relationship in both resting and dividing cells...