Clotilde Thery

Summary

Affiliation: Institut Curie
Country: France

Publications

  1. doi request reprint Membrane vesicles as conveyors of immune responses
    Clotilde Thery
    Institut National de la Santé et de la Recherche Médicale U932, Institut Curie, 26 Rue d Ulm, Paris, 75005, France
    Nat Rev Immunol 9:581-93. 2009
  2. ncbi request reprint The cell biology of antigen presentation in dendritic cells
    C Thery
    U520 Institut National de la Santé et de la Recherche Médicale INSERM, Institut Curie, Section Recherche, 12 rue Lhomond, 75005 Paris, France
    Curr Opin Immunol 13:45-51. 2001
  3. doi request reprint [In vivo secreted vesicles allow improvement of anti-tumor immune response]
    Clotilde Thery
    INSERM U653, Institut Curie, Section Recherche, Paris, France
    Med Sci (Paris) 24:581-3. 2008
  4. ncbi request reprint Exosomes: composition, biogenesis and function
    Clotilde Thery
    INSERM U520, Institut Curie, 12 rue Lhomond, 75005 Paris, France
    Nat Rev Immunol 2:569-79. 2002
  5. ncbi request reprint Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles
    C Thery
    Institut National de la Sante et de la Recherche Medical, Unité 520, Institut Curie, Paris, France
    J Immunol 166:7309-18. 2001
  6. ncbi request reprint Indirect activation of naïve CD4+ T cells by dendritic cell-derived exosomes
    Clotilde Thery
    INSERM U520, Institut Curie, 12 rue Lhomond, 75005 Paris, France
    Nat Immunol 3:1156-62. 2002
  7. ncbi request reprint Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses
    Elodie Segura
    INSERM U653, Institut Curie, 26 Rue d Ulm, 75245 Paris Cedex 05, France
    Blood Cells Mol Dis 35:89-93. 2005
  8. ncbi request reprint Accumulation of MFG-E8/lactadherin on exosomes from immature dendritic cells
    Philippe Veron
    INSERM U653, Institut Curie, 26 Rue d Ulm, 75245 Paris Cedex 05, France
    Blood Cells Mol Dis 35:81-8. 2005
  9. ncbi request reprint CD8+ dendritic cells use LFA-1 to capture MHC-peptide complexes from exosomes in vivo
    Elodie Segura
    Centre de Recherche, Institut Curie, Paris, France
    J Immunol 179:1489-96. 2007
  10. ncbi request reprint Antigen presentation and T cell stimulation by dendritic cells
    Pierre Guermonprez
    Institut Curie, INSERM U520, 12 rue Lhomond, 75005 Paris, France
    Annu Rev Immunol 20:621-67. 2002

Collaborators

Detail Information

Publications24

  1. doi request reprint Membrane vesicles as conveyors of immune responses
    Clotilde Thery
    Institut National de la Santé et de la Recherche Médicale U932, Institut Curie, 26 Rue d Ulm, Paris, 75005, France
    Nat Rev Immunol 9:581-93. 2009
    ..This Review focuses on the role of membrane vesicles, in particular exosomes, in the communication between immune cells, and between tumour and immune cells...
  2. ncbi request reprint The cell biology of antigen presentation in dendritic cells
    C Thery
    U520 Institut National de la Santé et de la Recherche Médicale INSERM, Institut Curie, Section Recherche, 12 rue Lhomond, 75005 Paris, France
    Curr Opin Immunol 13:45-51. 2001
    ..The molecular mechanisms responsible for the control of antigen uptake and processing, for the generation of MHC-peptide complexes and for their transport to the cell surface have been partially unraveled in the past two years...
  3. doi request reprint [In vivo secreted vesicles allow improvement of anti-tumor immune response]
    Clotilde Thery
    INSERM U653, Institut Curie, Section Recherche, Paris, France
    Med Sci (Paris) 24:581-3. 2008
  4. ncbi request reprint Exosomes: composition, biogenesis and function
    Clotilde Thery
    INSERM U520, Institut Curie, 12 rue Lhomond, 75005 Paris, France
    Nat Rev Immunol 2:569-79. 2002
  5. ncbi request reprint Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles
    C Thery
    Institut National de la Sante et de la Recherche Medical, Unité 520, Institut Curie, Paris, France
    J Immunol 166:7309-18. 2001
    ..Therefore, in addition to cytokines, dendritic cells produce a specific population of membrane vesicles, exosomes, with unique molecular composition and strong immunostimulating properties...
  6. ncbi request reprint Indirect activation of naïve CD4+ T cells by dendritic cell-derived exosomes
    Clotilde Thery
    INSERM U520, Institut Curie, 12 rue Lhomond, 75005 Paris, France
    Nat Immunol 3:1156-62. 2002
    ..Such a mechanism may increase the number of DCs bearing a particular peptide, thus amplifying the initiation of primary adaptive immune responses...
  7. ncbi request reprint Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses
    Elodie Segura
    INSERM U653, Institut Curie, 26 Rue d Ulm, 75245 Paris Cedex 05, France
    Blood Cells Mol Dis 35:89-93. 2005
    ..MHC class II and ICAM-1 were necessary for the increased immune activity of exosomes secreted by mature DCs. Therefore, changes in protein composition and priming abilities of exosomes reflect the maturation signals received by DCs...
  8. ncbi request reprint Accumulation of MFG-E8/lactadherin on exosomes from immature dendritic cells
    Philippe Veron
    INSERM U653, Institut Curie, 26 Rue d Ulm, 75245 Paris Cedex 05, France
    Blood Cells Mol Dis 35:81-8. 2005
    ..We conclude that MFG-E8 is efficiently targeted to exosomes but is not essential to address exosomes to mouse BMDCs. Involvement of MFG-E8/lactadherin in exosome targeting to other DC subpopulations, or to human DCs, is still possible...
  9. ncbi request reprint CD8+ dendritic cells use LFA-1 to capture MHC-peptide complexes from exosomes in vivo
    Elodie Segura
    Centre de Recherche, Institut Curie, Paris, France
    J Immunol 179:1489-96. 2007
    ..We propose a new role for LFA-1 on DCs, as a receptor for exosomes to favor Ag transfer between DCs in vivo...
  10. ncbi request reprint Antigen presentation and T cell stimulation by dendritic cells
    Pierre Guermonprez
    Institut Curie, INSERM U520, 12 rue Lhomond, 75005 Paris, France
    Annu Rev Immunol 20:621-67. 2002
    ..These specializations account for dendritic cells' unique role in the initiation of immune responses and the induction of tolerance...
  11. pmc CD8+ tumor-infiltrating T cells are trapped in the tumor-dendritic cell network
    Alexandre Boissonnas
    Institut National de la Sante et de la Recherche Medicale, UMR S945, Immunité et Infection, Hopital Pitie Salpetriere, Paris, France
    Neoplasia 15:85-94. 2013
    ..We propose that the TuDC network exerts antigen-dependent unproductive retention that trap T cells and limit their antitumor effectiveness...
  12. doi request reprint Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses
    Ingrid S Zeelenberg
    Institut National de la Sante et de la Recherche Medicale U653, Paris, France
    Cancer Res 68:1228-35. 2008
    ..We conclude that the mode of secretion can determine the immunogenicity of tumor antigens and that manipulation of the mode of antigen secretion may be used to optimize antitumor vaccination protocols...
  13. doi request reprint Rab27a and Rab27b control different steps of the exosome secretion pathway
    Matias Ostrowski
    INSERM U932, 26 Rue d Ulm, 75005 Paris, France
    Nat Cell Biol 12:19-30; sup pp 1-13. 2010
    ..Our results therefore strengthen the link between MVEs and exosomes, and introduce ways of manipulating exosome secretion in vivo...
  14. ncbi request reprint ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming
    Elodie Segura
    Institut National de la Sante et de la Recherche Medicale, Laboratory of Mass Spectrometry and Proteomics, Centre National de la Recherche Scientifique Unite Mixte de Recherche, Paris, France
    Blood 106:216-23. 2005
    ..2 and MFG-E8 are dispensable. Therefore, changes in protein composition and priming abilities of exosomes reflect the maturation signals received by DCs...
  15. doi request reprint Exosome secretion: molecular mechanisms and roles in immune responses
    Angélique Bobrie
    Institut Curie, Paris, France
    Traffic 12:1659-68. 2011
    ....
  16. doi request reprint Updated technology to produce highly immunogenic dendritic cell-derived exosomes of clinical grade: a critical role of interferon-γ
    Sophie Viaud
    Institut National de la Sante et de la Recherche Medicale INSERM, U1015, Paris, France
    J Immunother 34:65-75. 2011
    ..In this study, we describe the clinical grade process to manufacture large-scale interferon-γ-Dex vaccines and their quality control parameters currently used in a phase II trial...
  17. doi request reprint Isolation and characterization of exosomes from cell culture supernatants and biological fluids
    Clotilde Thery
    Institut Curie, Paris, France
    Curr Protoc Cell Biol . 2006
    ..This unit describes different approaches for exosome purification from various sources, and discusses methods to evaluate the purity and homogeneity of the purified exosome preparations...
  18. doi request reprint Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression
    Angélique Bobrie
    Institut Curie Centre de Recherche, INSERM U932, Paris, France
    Cancer Res 72:4920-30. 2012
    ..Our findings offer in vivo validation of the concept that exosome secretion can exert key pathophysiologic roles during tumor formation and progression, but they also highlight the idiosyncratic character of the tumor context...
  19. pmc MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation
    Michael Fricker
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK
    J Neurosci 32:2657-66. 2012
    ..Our data show that blocking MFG-E8-dependent phagocytosis preserves live neurons, implying that phagocytosis actively contributes to neuronal death during brain inflammation...
  20. doi request reprint Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles
    Marina Colombo
    Institut Curie Section Recherche, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Cell Sci 126:5553-65. 2013
    ..The results reveal a role for selected ESCRT components and accessory proteins in exosome secretion and composition by HeLa-CIITA. They also highlight biogenetic differences in vesicles secreted by a tumour cell line and primary DCs. ..
  21. pmc MFGE8 does not influence chorio-retinal homeostasis or choroidal neovascularization in vivo
    William Raoul
    INSERM, U968, Paris, France
    PLoS ONE 7:e33244. 2012
    ..We studied the effect of MFGE8 deficiency on retinal homeostasis with age and on choroidal neovascularization (CNV) in mice...
  22. doi request reprint Exosomes and communication between tumours and the immune system: are all exosomes equal?
    Angélique Bobrie
    Institut Curie, Section Recherche, 26 Rue d Ulm, 75005 Paris, France
    Biochem Soc Trans 41:263-7. 2013
    ....
  23. ncbi request reprint TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway
    Nathalie Amzallag
    Molecular Engines Laboratories, 20 Rue Bouvier, 75011 Paris and Institut Curie, Paris, France
    J Biol Chem 279:46104-12. 2004
    ..Altogether, these data identify a novel role for TSAP6 in the export of TCTP and indicate that this multipass membrane protein could have a general role in the regulation of vesicular trafficking and secretion...
  24. doi request reprint An essential role for decorin in bladder cancer invasiveness
    Mohamed El Behi
    Institut Curie Research Center, Paris, France INSERM U932, Paris, France
    EMBO Mol Med 5:1835-51. 2013
    ..We thus propose decorin as a new therapeutic target for these aggressive tumours. ..