Affiliation: Institut Pasteur
- DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cellsLudovic Tailleux
INSERM EMI 0013 Institut Universitaire d Hématologie, Assistance Publique Hopitaux de Paris, France
J Exp Med 197:121-7. 2003..Thus, as for human immunodeficiency virus (HIV), which is captured by the same receptor, DC-SIGN-mediated entry of M. tuberculosis in DCs in vivo is likely to influence bacterial persistence and host immunity...
- Constrained intracellular survival of Mycobacterium tuberculosis in human dendritic cellsLudovic Tailleux
Institut National de la Santé et de la Recherche Médicale EPI 0013 and Laboratoire d Immunologie Cellulaire et Immunopathologie de l Ecole Pratique des Hautes Etudes, Hopital Saint Louis, 1 avenue C Vellefaux, 75010 Paris, France
J Immunol 170:1939-48. 2003..DCs have evolved unique subcellular trafficking mechanisms to achieve their Ag-presenting functions when infected by intracellular mycobacteria...
- Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophagesVania Rosas-Magallanes
Unit of Mycobacterial Genetics, Institut Pasteur, Paris, France
Infect Immun 75:504-7. 2007..Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells...
- Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophagesLudovic Tailleux
Institut Pasteur, Unit of Mycobacterial Genetics, Paris, France
PLoS ONE 3:e1403. 2008..Here, for the first time, we have been able to investigate gene expression changes in both Mycobacterium tuberculosis, a major human pathogen, and its human host cells, macrophages and dendritic cells...
- Is adipose tissue a place for Mycobacterium tuberculosis persistence?Olivier Neyrolles
Genetics and Biochemistry of Microorganisms, Centre National de la Recherche Scientifique, Paris, France
PLoS ONE 1:e43. 2006..Long-term mycobacterial persistence in the lungs has been reported, but this may not sufficiently account for strictly extra-pulmonary TB, which represents 10-15% of the reactivation cases...
- DC-SIGN induction in alveolar macrophages defines privileged target host cells for mycobacteria in patients with tuberculosisLudovic Tailleux
Institut Pasteur, Unite de Genetique Mycobacterienne, Paris, France
PLoS Med 2:e381. 2005....
- Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosisLuis B Barreiro
CNRS FRE2849, Unit of Molecular Prevention and Therapy of Human Diseases, Institut Pasteur, Paris, France
PLoS Med 3:e20. 2006..We reasoned that if DC-SIGN interacts with M. tuberculosis, as well as with other pathogens, variation in this gene might have a broad range of influence in the pathogenesis of a number of infectious diseases, including tuberculosis...
- Population variation in NAIP functional copy number confers increased cell death upon Legionella pneumophila infectionMichele Boniotto
Unit of Human Evolutionary Genetics, Institut Pasteur, F 75015 Paris, France
Hum Immunol 73:196-200. 2012..We postulate that the NAIPFull gene duplication might have been evolutionary maintained, or even selected for, because it may confer an advantage to the host against flagellated bacteria...
- How is the phagocyte lectin keyboard played? Master class lesson by Mycobacterium tuberculosisLudovic Tailleux
Institut Pasteur, Unite de Genetique Mycobacterienne, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
Trends Microbiol 11:259-63. 2003..A set of recent reports has shed light on exploitation of phagocyte surface lectins by the tubercle bacillus. These findings could lead the way to innovative therapeutic approaches...
- Activation of type III interferon genes by pathogenic bacteria in infected epithelial cells and mouse placentaHelene Bierne
Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
PLoS ONE 7:e39080. 2012..In addition, the feto-placental tissue was responsive to IFN-λ2. Together, these results suggest that IFN-λ may be an important modulator of the immune response to Gram-positive intracellular bacteria in epithelial tissues...
- [DC-SIGN, a key receptor of Mycobacterium tuberculosis?]Ludovic Tailleux
Med Sci (Paris) 19:658-60. 2003