Jacques Theze

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. ncbi request reprint [CD4 lymphocytes as targets and actors in the pathogenesis of HIV infection--therapeutic implications]
    Jacques Theze
    Unité d Immunogénétique Cellulaire, Centre d Infectiologie Necker Pasteur, Institut Pasteur, 25 28 Rue du Docteur Roux, 75015 Paris
    Bull Acad Natl Med 192:1453-66; discussion 1466-8. 2008
  2. ncbi request reprint [Role of CD4 lymphocytes in the efficient immune response of HIV controllers]
    Jacques Theze
    Unité d Immunogénétique Cellulaire, Centre d Infectiologie Necker Pasteur, Institut Pasteur, 25 28 Rue du Docteur Roux, 75015 Paris
    Bull Acad Natl Med 195:545-57; discussion 557-9. 2011
  3. pmc The first alpha helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta chain, and induces lymphokine-activated killer cells
    R Eckenberg
    Unité d Immunogénétique Cellulaire, Institut Pasteur, 75015 Paris, France
    J Exp Med 191:529-40. 2000
  4. pmc HIV controllers: a multifactorial phenotype of spontaneous viral suppression
    Jacques Theze
    Unité d Immunogénétique Cellulaire, Institut Pasteur, 75015, Paris, France
    Clin Immunol 141:15-30. 2011
  5. doi request reprint IL-2 induces conformational changes in its preassembled receptor core, which then migrates in lipid raft and binds to the cytoskeleton meshwork
    Anne Hélène Pillet
    Institut Pasteur, Département Infection et Epidémiologie, Departement d Immunologie, Unité d Immunogénétique Cellulaire, Paris, France
    J Mol Biol 403:671-92. 2010
  6. ncbi request reprint Constitutive expression of IL-2Rbeta chain and its effects on IL-2-induced vascular leak syndrome
    Eric Assier
    Unite de Pharmacologie Cellulaire, Institut Pasteur, Paris, France
    Cytokine 32:280-6. 2005
  7. ncbi request reprint Defective interleukin-2-dependent STAT5 signalling in CD8 T lymphocytes from HIV-positive patients: restoration by antiretroviral therapy
    Marko Kryworuchko
    Unit of Cellular Immunogenetics, Institut Pasteur, Paris
    AIDS 18:421-6. 2004
  8. ncbi request reprint Regulatory dysfunction of the interleukin-7 receptor in CD4 and CD8 lymphocytes from HIV-infected patients--effects of antiretroviral therapy
    Jean Hervé Colle
    Unité Immunogénétique Cellulaire, Département de Médecine Moléculaire, Institut Pasteur, Paris, France
    J Acquir Immune Defic Syndr 42:277-85. 2006
  9. doi request reprint HIV infection impairs CCR7-dependent T-cell chemotaxis independent of CCR7 expression
    Santiago Perez-Patrigeon
    Institut Pasteur, Paris, France
    AIDS 23:1197-207. 2009
  10. pmc Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway
    Olivier Juffroy
    Institut Pasteur, Unité d Immunogénétique Cellulaire, 75724 Paris Cedex 15, France
    J Virol 84:96-108. 2010

Collaborators

  • Lisa A Chakrabarti
  • Olivier Lambotte
  • Thierry Rose
  • Arnaud Fontanet
  • Ivan Landires
  • Jean Paul Viard
  • William W Kwok
  • Daniel Scott-Algara
  • S Chouaib
  • S Dubois
  • Cecile Goujard
  • Jean Philippe Herbeuval
  • Olivier Lortholary
  • James P Di Santo
  • Ioannis Theodorou
  • Anne Hélène Pillet
  • Jean Francois Delfraissy
  • Jean Hervé Colle
  • Benoit Vingert
  • Florence Bugault
  • Santiago Perez-Patrigeon
  • Jean Louis Moreau
  • Stéphanie Beq
  • Franck Gesbert
  • Faroudy Boufassa
  • Olivier Juffroy
  • Eric Assier
  • Blanche Tamarit
  • Daniela Benati
  • Vincent Lavergne
  • Patricia Chastagner
  • Patricia Jeannin
  • Marcel Joussemet
  • Fabrice Lemaitre
  • Denis David
  • Simon J Potter
  • Virginie Pasquier
  • Jose R Lapa e Silva
  • Jean Lefort
  • B Boris Vargaftig
  • Valérie Jullien
  • Marko Kryworuchko
  • Hélène Keller
  • Nathalie Garin
  • Ulf Schwarz
  • Pascal Bochet
  • Vincent Pestre
  • Pierre Rohrlich
  • Luc Mouthon
  • Laurence Slama
  • Moran Galperin
  • Pierre de Truchis
  • R Eckenberg
  • Loïc Niel
  • Virginie Mazard-Pasquier
  • Martine Sinet
  • Alejandra Urrutia
  • Alain Venet
  • Christine Lacabaratz
  • Sylvie Jacod
  • Jacques Gilquin
  • Marie Thérèse Rannou
  • Bertrand Gachot
  • Lella Naït-Ighil
  • Jean Maral
  • Bertrand Dupont
  • Jay Reddy
  • Marie Pierre Treilhou
  • P M Alzari
  • M Bossus
  • H Gras
  • J L Moreau
  • M Goldberg
  • D Tello
  • J Bertoglio
  • R Weil
  • Y Jacques
  • A Tartar
  • F Gesbert

Detail Information

Publications31

  1. ncbi request reprint [CD4 lymphocytes as targets and actors in the pathogenesis of HIV infection--therapeutic implications]
    Jacques Theze
    Unité d Immunogénétique Cellulaire, Centre d Infectiologie Necker Pasteur, Institut Pasteur, 25 28 Rue du Docteur Roux, 75015 Paris
    Bull Acad Natl Med 192:1453-66; discussion 1466-8. 2008
    ..Our studies have opened the door to cytokine-based immunotherapy and to the development of new drug- and vaccine-based strategies...
  2. ncbi request reprint [Role of CD4 lymphocytes in the efficient immune response of HIV controllers]
    Jacques Theze
    Unité d Immunogénétique Cellulaire, Centre d Infectiologie Necker Pasteur, Institut Pasteur, 25 28 Rue du Docteur Roux, 75015 Paris
    Bull Acad Natl Med 195:545-57; discussion 557-9. 2011
    ..Our new findings should help to guide antiretroviral therapy and vaccination strategies...
  3. pmc The first alpha helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta chain, and induces lymphokine-activated killer cells
    R Eckenberg
    Unité d Immunogénétique Cellulaire, Institut Pasteur, 75015 Paris, France
    J Exp Med 191:529-40. 2000
    ..Altogether, our data suggest that p1-30 has therapeutic potential...
  4. pmc HIV controllers: a multifactorial phenotype of spontaneous viral suppression
    Jacques Theze
    Unité d Immunogénétique Cellulaire, Institut Pasteur, 75015, Paris, France
    Clin Immunol 141:15-30. 2011
    ..We discuss major controversies in the field and the relevance of the study of HIV controllers for the development of novel therapeutic strategies and vaccines...
  5. doi request reprint IL-2 induces conformational changes in its preassembled receptor core, which then migrates in lipid raft and binds to the cytoskeleton meshwork
    Anne Hélène Pillet
    Institut Pasteur, Département Infection et Epidémiologie, Departement d Immunologie, Unité d Immunogénétique Cellulaire, Paris, France
    J Mol Biol 403:671-92. 2010
    ....
  6. ncbi request reprint Constitutive expression of IL-2Rbeta chain and its effects on IL-2-induced vascular leak syndrome
    Eric Assier
    Unite de Pharmacologie Cellulaire, Institut Pasteur, Paris, France
    Cytokine 32:280-6. 2005
    ..This study also characterizes a humanized animal model that could be further used to study human IL-2 activity and side effects in vivo...
  7. ncbi request reprint Defective interleukin-2-dependent STAT5 signalling in CD8 T lymphocytes from HIV-positive patients: restoration by antiretroviral therapy
    Marko Kryworuchko
    Unit of Cellular Immunogenetics, Institut Pasteur, Paris
    AIDS 18:421-6. 2004
    ..The STAT5 transcription factor is important in IL-2-dependent biological responses and it is known that there are defects in unstimulated CD3 and CD4 cells in HIV-infected patients...
  8. ncbi request reprint Regulatory dysfunction of the interleukin-7 receptor in CD4 and CD8 lymphocytes from HIV-infected patients--effects of antiretroviral therapy
    Jean Hervé Colle
    Unité Immunogénétique Cellulaire, Département de Médecine Moléculaire, Institut Pasteur, Paris, France
    J Acquir Immune Defic Syndr 42:277-85. 2006
    ..This may be due to abnormal activation of the immune system in HIV-infected patients and may contribute to the reduced CD4 count and the altered function of the CD8 compartment...
  9. doi request reprint HIV infection impairs CCR7-dependent T-cell chemotaxis independent of CCR7 expression
    Santiago Perez-Patrigeon
    Institut Pasteur, Paris, France
    AIDS 23:1197-207. 2009
    ..We investigated CCR7 expression and chemotactic function in patient T cells, to gain further insights into mechanisms of T-cell dysfunction in HIV infection...
  10. pmc Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway
    Olivier Juffroy
    Institut Pasteur, Unité d Immunogénétique Cellulaire, 75724 Paris Cedex 15, France
    J Virol 84:96-108. 2010
    ..Thus, HIV infection perturbs IL-7 responses at both receptor binding and signaling steps, which likely compromises the regenerative capacity of the CD4(+) T-cell pool and may contribute to CD4(+) T-cell depletion...
  11. pmc HIV controllers maintain a population of highly efficient Th1 effector cells in contrast to patients treated in the long term
    Benoit Vingert
    Unité d Immunogénétique Cellulaire, Institut Pasteur, Paris, France
    J Virol 86:10661-74. 2012
    ..In conclusion, HIV controllers maintained a population of highly efficient Th1 effectors directed against Gag in spite of a persistently low antigenemia, while patients treated in the long term showed a loss of CD4 effector functions...
  12. ncbi request reprint Interleukin-7 (IL-7): immune function, involvement in the pathogenesis of HIV infection and therapeutic potential
    Stéphanie Beq
    Unité d Immunogénétique Cellulaire, Département de Médecine Moléculaire, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Eur Cytokine Netw 15:279-89. 2004
    ..IL-7, based therapy, combined with efficient antiretroviral treatment, may be beneficial to HIV-infected patients by promoting thymic output, sustaining naive T cell counts and increasing memory T cell activation...
  13. ncbi request reprint The correlation between levels of IL-7Ralpha expression and responsiveness to IL-7 is lost in CD4 lymphocytes from HIV-infected patients
    Jean Hervé Colle
    Unité Immunogénétique Cellulaire, Département Infection et Epidémiologie, Institut Pasteur, Paris, France
    AIDS 21:101-3. 2007
    ..IL-7 responsiveness is only partly restored by HAART...
  14. pmc Altered responses to homeostatic cytokines in patients with idiopathic CD4 lymphocytopenia
    Florence Bugault
    Unité d Immunogénétique Cellulaire, Institut Pasteur, Paris, France
    PLoS ONE 8:e55570. 2013
    ..Increased TSLP responses point to a compensatory homeostatic mechanism that may mitigate defects in γc cytokine responses...
  15. pmc Membrane microdomains and cytoskeleton organization shape and regulate the IL-7 receptor signalosome in human CD4 T-cells
    Blanche Tamarit
    Institut Pasteur, Département Infection et Epidémiologie, Departement d Immunologie, Unité d Immunogénétique Cellulaire, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 288:8691-701. 2013
    ..Radial microtubules disappear 15 min later, while transversal microtubules, independent of phospho-STAT5 transport, begin to bud from the microtubule organization center...
  16. doi request reprint HIV infection perturbs interleukin-7 signaling at the step of STAT5 nuclear relocalization
    Ivan Landires
    Pasteur Institute, Cellular Immunogenetics Unit, Paris, France
    AIDS 25:1843-53. 2011
    ..We set to investigate the nature of IL-7-dependent signaling defects in patients with progressive HIV-1 infection...
  17. pmc HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity
    Benoit Vingert
    Unité d Immunogénétique Cellulaire, Institut Pasteur, Paris, France
    PLoS Pathog 6:e1000780. 2010
    ..Thus, HIV controllers harbor a pool of memory CD4+ T cells with the intrinsic ability to recognize minimal amounts of Gag antigen, which may explain how they maintain an active antiviral response in the face of very low viremia...
  18. doi request reprint Human IL-Rbeta chains form IL-2 binding homodimers
    Anne Hélène Pillet
    Unité d Immunogénétique Cellulaire, Département Infection et Epidémiologie, Institut Pasteur, Paris, France
    Eur Cytokine Netw 19:49-59. 2008
    ..IL-2Rbeta/IL-2Rbeta could represent either a decoy receptor or a new form of IL-2R involved in signaling when gammac expression is low...
  19. pmc Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response
    Thierry Rose
    Département Infection et Epidémiologie, Institut Pasteur, Unité d Immunogénétique Cellulaire, Paris, France
    J Biol Chem 285:14898-908. 2010
    ..Thus, early events leading to IL-7 signal transduction involve its receptor compartmentalization into membrane nanodomains and cytoskeleton recruitment...
  20. ncbi request reprint IL-2 responsiveness of CD4 and CD8 lymphocytes: further investigations with human IL-2Rbeta transgenic mice
    Franck Gesbert
    Unité d Immunogénétique Cellulaire, Département de Médecine Moléculaire, Institut Pasteur, 25 28, rue du Dr Roux, 75724 Paris Cedex 15, France
    Int Immunol 17:1093-102. 2005
    ..But in CD8 lymphocytes, IL-2 down-modulates p27(kip1). These results indicate that, aside from IL-2R expression and function, IL-2 responsiveness is also controlled by lineage-specific mechanisms...
  21. ncbi request reprint Involvement of Bcl-2 and IL-2R in HIV-positive patients whose CD4 cell counts fail to increase rapidly with highly active antiretroviral therapy
    Denis David
    Unité d Immunogénétique Cellulaire, Département d Immunologie and Centre de Recherche Clinique, Institut Pasteur, Paris, France
    AIDS 16:1093-101. 2002
    ..The mechanism responsible for this failure was investigated...
  22. pmc Preserved central memory and activated effector memory CD4+ T-cell subsets in human immunodeficiency virus controllers: an ANRS EP36 study
    Simon J Potter
    Unité d Immunogénétique Cellulaire, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Virol 81:13904-15. 2007
    ..These findings suggest the induction of an efficient, nondetrimental type of immune activation in patients who spontaneously control HIV...
  23. ncbi request reprint HIV infection: pre-highly active antiretroviral therapy IL-7 plasma levels correlate with long-term CD4 cell count increase after treatment
    Stéphanie Beq
    Unité d Immunogénétique Cellulaire, Institut Pasteur, Paris, France
    AIDS 18:563-5. 2004
    ..A positive correlation was found in a cohort of 18 patients between pre-HAART IL-7 plasma levels and CD4 cell increases after 20 +/- 7.8 months of HAART...
  24. doi request reprint A programmed switch from IL-15- to IL-2-dependent activation in human NK cells
    Anne Hélène Pillet
    Départment d Infection et d Epidémiologie, Unité d Immunogénétique Cellulaire, Institut Pasteur, Paris, France
    J Immunol 182:6267-77. 2009
    ..Such a program may prevent excessive human NK cell activation by effectors of innate immunity and regulate the transition between the innate and adaptive stages of immune responses...
  25. doi request reprint Interleukin (IL)-2 and IL-15 have different effects on human natural killer lymphocytes
    Anne Hélène Pillet
    Institut Pasteur, Unité d Immunogénétique Cellulaire, Département d Infection et d Epidémiologie, Paris, France
    Hum Immunol 72:1013-7. 2011
    ..By contrast, IL-2 induces the rapid disappearance of IL-2Rα and γ(c) chains when the gene transcription is downregulated, shutting down IL-2-responses as demonstrated by the absence of STAT5 phosphorylation and BCL2 expression...
  26. ncbi request reprint NK cells and polymorphonuclear neutrophils are both critical for IL-2-induced pulmonary vascular leak syndrome
    Eric Assier
    Unite de Pharmacologie Cellulaire, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Immunol 172:7661-8. 2004
    ..Together our results indicate that both NK and PMN cells play a central role in the late events of IL-2-induced VLS...
  27. doi request reprint Short communication: nuclear JAK3 and its involvement in CD4 activation in HIV-infected patients
    Ivan Landires
    Unité d Immunogénétique Cellulaire, Département Infection et Epidémiologie et Département d Immunologie, Institut Pasteur, Paris, France
    AIDS Res Hum Retroviruses 29:784-7. 2013
    ....
  28. ncbi request reprint IL-7 and Flt-3L plasma levels are increased during highly active antiretroviral therapy-associated IL-2 therapy
    Stéphanie Beq
    Unité d Immunogénétique Cellulaire, Institut Pasteur, Paris, France
    AIDS 18:2089-91. 2004
    ..This supports the hypothesis that aside from stimulating CD4 T cells IL-2 may also indirectly affect lymphocyte production through the stimulation of lymphopoietic cytokines...
  29. ncbi request reprint Structural analysis and modeling of a synthetic interleukin-2 mimetic and its interleukin-2Rbeta2 receptor
    Thierry Rose
    Departement de Biologie Structurale et Chimie, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 278:22868-76. 2003
    ....
  30. ncbi request reprint Lymphoadenopathy in IL-2-deficient mice: further characterization and overexpression of the antiapoptotic molecule cellular FLIP
    Patricia Chastagner
    Unité d Immunogénétique Cellulaire, Département de Médecine Moléculaire, Institut Pasteur, Paris, France
    J Immunol 169:3644-51. 2002
    ..These results suggest that FLIP, in conjunction with other IL-2-regulated genes previously characterized in our laboratory, is involved in controlling lymphoadenopathy in IL-2(-/-) mice...
  31. pmc Characteristics of plasmacytoid dendritic cell and CD4+ T cell in HIV elite controllers
    Jean Philippe Herbeuval
    CNRS UMR 8147 and Hôpital Necker, Universite Paris Descartes, 149 161 Rue de Sèvres, 75015 Paris, France
    Clin Dev Immunol 2012:869505. 2012
    ..Controllers represent a heterogeneous population; we describe in this paper some common characteristics concerning innate immune response and CD4+ T cells of HIV controllers...