Isabelle Treilleux

Summary

Affiliation: Institut Paoli-Calmettes
Country: France

Publications

  1. doi request reprint [Basal-like breast cancer: a review]
    Isabelle Treilleux
    Service d Anatomie Pathologique, Centre Leon Berard, 69373 Lyon Cedex 08, France
    Ann Pathol 29:180-6. 2009
  2. ncbi request reprint Collagenous spherulosis mimicking keratinizing squamous metaplasia in a borderline endometrioid tumour of the ovary
    I Treilleux
    Departement d Anatomie et de Cytologie Pathologiques, Centre Leon Berard, Lyon, France
    Histopathology 35:271-6. 1999
  3. ncbi request reprint Tamoxifen and malignant epithelial-nonepithelial tumours of the endometrium: report of six cases and review of the literature
    T Treilleux
    Département d gt gt Anatomie et de Cytologie Pathologiques, Centre Leon Berard, 28 rue Laennec, Lyon, Cedex 08, 69373, France
    Eur J Surg Oncol 25:477-82. 1999
  4. ncbi request reprint TIF1γ requires sumoylation to exert its repressive activity on TGFβ signaling
    Laurent Fattet
    INSERM U1052, Centre de Recherche en Cancérologie de Lyon, 69373 Lyon, Cedex 08, France
    J Cell Sci 126:3713-23. 2013
  5. doi request reprint The conditional expression of KRAS G12D in mouse pancreas induces disorganization of endocrine islets prior the onset of ductal pre-cancerous lesions
    Johann Gout
    TGFβ and Pancreatic Cancer Laboratory, INSERM U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France
    Pancreatology 13:191-5. 2013
  6. doi request reprint Breast cancer-derived transforming growth factor-β and tumor necrosis factor-α compromise interferon-α production by tumor-associated plasmacytoid dendritic cells
    Vanja Sisirak
    Universite de Lyon, Lyon, France
    Int J Cancer 133:771-8. 2013
  7. pmc Prognostic value of the expression of C-Chemokine Receptor 6 and 7 and their ligands in non-metastatic breast cancer
    Philippe A Cassier
    Department of Medecine, Centre Leon Berard, Lyon, France
    BMC Cancer 11:213. 2011
  8. doi request reprint Impaired IFN-α production by plasmacytoid dendritic cells favors regulatory T-cell expansion that may contribute to breast cancer progression
    Vanja Sisirak
    Universite de Lyon, Lyon, France
    Cancer Res 72:5188-97. 2012
  9. doi request reprint Bevacizumab and paclitaxel for breast cancer patients with central nervous system metastases: a case series
    Sana Intidhar Labidi
    Department of Medical Oncology, Centre Leon Berard, Laennec, France
    Clin Breast Cancer 9:118-21. 2009
  10. doi request reprint Molecular characterization of anastrozole resistance in breast cancer: pivotal role of the Akt/mTOR pathway in the emergence of de novo or acquired resistance and importance of combining the allosteric Akt inhibitor MK-2206 with an aromatase inhibitor
    Paul Vilquin
    ISPB, Faculte de Pharmacie, Universite Lyon 1, Lyon, France
    Int J Cancer 133:1589-602. 2013

Detail Information

Publications43

  1. doi request reprint [Basal-like breast cancer: a review]
    Isabelle Treilleux
    Service d Anatomie Pathologique, Centre Leon Berard, 69373 Lyon Cedex 08, France
    Ann Pathol 29:180-6. 2009
    ..Pure basal and basal/myoepithelial subtypes have a poor prognosis in contrast to the myoepithelial subtype...
  2. ncbi request reprint Collagenous spherulosis mimicking keratinizing squamous metaplasia in a borderline endometrioid tumour of the ovary
    I Treilleux
    Departement d Anatomie et de Cytologie Pathologiques, Centre Leon Berard, Lyon, France
    Histopathology 35:271-6. 1999
    ..It is characterized by fibrillar spherules exhibiting an intrinsic radiating or concentric pattern which are surrounded by myoepithelial cells. This entity can be misdiagnosed as adenoid cystic carcinoma and in-situ ductal carcinoma...
  3. ncbi request reprint Tamoxifen and malignant epithelial-nonepithelial tumours of the endometrium: report of six cases and review of the literature
    T Treilleux
    Département d gt gt Anatomie et de Cytologie Pathologiques, Centre Leon Berard, 28 rue Laennec, Lyon, Cedex 08, 69373, France
    Eur J Surg Oncol 25:477-82. 1999
    ..These tumours include endometrial carcinomas, stromal sarcomas, leiomyosarcomas as well as malignant mixed (epithelial-nonepithelial) tumours...
  4. ncbi request reprint TIF1γ requires sumoylation to exert its repressive activity on TGFβ signaling
    Laurent Fattet
    INSERM U1052, Centre de Recherche en Cancérologie de Lyon, 69373 Lyon, Cedex 08, France
    J Cell Sci 126:3713-23. 2013
    ..Taken together, our results identify a new TGFβ regulatory layer, whereby sumoylation strengthens the TIF1γ repressive action on canonical TGFβ signaling...
  5. doi request reprint The conditional expression of KRAS G12D in mouse pancreas induces disorganization of endocrine islets prior the onset of ductal pre-cancerous lesions
    Johann Gout
    TGFβ and Pancreatic Cancer Laboratory, INSERM U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France
    Pancreatology 13:191-5. 2013
    ..Although Pdx1-Cre is expressed in the embryonic endoderm, which gives rise to all pancreatic lineages, the possible consequences of KRAS(G12D) expression in the endocrine compartment have never been finely explored...
  6. doi request reprint Breast cancer-derived transforming growth factor-β and tumor necrosis factor-α compromise interferon-α production by tumor-associated plasmacytoid dendritic cells
    Vanja Sisirak
    Universite de Lyon, Lyon, France
    Int J Cancer 133:771-8. 2013
    ..Our findings indicate that targeting TApDC to restore their IFN-α production might be an achievable strategy to induce antitumor immunity in breast cancer by combining TLR7/9-based immunotherapy with TGF-β and TNF-α antagonists...
  7. pmc Prognostic value of the expression of C-Chemokine Receptor 6 and 7 and their ligands in non-metastatic breast cancer
    Philippe A Cassier
    Department of Medecine, Centre Leon Berard, Lyon, France
    BMC Cancer 11:213. 2011
    ..Chemokines CCL19, CCL20 and CCL21 and their receptors CCR6 and CCR7, were assessed as potential biomarkers of metastatic dissemination in primary breast cancer...
  8. doi request reprint Impaired IFN-α production by plasmacytoid dendritic cells favors regulatory T-cell expansion that may contribute to breast cancer progression
    Vanja Sisirak
    Universite de Lyon, Lyon, France
    Cancer Res 72:5188-97. 2012
    ..Thus, targeting pDC to restore their IFN-α production may represent an attractive therapeutic strategy to overcome immune tolerance in breast cancer...
  9. doi request reprint Bevacizumab and paclitaxel for breast cancer patients with central nervous system metastases: a case series
    Sana Intidhar Labidi
    Department of Medical Oncology, Centre Leon Berard, Laennec, France
    Clin Breast Cancer 9:118-21. 2009
    ....
  10. doi request reprint Molecular characterization of anastrozole resistance in breast cancer: pivotal role of the Akt/mTOR pathway in the emergence of de novo or acquired resistance and importance of combining the allosteric Akt inhibitor MK-2206 with an aromatase inhibitor
    Paul Vilquin
    ISPB, Faculte de Pharmacie, Universite Lyon 1, Lyon, France
    Int J Cancer 133:1589-602. 2013
    ....
  11. doi request reprint ICOS-ligand expression on plasmacytoid dendritic cells supports breast cancer progression by promoting the accumulation of immunosuppressive CD4+ T cells
    Julien Faget
    Team 11, Cancer Research Center of Lyon, INSERM, France
    Cancer Res 72:6130-41. 2012
    ..These findings strongly rationalize antibody-mediated ICOS blockade as a powerful clinical strategy to correct immune escape and promote therapeutic responses in breast cancer...
  12. doi request reprint First-line endocrine therapy alone could be a reasonable treatment option for hormone-positive, HER2-positive metastatic breast cancer
    Julien Peron
    Centre Leon Berard, Department of Medical Oncology, 28, rue Laennec, 69008 Lyon, France
    Bull Cancer 99:E18-25. 2012
    ..Previously validated clinical practice guidelines recommending the use of endocrine therapy alone in first line might be changed...
  13. doi request reprint Early detection of tumor cells by innate immune cells leads to T(reg) recruitment through CCL22 production by tumor cells
    Julien Faget
    Centre Leon Berard, F 69000 Lyon, France
    Cancer Res 71:6143-52. 2011
    ....
  14. doi request reprint Tumor promotion by intratumoral plasmacytoid dendritic cells is reversed by TLR7 ligand treatment
    Isabelle Le Mercier
    Universite de Lyon, Lyon, France
    Cancer Res 73:4629-40. 2013
    ..Our results establish a direct contribution of TApDC to primary breast tumor progression and rationalize the application of TLR7 ligands to restore TApDC activation in breast cancer. Cancer Res; 73(15); 4629-40. ©2013 AACR. ..
  15. ncbi request reprint Primary ovarian borderline tumor in the inguinal lymph node
    Nicolas Carrabin
    Department of Surgical Oncology, Centre Leon Berard, Lyon, France
    Int J Gynecol Pathol 32:167-70. 2013
    ..Ectopic ovarian tissue can be observed in lymph node. We don't believe ectopic location of ovarian tissue increase the risk of neoplastic change...
  16. doi request reprint [Adjuvant treatments in breast cancer: interest of completion of axillary dissection in case of micrometastases or isolated tumor cells in sentinel lymph node]
    Caroline Schmitt
    Centre Leon Berard, 28, Lyon, France
    Bull Cancer 99:463-9. 2012
    ..The results of our study show that non-sentinel lymph node status modify systemic therapy for a very few patients (less than 4% concerning chimiotherapy and less than 15% concerning radiotherapy)...
  17. doi request reprint [Antihormonal therapy in breast cancer and mTOR inhibitors]
    Pierre Etienne Heudel
    Centre Leon Berard, Oncologie Médicale, Lyon, France
    Bull Cancer 98:1431-7. 2011
    ....
  18. pmc ADP ribosylation factor like 2 (Arl2) regulates breast tumor aggressivity in immunodeficient mice
    Anne Beghin
    INSERM U590, Universite Lyon 1, ISPB, Lyon, France
    PLoS ONE 4:e7478. 2009
    ..These data underline the role of Arl2, a small GTPase, as an important regulator of breast tumor cell aggressivity, both in vitro and in vivo...
  19. doi request reprint Multidisciplinarity and medical decision, impact for patients with cancer: sociological assessment of two tumour committees' organization
    Patrick Castel
    Centre Leon Berard, Lyon, France
    Bull Cancer 99:E34-42. 2012
    ..In the present study, we evaluated the organization of two multidisciplinary committees, one for breast cancer and one for sarcoma, in a French Comprehensive Cancer Centre...
  20. ncbi request reprint BCIRG 001 molecular analysis: prognostic factors in node-positive breast cancer patients receiving adjuvant chemotherapy
    Charles Dumontet
    INSERM 590, Faculté Rockefeller, 8 avenue Rockefeller, Lyon, France
    Clin Cancer Res 16:3988-97. 2010
    ....
  21. doi request reprint Impact of a second opinion using expression and molecular analysis of FOXL2 for sex cord-stromal tumors. A study of the GINECO group & the TMRO network
    Denis Maillet
    Centre Leon Berard, Lyon, France Université Claude Bernard Lyon1 Université de Lyon, Lyon, France
    Gynecol Oncol 132:181-7. 2014
    ..This study aims to assess the benefit of an algorithm incorporating these new tools for a better diagnosis and classification of SCSTs..
  22. pmc Combining chemotherapeutic agents and netrin-1 interference potentiates cancer cell death
    Andrea Paradisi
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, LabEx DEVweCAN, Centre de Cancérologie de Lyon, INSERM U1052 CNRS UMR5286, Universite de Lyon, Centre Leon Berard, Lyon, France
    EMBO Mol Med 5:1821-34. 2013
    ..Together these data suggest that combining conventional chemotherapies with netrin-1 interference could be a promising therapeutic approach. ..
  23. doi request reprint Tif1γ is essential for the terminal differentiation of mammary alveolar epithelial cells and for lactation through SMAD4 inhibition
    Cédric Hesling
    Centre de Recherche en Cancérologie de Lyon, Inserm UMR S1052, CNRS UMR5286, Centre Leon Berard, Lyon, France
    Development 140:167-75. 2013
    ..We propose that Tif1γ contributes to the repression of TGFβ activity during late pregnancy and prevents lactation by inhibiting SMAD4...
  24. ncbi request reprint High incidence of mammary intraepithelial neoplasia development in Men1-disrupted murine mammary glands
    Christelle Seigne
    Universite Lyon, F 69000, Lyon, France
    J Pathol 229:546-58. 2013
    ..Taken together, the current work indicates a role of Men1 inactivation in the development of mammary pre-cancerous lesions in mice and a potential role in human mammary cancer...
  25. doi request reprint Generation of mice with conditionally activated transforming growth factor beta signaling through the TbetaRI/ALK5 receptor
    Laurent Bartholin
    INSERM, U590, INSERM Avenirgroup, Oncogenèse et progression tumorale, Centre Leon Berard, 28 rue Laennec, Lyon Cedex 08, France
    Genesis 46:724-31. 2008
    ..In addition to the information provided on TGFbeta effects on T-cell biology, LSL-TbetaRI(CA) mouse constitutes an attractive tool to address the effect of TGFbeta signaling upregulation in any cell type expressing the cre-recombinase...
  26. ncbi request reprint Silencing of FLRG, an antagonist of activin, inhibits human breast tumor cell growth
    Diane Razanajaona
    INSERM, U590, Lyon, France
    Cancer Res 67:7223-9. 2007
    ..Our data provide strong evidence that endogenous FLRG contributes to tumor cell proliferation through antagonizing endogenous activin effects...
  27. pmc Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer
    Julien Fitamant
    Apoptosis, Cancer, and Development Laboratory Equipe Labellisée La Ligue, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5238, Centre Leon Berard, Université de Lyon 69008 Lyon, France
    Proc Natl Acad Sci U S A 105:4850-5. 2008
    ....
  28. ncbi request reprint Quantitative and functional alterations of plasmacytoid dendritic cells contribute to immune tolerance in ovarian cancer
    Sana Intidhar Labidi-Galy
    Departments of Medical Oncology, Centre de Recherche en Cancérologie de Lyon, Centre Leon Berard, Lyon, France
    Cancer Res 71:5423-34. 2011
    ..Taken together, our findings indicate that both local and systemic dysfunction of pDC play a critical role in the progression of ovarian cancer via induction of immune tolerance...
  29. pmc EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice
    Anne Pierre Morel
    Inserm UMR S1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France
    PLoS Genet 8:e1002723. 2012
    ..Challenging this prevailing view, we propose that these aggressive tumors arise from cells committed to luminal differentiation, through a process driven by EMT inducers and combining malignant transformation and transdifferentiation...
  30. doi request reprint ZNF217 is a marker of poor prognosis in breast cancer that drives epithelial-mesenchymal transition and invasion
    Julie A Vendrell
    ISPB, Faculte de Pharmacie, Universite Lyon 1, Lyon, France
    Cancer Res 72:3593-606. 2012
    ..Therapeutic targeting of ZNF217 of the TGF-β signaling pathway may benefit the subset of patients whose tumors express high levels of ZNF217...
  31. doi request reprint Management of rare ovarian cancers: the experience of the French website "Observatory for rare malignant tumours of the ovaries" by the GINECO group: interim analysis of the first 100 patients
    Isabelle Ray-Coquard
    Centre Leon Berard, SIS 4921, 28 rue Laennec, 69008 Lyon, France
    Gynecol Oncol 119:53-9. 2010
    ..We report the results of the first 100 patients with germ cell (GCT) and sex cord-stromal (SCT) tumours...
  32. doi request reprint Regulation of estrogen rapid signaling through arginine methylation by PRMT1
    Muriel Le Romancer
    INSERM, U590, Lyon F 69008, France Université de Lyon, Lyon 1, ISPB and IFR62, Lyon F 69003, France
    Mol Cell 31:212-21. 2008
    ..Our data indicate that the methylation of ERalpha is a physiological process occurring in the cytoplasm of normal and malignant epithelial breast cells and that ERalpha is hypermethylated in a subset of breast cancers...
  33. doi request reprint Mutational characterization of individual breast tumors: TP53 and PI3K pathway genes are frequently and distinctively mutated in different subtypes
    Sandrine Boyault
    Laboratoire de Recherche Translationnelle, Centre Leon Berard, 28 rue Laennec, 69373 Lyon Cedex 08, France
    Breast Cancer Res Treat 132:29-39. 2012
    ..These two distinct mutation patterns were significantly associated to hormone receptor expression but independent of HER2 status...
  34. ncbi request reprint Cost-effectiveness analysis of strategies for HER2 testing of breast cancer patients in France
    Magali Morelle
    Health Economics Research Group in Oncology, Centre Leon Berard, Lyon, France
    Int J Technol Assess Health Care 22:396-401. 2006
    ..A cost-effectiveness analysis was conducted comparing diagnostic strategies for determining the HER2 status of invasive breast carcinomas, as an indication for trastuzumab at metastatic relapse...
  35. doi request reprint Predicting everolimus treatment efficacy in patients with advanced endometrial carcinoma: a GINECO group study
    Olivier Tredan
    Department of Medical Oncology, Leon Berard Cancer Center, 28 rue Laennec, Lyon, 69008, France
    Target Oncol 8:243-51. 2013
    ..However, endometrial cancer patients with K-RAS mutations do not seem to derive benefit from everolimus treatment...
  36. pmc Activation of rapid oestrogen signalling in aggressive human breast cancers
    Coralie Poulard
    Universite de Lyon, France
    EMBO Mol Med 4:1200-13. 2012
    ..Our data introduces the new concept that the rapid oestrogen pathway is operative in vivo. It also provides a rationale for patient stratification defined by the activation of this pathway and the identification of target therapies...
  37. pmc Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway
    David F Vincent
    INSERM U1052, Cancer Research Center of Lyon CRCL, Lyon, France
    Am J Pathol 180:2214-21. 2012
    ..These findings establish, for the first time to our knowledge, that Tif1γ and Smad4 both regulate an intraductal papillary mucinous neoplasm-to-PDAC sequence through distinct tumor-suppressor programs...
  38. ncbi request reprint Prognosis of early-onset breast cancer based on BRCA1/2 mutation status in a French population-based cohort and review
    Valerie Bonadona
    Centre Leon Berard, Unit of Prevention and Genetic Epidemiology, 28 rue Laennec, 69 373 Lyon cedex 08, France
    Breast Cancer Res Treat 101:233-45. 2007
    ..The debate concerning poorer survival for patients with breast cancer (BC) carrying a BRCA1 germline mutation is unresolved, and requires additional data from population-based studies...
  39. ncbi request reprint Tumor alphavbeta3 integrin is a therapeutic target for breast cancer bone metastases
    Yingshe Zhao
    Institut National de la Sante et de la Recherche Medicale, UMR 664, IFR62, Lyon, France
    Cancer Res 67:5821-30. 2007
    ..Overall, our data show that tumor alphavbeta3 integrin stands as a therapeutic target for the prevention of skeletal metastases...
  40. ncbi request reprint [Neoadjuvant chemotherapy and ovarian cancer]
    Isabelle Ray-Coquard
    Centre Leon Berard, Lyon
    Bull Cancer 93:669-76. 2006
    ..The strategy of neoadjuvant chemotherapy, followed by interval debulking surgery, should be confirmed in a prospective randomized trial. The EORTC55971 trial is currently addressing this issue...
  41. ncbi request reprint Breast carcinoma cells promote the differentiation of CD34+ progenitors towards 2 different subpopulations of dendritic cells with CD1a(high)CD86(-)Langerin- and CD1a(+)CD86(+)Langerin+ phenotypes
    Marie Cécile Thomachot
    Equipe Cytokines et Cancers, INSERM U 590, Centre Léon B, Lyon, France
    Int J Cancer 110:710-20. 2004
    ..The infiltration of BCC by these altered DC may contribute to the impaired immune response against the tumor...
  42. ncbi request reprint Is surgical biopsy mandatory in case of atypical ductal hyperplasia on 11-gauge core needle biopsy? A retrospective study of 300 patients
    Caroline Forgeard
    Department of Pathology, Leon Berard Centre, 28 rue Laennec, 69373 Lyon Cedex 08, France
    Am J Surg 196:339-45. 2008
    ..Since the underestimation rate varies from 7% to 36%, surgical excision is still recommended, although some authors have tried to identify a subset of patients who can be spared surgery...
  43. pmc Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas
    David F Vincent
    INSERM, U590, IFR62, Lyon, France
    PLoS Genet 5:e1000575. 2009
    ....