J P Thiery

Summary

Affiliation: Institut Curie
Country: France

Publications

  1. doi Modulation of several waves of gene expression during FGF-1 induced epithelial-mesenchymal transition of carcinoma cells
    Clotilde Billottet
    CNRS UMR 144 Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Cell Biochem 104:826-39. 2008
  2. pmc Host microenvironment in breast cancer development: epithelial-mesenchymal transition in breast cancer development
    Anne Vincent-Salomon
    Medical Division, Department of Tumor Biology, Institut Curie, Paris, France
    Breast Cancer Res 5:101-6. 2003
  3. ncbi [Role of growth factor signaling in epithelial cell plasticity during development and in carcinogenesis]
    J P Thiery
    UMR 144 CRNS, Institut Curie, 26 Rue d Ulm, 75248 Paris
    Bull Acad Natl Med 185:1279-92; discussion 1293-4. 2001
  4. ncbi Cell adhesion in development: a complex signaling network
    Jean Paul Thiery
    Unit Mixte de Recherche, 144 Centre National Recherche Scientifique, Institut Curie, 26 Rue d Ulm, 75248 Cedex 05, France
    Curr Opin Genet Dev 13:365-71. 2003
  5. ncbi Epithelial-mesenchymal transitions in tumour progression
    Jean Paul Thiery
    Centre National Recherche Scientifique Unité Mixte Recherche, 144 Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Rev Cancer 2:442-54. 2002
  6. ncbi Epithelial cell plasticity in development and tumor progression
    J P Thiery
    UMR 144 CNRS, Laboratoire de Morphogenèse Cellulaire et Progression Tumorale, Institut Curie, Paris, France
    Cancer Metastasis Rev 18:31-42. 1999
  7. ncbi Epithelial-mesenchymal transitions in development and pathologies
    Jean Paul Thiery
    Unite Mixte de Recherche 144, Centre National Recherche Scientifique, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Curr Opin Cell Biol 15:740-6. 2003
  8. doi Prognosis of women with stage IV breast cancer depends on detection of circulating tumor cells rather than disseminated tumor cells
    F C Bidard
    Department of Medical Oncology, Institut Curie, Paris, France
    Ann Oncol 19:496-500. 2008
  9. ncbi Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis
    A A Mailleux
    UMR144 CNRS Institut Curie, 26 Rue d Ulm, 75248 Cedex 05, Paris, France
    Mech Dev 102:81-94. 2001
  10. ncbi Xenopus cadherin-11 is expressed in different populations of migrating neural crest cells
    J Vallin
    Laboratoire de Morphogenèse Cellulaire et Progression Tumorale, UMR 144, CNRS Institut Curie, 26 Rue d Ulm, 75248, Paris Cedex 05, France
    Mech Dev 75:171-4. 1998

Detail Information

Publications90

  1. doi Modulation of several waves of gene expression during FGF-1 induced epithelial-mesenchymal transition of carcinoma cells
    Clotilde Billottet
    CNRS UMR 144 Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Cell Biochem 104:826-39. 2008
    ....
  2. pmc Host microenvironment in breast cancer development: epithelial-mesenchymal transition in breast cancer development
    Anne Vincent-Salomon
    Medical Division, Department of Tumor Biology, Institut Curie, Paris, France
    Breast Cancer Res 5:101-6. 2003
    ..DNA profiling technology is also being applied to uncover pathways that lead to a metastatic phenotype...
  3. ncbi [Role of growth factor signaling in epithelial cell plasticity during development and in carcinogenesis]
    J P Thiery
    UMR 144 CRNS, Institut Curie, 26 Rue d Ulm, 75248 Paris
    Bull Acad Natl Med 185:1279-92; discussion 1293-4. 2001
    ..These results emphasize the need for caution in the interpretation of studies evaluating the potential of novel anti-cancer agents and for better designs of in vitro and in vivo biological assays...
  4. ncbi Cell adhesion in development: a complex signaling network
    Jean Paul Thiery
    Unit Mixte de Recherche, 144 Centre National Recherche Scientifique, Institut Curie, 26 Rue d Ulm, 75248 Cedex 05, France
    Curr Opin Genet Dev 13:365-71. 2003
    ..Clearly, a wide variety of new biophysical techniques and genomic approaches will permit analysis of the roles of adhesive interactions in development to be addressed with far greater precision...
  5. ncbi Epithelial-mesenchymal transitions in tumour progression
    Jean Paul Thiery
    Centre National Recherche Scientifique Unité Mixte Recherche, 144 Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Rev Cancer 2:442-54. 2002
  6. ncbi Epithelial cell plasticity in development and tumor progression
    J P Thiery
    UMR 144 CNRS, Laboratoire de Morphogenèse Cellulaire et Progression Tumorale, Institut Curie, Paris, France
    Cancer Metastasis Rev 18:31-42. 1999
    ..The identification of critical changes in the growth factor pathways involved in tumor progression will not only provide insight into the genetic and molecular basis of this process, but should also identify targets for new therapies...
  7. ncbi Epithelial-mesenchymal transitions in development and pathologies
    Jean Paul Thiery
    Unite Mixte de Recherche 144, Centre National Recherche Scientifique, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Curr Opin Cell Biol 15:740-6. 2003
    ..Current studies further emphasise the critical importance of EMT and provide a better molecular and functional definition of mesenchymal cells and how they emerged >500 million years ago as a key event in evolution...
  8. doi Prognosis of women with stage IV breast cancer depends on detection of circulating tumor cells rather than disseminated tumor cells
    F C Bidard
    Department of Medical Oncology, Institut Curie, Paris, France
    Ann Oncol 19:496-500. 2008
    ..Detection of disseminated tumor cells (DTC) in bone marrow (BM) is an independent prognostic factor in early breast cancer. We evaluated the prognostic value of DTC detection in the BM of metastatic breast cancer patients...
  9. ncbi Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis
    A A Mailleux
    UMR144 CNRS Institut Curie, 26 Rue d Ulm, 75248 Cedex 05, Paris, France
    Mech Dev 102:81-94. 2001
    ..These results indicate for the first time that mSPROUTY2 functions as a negative regulator of embryonic lung morphogenesis and growth...
  10. ncbi Xenopus cadherin-11 is expressed in different populations of migrating neural crest cells
    J Vallin
    Laboratoire de Morphogenèse Cellulaire et Progression Tumorale, UMR 144, CNRS Institut Curie, 26 Rue d Ulm, 75248, Paris Cedex 05, France
    Mech Dev 75:171-4. 1998
    ..It is expressed in different neural crest cell populations, during their migration and differentiation. This pattern, unexpected for an adhesion molecule, reinforces the idea of novel functions for type II cadherins...
  11. pmc Differential function of N-cadherin and cadherin-7 in the control of embryonic cell motility
    S Dufour
    UMR 144, Compartimentation et Dynamique Cellulaires, Centre National de la Recherche Scientifique et Institut Curie, 75248 Paris Cedex 05, France
    J Cell Biol 146:501-16. 1999
    ..In addition, adhesions mediated by different cadherins differentially regulate FN-dependent signaling. The transient contacts specifically observed in cadherin- 7-expressing cells may also be important in the control of cell motility...
  12. ncbi Targeted activation of beta-catenin signaling in basal mammary epithelial cells affects mammary development and leads to hyperplasia
    Jérôme Teulière
    UMR 144 CNRS Institut Curie, Institut Curie, Section de Recherche, 26 Rue d Ulm, 75248, Paris, Cedex 05, France
    Development 132:267-77. 2005
    ....
  13. ncbi A hormone-dependent post-translationally regulated mutant for investigating type I cadherin function
    E Giacomello
    Institut Curie, CNRS UMR 144, Laboratoire de Morphogénèse et progression tumorale, Paris, France
    Int J Dev Biol 45:833-8. 2001
    ..The function of the mutant deltaE-HBDER was strictly dependent on hormone induction. This conditional mutant had the same effects and exerted the same dominant negative function as the corresponding constitutive mutant...
  14. ncbi Medial cell mixing during axial morphogenesis of the amphibian embryo requires cadherin function
    M Delarue
    Laboratoire de Biologie Moléculaire et Cellulaire du Developpement, Equipe de Biologie Expérimentale, Universite Pierre et Marie Curie, Paris, France
    Dev Dyn 213:248-60. 1998
    ..They extend to Pleurodeles the observations made in Xenopus, illustrating that despite differences in morphogenetic processes, the molecular mechanisms are conserved in these two species...
  15. ncbi Wide metastatic spreading in infiltrating lobular carcinoma of the breast
    S Ferlicot
    Department of Pathology, Institut Curie, 26 Rue d Ulm, 75231 Cedex, Paris, France
    Eur J Cancer 40:336-41. 2004
    ..A high rate of pleomorphic tumours was observed in the group of metastatic ILC, but the pattern of metastatic site(s) was not related to the histological subtype of the primary...
  16. pmc Clinical significance of proliferative potential of occult metastatic cells in bone marrow of patients with breast cancer
    J Y Pierga
    Medical Oncology Department, Institut Curie, 75248 Paris Cedex 05, France
    Br J Cancer 89:539-45. 2003
    ..In conclusion, viable tumour cells can be detected in the bone marrow of breast cancer patients. Their proliferative potential could be predictive of outcome and deserves further investigation...
  17. ncbi Increased cell size and Akt activation in HER-2/neu-overexpressing invasive ductal carcinoma of the breast
    X Sastre-Garau
    Department of Pathology, CNRS UMR144, Institut Curie, Paris, France
    Histopathology 45:142-7. 2004
    ..Akt has been found to be involved in the HER-2/neu signal transduction pathway and Akt activation has been associated with increased cell size in various models...
  18. pmc Growth defects induced by perturbation of beta1-integrin function in the mammary gland epithelium result from a lack of MAPK activation via the Shc and Akt pathways
    M M Faraldo
    UMR 144, CNRS-Institut Curie, Section de Recherche, 26, rue d'Ulm, 75248, Paris, Cedex 05, France
    EMBO Rep 2:431-7. 2001
    ..These results provide an insight into the mechanisms of growth control by integrin-mediated adhesion that operate in vivo...
  19. ncbi The mesenchymal cadherin-11 is expressed in restricted sites during the ontogeny of the rat brain in modes suggesting novel functions
    L Simonneau
    Morphogénèse Cellulaire et Progression Tumoral, UMR 144 CNRS Institut Curie, Paris, France
    Cell Adhes Commun 6:431-50. 1998
    ..These data are discussed, and hypotheses for additional and novel properties for cad-11 are suggested...
  20. pmc beta-catenin-dependent and -independent effects of DeltaN-plakoglobin on epidermal growth and differentiation
    J Teulière
    UMR 144 CNRS Institut Curie, Institut Curie, Section de Recherche, 26 Rue d Ulm, 75248 Paris, Cedex 05, France
    Mol Cell Biol 24:8649-61. 2004
    ....
  21. ncbi Sequence and distribution of Xenopus laevis E-cadherin transcripts
    F Broders
    Laboratory of Physiopathology of Development, CNRS URA 1337, Paris, France
    Cell Adhes Commun 1:265-77. 1993
    ..In contrast to mouse E-cadherin, Xenopus E-cadherin was not detected transiently in the nervous system during embryogenesis and in the post-metamorphic stages...
  22. ncbi Challenges in the stratification of breast tumors for tailored therapies
    J P Thiery
    Institut Curie, 26, rue d Ulm, 75248 Paris Cedex 05
    Bull Cancer 93:E81-9. 2006
    ....
  23. pmc HER2 status of bone marrow micrometastasis and their corresponding primary tumours in a pilot study of 27 cases: a possible tool for anti-HER2 therapy management?
    A Vincent-Salomon
    Department of Tumor Biology, Institut Curie, Paris, France
    Br J Cancer 96:654-9. 2007
    ..Therefore, the efficiency of anti-HER2 adjuvant therapy could be evaluated, in a clinical trial, by sequential detection of HER2-positive micrometastatic cells within the bone marrow, before and after treatment...
  24. ncbi Cloning and characterization of three Xenopus slug promoters reveal direct regulation by Lef/beta-catenin signaling
    J Vallin
    UMR 144, CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Biol Chem 276:30350-8. 2001
    ..As the Lef.beta-catenin complex is a downstream effector of Wnt signaling, these results suggest that Xenopus Slug is a direct target of NCC determination signals...
  25. ncbi Tumour suppressive properties of fibroblast growth factor receptor 2-IIIb in human bladder cancer
    D Ricol
    UMR 144, Centre National de la Recherche Scientifique, Institut Curie, Section de Recherche, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Oncogene 18:7234-43. 1999
    ..Altogether, these results show that FGFR2-IIIb has tumour growth suppressive properties in bladder carcinomas and suggest possible mechanisms of FGFR2 gene inactivation...
  26. pmc EGF controls the in vivo developmental potential of a mammary epithelial cell line possessing progenitor properties
    Marie Ange Deugnier
    CNRS Institut Curie, Section de Recherche, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Cell Biol 159:453-63. 2002
    ....
  27. ncbi Alpha 2 beta 1 integrin is required for the collagen and FGF-1 induced cell dispersion in a rat bladder carcinoma cell line
    A M Valles
    UMR 144, CNRS, Subcellular Structure and Cellular Dynamics, Institute Curie Research Division, Paris, France
    Cell Adhes Commun 4:187-99. 1996
    ..They also indicate that a functional alpha 2 integrin is essential for the motile behavior of NBT-II cells during the FGF-1 induced EMT...
  28. ncbi Decreased expression of keratinocyte growth factor receptor in a subset of human transitional cell bladder carcinomas
    S G Diez de Medina
    UMR 144, CNRS Institut Curie, Paris, France
    Oncogene 14:323-30. 1997
    ..Our results suggest that decreased expression of KGF-R can be considered as a marker of tumor progression in muscle invasive TCCs...
  29. ncbi Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas
    D Cappellen
    Laboratoire de Morphogenèse Cellulaire et Progression Tumorale, UMR 144, Centre National de la Recherche Scientifique, Institut Curie, Section de Recherche, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Genet 23:18-20. 1999
  30. ncbi Relationship between cell migration and cell cycle during the initiation of epithelial to fibroblastoid transition
    C Bonneton
    UM144 Compartimentation et Dynamique Cellulaires Centre National de la Recherche Scientifique et Institut Curie, Paris, France
    Cell Motil Cytoskeleton 43:288-95. 1999
    ..These results indicate that the G1 phase was a critical phase for FGF-1 induced cell migration during epithelial to fibroblastoid transition...
  31. pmc Perturbation of beta1-integrin function in involuting mammary gland results in premature dedifferentiation of secretory epithelial cells
    Marisa M Faraldo
    Unité Mixte Recherche 144, Centre National de la Recherche Scientifique Institut Curie, Section de Recherche, 75248 Paris, France
    Mol Biol Cell 13:3521-31. 2002
    ....
  32. ncbi Myoepithelial cells in the control of mammary development and tumorigenesis: data from genetically modified mice
    Marisa M Faraldo
    Institut Curie, CNRS UMR144, 26 Rue d Ulm, 75248, Paris Cedex 05, France
    J Mammary Gland Biol Neoplasia 10:211-9. 2005
    ....
  33. ncbi Cloning and expression pattern of a mouse homologue of drosophila sprouty in the mouse embryo
    A A de Maximy
    Institut Curie UMR 144 CNRS, 26 Rue d Ulm, 75248, Paris Cedex 05, France
    Mech Dev 81:213-6. 1999
    ..Sprouty4 expression is also detected in the lateral region of the somites. In the developing lung, Sprouty4 is expressed broadly in the distal mesenchyme...
  34. pmc Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells
    P Savagner
    Laboratoire de Physiopathologie du Developpement, Centre National de la Recherche Scientifique Ecole Normale Supérieure, Paris, France
    Mol Biol Cell 5:851-62. 1994
    ..Such transfected cells could bind bFGF as well as aFGF. Therefore, EMT can be induced through different FGF receptors, but EMT may also regulate FGF receptor expression itself...
  35. ncbi Involvement of epidermal growth factor receptor in chemically induced mouse bladder tumour progression
    A el-Marjou
    UMR 144, CNRS, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Carcinogenesis 21:2211-8. 2000
    ..These results suggest that EGFR plays a critical role in bladder tumour progression...
  36. pmc Src and Ras are involved in separate pathways in epithelial cell scattering
    B Boyer
    Laboratoire de Compartimentation et Dynamique cellulaires, UMR CNRS 144, Institut Curie Section de Recherche, 26 rue d Ulm F 75248 Paris Cedex 05, France
    EMBO J 16:5904-13. 1997
    ....
  37. ncbi Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma
    Christophe Rosty
    Departement de Biologie des Tumeurs, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Oncogene 24:7094-104. 2005
    ..HPV expression level may thus provide a biological marker useful for prognosis assessment and specific therapy of the disease...
  38. ncbi YY1 regulates the neural crest-associated slug gene in Xenopus laevis
    Matthew J Morgan
    Institut Curie CNRS UMR144, Morphogenèse cellulaire et progression tumorale, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Biol Chem 279:46826-34. 2004
    ....
  39. ncbi Analysis of array CGH data: from signal ratio to gain and loss of DNA regions
    Philippe Hupe
    Service Bioinformatique, UMR 144 CNRS Institut Curie, 26, rue d Ulm, Paris, 75248 Cedex 05, France
    Bioinformatics 20:3413-22. 2004
    ..The achievement of these goals requires a methodology for detecting the breakpoints delimiting altered regions in genomic patterns and assigning a status (normal, gained or lost) to each chromosomal region...
  40. pmc Clinical and biological characteristics of cervical neoplasias with FGFR3 mutation
    Christophe Rosty
    Departement de Pathologie, Institut Curie, Section Médicale, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Mol Cancer 4:15. 2005
    ..To further analyze the role of FGFR3 in cervical tumor progression, we extended our study to screen a total of 75 invasive tumors and 80 cervical intraepithelial neoplasias (40 low-grade and 40 high-grade lesions)...
  41. ncbi Complex networks orchestrate epithelial-mesenchymal transitions
    Jean Paul Thiery
    Centre National de la Recherche Scientifique CNRS Unité Mixte Recherche UMR 144 and Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Rev Mol Cell Biol 7:131-42. 2006
    ..Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression...
  42. ncbi Isolation of mouse mammary epithelial progenitor cells with basal characteristics from the Comma-Dbeta cell line
    Marie Ange Deugnier
    Institut Curie, UMR144 CNRS, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Dev Biol 293:414-25. 2006
    ..These data provide evidence for the existence of basal-type mouse mammary progenitors able to participate in the morphogenetic processes characteristic of mammary gland development...
  43. ncbi Mouse embryonic mammogenesis as a model for the molecular regulation of pattern formation
    Jacqueline M Veltmaat
    UMR 144 CNRS Institut Curie, Section de Recherche, Equipe de Morphogenèse Cellulaire et Progression Tumorale, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Differentiation 71:1-17. 2003
    ..For future investigations in the field, such a unique molecular identity of each mammary rudiment should be of critical concern...
  44. ncbi beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells
    Marisa M Faraldo
    UMR 144, CNRS Institut Curie, Section de Recherche, 26, rue d Ulm, 75248 Paris, Cedex 05, France
    FEBS Lett 581:831-6. 2007
    ..These data suggest that beta-catenin-dependent modulation of P-cadherin expression can contribute to the establishment of the basal phenotype...
  45. pmc A nonneural epithelial domain of embryonic cranial neural folds gives rise to ectomesenchyme
    Marie Anne Breau
    Centre National de la Recherche Scientifique, Unite Mixte de Recherche 144, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Proc Natl Acad Sci U S A 105:7750-5. 2008
    ....
  46. ncbi Regulation of XSnail2 expression by Rho GTPases
    Florence Broders-Bondon
    Laboratoire de Morphogenèse Cellulaire et Progression Tumorale, UMR144 CNRS Institut Curie, Paris, France
    Dev Dyn 236:2555-66. 2007
    ..These results show that Rho GTPases can regulate the expression of XSnail2 during NC ontogeny...
  47. pmc Perturbation of beta1-integrin function alters the development of murine mammary gland
    M M Faraldo
    UMR 144, CNRS Institut Curie, Section de Recherche, 26, rue d Ulm, 75248, Paris, Cedex 05, France
    EMBO J 17:2139-47. 1998
    ....
  48. ncbi Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans
    Armelle Logie
    UMR 144, Centre National de la Recherche Scientifique, Section de Recherche, Institut Curie, Paris, France
    Hum Mol Genet 14:1153-60. 2005
    ..Our findings directly implicate FGFR3 activation as a major cause of benign epidermal tumors in humans...
  49. ncbi Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage
    Arnaud A Mailleux
    UMR144 CNRS Institut Curie, 75248 Paris Cedex 05, France
    Development 132:2157-66. 2005
    ..We provide support for a role of epithelial BMP4 in mediating the formation of parabronchial smooth muscle cells...
  50. pmc Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells
    Ilaria Taddei
    Institut Curie, Centre de Recherche, Centre National de la Recherche Scientifique UMR144, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Cell Biol 10:716-22. 2008
    ....
  51. ncbi Regional copy number-independent deregulation of transcription in cancer
    Nicolas Stransky
    UMR 144 Centre National de la Recherche Scientifique CNRS Institut Curie, 75248 Paris Cedex 05, France
    Nat Genet 38:1386-96. 2006
    ..We validated one candidate region experimentally, demonstrating histone methylation leading to the loss of expression of neighboring genes without DNA methylation...
  52. ncbi Oncogenic properties of the mutated forms of fibroblast growth factor receptor 3b
    Isabelle Bernard-Pierrot
    UMR 144, CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, and INSERM 0337 and Service d Urologie, Centre Hospitalier Universitaire Henri Mondor, AP HP, Universite Paris XII, 94010 Creteil Cedex, France
    Carcinogenesis 27:740-7. 2006
    ..We showed using siRNA and SU5402, an FGFR inhibitor, that the tumour properties of MGH-U3 depended on mutated receptor activity. Thus, in two different models, mutated FGFR3b presents oncogenic properties...
  53. pmc Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells
    Bérengère Marty
    Département de Transfert, Institut Curie, 26 Rue d Ulm, 75005 Paris, France
    Breast Cancer Res 10:R101. 2008
    ..In contrast to HER2+ carcinomas, no targeted therapy is currently available for the treatment of patients with BLCs. In order to discover potential therapeutic targets, we aimed to discover deregulated signalling pathways in human BLCs...
  54. ncbi Integrins in mammary gland development and differentiation of mammary epithelium
    Ilaria Taddei
    UMR 144 CNRS Institut Curie, Section de Recherche, 26, rue d Ulm, 75248 Paris Cedex 05, France
    J Mammary Gland Biol Neoplasia 8:383-94. 2003
    ....
  55. doi Integrins stimulate E-cadherin-mediated intercellular adhesion by regulating Src-kinase activation and actomyosin contractility
    Clara Martinez-Rico
    UMR144 CNRS Institut Curie, 75248 Paris Cedex 05, France
    J Cell Sci 123:712-22. 2010
    ..These findings highlight the importance and mechanisms of molecular crosstalk between cadherins and integrins in the control of cell plasticity during histogenesis and morphogenesis...
  56. ncbi Identification of the mammary line in mouse by Wnt10b expression
    Jacqueline M Veltmaat
    UMR 144 CNRS Institut Curie, Equipe de Morphogenèse Cellulaire et Progression Tumorale, Paris, France
    Dev Dyn 229:349-56. 2004
    ..To date, the formation of the mammary line expressing Wnt10b is the earliest discernible ectodermal event in murine embryonic mammary gland development...
  57. pmc Fast dissociation kinetics between individual E-cadherin fragments revealed by flow chamber analysis
    Emilie Perret
    Laboratoire de Morphogenèse Cellulaire et Différenciation Tumorale, UMR 144, CNRS Institut Curie, 26 Rue d Ulm, F 75248 Paris Cedex 05, France
    EMBO J 21:2537-46. 2002
    ..A fast off rate and the low tensile strength of the E-cadherin bond may be necessary to support the high selectivity and plasticity of epithelial cell interactions...
  58. ncbi Differential expression of beta3 integrin gene in chick and mouse cranial neural crest cells
    Thomas Pietri
    UMR 144 Compartimentation et Dynamique Cellulaire, Centre National de la Recherche Scientifique et Institut Curie, Paris, France
    Dev Dyn 227:309-13. 2003
    ..Therefore, the difference in the beta3 integrin expression suggests that mouse and chicken cranial neural crest cells may have distinct integrin requirements during their ontogenesis...
  59. ncbi Prognostic value of cytokeratin 19 fragment (CYFRA 21-1) and cytokeratin-positive cells in bone marrow samples of breast cancer patients
    J Y Pierga
    Department of Medical Oncology, Institut Curie, Paris, France
    Int J Biol Markers 19:23-31. 2004
    ..The presence of CK+ cells in bone marrow remains a strong independent prognostic factor in primary breast cancer...
  60. ncbi [From biology to innovating treatments for tumors: a long struggle]
    J P Thiery
    Institut Curie, Paris, France
    Ann Pharm Fr 63:7-9. 2005
  61. ncbi Linking epithelial-mesenchymal transition to the well-known polarity protein Par6
    Jean Paul Thiery
    CNRS UMR 144, Translational Research Department, Institut Curie, 26 Rue d Ulm, 75248 Paris, Cedex 05, France
    Dev Cell 8:456-8. 2005
    ..This new study provides further insight into the protein networks involved in topologically regulated control of epithelial cell polarity and plasticity...
  62. ncbi The human tissue plasminogen activator-Cre mouse: a new tool for targeting specifically neural crest cells and their derivatives in vivo
    Thomas Pietri
    UMR 144 Compartimentation et Dynamique Cellulaire Centre National de la Recherche Scientifique et Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Dev Biol 259:176-87. 2003
    ..Our Ht-PA-Cre mice represent a novel model to specifically target conditional mutations in migratory NCC...
  63. ncbi Real-time quantitative PCR determination of urokinase-type plasminogen activator receptor (uPAR) expression of isolated micrometastatic cells from bone marrow of breast cancer patients
    Jean Yves Pierga
    Medical Oncology Department, Institut Curie, 26 Rue d Ulm, 75231 Paris Cedex 05, France
    Int J Cancer 114:291-8. 2005
    ..A larger study would be useful to confirm the importance of uPAR to define higher risk subgroups of breast cancer patients with micrometastatic disease...
  64. pmc Force measurements in E-cadherin-mediated cell doublets reveal rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc42
    Yeh Shiu Chu
    Centre National de la Recherche Scientifique Institut Curie, Paris, France
    J Cell Biol 167:1183-94. 2004
    ..Our findings highlight the crucial roles played by Rac, Cdc42, and actin cytoskeleton dynamics in the development and regulation of strong cell adhesion, defined in terms of mechanical forces...
  65. ncbi Separation force measurements reveal different types of modulation of E-cadherin-based adhesion by nectin-1 and -3
    Clara Martinez-Rico
    UMR 144 CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Biol Chem 280:4753-60. 2005
    ....
  66. ncbi N-cadherin transcripts in Xenopus laevis from early tailbud to tadpole
    L Simonneau
    Laboratoire de Physiopathologie du Developpement, CNRS URA 1337, Paris, France
    Dev Dyn 194:247-60. 1992
    ..In the brain and the heart, high levels of hybridization are observed with probes corresponding to both copies of the N-cadherin pseudo-allelic genes in their 5' non-coding region, indicating that both alleles are transcribed...
  67. pmc Design of a real time quantitative PCR assay to assess global mRNA amplification of small size specimens for microarray hybridisation
    V Choesmel
    UMR144 CNRS, Research Division, Institut Curie, 75248 Paris Cedex 05, France
    J Clin Pathol 57:1278-87. 2004
    ..Low RNA yields from clinical samples are a limiting step for microarray technology...
  68. ncbi Absence of FGFR3 mutations in urinary bladder tumours of rats and mice treated with N-butyl-N-(-4-hydroxybutyl)nitrosamine
    Claire Dunois-Lardé
    Laboratoire de Morphogenèse Cellulaire et Progression Tumorale, UMR 144, Centre National de la Recherche Scientifique, Institut Curie, Section de Recherche, Paris, France
    Mol Carcinog 42:142-9. 2005
    ..The absence of FGFR3 mutations in the rat bladder tumours suggests that, at least at the genetic level, rat superficial papillary tumours differ from their human counterparts...
  69. ncbi Inhibition of human bladder tumour cell growth by fibroblast growth factor receptor 2b is independent of its kinase activity. Involvement of the carboxy-terminal region of the receptor
    Isabelle Bernard-Pierrot
    UMR144, CNRS Institut Curie, Section de Recherche, 26 Rue d Ulm, 75248 Paris Cedex, France
    Oncogene 23:9201-11. 2004
    ..Our data suggest that FGFR2b inhibits the growth of bladder carcinoma cells by reducing IGF-II levels via its carboxy-terminal domain, independent of its tyrosine kinase activity...
  70. ncbi FGFR3 and TP53 gene mutations define two distinct pathways in urothelial cell carcinoma of the bladder
    Ashraf A Bakkar
    Equipe mixte Inserm Institut National de la Santé et de la Recherche Médicale, and Service d Urologie, Paris, France
    Cancer Res 63:8108-12. 2003
    ..003), high-grade (P < 0.02) tumors. Mutations in these two genes were almost mutually exclusive. Our results suggest that FGFR3 and TP53 mutations define separate pathways at initial diagnosis of urothelial cell carcinoma...
  71. pmc Enrichment methods to detect bone marrow micrometastases in breast carcinoma patients: clinical relevance
    Valerie Choesmel
    UMR144 CNRS, Research Division, Institut Curie, Paris, France
    Breast Cancer Res 6:R556-70. 2004
    ..In the present study, we have assessed the clinical relevance of current methods aimed at detecting rare disseminated carcinoma cells...
  72. pmc The importance of being a myoepithelial cell
    Marie Ange Deugnier
    UMR 144 CNRS Institut Curie, Section de Recherche, Paris, France
    Breast Cancer Res 4:224-30. 2002
    ..These functions include their effects on luminal cell growth and differentiation, their key role in the establishment of the polarised mammary epithelial bilayer and the control of stromal invasion in breast cancer...
  73. doi Integrated genomic and transcriptomic analysis of ductal carcinoma in situ of the breast
    Anne Vincent-Salomon
    Institut Curie, Department of Tumor Biology, Paris, France
    Clin Cancer Res 14:1956-65. 2008
    ..To gain insight into genomic and transcriptomic subtypes of ductal carcinomas in situ of the breast (DCIS)...
  74. ncbi Prototypical type I E-cadherin and type II cadherin-7 mediate very distinct adhesiveness through their extracellular domains
    Yeh Shiu Chu
    UMR 144 CNRS Institut Curie, 75248 Paris, France
    J Biol Chem 281:2901-10. 2006
    ....
  75. ncbi Nuclear FGF-2 facilitates cell survival in vitro and during establishment of metastases
    Rachel J Thomas-Mudge
    UMR144 CNRS, Institut Curie, Research Division, 26 Rue d Ulm, 75248 Paris 05, France
    Oncogene 23:4771-9. 2004
    ..This study provides both in vitro and in vivo evidence that the role of the nuclear 24 kDa FGF-2 isoform in carcinoma is the promotion of cell survival, thereby defining its association with poor prognosis in some human carcinomas...
  76. pmc Role of E-cadherin in membrane-cortex interaction probed by nanotube extrusion
    Erdem Tabdanov
    Unite Mixte de Recherche 144, Centre National de la Recherche Scientifique Institut Curie, Paris, France
    Biophys J 96:2457-65. 2009
    ..Occasional giant "cortex" tubes were extruded with specifically anchored cells, demonstrating that the cortex remained tightly bound to the membrane through Ecad-mediated adhesion at the contact site...
  77. pmc Evaluation of methods for amplification of picogram amounts of total RNA for whole genome expression profiling
    Mathieu Clément-Ziza
    Institut Curie, Département de Transfert, 26 Rue d Ulm, F 75248, Paris Cedex 05, France
    BMC Genomics 10:246. 2009
    ..To address this issue, RNA amplification methods have been developed to generate sufficient targets from picogram amounts of total RNA to perform microarray hybridisation...
  78. ncbi Visualizing chromosomes as transcriptome correlation maps: evidence of chromosomal domains containing co-expressed genes--a study of 130 invasive ductal breast carcinomas
    Fabien Reyal
    Unite Mixte de Recherche 144, Centre National de la Recherche Scientifique, Paris, France
    Cancer Res 65:1376-83. 2005
    ..Transcription correlation maps are a new way of visualizing transcriptome data. They will help to identify new genes involved in tumor progression and new mechanisms of gene regulation in tumors...
  79. ncbi Johnson-Kendall-Roberts theory applied to living cells
    Yeh Shiu Chu
    UMR 144, Centre National de la Recherche Scientifique et Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Phys Rev Lett 94:028102. 2005
    ..When the cytoskeleton is disrupted, JKR theory is no longer applicable...
  80. ncbi Conditional beta1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system
    Thomas Pietri
    UMR144, CNRS, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Development 131:3871-83. 2004
    ..Thus, beta1-integrins are important for the control of embryonic and postnatal peripheral nervous system development...
  81. ncbi Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer
    Geert Berx
    Department for Molecular Biomedical Research, Molecular and Cellular Oncology, VIB, Technologiepark 927, 9052, Ghent Zwijnaarde, Belgium
    Clin Exp Metastasis 24:587-97. 2007
    ..Finally we review the recent literature concerning the mechanisms that regulate EMT in the tumour context, with a particular focus on breast cancer...
  82. ncbi Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes
    Jacqueline M Veltmaat
    The Saban Research Institute of Childrens Hospital Los Angeles University of Southern California, Developmental Biology Program, Los Angeles, CA 90027, USA
    Development 133:2325-35. 2006
    ..We propose that the intra-somitic Fgf10 gradient, together with ventral elongation of the somites, determines the correct dorsoventral position of mammary epithelium along the flank...
  83. ncbi Breast cancer progression with a Twist
    Jean Paul Thiery
    Nat Med 10:777-8. 2004
  84. ncbi Profiles of the 2 INK4a gene products, p16 and p14ARF, in human reference urothelium and bladder carcinomas, according to pRb and p53 protein status
    Marie Aude Le Frere-Belda
    Service d Anatomie et de Cytologie Pathologiques and Oncogénèse respiratoire et uro génitale EMI Institut National de la Santé de la Recherche Medical INSERM, Centre Hospitalier Universitaire Henri Mondor, Creteil, France
    Hum Pathol 35:817-24. 2004
    ..In invasive UCs, the p16-pRb pathway, the p14(ARF)-p53 pathway, or in many cases both pathways were altered or not activated, demonstrating the involvement of these pathways in invasive bladder tumorigenesis...
  85. pmc Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin
    Christine E Wong
    Department of Biology, Institute of Cell Biology, Swiss Federal Institute of Technology ETH Zurich, CH 8093 Zurich, Switzerland
    J Cell Biol 175:1005-15. 2006
    ..These findings are relevant for the design of therapeutic strategies because the potential of stem and progenitor cells in vivo likely depends on their nature and origin...
  86. pmc The physiology and pathology of the EMT. Meeting on the epithelial-mesenchymal transition
    Hervé Acloque
    Instituto de Neurociencias de Alicante, CSIC UMH, Apartado 18, San Juan de Alicante, 03550 Spain
    EMBO Rep 9:322-6. 2008
  87. ncbi Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo
    Arnaud André Mailleux
    UMR144 CNRS Institut Curie, 26 rue d Ulm 75248 Paris Cedex 05, France
    Development 129:53-60. 2002
    ..Our results also suggest that FGF signaling is involved in the maintenance of mammary bud 4, and that Fgf10 deficient epithelium can undergo branching morphogenesis into the mammary fat pad precursor...
  88. ncbi Changes in cholesterol levels in the plasma membrane modulate cell signaling and regulate cell adhesion and migration on fibronectin
    O G Ramprasad
    Center for Cellular and Molecular Biology, Hyderabad, India
    Cell Motil Cytoskeleton 64:199-216. 2007
    ..Thus, membrane cholesterol content has a specific effect on certain signaling pathways specifically involved in regulating cell motility on fibronectin and organization of the actin cytoskeleton...
  89. ncbi Growth, differentiation and senescence of normal human urothelium in an organ-like culture
    Ahmad Daher
    INSERM EMI 03 37, Faculte de Medecine, 8, rue du Général Sarrail, Universite Paris 12, 94000 Creteil Cedex, France
    Eur Urol 45:799-805. 2004
    ..To examine the kinetics of growth, differentiation and senescence of normal human urothelium in an organoid-like culture model...
  90. ncbi Differential regulation of the lateral mobility of plasma membrane phospholipids by the extracellular matrix and cholesterol
    O G Ramprasad
    Center for Cellular and Molecular Biology, Hyderabad, India
    J Cell Physiol 215:550-61. 2008
    ..Our results outline a new role of integrin-matrix interactions in the regulation of membrane phospholipid behavior...