Olga Soutourina

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. doi request reprint RcsB plays a central role in H-NS-dependent regulation of motility and acid stress resistance in Escherichia coli
    Evelyne Krin
    Institut Pasteur, Unité de Génétique des Génomes Bactériens, CNRS URA2171, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Res Microbiol 161:363-71. 2010
  2. pmc Genome-wide identification of regulatory RNAs in the human pathogen Clostridium difficile
    Olga A Soutourina
    Laboratoire Pathogenèse des Bactéries Anaérobies, Institut Pasteur, Paris, France
    PLoS Genet 9:e1003493. 2013
  3. doi request reprint CymR, the master regulator of cysteine metabolism in Staphylococcus aureus, controls host sulphur source utilization and plays a role in biofilm formation
    Olga Soutourina
    Unité de Génétique des Génomes Bactériens, CNRS URA 2171, France
    Mol Microbiol 73:194-211. 2009
  4. pmc The pleiotropic CymR regulator of Staphylococcus aureus plays an important role in virulence and stress response
    Olga Soutourina
    Institut Pasteur, Unité de Génétique des Génomes Bactériens, CNRS URA 2171, Paris, France
    PLoS Pathog 6:e1000894. 2010
  5. pmc Global control of cysteine metabolism by CymR in Bacillus subtilis
    Sergine Even
    Unité de Génétique des Génomes Bactériens, Institut Pasteur, URA CNRS 2171, 75724 Paris Cedex 15, France
    J Bacteriol 188:2184-97. 2006
  6. pmc Conversion of methionine to cysteine in Bacillus subtilis and its regulation
    Marie Francoise Hullo
    Unité de Génétique des Génomes Bactériens, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Bacteriol 189:187-97. 2007
  7. doi request reprint Complex phenotypes of a mutant inactivated for CymR, the global regulator of cysteine metabolism in Bacillus subtilis
    Marie Francoise Hullo
    Unité de Génétique des Génomes Bactériens, Institut Pasteur, Paris, France
    FEMS Microbiol Lett 309:201-7. 2010
  8. doi request reprint The CymR regulator in complex with the enzyme CysK controls cysteine metabolism in Bacillus subtilis
    Catherine Tanous
    Institut Pasteur, UnitédeGénétique des Génomes Bactériens, Plate forme de Biophysique des Macromolecules et de leurs interactions, 75724 Paris Cedex 15, France
    J Biol Chem 283:35551-60. 2008
  9. pmc Decrypting the H-NS-dependent regulatory cascade of acid stress resistance in Escherichia coli
    Evelyne Krin
    Unité de Plasticité du Génome Bactérien, Institut Pasteur, France
    BMC Microbiol 10:273. 2010
  10. ncbi request reprint Effect of mild acid pH on the functioning of bacterial membranes in Vibrio cholerae
    Florence Hommais
    Unité de Génétique des Génomes Bactériens, Institut Pasteur, Paris, France
    Proteomics 2:571-9. 2002

Collaborators

Detail Information

Publications11

  1. doi request reprint RcsB plays a central role in H-NS-dependent regulation of motility and acid stress resistance in Escherichia coli
    Evelyne Krin
    Institut Pasteur, Unité de Génétique des Génomes Bactériens, CNRS URA2171, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Res Microbiol 161:363-71. 2010
    ..In addition, we showed that H-NS positively affects motility via the flhDC master operon repression by RcsB. This substantiates the central role of RcsB in H-NS-mediated control of motility and acid stress resistance...
  2. pmc Genome-wide identification of regulatory RNAs in the human pathogen Clostridium difficile
    Olga A Soutourina
    Laboratoire Pathogenèse des Bactéries Anaérobies, Institut Pasteur, Paris, France
    PLoS Genet 9:e1003493. 2013
    ..difficile sRNAs provides a firm basis for future RNome characterization and identification of molecular mechanisms of sRNA-based regulation of gene expression in this emergent enteropathogen...
  3. doi request reprint CymR, the master regulator of cysteine metabolism in Staphylococcus aureus, controls host sulphur source utilization and plays a role in biofilm formation
    Olga Soutourina
    Unité de Génétique des Génomes Bactériens, CNRS URA 2171, France
    Mol Microbiol 73:194-211. 2009
    ..aureus via an ica-independent mechanism. These data indicate that fine-tuning of sulphur metabolism plays an important part in the physiology of this major pathogen and its adaptation to environmental conditions and survival in the host...
  4. pmc The pleiotropic CymR regulator of Staphylococcus aureus plays an important role in virulence and stress response
    Olga Soutourina
    Institut Pasteur, Unité de Génétique des Génomes Bactériens, CNRS URA 2171, Paris, France
    PLoS Pathog 6:e1000894. 2010
    ..aureus inside macrophages, whereas virulence of the DeltacymR mutant is highly impaired in mice. These data indicate that CymR plays a major role in virulence and adaptation of S. aureus for survival within the host...
  5. pmc Global control of cysteine metabolism by CymR in Bacillus subtilis
    Sergine Even
    Unité de Génétique des Génomes Bactériens, Institut Pasteur, URA CNRS 2171, 75724 Paris Cedex 15, France
    J Bacteriol 188:2184-97. 2006
    ..Transcriptome analysis of a delta cymR mutant and the wild-type strain also brought out significant changes in the expression level of a large set of genes related to stress response or to transition toward anaerobiosis...
  6. pmc Conversion of methionine to cysteine in Bacillus subtilis and its regulation
    Marie Francoise Hullo
    Unité de Génétique des Génomes Bactériens, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Bacteriol 189:187-97. 2007
    ..The addition of O-acetyl-serine prevented the formation of this protein-DNA complex...
  7. doi request reprint Complex phenotypes of a mutant inactivated for CymR, the global regulator of cysteine metabolism in Bacillus subtilis
    Marie Francoise Hullo
    Unité de Génétique des Génomes Bactériens, Institut Pasteur, Paris, France
    FEMS Microbiol Lett 309:201-7. 2010
    ....
  8. doi request reprint The CymR regulator in complex with the enzyme CysK controls cysteine metabolism in Bacillus subtilis
    Catherine Tanous
    Institut Pasteur, UnitédeGénétique des Génomes Bactériens, Plate forme de Biophysique des Macromolecules et de leurs interactions, 75724 Paris Cedex 15, France
    J Biol Chem 283:35551-60. 2008
    ..We propose an original model, supported by the determination of the intracellular concentrations of the different partners, by which CysK positively regulates CymR in sensing the bacterial cysteine pool...
  9. pmc Decrypting the H-NS-dependent regulatory cascade of acid stress resistance in Escherichia coli
    Evelyne Krin
    Unité de Plasticité du Génome Bactérien, Institut Pasteur, France
    BMC Microbiol 10:273. 2010
    ..H-NS regulates the acid stress resistance. The present study aimed to characterize the H-NS-dependent cascade governing the acid stress resistance pathways and to define the interplay between the different regulators...
  10. ncbi request reprint Effect of mild acid pH on the functioning of bacterial membranes in Vibrio cholerae
    Florence Hommais
    Unité de Génétique des Génomes Bactériens, Institut Pasteur, Paris, France
    Proteomics 2:571-9. 2002
    ..Our results suggest that V. cholerae is able to sense a moderate decrease in pH and to modify accordingly its structure and physiology...
  11. pmc Tissue compartment analysis for biomarker discovery by gene expression profiling
    Antoine Disset
    UPMC Univ Paris 06, UMRS 872, Laboratoire de Génomique, Physiologie et Physiopathologie Rénales, Paris, France
    PLoS ONE 4:e7779. 2009
    ..As an alternate approach, we developed a tissue compartment analysis (TCA) method to assess the cell composition of tissue samples, and applied it to standardize data and to identify biomarkers...