J A Triccas

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. ncbi request reprint An inducible expression system permitting the efficient purification of a recombinant antigen from Mycobacterium smegmatis
    J A Triccas
    Unite de Genetique Mycobacterienne, Institut Pasteur, Paris, France
    FEMS Microbiol Lett 167:151-6. 1998
  2. pmc Specific serological diagnosis of leprosy with a recombinant Mycobacterium leprae protein purified from a rapidly growing mycobacterial host
    J A Triccas
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    J Clin Microbiol 36:2363-5. 1998
  3. ncbi request reprint DNA encoding a single mycobacterial antigen protects against leprosy infection
    E Martin
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No. 6, NSW 2042, Newtown, Australia
    Vaccine 19:1391-6. 2001
  4. pmc A 35-kilodalton protein is a major target of the human immune response to Mycobacterium leprae
    J A Triccas
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    Infect Immun 64:5171-7. 1996
  5. pmc Molecular and immunological analyses of the Mycobacterium avium homolog of the immunodominant Mycobacterium leprae 35-kilodalton protein
    J A Triccas
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales 2042, Australia
    Infect Immun 66:2684-90. 1998
  6. pmc Protection against virulent Mycobacterium avium infection following DNA vaccination with the 35-kilodalton antigen is accompanied by induction of gamma interferon-secreting CD4(+) T cells
    E Martin
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales 2042, Australia
    Infect Immun 68:3090-6. 2000
  7. pmc Comparative protective effects of recombinant DNA and Mycobacterium bovis bacille Calmette-Guérin vaccines against M. avium infection
    E Martin
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
    Clin Exp Immunol 126:482-7. 2001
  8. ncbi request reprint Isolation of strong expression signals of Mycobacterium tuberculosis
    J A Triccas
    Unite de Genetique Mycobacterienne, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Microbiology 147:1253-8. 2001
  9. ncbi request reprint Inactivation of the Mycobacterium tuberculosis fadB4 gene results in increased virulence in host cell and mice
    G M Scandurra
    Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney, NSW 2006, Australia
    Microbes Infect 10:38-44. 2008
  10. ncbi request reprint Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier
    L R Camacho
    , Institut Pasteur, 25 rue du Dr. Roux, 75725 Paris Cedex 15, France
    J Biol Chem 276:19845-54. 2001

Collaborators

Detail Information

Publications14

  1. ncbi request reprint An inducible expression system permitting the efficient purification of a recombinant antigen from Mycobacterium smegmatis
    J A Triccas
    Unite de Genetique Mycobacterienne, Institut Pasteur, Paris, France
    FEMS Microbiol Lett 167:151-6. 1998
    ....
  2. pmc Specific serological diagnosis of leprosy with a recombinant Mycobacterium leprae protein purified from a rapidly growing mycobacterial host
    J A Triccas
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    J Clin Microbiol 36:2363-5. 1998
    ..The assay proved highly specific (97.5%) and sensitive (90%) and compared favorably with two other established methods routinely utilized for leprosy serodiagnosis...
  3. ncbi request reprint DNA encoding a single mycobacterial antigen protects against leprosy infection
    E Martin
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No. 6, NSW 2042, Newtown, Australia
    Vaccine 19:1391-6. 2001
    ..Therefore, DNA immunization with the 35 kDa antigen is effective against M. leprae infection and genetic immunization with a combination of antigens holds the potential for an improved vaccine against leprosy...
  4. pmc A 35-kilodalton protein is a major target of the human immune response to Mycobacterium leprae
    J A Triccas
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    Infect Immun 64:5171-7. 1996
    ..leprae 35-kDa protein appears to be a major and relatively specific target of the human immune response to M. leprae and is a potential component of a diagnostic test to detect exposure to leprosy or a vaccine to combat the disease...
  5. pmc Molecular and immunological analyses of the Mycobacterium avium homolog of the immunodominant Mycobacterium leprae 35-kilodalton protein
    J A Triccas
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales 2042, Australia
    Infect Immun 66:2684-90. 1998
    ..Strong delayed-type hypersensitivity was elicited by the protein in guinea pigs sensitized with M. avium...
  6. pmc Protection against virulent Mycobacterium avium infection following DNA vaccination with the 35-kilodalton antigen is accompanied by induction of gamma interferon-secreting CD4(+) T cells
    E Martin
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales 2042, Australia
    Infect Immun 68:3090-6. 2000
    ..These results illustrate the importance of the 35-kDa protein in the protective response to M. avium infection and indicate that DNA vaccination successfully promotes a sustained level of protection during chronic M. avium infection...
  7. pmc Comparative protective effects of recombinant DNA and Mycobacterium bovis bacille Calmette-Guérin vaccines against M. avium infection
    E Martin
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
    Clin Exp Immunol 126:482-7. 2001
    ..Therefore, recombinant BCG-35 and BCG induced similar levels of protection in this model, and maximal protection against M. avium infection was attained by immunization with DNA encoding the 35 kDa protein...
  8. ncbi request reprint Isolation of strong expression signals of Mycobacterium tuberculosis
    J A Triccas
    Unite de Genetique Mycobacterienne, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Microbiology 147:1253-8. 2001
    ..Furthermore, this study demonstrated that FACS provides a sensitive and efficient technique to measure and select strong mycobacterial expression signals...
  9. ncbi request reprint Inactivation of the Mycobacterium tuberculosis fadB4 gene results in increased virulence in host cell and mice
    G M Scandurra
    Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney, NSW 2006, Australia
    Microbes Infect 10:38-44. 2008
    ..tuberculosis lacking the fadB4 gene. Therefore fadB4 is part of the family of genes whose expression serves to regulate the virulence of M. tuberculosis within the host...
  10. ncbi request reprint Analysis of the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis. Evidence that this lipid is involved in the cell wall permeability barrier
    L R Camacho
    , Institut Pasteur, 25 rue du Dr. Roux, 75725 Paris Cedex 15, France
    J Biol Chem 276:19845-54. 2001
    ..tuberculosis play a role in the cell envelope architecture and permeability. This function may represent one of the molecular mechanisms by which DIMs are involved in the virulence of M. tuberculosis...
  11. ncbi request reprint Life on the inside: probing mycobacterium tuberculosis gene expression during infection
    J A Triccas
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    Immunol Cell Biol 78:311-7. 2000
    ..This information is expected to provide new strategies to prevent tuberculosis infection, new targets for antimicrobial therapy and new insights into the infectious process...
  12. pmc Analysis of stress- and host cell-induced expression of the Mycobacterium tuberculosis inorganic pyrophosphatase
    J A Triccas
    Unite de Genetique Mycobacterienne, Institut Pasteur, 25 rue du Dr, Roux, 75724 Paris Cedex 15, France
    BMC Microbiol 1:3. 2001
    ..The causative agent of tuberculosis, Mycobacterium tuberculosis, contains a well conserved copy of PPase. We sought to determine if expression of the M. tuberculosis PPase is regulated by the intracellular environment...
  13. ncbi request reprint Characterization of the gene encoding the immunodominant 35 kDa protein of Mycobacterium leprae
    N Winter
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    Mol Microbiol 16:865-76. 1995
    ..smegmatis. The availability of the recombinant 35 kDa protein will permit dissection of both antibody- and T-cell-mediated immune responses in leprosy patients...
  14. ncbi request reprint Effect of phthiocerol dimycocerosate deficiency on the transcriptional response of human macrophages to Mycobacterium tuberculosis
    G M Scandurra
    Mycobacterial Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, NSW 2042, Australia
    Microbes Infect 9:87-95. 2007
    ..Therefore, although fadD26 deficiency is responsible for the early attenuation of the growth of M. tuberculosis in vivo, this effect is not associated with differences in the initial macrophage transcriptional response...