Franck Toledo

Summary

Affiliation: Institut Curie
Country: France

Publications

  1. ncbi Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
    Franck Toledo
    Institut Curie, Centre de Recherche, UMR CNRS 7147, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Rev Cancer 6:909-23. 2006
  2. ncbi Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression
    Franck Toledo
    Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell Biol 27:1425-32. 2007
  3. ncbi MDM2 and MDM4: p53 regulators as targets in anticancer therapy
    Franck Toledo
    Institut Curie, Centre de Recherche, UMR CNRS 7147, 26 Rue d Ulm, 75728 Paris Cedex 05, France
    Int J Biochem Cell Biol 39:1476-82. 2007
  4. ncbi [The activation of p53 in tumors: a promising strategy against cancer]
    Franck Toledo
    , Institut Curie, Centre de Recherche, , UMR 7147 IC/UPMC/CNRS, 26, rue d'Ulm, 75248 Paris Cedex 05, France
    Med Sci (Paris) 23:565-7. 2007
  5. ncbi A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network
    Franck Toledo
    The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Cancer Cell 9:273-85. 2006
  6. ncbi RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses
    Franck Toledo
    The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Nucleic Acids Res 34:e92. 2006
  7. ncbi The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation
    Kurt A Krummel
    The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:10188-93. 2005
  8. ncbi Fuzzy tandem repeats containing p53 response elements may define species-specific p53 target genes
    Iva Simeonova
    Institut Curie, Centre de Recherche, Paris, France
    PLoS Genet 8:e1002731. 2012
  9. ncbi Replication initiation in mammalian cells: changing preferences
    Michelle Debatisse
    Institut Curie, Paris, France
    Cell Cycle 3:19-21. 2004

Collaborators

Detail Information

Publications9

  1. ncbi Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
    Franck Toledo
    Institut Curie, Centre de Recherche, UMR CNRS 7147, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Rev Cancer 6:909-23. 2006
    ..Importantly, MDM4 emerges as an independent target for drug development, as its inactivation is crucial for full p53 activation...
  2. ncbi Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression
    Franck Toledo
    Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell Biol 27:1425-32. 2007
    ..These results may explain why the sequence of the p53 PRD is so variable in evolution...
  3. ncbi MDM2 and MDM4: p53 regulators as targets in anticancer therapy
    Franck Toledo
    Institut Curie, Centre de Recherche, UMR CNRS 7147, 26 Rue d Ulm, 75728 Paris Cedex 05, France
    Int J Biochem Cell Biol 39:1476-82. 2007
    ....
  4. ncbi [The activation of p53 in tumors: a promising strategy against cancer]
    Franck Toledo
    , Institut Curie, Centre de Recherche, , UMR 7147 IC/UPMC/CNRS, 26, rue d'Ulm, 75248 Paris Cedex 05, France
    Med Sci (Paris) 23:565-7. 2007
  5. ncbi A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network
    Franck Toledo
    The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Cancer Cell 9:273-85. 2006
    ..Furthermore, Mdm4 loss dramatically improved p53DeltaP-mediated suppression of oncogene-induced tumors, emphasizing the importance of targeting Mdm4 in chemotherapies designed to activate p53...
  6. ncbi RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses
    Franck Toledo
    The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Nucleic Acids Res 34:e92. 2006
    ..These general principles should make RMCE-ASAP applicable to any locus...
  7. ncbi The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation
    Kurt A Krummel
    The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:10188-93. 2005
    ..We propose that the C-terminal modifications believed to be critical for proper P53 regulation are not essential, but contribute to a fine-tuning mechanism of homeostatic control in vivo...
  8. ncbi Fuzzy tandem repeats containing p53 response elements may define species-specific p53 target genes
    Iva Simeonova
    Institut Curie, Centre de Recherche, Paris, France
    PLoS Genet 8:e1002731. 2012
    ..Our results indicate a role for the rapid evolution of tandem repeats in shaping differences in p53 regulatory networks between mammalian species...
  9. ncbi Replication initiation in mammalian cells: changing preferences
    Michelle Debatisse
    Institut Curie, Paris, France
    Cell Cycle 3:19-21. 2004
    ..Functional relationships between matrix anchorage and origin selection are discussed...