Franck Toledo

Summary

Affiliation: Institut Curie
Country: France

Publications

  1. pmc Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression
    Franck Toledo
    Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell Biol 27:1425-32. 2007
  2. ncbi request reprint [The activation of p53 in tumors: a promising strategy against cancer]
    Franck Toledo
    Universite Pierre et Marie Curie Paris 6, Institut Curie, Centre de Recherche, Génétique de la Suppression Tumorale, UMR 7147 IC UPMC CNRS, 26, rue d Ulm, 75248 Paris Cedex 05, France
    Med Sci (Paris) 23:565-7. 2007
  3. pmc MDM2 and MDM4: p53 regulators as targets in anticancer therapy
    Franck Toledo
    Institut Curie, Centre de Recherche, UMR CNRS 7147, 26 Rue d Ulm, 75728 Paris Cedex 05, France
    Int J Biochem Cell Biol 39:1476-82. 2007
  4. ncbi request reprint Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
    Franck Toledo
    Institut Curie, Centre de Recherche, UMR CNRS 7147, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Rev Cancer 6:909-23. 2006
  5. ncbi request reprint A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network
    Franck Toledo
    The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Cancer Cell 9:273-85. 2006
  6. doi request reprint Mutant mice lacking the p53 C-terminal domain model telomere syndromes
    Iva Simeonova
    Genetics of Tumor Suppression, Institut Curie, Centre de Recherche, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Cell Rep 3:2046-58. 2013
  7. pmc Of mice and men: fuzzy tandem repeats and divergent p53 transcriptional repertoires
    Aurélie Morin
    Institut Curie, Centre de Recherche, Paris, France
    Transcription 4:67-71. 2013
  8. pmc RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses
    Franck Toledo
    The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Nucleic Acids Res 34:e92. 2006
  9. pmc The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation
    Kurt A Krummel
    The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:10188-93. 2005
  10. pmc Fuzzy tandem repeats containing p53 response elements may define species-specific p53 target genes
    Iva Simeonova
    Institut Curie, Centre de Recherche, Paris, France
    PLoS Genet 8:e1002731. 2012

Collaborators

  • GEOFFREY MYLES WAHL
  • Michelle Debatisse
  • Iva Simeonova
  • Rachida Bouarich-Bourimi
  • Aurélie Morin
  • Boris Bardot
  • Vincent Lejour
  • Laure Charbonnier
  • Ming Fang
  • Kurt A Krummel
  • Irena Draskovic
  • Jean Christophe Bourdon
  • Claire Soudais
  • Arturo Londono-Vallejo
  • Sara Jaber
  • Michel Huerre
  • Crystal J Lee

Detail Information

Publications11

  1. pmc Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression
    Franck Toledo
    Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell Biol 27:1425-32. 2007
    ..These results may explain why the sequence of the p53 PRD is so variable in evolution...
  2. ncbi request reprint [The activation of p53 in tumors: a promising strategy against cancer]
    Franck Toledo
    Universite Pierre et Marie Curie Paris 6, Institut Curie, Centre de Recherche, Génétique de la Suppression Tumorale, UMR 7147 IC UPMC CNRS, 26, rue d Ulm, 75248 Paris Cedex 05, France
    Med Sci (Paris) 23:565-7. 2007
  3. pmc MDM2 and MDM4: p53 regulators as targets in anticancer therapy
    Franck Toledo
    Institut Curie, Centre de Recherche, UMR CNRS 7147, 26 Rue d Ulm, 75728 Paris Cedex 05, France
    Int J Biochem Cell Biol 39:1476-82. 2007
    ....
  4. ncbi request reprint Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
    Franck Toledo
    Institut Curie, Centre de Recherche, UMR CNRS 7147, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Rev Cancer 6:909-23. 2006
    ..Importantly, MDM4 emerges as an independent target for drug development, as its inactivation is crucial for full p53 activation...
  5. ncbi request reprint A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network
    Franck Toledo
    The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Cancer Cell 9:273-85. 2006
    ..Furthermore, Mdm4 loss dramatically improved p53DeltaP-mediated suppression of oncogene-induced tumors, emphasizing the importance of targeting Mdm4 in chemotherapies designed to activate p53...
  6. doi request reprint Mutant mice lacking the p53 C-terminal domain model telomere syndromes
    Iva Simeonova
    Genetics of Tumor Suppression, Institut Curie, Centre de Recherche, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Cell Rep 3:2046-58. 2013
    ..Together, these data reveal that a truncating mutation can activate p53 and that p53 plays a major role in the regulation of telomere metabolism...
  7. pmc Of mice and men: fuzzy tandem repeats and divergent p53 transcriptional repertoires
    Aurélie Morin
    Institut Curie, Centre de Recherche, Paris, France
    Transcription 4:67-71. 2013
    ..Here we summarize mechanisms underlying the divergence of mammalian p53 transcriptional repertoires, with an emphasis on the rapid evolution of fuzzy tandem repeats containing p53 response elements. ..
  8. pmc RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses
    Franck Toledo
    The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Nucleic Acids Res 34:e92. 2006
    ..These general principles should make RMCE-ASAP applicable to any locus...
  9. pmc The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation
    Kurt A Krummel
    The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:10188-93. 2005
    ..We propose that the C-terminal modifications believed to be critical for proper P53 regulation are not essential, but contribute to a fine-tuning mechanism of homeostatic control in vivo...
  10. pmc Fuzzy tandem repeats containing p53 response elements may define species-specific p53 target genes
    Iva Simeonova
    Institut Curie, Centre de Recherche, Paris, France
    PLoS Genet 8:e1002731. 2012
    ..Our results indicate a role for the rapid evolution of tandem repeats in shaping differences in p53 regulatory networks between mammalian species...
  11. ncbi request reprint Replication initiation in mammalian cells: changing preferences
    Michelle Debatisse
    Institut Curie, Paris, France
    Cell Cycle 3:19-21. 2004
    ..Functional relationships between matrix anchorage and origin selection are discussed...